정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

비부비동의 국균증에 대한 임상적 연구

나기상,최원조,이범식 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Fungal infections of the nose and paranasal sinuses are more common than previously suspected. This may be related to increased recognition of the problem with improvement of diagnostic techniques. And the factors that predispose to fungal infections have also increased. These factors include diabetes, malignant diseases, radiation, immunosuppressive therapy, long-term corticosteroid and antibiotic regimens, etc. But most of the aspergillosis of the paramnasal sinuses are found in patients in general good health. In these cases, it has been suggested that local predisposing factors such as anatomic variations and pathologic changes in ostiomeatal complex lead to a fungus infection. Twenty five cases of aspergillosis of the nose and paranasal sinuses seen during a period of 5.5 years from January 1991 through June 1996 at the Chungnam National University Hospital are reported and a review of the literature on aspergillosis is presented.

Acute Toxicity Assessment of Neem Extract Biological Pesticides Using Daphnia

Ki-Joong KIM,Hyun YANG,Ah-Hae JO,Bum-Woo LEE,Seong-Jun KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10

Azadirachtin contained in Neem extract has the properties of inhibiting the feeding and growth of 413 kinds of insects such as Lepidoptera, Hemiptera, Locustaceae, and Nematodes. This study evaluated the acute toxicity of bioexposure to Daphnia magna, which has excellent toxic effect recognition effect, in order to analyze the effect of Neem extract biological pesticides on the aquatic ecosystem. Neem extract biopesticides used for acute toxicity evaluation contain about 1.6% of Azadirachtin, an insecticidal active ingredient. The first dilution ratio is at least 2.00x10-3, azeotrope 2 is 5 concentrations, the second dilution ratio is 1.00x10-4, azeotrope 3 is 5 concentrations, the dilution ratio in this experiment is 1.00x10-4, azeotrope 2 is the lowest. Acute toxicity test against daphnia was performed a total of 3 times with 5 concentrations. Neem extract biological pesticide 48hr-EC50 calculated by logistic method was 518.53 μg/L of Azadirachtin concentration, NOEC was 19.75 ㎍/L of Azadirachtin, and predicted no-effect concentration (PNEC) was 0.52 ㎍/L of Azadirachtin. It was L. The biological pesticides used in this study are sprayed at a rather high concentration in the area of use. However, due to dilution by rainfall and adsorption and infiltration into the soil, a decrease in the amount discharged into the watershed is expected. Azadirachtin has biodegradation and photodegradation characteristics by microorganisms, so it is thought that the effect on the ecosystem in the sprayed area and water body will be different.

Exhaled breath Analysis for Body Burden Estimates of Aromatic Volatile Organic Compounds

Jo, Wan-Kuen,Song, Ki-Bum,Nam, Chang-Mo The Korean Environmental Sciences Society 2000 Environmental sciences Vol.4 No.1

The present study evaluated the body burden of aromatic VOCs in roadside and underground storekeepers. The Method Detection Limit(MDL) of the analytical system ranged from 0.2 to 0.4$\mu\textrm{g}$/m3 for the target VOCs. The recovery of the sampling system for the compounds was above 80%. For all the target compounds, the breath concentrations of the smokes were similar to or slightly higher than those of the nonsmokers for both the roadside and underground storekeepers. For Ethylbenzene, p-Xylene, and o-Xylene, the breath concentrations of the underground storekeepers were somewhat higher than those of the roadside storekeepers. In contrast, the breath m-xylene concentration of underground storekeepers was similar to that of roadside storekeepers. For both the roadside and underground storekeepers, the breath concentrations prior to and after work were not significantly different.

아이폰 기반의 디지털 아카이브즈 애플리케이션 구현

김기범 ( Ki-bum Kim ),이정송 ( Jung-song Lee ),조훈 ( Hoon Jo ),박순철 ( Soon-chul Park ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.2

본 논문은 최근 스마트폰의 이용률의 급증에 따라 각종 애플리케이션이 개발되고 있는 가운데, 20세기 민중생활사 연구단의 무형문화유산 디지털 아카이브즈 시스템의 자료 입력과 자료 검색을 보다 편리하게 접근하고 효율적으로 사용하기 위한 방안을 제시한다. 이를 위해 아이폰의 기본 기능(GPS, 사진 및 동영상 촬영 등)을 활용하여 시간과 장소에 구애받지 않으면서 아카이브즈 자료를 손쉽게 업로드하고 검색 할 수 있는 무형문화유산 디지털 아카이브즈 애플리케이션을 구현하였다.

