한약 치료를 시행한 트리메틸아민뇨증 환자 1례 증례보고

이정은,한성준,이엄지,이재형,남성욱,하나연,김진성,Lee, Jung-eun,Han, Seong-jun,Lee, Eom-jee,Lee, Jae-hyung,Nam, Seong-uk,Ha, Na-yeon,Kim, Jin-sung 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.2

Objective: This case reports on the efficacy of herbal medicine treatment for trimethylaminuria.Method: A 29-year-old female Korean patient with trimethylaminuria received herbal medicine treatment for three months. We evaluated her symptoms with the methacholine challenge test and OralChroma.Results: The odor intensity shown in the methacholine challenge test demonstrated improvement.Conclusion: Herbal medicine treatment could improve trimethylaminuria symptoms.

양성 고페닐알라닌혈증 환자에 대한 임상적 고찰과 유전자 분석

이정은,이정호,이동환,Lee, Jeongeun,Lee, Jeongho,Lee, Dong Hwan 대한유전성대사질환학회 2016 대한유전성대사질환학회지 Vol.16 No.2

목적: 본 연구의 목적은 국내 양성 고페닐알라닌혈증의 돌연변이 유전자 분석, 임상 양상, 치료에 대해 조사하는 것이다. 방법: 2010년도 4월부터 2015년도 8월까지, 신생아 선별검사에서 페닐알라닌의 상승으로 본원으로 전원되어 양성 고페닐알라닌혈증으로 진단된 10명의 환자를 대상으로 시행되었다. 조사항목으로는 환자들의 특징 및 임상 양상과 직접 염기서열 분석을 통한 PAH 유전자 돌연변이 형태 분석을 포함하였다. 결과: 10명의 환자들 중 2명은 고페닐알라닌혈증으로 진단된 자녀의 부모였으며, 환자들 중 특이 과거력이나 임상 증상이 있는 경우는 없었다. 혈장 아미노산 분석에서는 페닐알라닌이 1.2 mg/dL부터 4.2 mg/dL까지의 범위로 측정되었다. BH4 부하검사에서는 모든 환자들이 BH4에 무반응이었다. 확진 검사로 시행한 페닐알라닌수산화효소 유전자 분석에서는, 총 20개의 대립유전자들 중에서 11개의 각기 다른 대립유전자형을 확인할 수 있었는데, 이 중 제일 흔한 대립유전자는 R53H (c.158G>A)였다. 뿐만 아니라, 직접염기서열분석 상에서 2가지의 새로운 돌연변이 형태인 V423A (c.1268T>C)와 V51A (c.152T>C)를 발견하였다. 본 연구에 포함된 환자들은 약물을 복용하거나 식사 조절을 하지 않았음에도, 지속적인 외래 추적 관찰 결과 모든 환자들의 페닐알라닌 치는 6 mg/dL 이하로 유지되었으며, 정상적인 신경 인지발달을 하고 있는 것을 확인하였다. 결론: 이 연구는 양성 고페닐알라닌혈증 환자에 대한 분석이며 국내에서 처음으로 시행한 것이다. 모든 양성 고페닐알라닌혈증 환자들은 지속적인 치료 없이도 혈장 페닐알라닌 치를 6 mg/dL 이하로 유지하였고 정상적인 신경 인지발달을 하였다. 그러므로, 돌연변이 검사를 시행하여 양성 고페닐알라닌혈증 환자를 페닐케톤뇨증과 감별함으로써 불필요한 식사 요법이나 약물 투여를 줄여 환자의 삶의 질을 높일 수 있다. Purpose: This study aimed to analyze genetic mutations, clinical manifestations, and treatment of patients with benign HPA in Korea. Methods: This case series study involved ten HPA patients who were referred to our hospital because of high phenylalanine concentration. We investigated their demographic features, clinical manifestations, and mutations of the PAH gene through direct DNA sequencing. Results: Among ten patients with benign HPA, two pairs of patients were related (father-daughter, mother-daughter relationship) cases, and all of them showed no specific clinical manifestations or notable past history. Their plasma phenylalanine levels ranged between 1.2 and 4.2 mg/dL. In the tetrahydrobiopterin (BH4) loading test, all patients were nonresponsive to BH4. In the confirmation test of PAH mutation analysis, we identified eleven different alleles out of twelve. The most common allele was R53H (c.158G> A). In addition, two novel PAH gene mutations, V423A (c.1268T>C) and V51A (c.152T>C), were identified. Although the patients did not receive any pharmacologic treatment or continuous phenylalanine restriction dietary therapy, their neurocognitive development was normal. Moreover, on serial outpatient follow-up tests, all patients maintained phenylalanine levels below 6 mg/dL. Conclusion: This study is the first in Korea to analyze benign HPA patients. All patients with benign HPA could maintain phenylalanine levels below 6 mg/dL with normal neurocognitive development, without continuous therapy. Therefore, performing mutation analysis and distinguishing benign HPA from phenylketonuria (PKU) are important to help improve life quality in patients with benign HPA by avoiding unnecessary lifelong therapy.

