退行性關節炎 韓方治療에 對한 最近 硏究 動向 : 臨床硏究 方法論을 中心으로 Herbal Medicines in the Treatment of Osteoarthritis in Pubmed and Chinese Medical Journals

서병관,류성룡,이송실,허정은,백용현,이재동,최도영,조윤제,김남재,박동석 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.

급성 신부전증을 초래한 Wegener씨 육아종증 1례

박일,임영국,최성도,임현성,정종훈,문철웅 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.1

호흡기 증상과 급성신부전증이 발생된 환자에서 혈액검사, 혈청학적 검사, 방사선학적 검사, ANCA test 및 신생검을 통하여 Wegener씨 육아종증을 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 본질환이 재발하는 경우는 cyclophosphamide에서 azathioprine으로 치료약을 바꾸었을때나 특히 ANCA 반응이 양성으로 지속시 발생한다. Godman과 Churg는 상기도의 괴사성 육아성 병변, 하기도의 괴사성 혈관염, 국한성 신사구체염을 진단의 지표로 삼았다. 특히 상기도 점막의 생검 소견상 괴사성 육아성 혈관염이 보이면 일단 본 증을 의심하고 폐 생검과 신 생검이 필요로 한다. Wegener's Granulomatosis is an uncommon disease which is characterized by granulomatous vasculitis of both lung and kidney. Although the cause is unknown, it's suggesting that disordered immunity with both antibody and cell-mediated tissue damage occurs. The disease affects patients of any age. Characteristic clinical manifestations are diverse but in clude saddle nose deformity, sinusitis, productive coughing, myalgia, fever etc. Characteristic laboratory abnormalities include elevated ESR, neutrophilic leukocytosis, anemia and positive test for ANCA test. Renal biopsy is important for diagnosis. The treatment of choice is a combination of corticosteroid and cytotoxic agent. A53-year-old woman was admitted to our hospital because of productive coughing, short of breathing, oliguria, nausea, and vomiting. Three months ago, she was suffered from general weakness, poor appetite, tingling sensation on extremity, and loosely stool. Twenty days ago, above symptoms were aggravated, she admitted local clinic. Six days ago, because of CBC showed anemia , she was done transfusion. During transfusion, she was developed urticaha then productive coughing, dyspnea, increased serum BUN and creatinine levels. She was transferred to our hospital under the impression of ARF. On the admission, she was chronic ill-looking appearance with pale conjunctiva, tachypnea, dyspnea, and cold sweating. We have checked the patient by CBC, serum and serologic test, X-ray, ANCA test, renal biopsy. With renal biopsy microscopic examination study revealed necrotizing vasculitis, We treated a combination therapy with methyl-PDS and cyclophosphamide. She had a good response. So we report wegener's granulomatosis with the review of relevant literature.

간월호 퇴적토에서의 영양염류 용출 특성 분석

황순호 ( Soonho Hwang ),전상민 ( Sang Min Jun ),이도길 ( Do Gil Lee ),김석현 ( Seok Hyeon Kim ),이현지 ( Hyunji Lee ),김계웅 ( Kyeung Kim ),강문성 ( Moon Seong Kang ) 한국농공학회 2018 한국농공학회 학술대회초록집 Vol.2018 No.-

간월호는 서산시에 위치한 수혜면적이 6,446 ha에 이르는 담수화된 농업용 저수지로서, 해수 차단 후 수질이 지속적으로 악화되어 최근 들어 호내 수질이 농업용수 목표수질인 Ⅳ등급을 상회하는 등 농업용수로 활용에 어려움을 겪고 있다. 이에 따라 수질 악화 원인을 규명하기 위한 다양한 연구가 이루어지고 있으며, 수질 오염을 야기하는 상류 유역에 대한 연구뿐만 아니라 호내 퇴적물 관리 및 퇴적물로 인한 영양염류의 용출 문제에 대한 연구도 중요하다고 할 수 있다. 따라서 본 연구에서는 간월호 퇴적토로부터의 호내 수질 오염 기여도를 평가하기 위한 기초자료로서 용출 실험을 실시하였다. 용출 실험은 간월호 호내 3지점 (상류, 중류, 하류)에 대해 각각 호기성, 혐기성 실험을 2회 반복하였으며, 오염물질 조사 항목은 TOC, NH₄-N, NO₂-N, NO₃-N, PO₄-P, T-P, T-N, COD로 총 8항목이다. 간월호 용출 실험에 앞서 용출 실험 재료인 퇴적토의 간월호 퇴적물의 오염도를 확인하기 위하여, 입도 분석뿐만 아니라 강열감량, 유기물함량, T-N, T-P 항목에 대한 분석을 실시하였으며, 퇴적토는 풍건 및 2 mm 체 선별 후 지름 10cm, 높이 44cm의 유리컬럼에 충진하여 이용하였다. 현장 조건 중 호기 및 혐기 조건을 모의하기 위해, 호기성 조건은 DO의 일정 농도가 유지되도록 폭기 장치를 이용하였으며, 혐기조건은 알루미늄 호일로 컬럼 외부를 감싸 빛을 차단하는 동시에 질소가스를 계속 주입하여 혐기상태를 유지하였다.

