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A549 기도 상피세포에서 GRβ의 과발현이 스테로이드에 의한 전체 유전자 변화에 미치는 영향
이호연 ( Ho Youn Lee ),김남희 ( Nam Hee Kim ),김도형 ( Doh Hyung Kim ),김윤섭 ( Youn Seop Kim ),박재석 ( Jae Seuk Park ),김동훈 ( Dong Hoon Kim ),지영구 ( Young Koo Jee ) 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.3
Background: Glucocorticoid receptor β (GRβ) may not bind to ligands and is thought to affect gene transcription only by acting as a dominant negative inhibitor of Glucocorticoid receptor α (GRα). However, there have been few reports about the functional roles of GRβ in the steroid-induces changes of gene expression. Objective: To investigate the functional role of GRβ overexpression in the steroid-induced changes of gene expression. Method: The changes in gene expressions such as steroid-induced synthesis of genes, TNF-α-induced synthesis of inflammatory genes and steroid induced suppression of activated genes by TNF-α treatment were compared with and without pCMV GRβ expression. Result: The number of genes increased by dexamethasone treatment only in the GRβ transfected group were 54. Increased expressions of genes by dexamethasone treatment were not affected by GRβ overexpression. The number genes increased by TNF-α treatment only in the GRβ-transfected group were 69. Expressions of genes increased by TNF-α treatment in both the control and the GRβ-transfected group were decreased by further dexamethasone treatment in a similar manner. Conclusion: The results of this study suggest that GRβ may not be a dominant negative inhibitor in the steroid-induced changes of genes and that it may have some functional roles in the regulation of gene expressions. (Korean J Asthma Allergy Clin Immunol 2008;28: 220-225)
증례 : 호흡기 ; 신우신염에 의해 유발된 패혈색전증 1예
이호연 ( Ho Youn Lee ),김남희 ( Nam Hee Kim ),김지환 ( Ji Hwan Kim ),김도형 ( Do Hyung Kim ),김윤섭 ( Yoon Seop Kim ),지영구 ( Young Koo Jee ),박재석 ( Jae Seuk Park ) 대한내과학회 2009 대한내과학회지 Vol.76 No.1
패혈색전증은 다양한 감염성 질환에서 동반될 수 있는 비교적 드문 질환이다. 저자들은 당뇨병 환자에서 Klebsiella pneumoniae에 의한 신우신염의 합병증으로 인해 신정맥 혈전증 및 패혈색전증이 발생하여 항생제 투여로 호전된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. A septic pulmonary embolism (SPE) is a rare disease originating from septic thrombi from a primary site of infection. Pyelonephritis is a rare cause of inferior vena cava (IVC) thrombosis and SPE. We experienced a case of SPE associated with pyelonephritis, a perirenal abscess, and renal vein and IVC thrombosis in a patient with diabetes mellitus. Prompt antimicrobial therapy led to a successful outcome, with complete resolution of the thrombi. We report a case of SPE due to pyelonephritis with a review of the literature. (Korean J Med 76:105-109,2009)