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황인구,이충현,유기연,최정훈,Ok Kyu Park,임순성,강일준,권대영,박진서,이재선,배영수,원무호 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.5
Onion has several well-known biological functionalities, including antioxidant effects, and contains quercetin (3,3′,4,5,7-pentahydroxyflavone), a powerful antioxidant. In the present study, we observed neuroprotective effects of onion extract (OE) and its major component, quercetin, on ischemic damage in the gerbil hippocampus, which is related to memory function. Repeated treatment with 100mg/kg OE and 20mg/kg quercetin for 15 days before ischemic surgery protected pyramidal neurons of the hippocampal CA1 region from ischemic damage. In the OE-treated ischemic group, gliosis (activation of astrocytes and microglia) was attenuated in the CA1 4 days after ischemia/reperfusion. In addition, treatment with OE and quercetin decreased protein levels of 4-hydroxy-2-nonenal (a marker for lipid peroxidation) in the ischemic CA1. We suggest that repeated administration of OE and quercetin can protect against neuronal damage from transient cerebral ischemia.
황인구,유기연,유대영,최정훈,이충현,강일준,Dae Young Kwon,김영섭,Dong-Woo Kim,원무호 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.3
Zizyphus jujuba is considered to have various physiological functions in the brain. We obtained a Z. jujuba methanol extract (ZJE) and observed its effects on neurogenesis in middle-aged mice. Twelve-month-old mice received repeated oral administrations of ZJE for 30 days. The administration of ZJE significantly increased the number of Ki67 (a marker for cell proliferation)-positive cells in the subgranular zone of the dentate gyrus of middle-aged mice. Furthermore, ZJE significantly increased doublecortin (a marker for neuroblast differentiation)-immunoreactive neuroblasts with tertiary dendrites, but not those without tertiary dendrites, in the dentate gyrus. In addition, doublecortin protein levels in the ZJE-treated groups tended to increase dose-dependently. These results suggest that the repeated supplement of ZJE may increase the hippocampal plasticity in middle-aged mice.
황인구,권오규,Hwang, In-Koo,Kwon, Oh-Kyu 대한전자공학회 1990 전자공학회논문지 Vol.27 No.10
이 논문은 비선혀성, 모델링오차 그리고 잡음입력이 존재하는 선형 및 비선형시스템에서의 모델에 근거한 이상검출방법을 제시한다. 대상 시스템은 연속형이나 이산형 모두에 적용할 수 있도록 통합연산자$(unified operator)^[5]$로써 표시한다. 이 논문에서 제시되는 이상검출법은 잡음과 모델의 부정합과 비선형성을 고려한 것이다. 모델링 오차는 더하기꼴로 나타내며 계수추정에서 불확실성의 한계를 정량화시키기 위해 공칭모델 분모는 사건실험을 통해 고정시키는 것으로 한다. 공칭모델의 분자 계수들은 최소자승법으로 추정한다. 컴퓨터 모의실험을 추정하여 이 논문에서 제시한 방법이 기존의 방법보다 우수한 성능을 지니고 있음을 보인다. This paper proposes a model-based fault detection method for linear/nonlinear system having modelling errors, nonlinearities and measurement noise. The system model is represented by the unified operator [5] in order to apply to both the continuous-time and discrete-time problems. The fault detection method suggested here accounts for the effects of noise, model mismatch and nonlinearities. Modelling errors are depicted by additive forms and the nominal model denominator is fixed via prior experiments in order to quantify the nucertainty bound on the parameter estima-tion. The least square method is used to estimate the numerator parameters of the nominal model. performance than traditional methods.
황인구,김연태 한국철도학회 2004 한국철도학회 학술발표대회논문집 Vol.- No.-
Despite the number of steel bridges being under in service more than 50 years reaches about 50% in present, the quantitative estimation in maintenance on steel railway bridges is not possible because a ton of the field data in the bridges have not been plentifully accumulated. Therefore, a series of field tests on the steel plate girder bridge, the typical types of steel railway bridges, are executed, and the stress characteristics of main members in steel plate girder railway bridges are quantitatively estimated in this study.