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杜沖(Eucommiae Cortex)엑기스가 白鼠의 實驗的高指血症에 미치는 影響
丁明鉉,金庚完,李炳柱 조선대학교 약학연구소 1992 藥學硏究誌 Vol.14 No.1
This study was attempted to investigate the effect of Eucommiae Cortex extract on the activities of S-GOT S-GPT, and level of total lipid triglyceride β-lipoprotein phospholipid and total cholesterol in the serum of experimentally induced hyperlipermic rats, and on the effect of body, liver and spleen weight in rats. The activities of S-GOT S-GPT were remarkably decreased in all sample group, when compared with the control group. The level of total lipid phospholipid and total-cholesterol were remakably decreased in all sample group, and the level of triglyceride and β-lipoprotein were significantly decreased in all sample group. The body liver and spleen weight increased in hyperlipermic rats were significantly decreased by the administration of the extracts, especially spleen weight are remarkably decreased in all sample group.
Gyoung Wan Lee,Jae Hyo Kim,Min Sun Kim 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.13 No.1
Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes in long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in the CA1 area of the hippocampus during vestibular compensation. The input-output (I/O) relationships of fEPSP amplitudes and LTP induced by theta burst stimulation to Schaffer’s collateral commissural fibers were evaluated from the CA1 area of hippocampal slices at 1 day, 1 week, and 1 month after unilateral labyrinthectomy (UL). The I/O relationships of fEPSPs in the CA1 area was significantly reduced within 1 week post-op and then showed a non-significant reduction at 1 month after UL. Compared with sham-operated animals, there was a significant reduction of LTP induction in the hippocampus at 1 day and 1 week after UL. However, LTP induction levels in the CA1 area of the hippocampus also returned to those of sham-operated animals 1 month following UL. These data suggest that unilateral injury of the peripheral vestibular end organs results in a transient deficit in synaptic plasticity in the CA1 hippocampal area at acute stages of vestibular compensation.
Gyoung Wan Lee,Min Sun Kim 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
The purpose of this study was to evaluate the effects of the water extract of Samultang (SMT), a Chinese herb, on apoptotic cell death by H<sub>2</sub>O<sub>2</sub>-induced oxidative stress in SK-N-MC cells. A nuclear fragmentation was observed via fluorescence imaging 12 h after exposure to 30</SUB>ՌM H<sub>2</sub>O<sub>2</sub> and DNA laddering was detected via agarose electrophoresis gel. In addition, increases in sub-G1 phase and cleavage of the PARP protein were observed. However, treatment with SMT for 2 h prior to H<sub>2</sub>O<sub>2</sub> exposure significantly reduced apoptotic cell death induced by incubation with 30ՌM H<sub>2</sub>O<sub>2</sub> in SK-N-MC cells. Pre-incubation with water extract of SMT for 2 h prevented the H<sub>2</sub>O<sub>2</sub>-induced decrease in mitochondrial transmembrane potential. SMT also attenuated the increase in caspase-3 activity and the breakdown of PARP protein caused by H<sub>2</sub>O<sub>2</sub>-induced oxidative stress. These results suggest that the water extract of SMT provides inhibition of apoptotic cell death against oxidative injury in SK-N-MC cells.
Lee, Gyoung-Wan,Kim, Min-Sun The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
The purpose of this study was to evaluate the effects of the water extract of Samultang (SMT), a Chinese herb, on apoptotic cell death by $H_2O_2$-induced oxidative stress in SK-N-M C cells. A nuclear fragmentation was observed via fluorescence imaging 12 h after exposure to 30 ${\mu}M$ $H_2O_2$ and DNA laddering was detected via agarose electrophoresis gel. In addition, increases in sub-G1 phase and cleavage of the PARP protein were observed. However, treatment with SMT for 2 h prior to $H_2O_2$ exposure significantly reduced apoptotic cell death induced by incubation with 30 ${\mu}M$ $H_2O_2$ in SK-N-MC cells. Pre-incubation with water extract of SMT for 2 h prevented the $H_2O_2$-induced decrease in mitochondrial transmembrane potential. SMT also attenuated the increase in caspase-3 activity and the breakdown of PARP protein caused by $H_2O_2$-induced oxidative stress. These results suggest that the water extract of SMT provides inhibition of apoptotic cell death against oxidative injury in SK-N-MC cells.
