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다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과
류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-
Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.
자궁경부 상피내 종양과 침윤성 자궁경부암에서의 FHIT 단백 발현 소실
이봉규(Bong Gyu Lee),이종섭(Jong Seob Lee),이동혁(Dong Hyeok Lee),김미진(Mi Jin Kim),이영기(Young Gi Lee),박윤기(Yoon Kee Park),이두진(Doo Jin Lee),이승호(Sung Ho Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
Objective : The author evaluated the relationship between the loss of Fhit and prognostic factors of invasive cervical carcinomas. Methods : The formalin prepared tissue specimens of 64 CINs and 27 invasive cervical carcinomas patients diagnosed and treated at the department of obstetrics and gynecology, Yeungnam university hospital from June 1977 to February 2001 were obtained. And then the tissue specimens were analysed & measured by immunohistochemical methods. Results : The loss of Fhit was significantly reduced in invasive cervical carcinomas compared to CINs. But we found there is no relationships between the loss of Fhit and prognostic factors, stage, tumor marker, lymphatic spread and radiation therapy of invasive cervical carcinomas. Conclusions : Although the loss of Fhit was not related to the precancerous lesion of cervix, we could confirm that the loss of Fhit was important in the progression of precancerous lesions to invasive cervical carcinomas.
Isolation and Analysis of the Enzymatic Properties of Thermophilic Fungi from Compost
Lee, Hanbyul,Lee, Young Min,Jang, Yeongseon,Lee, Sangjoon,Lee, Hwanhwi,Ahn, Byoung Jun,Kim, Gyu-Hyeok,Kim, Jae-Jin The Korean Society of Mycology 2014 Mycobiology Vol.42 No.2
To the best of our knowledge, this is the first report on thermophilic fungi isolated in Korea. Three species of thermophiles were isolated from compost and were identified as Myriococcum thermophilum, Thermoascus aurantiacus, and Thermomyces lanuginosus. They can grow at temperatures above $50^{\circ}C$ and produce high levels of cellulolytic and xylanolytic enzymes at high temperatures. Notably, the considerable thermostability of the endo-glucanase produced by T. aurantiacus has made the fungus an attractive source of industrial enzymes.
Lee, Kun Seok,Kwon, Jeong,Im, Jeong Hyeok,Lee, Chang Ryul,Park, Nam-Gyu,Park, Jong Hyeok American Chemical Society 2012 ACS APPLIED MATERIALS & INTERFACES Vol.4 No.8
<P>Size-tunable titanium oxide (TiO<SUB>2</SUB>) nanotube powders offering both a light-scattering effect and a light-harvesting function were synthesized by a fast and facile anodizing method. When used to prepare the TiO<SUB>2</SUB> layer for a photoanode, their photovoltaic performances were much worse than that of a nanocrystal TiO<SUB>2</SUB> layer. However, when the TiO<SUB>2</SUB> nanotube powders were used as a light-scattering layer on a nanocrystal TiO<SUB>2</SUB> layer, the highest conversion efficiency was obtained because of more noticeable light absorption of the longer wavelength, which was not attainable from a pure nanocrystal TiO<SUB>2</SUB> layer or the combination of nanocrystal TiO<SUB>2</SUB>/commercialized light-scattering particles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2012/aamick.2012.4.issue-8/am300892j/production/images/medium/am-2012-00892j_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am300892j'>ACS Electronic Supporting Info</A></P>
Dye-sensitized solar cells with Pt- and TCO-free counter electrodes
Lee, Kun Seok,Lee, Hang Ken,Wang, Dong Hwan,Park, Nam-Gyu,Lee, Jun Young,Park, O Ok,Park, Jong Hyeok Royal Society of Chemistry 2010 Chemical communications Vol.46 No.25
<P>Here for the first time, we demonstrate novel DSSCs with a Pt- and TCO-free counter electrode, which have a highly conductive polymer exhibiting high catalytic ability and charge transport, and the photovoltaic performance increases as we increase the PEDOT film conductivity.</P> <P>Graphic Abstract</P><P>Here for the first time, we demonstrate novel DSSCs with a Pt- and TCO-free counter electrode, which have a highly conductive polymer exhibiting high catalytic ability and charge transport. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc00432d'> </P>
Lee, Eonju,Kim, Tae Gyu,Park, Hee Chul,Yu, Jeong Il,Lim, Do Hoon,Nam, Heerim,Lee, Hyebin,Lee, Joon Hyeok The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.3
Purpose: To investigate the outcomes of patients with spinal metastases from hepatocellular carcinoma (HCC), who were treated by stereotactic body radiotherapy (SBRT). Materials and Methods: This retrospective study evaluated 23 patients who underwent SBRT from October 2008 to August 2012 for 36 spinal metastases from HCC. SBRT consisted of approximately 2 fractionation schedules, which were 18 to 40 Gy in 1 to 4 fractions for group A lesions (n = 15) and 50 Gy in 10 fractions for group B lesions (n = 21). Results: The median follow-up period was 7 months (range, 2 to 16 months). Seven patients developed grade 1 or 2 gastrointestinal toxicity, and one developed grade 2 leucopenia. Compression fractures occurred in association with 25% of the lesions, with a median time to fracture of 2 months. Pain relief occurred in 92.3% and 68.4% of group A and B lesions, respectively. Radiologic response (complete and partial response) occurred in 80.0% and 61.9% of group A and B lesions, respectively. The estimated 1-year spinal-tumor progression-free survival rate was 78.5%. The median overall survival period and 1-year overall survival rate were 9 months (range, 2 to 16 months) and 25.7%, respectively. Conclusion: SBRT for spinal metastases from HCC is well tolerated and effective at providing pain relief and radiologic response. Because compression fractures develop at a high rate following SBRT for spinal metastases from primary HCC, careful follow up of the patient is required.
