Acute exacerbation of interstitial lung disease; subgroup analysis for causes, risk factors for mortality rate, and steroid responsiveness

( Seung Hyun Yong ),( Ah Young Leem ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Park ),( Hye Jin Jang ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Interstitial Lung Disease (ILD) has known as a poor prognosis disease, particularly idiopathic pulmonary fibrosis (IPF). Corticosteroid is widely used for treatment of acute exacerbation (AE)-ILD. This study aims to clarify efficacy of corticosteroid use, and compare the mortality rate depending on the subgroups of ILD. Materials and Methods: We collected the data from the patients who have diagnosed ILD and visited emergency room (ER) with the respiratory symptoms from January 1, 2016 to December 31, 2018. We classified AE-ILD patients into 3 groups depending on methylprednisolone dose per kilogram. Also, we compared the mortality of IPF patients to that of non-IPF patients. Results: A total case of AE-ILD visited ER from 2016 to 2018 was 209 cases, including IPF cases (n=122) and non-IPF cases (n=87). We divided total patients (n=209) into three groups depending on steroid use, and these include group 1 of 0-0.49 mg/kg (n=78), group 2 of 0.5-0.99 mg/kg (n=58), and above 1.0 mg/kg (n=41), each. We found poor prognosis from the cases of IPF compared to non-IPF cases (p=0.029, OR 2.463). Furthermore, there was significant differences of mortality rate according to steroid dose (p=0.036, OR 1.712), CRP elevation (p=0.016, OR 1.004), and intubated case (p=0.000, OR 8.152). Also, we categorized IPF (n=122) to non-IPF cases (n=87) and analyzed the mortality rate. Most of the patients were death from ILD itself (n=23, 63.9%), Pneumonia(n=8, 22.2%), and Lung cancer (n=5, 13.9%). Bacterial infection (n=26) was dominant cause of AE, followed by fungal infection (n=15), and viral infection (n=10). Conclusions: This retrospective analysis of corticosteroid treatment shows more fatal outcome when we use high dose steroid in AE-ILD cases, and there was significant difference in mortality rate depending on the subgroup of ILD and medical background, such as intubation status, higher CRP level, and IPF cases.

사업장 근로자의 건강위험 평가도구 개발

정규철,이용애,홍윤철,조희숙,박혜숙,임현술,하은희 이화여자대학교 환경문제연구소 1998 이화환경연구 Vol.2 No.-

Health Risk Appraisal(HRA) is usually defined as a process by which we expect of individual's chances of acquiring specific diseases within a defined period of time. The concept of worksite as an area of health maintenance and promotion is newly developing. Our movement for health promotion of employees has been increasingly known in the worksite. The aim of this study is to develop health risk appraisal tools about health promotion at the worksite for employees. We performed this study by two steps: one step was to develop a HRA questionnaire of worksites in Korea, another was to evaluate the reliability of the questionnaire. For developing HRA questionnaire, we reviewed scientific examples at first, and then weighted the score by delphi. To evaluate the reliability of developed questionnaire, we carried out survey by test-retest method. A total of 131 employees completed HRA questionnaire on two times. The results are as follows. The total score of health risk in unhealthy workers was higher than that of healthy workers. The range of test-retest reliability of responses to the questionnaire was 0.57-0.94. Therefore it seems that this questionnaire was very suitable to assess the health behavior of workers. In conclusion, the developed HRA questionnaire can be used as a tool for evaluating health behavior and for providing health counseling materials.

토란의 황화경으로부터 캘러스 형성 및 식물체 재생

윤애화,이지영,임순희,김현정,안장순 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

토란의 기지 shoot를 암배양하여 절간이 신장한 황하경을 얻고 이황하경의 절편을 계대배양하여 기내증식을 시도하였다. 황하경은 NAA 0.2mg/ℓ가 첨가된 배지에서 가장 길게 신장하였다. 황하경은 자구형성형이 모구배대형보다 길게 신장하였다. 호르몬이 첨가된 거의 모든 배지에서 protocorm이 형성되었으나 0.2mg/ℓ NAA + 0.2mg/ℓ BA를 첨가한 배지에서 특히 많이 형성되었고 이 protocorm을 MS기본 배지에 옮겼을 때 8.5%의 재분화율을 보였다. Etiolated stems with elongated internodes were obtained from the in vitro culture of shoots of Colocasia esculenta schout under dark condition and plant differntiation was achived by subculturing the ethiolated stem segments. The etiolated stems elongates better on the media containing 0.2mg/ℓNAA than of those lacking it. Subculture of the etiolated stem segments produced protocorm-like structures in all the media examined. The medium containing 0.2mg/ℓNAA and 0.2mg/ℓBA produced the higest number of protocorm-like structure, which regenerated into plantets at 85% when transferred to phytohormone-free MS medium.

