Cirsimaritin Contributes to the Estrogenic Activity of Cirsium japonicum var. maackii through the Activation of Estrogen Receptor α

이다혜,정유정,백지윤,신명숙,이상현,함대현,이상천,심재석,김수남,강기성 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.12

Phytoestrogens are naturally occurring plant-derived chemicals that exert female hormone-like activities similar to those of endogenous estrogens. The purpose of this study was to quantitate the estrogenic activity of six chemical constituents (apigenin, hispidulin, cirsimaritin, cirsimarin, pectolinarin, and linarin) of Cirsium japonicum var. maackii using several in vitro assays. Reporter gene activation by each compound was examined using a human breast cancer (MCF-7) cell-based transactivation assay. Proliferative activity was also examined using MCF-7 cells. Reporter gene activation in MCF-7 cells by cirsimaritin was significantly suppressed by co-administration of the estrogen receptor (ER) antagonist ICI 182,780, indicating that cirsimaritin is an ER agonist. Under experimental conditions simulating postmenopausal syndrome (i.e., a low concentration of estrogen), cirsimaritin exerted beneficial effects on MCF-7 cells by increasing estrogenic activity. These results suggest that cirsimaritin is an effective estrogenic compound that can improve postmenopausal symptoms.

청년세대의 리얼리티 TV 프로그램 수용에 관한 연구 : ‘쿡방’과 ‘집방’을 중심으로

이다혜,류웅재 한국소통학회 2016 한국소통학보 Vol.15 No.2

이 연구는 청년세대의 자기인식과 이를 둘러싼 사회문화적 담론을 매개하는 텔레비전 포맷의 등장과 수용을 신자유주의라는 경제적 문맥에서 탐색하고자 하였다. 이를 위해 이 연구는 새로운 리얼리티 TV의 형식인 쿡방과 집방을 사례로 이들의 콘텐츠적 특성과 힐링, 멘토링 문화, 그리고 자기계발 담론 등과의 연관성을 살펴보고자 했다. 분석을 위해 우선 선행 연구를 통해 리얼리티 TV 프로그램의 정의를 살펴보고 쿡방과 집방을 이 장르로 이해할 수 있는 이유를 논의하고 있다. 이를 토대로 이 프로그램들이 신자유주의 체제 하 청년세대의 음식과 주거를 둘러싼 소비문화를 어떻게 재현, 매개, 재구성하는지에 초점을 두어 분석하고 있다. 연구 방법으로 청년 14명을 대상으로 한 심층 인터뷰를 통해 리얼리티 TV 프로그램의 수용 경험을 채집하였다. 청년들은 쿡방과 집방의 수용과 전유를 통해 신자유주의 하 치열한 경쟁과 반복적 일상을 창의적으로 전유하면서도 동시에 기업가적 자아로 거듭나거나 이러한 신자유주의적 가치를 내면화하기도 했다. 이들은 프로그램의 수용을 통해 현실에서의 곤고한 삶에 대한 대리만족을 느끼거나 이것이 과잉이거나 물신화한 소비로 연결되는 문제에 대해 비교적 정확하고 성찰적인 문제의식을 갖고 있으면서도 힘겹고 여유 없는 일상에서 삶을 지속하는 기제로 이러한 리얼리티 TV 프로그램을 소비하고 있었다. 이러한 수용의 양상은 삼포세대로 대변되는 청년 문제를 포함해 신자유주의의 구조적인 모순을 인식하는 청년들에게도 나타났으며, 이들은 쿡방과 집방의 시청을 통해 적극적이고 능동적인 저항이나 정치적, 문화적 실천 대신 현실과 일상에 순응하는 일면을 보여주고 있었다. This study examines young generation’s self-awareness and the sociocultural phenomenon of young people fulfilling their needs and desires, both economic and cultural, through the consumption of media. In doing so, this study particularly explores the ‘cookbang’ and ‘jipbang’ as a form of reality tv program, and examines the features of these shows, especially in conjunction with ‘healing’ and ‘mentoring’ phenomena represented in diverse media texts and social discourses. Also, this study utilizes neoliberalism and Foucault’s notion of governmentality as theoretical backdrops to contextualize our discussion. We investigate the relationship between young generation’s consumption of reality tv shows and actual consumption of food and housing. Interviews with fourteen youths who are committed to, or watch the reality tv programs on a regular basis were conducted to collect qualitative data. Although the everyday life of young generation varies, young people tend to have more common and self-reflective thinking about their life and current Korean society, by creatively watching and appropriating the ‘cookbang’ and ‘jipbang’. Although the young generation has critical attitude and mind toward these reality tv shows, they tend to watch them regularly. Furthermore, many respondents have tried cooking and housing, in ways portrayed in, and introduced by these programs. This shows that young people recognize the structural contradictions related to a series of economic and social problems they experience today. At the same time, they tend to trivialize or privatize fundamentally systemic and structural issues and adapt to harsh reality without more active resistance, effective political actions, or other cultural practices, by consuming the ‘cookbang’ and ‘jipbang’.