State Indicator of Water Quality for Surface Water and Groundwater in Agriculture

Kim, Min-Kyeong,Jung, Goo-Bok,Ro, An-Sung,Choi, Seung-Chul,Choi, Won-Il,Kim, Eun-Jeong,Lee, Jong-Eun,Yun, Yeo-Uk,Kim, Kab-Cheol,Ko, Do-Young,Kim, Byeong-Ho,Kim, Hyeon-Ji,Park, Sang-Jo,Lee, Seong-Tae,H 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5

Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990's. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate ($NO_3{^-}$) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.

State Indicator of Water Quality for Surface Water and Groundwater in Agriculture

Min-Kyeong Kim,Goo-Bok Jung,An-Sung Ro,Seung-Chul Choi,Won-Il Choi,Eun-Jeong Kim,Jong-Eun Lee,Yeo-Uk Yun,Kab-Cheol Kim,Do-Young Ko,Byeong-Ho Kim,Hyeon-Ji Kim,Sang-Jo Park,Seong-Tae Lee,Jae-Young Heo,S 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5

Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990’s. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate(NO₃<SUP>-</SUP>) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.

Diplotriaena anthreptis (Nematoda: Spirurina) from Eurasian jay from in the Republic of Korea

Seong jun Park,Eui ju Hong,Si yun Ryu,Joon Seok Chae,Hyeon cheol Kim,Jin ho Park,Kyoung Seong Choi,Do Hyeon Yu,Bae keun Park 대한수의학회 2014 대한수의학회 학술대회발표집 Vol.2014 No.-

Metacercariocidal effects and infection status of Gymnophalloides seoi in oysters

Hyeon Cheol Kim,Eui Ju Hong,Si Yun Ryu,Joon Seok Chae,Jinho Park,Kyoung Seong Choi,Do Hyeon Yu,Bae Keun Park 한국예방수의학회 2019 예방수의학회지 Vol.43 No.2

We studied the infection rate of and various metacercariocidal approaches to controlling Gymnophalloides seoi for prevention of human infection in cultured and natural oysters in Korea. The selected survey areas were Aphae-do (Shinan-gun, Jeollanam-do), which is an endemic area for G. seoi, and Tongyeong (Geonsangnam-do), which is the main production area of oysters in Korea. In the Tongyeong area, the metacercariae of G. seoi were not detected in cultured oysters (0/201) or wild oysters (0/134). Seventy-two G. seoi metacercariae were observed in 33 of 265 natural oysters collected from Aphae-do; however, metacercariae were not detected in the cultured oysters (0/1101) purchased from the Daejeon Fish Market. To investigate the viability of G. seoi metacercariae, various metacercariocidal treatments were used with 3.5% saline and oyster juice used as positive controls. The metacercariae survived for 75.4 h in 3.5% saline and 112.6 h in oyster juice. After the metacercariocidal treatment, G. seoi metacercariae were survived for 13.29 min in tap water, < 20 sec in 4.3% vinegar, no effect in a rinse of the whole oyster body in 70°C water for 1 sec, but 1 sec in a rinse of the whole oyster body in 90°C water for 1 sec. The greatest metacercariocidal effect on G. seoi was from rinsing oysters in 90°C water followed by those from treatment with 20% ethyl alcohol, 4.3% vinegar, and tap water. However, we suggest that the most actual prevention to G. seoi human infection is rinsing the oysters with tap water for at least 30 min.