극저온 정제시스템의 품질관리를 위한 SF₆ 가스 분석방법 개선

이정은,조민,이원석,Lee, Jeong Eun,Cho, Min-ho,Lee, Won Seok 한국전력공사 2022 KEPCO Journal on electric power and energy Vol.8 No.1

Because sulfur hexafluoride(SF₆) is classified as one of the six major greenhouse gases, SF₆ handling in power plant such as recovery, purification, and reuse is considered to be important. KEPCO has focused to develop the advanced recovery and purification technology of SF₆ reuse. SF₆ analysis includes the on-site analyses and on-line analyzer; i.e., (1) on-site analysis has an error rate of ±0.5% and (2) on-line analysis has an error rate of ±0.1%, which is possible to adjust operating conditions and to make the work more conveniently by analyzing SF₆ concentration before and after purification step. This paper presents an online analysis method in the SF₆ purification and reuse system. In addition, the analysis results and quality guarantees for each section of the analysis system were presented.

삼자화담전(三子化痰煎)이 천식모델 생쥐의 면역세포에 미치는 영향

이정은,박양춘,Lee, Joung-Eun,Park, Yang-Chun 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3

Objective: The purpose of this study was to evaluate the effect of Samjawhadam-jeon (SJHDJ; 三子化痰煎) on immune cells in OVA-induced asthmatic mice. Material and Methods : C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four times a week) for asthma induction. Two experimental groups were treated with different concentrations of SJHDJ group (400 mg/kg) extracts and cyclosporin A (10 mg/kg) for the latter 8 weeks. At the end of the experiment, the mouse lung. peripheral lymph node (PLN) and spleen were removed and immune cells were analyzed by flow cytometer. Results : Lung weight, total cells in lung, PLN, and spleen of the SJHDJ group decreased significantly compared with that of the control group. Number of $CD3e^+/CD69^+$, $CD3e^+/DX5^+$ cells in lung, PLN and spleen, number of $CD3^+$ cells in PLN and spleen, number of $CD3e^-/CCR3^+$ cells in lung and PLN, and number of $B220^+/IgE^+$ cells in PLN of the SJHDJ group decreased compared with that of the control group. Number of $CD4^+/CD25^+$ cells in PLN and spleen of the SJHDJ group increased compared with that of the control group. Conclusion : These results demonstrate that SJHDJ will be a desirable alternative therapy for allergic asthma by inhibiting the expression of immune cells.

부모의 양육태도가 섭식장애의 발병과 심각도에 미치는 영향

이정은,이정현,정영철,박준영,남궁기,박동화,김경란,Lee, Jung Eun,Lee, Jung-Hyun,Jung, Young-Chul,Park, Jun Young,Kee, Namkoong,Park, Dong Wha,Kim, Kyung Ran 한국정신신체의학회 2015 정신신체의학 Vol.23 No.1