Lee, Gyoung Wan,Kim, Jae Hyo,Kim, Min Sun The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.4
Vestibular compensation is a recovery process from vestibular symptoms over time after unilateral loss of peripheral vestibular end organs. The aim of the present study was to observe time-dependent changes in long-term potentiation (LTP) at Schaffer collateral-CA1 synapses in the CA1 area of the hippocampus during vestibular compensation. The input-output (I/O) relationships of fEPSP amplitudes and LTP induced by theta burst stimulation to Schaffer's collateral commissural fibers were evaluated from the CA1 area of hippocampal slices at 1 day, 1 week, and 1 month after unilateral labyrinthectomy (UL). The I/O relationships of fEPSPs in the CA1 area was significantly reduced within 1 week post-op and then showed a non-significant reduction at 1 month after UL. Compared with sham-operated animals, there was a significant reduction of LTP induction in the hippocampus at 1 day and 1 week after UL. However, LTP induction levels in the CA1 area of the hippocampus also returned to those of sham-operated animals 1 month following UL. These data suggest that unilateral injury of the peripheral vestibular end organs results in a transient deficit in synaptic plasticity in the CA1 hippocampal area at acute stages of vestibular compensation.
알코올성 간질환 변증 설문, DSOM, SF-36을 이용한 알코올성 간질환 환자의 금주 효과 연구
이재왕,홍상훈,박상은,손호영,김도경,이승연,이수영,김보경,강창완,이인선,Lee, Jae-Wang,Hong, Sang-Hoon,Park, Sang-Eun,Son, Ho-Young,Kim, Do-Gyoung,Lee, Seung-Yeon,Lee, Su-Young,Kim, Bo-Kyoung,Kang, Chang-Wan,Lee, In-Sun 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.2
Objectives : This study was done to evaluate the effect of stopping drinking, using alcoholic liver disease questionnaire, Diagnosis System of Oriental Medicine (DSOM) and Health Related Quality of Life (HRQOL). Methods : 49 men who satisfied the requirement participated in this trial. They stopped drinking for 6 weeks. They were analyzed using DSOM, alcoholic liver disease questionnaire and SF-36. The data were classified by age (<47,$\geq$48) and alcoholic intake per day (<100g,$\geq$100g). For HRQOL, the SF-36v2 Health Survey was used and Quality Metric Health Outcomes Scoring Software 2.0 (QualityMetric, Lincoln, RI, USA) was applied for the analysis. Results : The alcoholic liver disease questionnaire had a partial correlation with DSOM. Generally stopping drinking decreased Heat (熱). Especially in the group drinking over 100g per day, the correlation was high. In the group over 48 years old, spleen (脾) was improved comparatively. In the group with low HRQOL (PCS<31.43, MCS<23.33) deficiency (虛) was improved. Conclusions : We found that stopping drinking can improve pathogenic factors of alcoholic liver disease and the alcoholic liver disease questionnaire be a useful diagnostic method on alcoholic liver disease by comparison with DSOM.
이창우,이영현,김정란,전창호,김성자,정병욱,양창헌,하경임,윤형진,권삼,김종목,김탁관,이승석,강승완 대한내과학회 1995 대한내과학회지 Vol.49 No.4
Anthrax, a zoonotic disease of herbivorous animals transmissible from animals to man, occurs primarily in three forms: cutaneous, inhalation (or pulmonary), and gastro-intestinal. It is caused by Bacillus anthracis, a gram-positive, aerobic, spore-forming bacillus, The complications of anthrax shuch as meningitis and septicemia usually occur secondary to one of the primary form. Among three forms, gastrointestinal anthrax caused by the ingestion of Racillus anthracis-contaminated food is rare and is associated with high mortality. There are two clinical presentations of gastrointestinal antrax: abdominal (or intestinal) and oropharyngeal. We present three patients who have a rare clinical form of severe gastrointestinal anthrax caused by ingestion of meat or products of cattle which died from anthrax, Case one had fever, nausea, vomiting, abdominal pain and massive ascites recovered completely with surgery and antibiotic therapy. The other two patients died of possible complications due to gastrointestinal anthrax (sepsis in the second case and hemorrhagic meningitis in the third case)within several hours in the hospital. Bacillus anthracis was isolated from the blood culture of all three patients.