쯔쯔가무시병에 동반된 간질성 폐렴에 관한 연구

이현숙(Hyeon Suk Lee),김대수(Dae Soo Kim),진영주(Young Joo Chin),김성진(Seong Jin Kim),송형근(Hyeong Keon Song),성노현(No Hyeon Seong),이상도(Sang Do Lee),김명수(Myeong Su Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.1

Objectives: Interstitial penumonia is a major cause of death in scrub typhus but little is known about its pathology and pathogenesis. To study the clinical findings, pathology and pathogenesis of interstitial pneumonia in scrub typhus, we performed this study. Methods: We performed clinical evaluation, laboratory tests, radiological evaluation including high resolution CT and pulmonary function tests in 53 scrub typhus patients. Bronchoalveolar lavage(BAL) and transbronchial lung biopsy(TBLB) were done in patients with interstitial pneumonia and electron microscopic examination and immunofluorescence study including monoclonal antibody against Rickettsia tsutsugamushi were done. Results: 1) Interstitial pneumonia was found in 13(26%) patients. 2) Radiological findings: High-resolution CT showed diffuse ground glass opacity, thickening of bronchovascular bundie and prominent central core of secondary pulmonary lobule with minimal thickening of interlobular septum and there were no findings suggesting vasculitis 3) Cells in HAL fluid: total cell count, (46±9)×104/ml, alveolar macrophage, 68±17%, lymphocyte, 28±15% and neutrophil, 5±3% Pathologic finding(TBLH): 4) Light microscope: interstitial edema with mononuclear cell infiltration, mainly lymphocyte, without any evidence of vasculitis or perivasculitis 5) Immunofluorescence and eletron microscope ' IF study, using anti-Ig G,A,M, anti-Cg, anti-fibrinogen and anti-rickettsial Ab, revealed negative reaction. Electron photomicrograph revealed no rickettsial organism. Conclusion: In interstital pneumonia associated with scrub typhus we noted lymphocytosis in BAL fluid and interstitial inflammation in histopathology without any evidence of vasculitis. Thus vasculitis is not the only main pathology but other mechanism including immunopathogenesis may operate in the pathogenesis of intersititial pneumonia in scrub typhus

베체트 환자에서의 monocyte chemoattractant protein-1의 상승

도주호 ( Do Ju Ho ),정지현 ( Jeong Ji Hyeon ),박찬석 ( Park Chan Seog ),고지송 ( Go Ji Song ),김순섭 ( Kim Sun Seob ),최현철 ( Choe Hyeon Cheol ),손장명 ( Son Jang Myeong ),민도준 ( Min Do Jun ),박성환 ( Park Seong Hwan ),조철수 ( 대한내과학회 2003 대한내과학회지 Vol.65 No.4

Background: Monocyte chemoattractant protein-1 (MCP-1) belongs to C-C subfamily of chemokines, which stimulates the migration of monocytes. MCP-1 exerts various effects on the monocytes, including the induction of integrin and tissue factor, and synthesis

만성 활동성 간염에 병발한 재발성 Guillain-Barre 증후군

임현성 ( Im Hyeon Seong ),신양수 ( Sin Yang Su ),김원민 ( Kim Won Min ),최성도 ( Choe Seong Do ),정태홍 ( Jeong Tae Hong ),김만우 ( Kim Man U ),조경원 ( Jo Gyeong Won ),정원영 ( Jeong Won Yeong ) 대한내과학회 1993 대한내과학회지 Vol.44 No.2

Guillain-Barre syndrome complicating chronic active hepatitis is rare. In its antecedent and associated illness, various viral infections are commonly involved (esp. viral hepatitis). A classic features that allow diagnosis of GBS is ascending symmetrical weakness, areflexia, minimal sensory loss, and albuminocytological dissociation in CSF. A number of neurological complications of viral hepatitis have been reported, including hepatic coma, hemorrhages into the CNS, both subdural and intraparenchymal. encephalitis, meningitis, myelitis, isolated pyramidal tract and extrapyramidal tract dysfunction, Meniere`s disease, dermatomyositis, seizures, mononeuritis, plexitis, and psychiatric disturbances. But there were no reports about GBS complicating chronic active viral hepatitis in Korea until now. We report a case of GBS complicating chronic active hepatitis in a 41-year-old male.