연구목적 한국에서 신경성 식욕부진증과 신경성 폭식증을 진단받은 환자 군에서 부모 양육태도의 차이와 각 아형에서 부모 양육태도의 차이가 발병 나이와 섭식장애 증상의 심각도에 미치는 영향을 알아보고자 하였다. 방 법 167명의 섭식장애 환자(신경성 식욕부진증, N=49 ; 신경성 폭식증, N=118)를 대상으로 하였다. 자가보고식 설문지인 부모 양육행동 척도(Parental Behavior Inventory, PBI)를 시행하여 환자가 인식하는 부모님의 양육행동을 측정하였으며, 섭식장애 검사 개정판(The Eating disorder Inventory-2, EDI-2)를 통하여 증상의 심각도를 평가하였다. 결 과 신경성 식욕부진증 환자를 발병 나이에 따라 분류하였을 때, 16세 이후에 발병한 군보다 16세 이전에 조기 발병한 경우 낮은 아버지의 애정, 높은 아버지의 합리적 설명, 낮은 어머니의 과잉간섭을 보고하였다. 섭식장애 증상의 심각도(EDI-2)는 신경성 식욕부진증과 신경성 폭식증에서 어머니의 애정, 합리적 설명과 음의 상관관계를 나타내었다. 단계별 회귀분석을 시행하였을 때, 아버지의 애정, 어머니의 과잉기대와 합리적 설명이 신경성 식욕부진증의 발병 나이에 중요한 영향을 준다는 것을 확인할 수 있었으며, 두 집단에서 모두 어머니의 애정이 높을 수록 EDI-2의 점수가 낮은 것으로 나타났다. 결 론 섭식장애 환자의 평가 및 치료에서 가족의 기능과 인식된 부모의 양육태도가 중요한 역할을 할 수 있겠다. 본 연구 결과는 아버지의 양육방식이 섭식장애 발병나이에 미치는 영향을 밝힘으로써 이제까지 상대적으로 부족하게 평가되었던 아버지 역할의 중요성을 확인하였다. 이뿐 아니라, 섭식장애 증상의 심각도와 어머니의 애정과의 관련성을 확인함으로써 가족 기능에 대한 평가가 치료에 필수적임을 입증하였다. 앞으로 본 연구 결과에 대한 해석 및 적용을 위한 후속 연구들이 필요하겠다. Objectives:To determine the influence of parental behaviors on the onset and severity of eating disorders, this study compared aspects of perceived parental styles, according to eating disorder subtypes and age at onset in Korean women with eating disorders. Methods:One hundred and sixty-seven patients with eating disorders[Anorexia Nervosa (AN), N=49; Bulimia Nervosa(BN), N=118] were recruited for this study. Perceived parent behaviors were assessed with Parental Behavior Inventory(PBI) self-rating scale. The study subjects also completed the Eating Disorder Inventory -2 (EDI-2) to assess the severity of eating disorder symptoms. Results:In anorexia nervosa, early onset group(<16 years) reported low paternal affection and high paternal rational expression, low maternal interference than group with age at onset over 16 years. The severity of eating disorder symptoms was negatively associated with mother affection and rational expression in two subtypes of eating disorder(AN and BN). On stepwise regression analysis, paternal affection and maternal over-protection were associated with age of onset only in AN group and maternal affection was associated with the severity of symptoms in both groups of eating disorder. Conclusions:Considering the role of family function and perceived parental styles could help improve the management of eating disorders. These results emphasize the importance of fathers' role in the eating disorder on the age of onset, a relatively unexplored area of eating disorder research. Also, we investigated the importance of mothers' affection on the severity of symptoms.

정책논단 - 국내 FTA 체결동향 및 석유산업에 미치는 영향

이정은,Lee, Jeong-Eun 대한석유협회 2009 석유와 에너지 Vol.274 No.-

북방수염하늘소(Monochamus saltuarius), 솔수염하늘소(Monochamus alternatus), 털두꺼비하늘소(Moechotypa diphysis) 성충의 표피탄화수소 비교

이정은,김은희,윤창만,김길하,Lee, Jeong-Eun,Kim, Eun-Hee,Yoon, Chang-Mann,Kim, Gil-Hah 한국응용곤충학회 2010 한국응용곤충학회지 Vol.49 No.3

북방수염하늘소, 솔수염하늘소, 털두꺼비하늘소 성충 암·수의 표피탄화수소를 GC와 GC-MS로 분석하고 비교하였다. 북방수염하늘소와 솔수염하늘소는 소나무재선충병의 대표적 매개충이지만 같은 과에 속한 털두꺼비하늘소는 그렇지 않다. 이들은 표피탄화수소 사슬을 다르게 가지고 있는데, 북방수염하늘소의 표피탄화수소 사슬은 $C_{23-35}$, 솔수염하늘소는 $C_{25-32}$, 그리고 털두꺼비하늘소는 $C_{23-29}$로 종간 차이를 보였다. 주 구성성분의 암 수간 차이에서 함량에 대한 차이는 있었지만, 조성에 대한 차이는 없었다. 북방수염하늘소는 n-pentacosane > n-nonacosane > n-heptacosane, 솔수염하늘소는 n-nonacosene > n-pentacosane > n-nonacosane을 가장 많이 포함하고 있었으며, 털두꺼비하늘소는 n-heptacosane > 13-methylheptacosane > 3-methylheptacosane을 가장 많이 포함하고 있는데 반해 n-nonacosene, n-pentacosane의 함량은 적었다. 3종하늘소 표피의 대부분은 n-alkane인 포화탄화수소로 이루어져 있고(40.2 - 65.7%) 그 다음으로, 북방수염하늘소와 솔수염하늘소는 하나 또는 두 개의 이중결합을 갖는 olefins > monomethylalkanes 순이었다. 이와 달리, 털두꺼비하늘소는 monomethylalkanes > olefins 순으로 함량에 차이가 있었다. Cuticular hydrocarbons (CHCs) of the pine sawyer (Monochamus saltuarius), Japanese pine sawyer (M. alternatus) and oak longicorn beetle (Moechotypa diphysis) were analyzed by GC, GC-MS and compared. Monochamus beetles are typical vectors of pine wilt disease but Moechotypa diphysis, which belongs to the same family, is not. They possess different CHCs in carbon number: 23-25 in M. saltuarius, 25-32 in M. alternatus, and 23-29 in M. diphysis. In comparison to inter-species, these three species of adult beetles have different numbers and chains of constituents of CHCs. In comparison between male and female in intra-species, the quantities of CHCs show the difference but constituents are not. Major constituent of M. saltuarius were analyzed as n-pentacosane > n-nonacosane > n-heptacosane; those of M. alternatus were n-nonacosene > n-pentacosane > n-nonacosane; and those of M. diphysis were n-heptacosane > 13-methylheptacosane > 3-methylheptacosane. From the body surface, most saturated carbohydrates of 3 species beetles are composed of n-alkane (40.2 - 65.7%) and followed by olefines > monomethylalkanes that one or two double bonds in M. saltuarius and M. alternatus. Otherwise, M. diphysis have the difference in order of monomethylalkanes > olefins.