PRISM 기법을 이용한 토석류 유발 강우량의 최적 평가

조범희(Bum-Hee Jo),박가현(Ka-Hyun Park),이찬호(Chan-Ho Lee),김경석(Kyung-Suk Kim),정충기(Choong-Ki Chung) 대한토목학회 2016 대한토목학회 학술대회 Vol.2016 No.10

압축 분산형 앵커의 하중 전이 메커니즘 분석을 위한 그라우트-지반 인터페이스 거동 평가

조범희(Jo, Bum Hee),신규범(Shin, Gyu Beom),정충기(Chung, Choong Ki) 대한토목학회 2022 대한토목학회 학술대회 Vol.2022 No.10

온도 구배가 금속유도측면결정화에 미치는 영향

김기범,윤여건,박혜향,주승기 대한금속재료학회(대한금속학회) 2001 대한금속·재료학회지 Vol.39 No.11

The effects of annealing condition and temperature gradient on the crystallization of amorphous silicon (a-Si) were investigated by metal-induced lateral crystallization (MILC). We performed poet annealing of a-Si using conventional rapid thermal annealing (RTA) and scan-type RTA. We found that the scan-type RTA was more favorable in term of growth rate than the conventional RTA. With the temperature profile, we carried out the theoretical calculation of the MILC length using the Arrhenius model and compared with the experimental value. Also, we found that there were clear temperature gradient effects on the crystallization of a-Si. Mosaic patterns of Ni on top of the a-Si enable us to measure the effects of temperature gradient, that is, positive and negative gradient, on the crystallization of a-Si. As a result, a-Si with positive temperature gradient was crystallized faster than that of with negative temperature gradient.

Exhaled Nitric Oxide in Patients with Stable Chronic Obstructive Pulmonary Disease: Clinical Implications of the Use of Inhaled Corticosteroids

( Yong Suk Jo ),( Junsu Choe ),( Sun Hye Shin ),( Hyeon-kyoung Koo ),( Won-yeon Lee ),( Yu Il Kim ),( Seung Won Ra ),( Kwang Ha Yoo ),( Ki Suck Jung ),( Hye Yun Park ),( Yong-bum Park ) 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.1

Background: Fractional exhaled nitric oxide (FeNO) is regarded as a potential biomarker for identifying eosinophilic inflammation. We aimed to evaluate the clinical implication of FeNO and its influence on inhaled corticosteroids (ICS) prescription rate in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: FeNO level and its association with clinical features were analyzed. Changes in the prescription rate of ICS before and after FeNO measurement were identified. Results: A total of 160 COPD patients were divided into increased (≥25 parts per billion [ppb], n=74) and normal (<25 ppb, n=86) FeNO groups according to the recommendations from the American Thoracic Society. Compared with the normal FeNO group, the adjusted odds ratio for having history of asthma without wheezing and with wheezing in the increased FeNO group were 2.96 (95% confidence interval [CI], 1.40-6.29) and 4.24 (95% CI, 1.37-13.08), respectively. Only 21 out of 74 patients (28.4%) with increased FeNO prescribed ICS-containing inhaler and 18 of 86 patients (20.9%) with normal FeNO were given ICS-containing inhaler. Previous exacerbation, asthma, and wheezing were the major factors to maintain ICS at normal FeNO level and not to initiate ICS at increased FeNO level. Conclusion: Increased FeNO was associated with the history of asthma irrespective of wheezing. However, FeNO seemed to play a subsidiary role in the use of ICS-containing inhalers in real-world clinics, which was determined with prior exacerbation and clinical features suggesting Th2 inflammation.

Paraplegia due to Acute Aortic Coarctation and Occlusion

Park, Chang-Bum,Jo, Dae-Jean,Kim, Min-Ki,Kim, Sang-Hyun The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.55 No.3

Coarctation and occlusion of the aorta is a rare condition that typically presents with hypertension or cardiac failure. However, neuropathy or myelopathy may be the presenting features of the condition when an intraspinal subarachnoid hemorrhage has compressed the spinal cord causing ischemia. We report two cases of middle-aged males who developed acute non-traumatic paraplegia. Undiagnosed congenital abnormalities, such as aortic coarctation and occlusion, should be considered for patients presenting with nontraumatic paraplegia in the absence of other identifiable causes. Our cases suggest that spinal cord ischemia resulting from acute spinal subarachnoid hemorrhage and can cause paraplegia, and that clinicians must carefully examine patients presenting with nontraumatic paraplegia because misdiagnosis can delay initiation of the appropriate treatment.