NMR Study of the pH Effect on the DNA Binding Affinity of Human RPA
Lee, Min-Woo,Choi, Ju-Hyeok,Choi, Jae-Gyu,Lee, Ae-Ree,Lee, Joon-Hwa 한국자기공명학회 2016 Journal of the Korean Magnetic Resonance Society Vol.20 No.3
The replication protein A (RPA) plays a crucial role in DNA replication, recombination, and repair. RPA consists of 70, 32 and 14 kDa subunits and has high single-stranded DNA (ssDNA) binding affinity. The largest subunit, RPA70, mainly contributes to bind to ssDNA as well as interact with many cellular and viral proteins. In this study, we performed nuclear magnetic resonance experiments on the complex of the DNA binding domain A of human RPA70 (RPA70A) with ssDNA, d(CCCCC), at various pH, to understand the effect of pH on the ssDNA binding of RPA70A. The chemical shift perturbations of binding residues were most significant at pH 6.5 and they reduced with pH increment. This study provides valuable insights into the molecular mechanism of the ssDNA binding of human RPA.
Protection of Streptozotocin Induced Pancreatic β-cells Dameged by Codium fragile ethanol extract
Gyu-Hyeok Lee,Dae-Hee Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Diabetes mellitus was divided type 2 diabetes mellitus(T2DM), type 1 diabetes mellitus(T1DM). Espacially T2DM has the highest incidence Furthermore, treatment is most insulin administration, blood glucose-lowering drug. There is necessary to develop a treatment for diabetes mellitus through damaged cells protection and without side effect. T2DM generated oxidative stress in pancreatic β-cells due to hyperglycemia, which is a relation to β-cells mass decrease. Consequently, in this study used antioxidants known Codium fragile ethanol extract(CFE). CFE was studied antioxidants and anti-inflammatory however that was unknown anti-diabetic effect. CFE protected from cell death by streptozotocin. Furthermore, CFE meaningfully inhibited apoptosis ratio by streptozotocin, decreased cleaved caspase 3, and cleaved PARP expression level. More importantly, that has appeared intracellular ROS scavenging and activation superoxide 2, catalase expression level with inhibition apoptosis. In case of animal testing, diabetes induced to streptozotocin. And there performed oral administration of CFE. as the results CFE 50mg/kg treated rats was decreased the blood glucose level from 3 weeks.
( Hanbyul Lee ),( Young Min Lee ),( Yeongseon Jang ),( Sangjoon Lee ),( Hwanhwi Lee ),( Byoung Jun Ahn ),( Gyu Hyeok Kim ),( Jae Jin Kim ) 한국균학회 2014 韓國菌學會誌 Vol.42 No.2
To the best of our knowledge, this is the first report on thermophilic fungi isolated in Korea. Three species of thermophiles were isolated from compost and were identified as Myriococcum thermophilum, Thermoascus aurantiacus, and Thermomyces lanuginosus. They can grow at temperatures above 50oC and produce high levels of cellulolytic and xylanolytic enzymes at high temperatures. Notably, the considerable thermostability of the endo-glucanase produced by T. aurantiacus has made the fungus an attractive source of industrial enzymes.
한-일 교차언어검색에서의 질의 문맥 정보를 이용한 대역어 변환 확률 모델
이규찬(Gyu-Chan Lee),강인수(In-Su Kang),나승훈(Seung-Hoon Na),이종혁(Jong-Hyeok Lee) 한국정보과학회 언어공학연구회 2005 한국정보과학회 언어공학연구회 학술발표 논문집 Vol.2005 No.10
교차언어 검색 과정에서는 질의나 문서의 언어를 일치시키기 위한 변환 과정이 필수적이며, 이런 변환 과정에서 어휘의 중의성으로 인해 하나의 어휘에 대응하는 다수의 대역어가 생성됨으로써 사용자의 정보 욕구를 왜곡시켜 검색의 성능을 저하시킬 수 있다. 본 논문에서는 어휘 중의성 문제를 해결하기 위해서 질의의 문맥 정보를 이용하여 변환 질의의 확률을 구함으로써 중의성을 해소하는 방식을 제시하고, 질의의 길이, 중의도, 중의성을 가진 어휘의 비율 등에 따라서 성능이 어떻게 변하는지 비교함으로써 이 방법의 장점과 단점을 분석한다. 또한 현재의 단점을 보완하기 위한 차후 연구 방향을 제시한다.