제조 방법이 다른 팽화미 분말의 이화학적 특성

이정은,김유진,조문경,박신영,김은미,조용식,최윤희,Lee, Jung-Eun,Kim, Yu-Jin,Cho, Mun-Gyeong,Park, Shin-Young,Kim, Eun-Mi,Cho, Yong-Sik,Choi, Yoon-Hee 한국식품영양학회 2012 韓國食品營養學會誌 Vol.25 No.4

This study is carried out in order to develop food materials for the promotion of rice consumption. In this study, we researched the physicochemical properties of extruded rice flour (ER) and gelatinization popped rice flour (GPR) by the extrusion process and by the popped method with milled rice and brown rice. The extrusion process used a couple of screw extruders. The extrusion parameter was kept constant at a feed moisture content of 25%, barrel temperature of $120^{\circ}C$ and screw speed of 400 rpm. GPR was prepared by batch popping machine after gelatinization of rice. In order to evaluate the physicochemical properties of ER and GPR, as well as the gelatinization rate, water soluble index (WSI), water adsorption index (WAI), DPPH radical scavenging activity and total dietary fiber content, the color value was carried out. The gelatinization rate was similar to 71.1~73.8%. Further, the results of WSI and WAI were increased at ER and GPR compared to the raw materials; ER was also higher than GPR. DPPH radical scavenging activity and total dietary fiber content showed a tendency to reduce after extrution and popping. As a result of the color value, the L value of ER decreased more than the raw materials, whereas GPR increased at a and b values.

아버지의 미취학자녀 돌봄시간 변화 추이 분석(2004-2019)

이정은,서지원,Lee, Jung-eun,Seo, Jiwon 한국가족자원경영학회 2021 가족자원경영과 정책 Vol.25 No.3

Recently, the importance of the fathers role in the care of young children has been emphasized in Korea for the balance of childcare responsibilities between mothers and fathers. This study investigates the trends in paternal childcare in Korea over the last 15 years. Childcare is divided into primary and developmental care and fathers's Childcare time and participation rates are inverstigated for dual- and single-income households. Data are collected from the four waves of the five-yearly Statistics of Korea Life Time Surveys between 2004(t₁) and 2019(t₄) including the workday time diaries of fathers with preschool children(n₁=2,264, n₂=1,242, n₃=959, n₄=952). Three major results are identified. First, paternal childcare time and participation rates have increased with dual-income fathers spending 24 more minutes a day with their young child(ren) in 2019 than in 2004, which is nearly double. Second, in the analysis of fathers' childcare time use and participation rates comparing primary and developmental care, primary care is found to have increased more than developmental care, especially among dual income fathers: this further exhibits a reversed relation between primary and developmental care over time. Third, the determinants of paternal childcare time are fathers' age, market labor time, commuting time, gender equality consciousness, and education. In particular, market labor time was significant in all four waves, while gender equality consciousness is only significant for single-income fathers. Based on these results, a specific agenda is provided for family-friendly policies to improve the balance of childcare roles between fathers and mothers, especially encouraging increased(significant and sufficient) participation of fathers in primary care activities.

세상의 빛을 모든 이들에게

이정은,Lee, Jeong-Eun 한국가톨릭의료협회 2002 한국가톨릭병원협회지 Vol.32 No.-