토란병 제조 전처리 과정 중의 토란의 이화학적 특성에 관한 연구

김은경,정은경,이현옥,염초애 동아시아식생활학회 1995 동아시아식생활학회지 Vol.5 No.3

Studies were carried out to investigate physicochemical properties of taro during the pretreatment process of making Toranbyung. Seventeen kinds of amino acids were found in taro. Aspartic acid and glutamic acid were most plentiful among those amino acids. Essential amino acids were about 42.7% of the total amino acids. Sulfur containing amino acids, methionine and cystine were about 2.7%. The amylograph indicated that the initial temperature triggering gelatinization of both rice flour mixed with taro and glutinous rice flour mixed with taro increased as the amount of taro increased. But the maximum viscosity of rice flour mixed with taro did not increase as the amount of taro increased while the maximum viscosity of glutinous rice flour mixed with taro increased as the amount of taro increased. And the peak temperature of both rice flour mixed with taro and glutinous rice flour mixed with taro increased as the amount of taro increased. The alkali degree of insoluble ash was higher than that of soluble ash. Glutinous rice dough had more total sugar than rice dough. Yellowness of rice dough was higher than that of glutinous rice dough.

토란병의 질감적 특성에 관한 연구

김은경,정은경,이현옥,염초애 동아시아식생활학회 1995 동아시아식생활학회지 Vol.5 No.3

The objective of this study was to evaluate Toranbyung, according as the ingredients of Toranbyung were changed in various phases: firstly, mixing of taro with either rice flour or glutinous rice flour, and secondly, the amount of taro to be mixed with either rice flour or glutinous rice flour. The results were as follows; According to the sensory evaluation, Toranbyung made from glutinous rice flour and 40% taro ingredients met with the most favorable responses except flavor. In the case of Toranbyung made from rice flour, those made with 50% taro ingredients were most favored in taste, flavor, moisture, color, consistency and texture. With respect to the rheological properties of Toranbyung, hardness, gumminess and springiness of Toranbyung made from glutinous rice flour were better. As the amount of taro increased, Toranbyung made from glutinous rice flour decreased in springiness, hardness, gumminess, and chewiness. As a result, Toranbyung made from glutinous rice flour and 40% taro ingredients and Toranbyung made from rice flour and 50% taro ingredients received the most favorable sensory evaluation.

사업장 근로자의 건강위험 평가도구 개발

홍윤철,임현술,하은희,정규철,조희숙,박혜숙,이용애 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

Health Risk Appraisal(HRA) is usually defined as a process by which we expect of individual's chances of death or acquiring specific diseases within a defined period of time. The concept of worksite as an area of health maintenance and promotion is newly developing. Our movement for health promotion of employees has been increasingly known in the worksite. The aim of this study is to develop health risk appraisal tools about health promotion at the worksite for employees. We performed this study by two steps; one step was to develop a HRA questionnaire of worksites in Korea, another was to evaluate the reliability of the questionnaire. For developing HRA questionnaire, we reviewed scientific examples at first, and then weighted the score by delphi. To evaluate the reliability of developed questionnaire, we carried out survey by test-retest method. A total of 131 employees completed HRA questionnaire on two times. The results are as follows. The total score of health risk in unhealthy workers was higher than that of healthy workers. The range of test-retest reliability of responses to the questionnaire was 0.57-0.94. Therefore it seems that this questionnaire was very suitable to assess the health behavior of workers. In conclusion, the developed HRA questionnaire can be used as a tool for evaluating health behavior and for providing health counseling materials.

사업체 급식의 HACCP 제도 도입을 위한 인지도 조사

이헌옥,심재영,신현아,정덕화,엄애선 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.3

For the introduction of HACCP to industry food service, a survey was conducted from 150 dieticians and 40 managers on their recognition on HACCP system. The questionnaire of the survey included the status of current food safety management, management responsibilities, recognition on HACCP, problems in HACCP introduction. The majority of respondents was satisfied with the current food safety management, and the food service managers were more confident than dieticians in terms of food safety. Foodservice managers (100%) and dieticians (96%) recognized HACCP system; however, they responded the application of HACCP to industry food service were only 27% and 12.5%, respectively. They pointed out the reasons that they cannot introduce HACCP to their industry food service were the lack of benefits and good facilities. Dieticians strongly recognized the need of correction of food safety management in industry food service, compared with food service managers. The results suggest that the introduction of HACCP to industry food service should be accomplished by continuous education and information on food safety, improving facilities and a variety of benefits to HACCP-implemented companies from the government.