Cyanidin 3-O-glucoside Isolated from Lonicera caerulea Fruit Improves Glucose Response in INS-1 Cells by Improving Insulin Secretion and Signaling

이다혜,함정엽,강기성,이해정 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.12

Cyaniding 3-O-glucoside is a flavonoid compound isolated from the fruits of the Lonicera caerulea. In the present study, we investigated the effects of L. caerulea extract and its active component cyaniding 3-O-glucoside on insulin release in INS-1 cells. L. caerulea extract and cyanidin 3-O-glucoside activated the secretion of insulin that lead to diminished glucose production in INS-1 cells. Cyanidin 3-O-glucoside also enhanced the phosphorylation of insulin receptor, insulin receptor substrate 1, and phosphoinositide 3-kinase protein expressions in INS-1 cells. These results suggest that cyanidin 3-O-glucoside is an active component of L. caerulea that enhances insulin production and activates insulin signaling.

2‐Bromo‐4,5‐Dimethoxy Chalcone Inhibits Cisplatin‐induced LLC‐PK1 Kidney Cell Death

이다혜,이희수,강기성,이재욱 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.5

제페토와 함께하는 현대해상 홍보 차별화 전략

이다혜,석시온,윤수진 한국서비스경영학회 2022 한국서비스경영학회 학술대회 Vol.2022 No.5

주의초점 간 맥락간섭이 배드민턴 하이클리어 학습에 미치는 영향

이다혜,김영준,신석환,권택용 한국스포츠심리학회 2020 한국스포츠심리학회지 Vol.31 No.3

Purpose: The purpose of this study was to investigate the effect of context interference in attentional focus on motor learning in beginners. Methods: Badminton novice college students(n=30) were randomly assigned to 3 groups(IFA: a constant-practice group with repeated internal attention instruction, EFA: a constant-practice group with repeated external attention instruction, R: a random-practice group with internal and external attention instructions randomly presented). The experimental task was to perform badminton high-clear skill. This experiment consisted of pre-test, acquisition stage, delayed retention test and transfer test. The absolute error, the variable error and the error were calculated for all trials. Results: The IFA group and the R group showed a significant delayed retention effect in terms of accuracy and although no statistically significant difference was shown, the R group showed a better delayed retention effect. In terms of consistency, no significant learning effect was shown and in terms of achievement, the only delayed retention effect showed in the R group. The transfer effect was not shown in all aspects. Conclusion: This results showed that randomly presenting internal/external attention instructions can be more effective than repeatedly presenting a single attention instruction in beginner's badminton high-clear learning.

Linear correlation of aliphatic diamines to response factors by number of carbons in GC–MS

이다혜,양영헌,가네산,서형민,이주희,김현중,김윤곤,장경순,이유경,박경문 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.30 No.-

Diamines are widely used as building blocks for the chemical synthesis of bio-based polymers such aspolyamides, polyimides, and polyurea. However, the detection and quantification of diamines are stillbeing as difficult tasks due to their high toxicity and polarity and other hazardous standards are neededto obtain the calibration curve for the diamine quantification. Hence, we have established a simplemethod for the analysis of aliphatic diamines using GC–MS based on the linear correlations betweencarbon number, retention time and response factors of diamines. The aliphatic diamines werederivatized with ethylchloroformate (ECF) by applying total ion current (TIC) and single ion monitoring(SIM) at the m/z of 102. The linear correlation of the aliphatic diamines to the retention time (RT)(R2 = 0.9949) and response factor (RF) (R2 = 0.9538) was determined by using carbon numbers from C3 toC12, via experimentation. The finding of linear correlations between aliphatic diamines are moreadvantageous and requires less authentic samples of using or calibrating of each diamine sample of thequantification and identification. The established method was successfully employed on a bacteriumShewanella oneidensis which is known to produce potential precursors of the biopolymer synthesis andassessed by, based on the predicted retention time and response factor of 1,4-diaminobutane for thequantification of secreted putrescine and cadaverine. By applying one or two diamines, the retentiontime, peak area and response factors can easily be expected depending on the concentration and thisapproach could be applied for the quantification of aliphatic diamines in various industrial sectors.

창작이라는 ‘노동’: 영화제작 종사자의 근로자성 판단 ○ 서울동부지방법원 2018. 10. 4. 선고 2018고단1331 판결, 대법원 2019. 10. 17. 선고 2019도9688 판결

이다혜 한국노동법학회 2020 노동법학 Vol.0 No.73

토픽모델링과 네트워크 분석을 활용한 바이오 에너지분야 동향분석

이다혜,최하영,윤장혁 대한산업공학회 2017 대한산업공학회 춘계학술대회논문집 Vol.2017 No.4

바이오 에너지는 친환경성과 활용성 측면에서 여러가지 신재생 에너지 중 가장 각광받고 있으나 이에 대한 계량분석은 다소 미흡한 실정이다. 따라서 본 연구는 바이오에너지에 관한 대량의 특허자료를 바탕으로 기술의 동향을 계량적으로 분석한다. 본 연구의 분석 과정은 1) 바이오 에너지와 관련된 특허를 수집하여 세부 기술을 분류하고, 2) 개별 기술 간의 동시 출현네트워크를 구성한 뒤, 3) 네트워크 분석을 통해 세부 기술 분야 내의 핵심기술 파악 및 기술 간 상호관계 등을 분석한다. 본 연구의 분석결과는 바이오 에너지 분야의 기업들이 기술개발의 방향을 설정하는데 활용될 것으로 기대된다.

Thermophysical Properties of Polymer Thin Films Measured on Ionic Liquid

이다혜,박진석,김동준,오은성,박현정,김택수,김범준 한국고분자학회 2023 한국고분자학회 학술대회 연구논문 초록집 Vol.48 No.1