S-471 Successful treatment with rituximab in cisplatin-induced refractory HUS patient

( Ji Ae Yang ),( Hyun Woo Kim ),( Sun Ae Han ),( Byungchul Shin ),( Hyun Lee Kim ),( Jong Hoon Chung ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Successful treatment with rituximab in cisplatin-induced refractory hemolytic-uremic syndrome patient Ji ae Yang, Hyun Woo Kim, Sun Ae Han, Byung Chul Shin, Hyun Lee Kim and Jong Hoon Chung Department of Internal Medicine, Division of Nephrology, Chosun University Medical School, Gwangju, Republic of Korea Abstract Hemolytic uremic syndrome (HUS) is a relatively rare disease that can have devastating consequences. It classically includes the triad of microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury. HUS may be associated with a variety of etiologies, and chemotherapeutic agents including mitomycin, cisplatin, bleomycin and gemcitabine have also been reported to be associated with HUS. A36-year-old woman patient with cervical cancer wasreceived chemotherapy with four cycles of cisplatin at 60 mg/m2 and radiotherapy. She complained of dizziness and oliguria. Microangiopathic hemolytic anemia was developed and rapidly declining renal function with proteinuria and hematuria. In spite of hemodialysis, plasmapheresis and corticosteroid therapy, the patient’s condition continued to deteriorate. After aggressive therapy with rituximab, MHA and thrombocytopenia was recovered. However, renal function was not recovered and the patient was maintained on regular hemodialysis. In this case, we report the successful treatment with rituximab in cisplatin-induced refractory HUS patient. Keywords: Hemolytic uremic syndrome, Cisplatin, Rituximab

LETTER TO THE EDITOR : Native valve endocarditis due to extended spectrum b-lactamase producing Klebsiella pneumoniae

( Hyun Ae Jung ),( Young Eun Ha ),( Da Min Kim ),( Ji Hyun Park ),( Cheol In Kang ),( Doo Ryeon Chung ),( Seung Woo Park ),( Ki Ik Sung ),( Jae Hoon Song ),( Kyong Ran Peck ) 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.3

Klebsiella species are common pathogensthat cause community-onsetand hospital-acquired pneumonia,intra-abdominal infections, andbloodstream infections. Infective endocarditisdue to Klebsiella species israre, accounting for less than 1% ofcases, and is frequently accompaniedby complications and a high in-hospitalmortality rate [1]. Moreover, withthe emergence of extended-spectrumb-lactamase (ESBL)-producing Enterobacteriaceae,endocarditis due toESBL-producing Klebsiella pneumonia(ESBL-KP) is of concern due to thelimited treatment options and notoriouslyhigh morbidity and mortality. Hospitalization is a significant riskfactor for bloodstream infections dueto ESBL-producing Enterobacteriaceae,but no cases of health-care-associatednative valve endocarditis causedby ESBL-KP have been reported. Here,we report a case of health-care-associatedinfective endocarditis due toESBL-KP with multiple metastaticinfectious complications, and discussthe optimal treatment strategies.

Design of Ergonomic Front-Entry Sitting Toilet System for People using Wheelchairs

Hyun Ae Chung,Jemo Park,Jung Bo Hwang,Hee Dong Kim,Hwa Shik Jung 대한인간공학회 2016 大韓人間工學會誌 Vol.35 No.5

Objective:The objective of this study is to develop an ergonomic toilet system along with constituent facilities that can be used with the front-entry sitting method when transferring from wheelchair to the toilet stool, instead of using the back-entry sitting method which is currently used. This system can offer more ease, convenience and safety for wheelchair users when using the restroom. Background: For users with disabilities, even a dedicated handicapped toilet requires maneuvering, especially when in a wheelchair. To transfer from wheelchair to the current back-entry sitting toilet, users need to get closer to the toilet and then turn or twist after erecting their body to get onto the toilet. This method induces inconvenience as well as secondary injury by falling when transferring to/from toilet. Method: To design a front-entry sitting toilet system, an ergonomics approach was applied which introduces a new design concept for people using wheelchairs. Using this toilet system, the wheelchair users don"t need to turn or twist but can simply slide forward off the wheelchair directly onto the toilet stool in an easier and safer way. Results: The newly developed front-entry sitting toilet system is easier and safer for wheelchair users, and also space efficient requiring only two-thirds of the space of existing handicapped toilet. It is also usable by both individuals with disabilities and the general population. Conclusion: With the spread of the front-entry sitting toilet system developed in this study, wheelchair users can benefit from enhanced convenience and safety as well as significant restroom space savings. Additional effects can also be achieved such as improved self-esteem of people with disabilities by enabling to use the toilet on their own. Application: The newly developed front-entry sitting toilet system should enhance toilet accessibility to wheelchair users and the elderly. Introduction is needed with efforts at the national policy level and a macroscopic objective to promote the health and safety of the handicapped.