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목지오,정찬희,김철희,유창범,김여주,김상진,박형규,서교일,유명희,변동원 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.6
Background/Aims: This study was performed to compare the mucosal findings after esophagogastroduodenoscopy in two groups before and after the use of alendronate only and following administration of the enteric-coated alendronate (5 mg) and calcitriol (0.5 μg) combined drug (Maxmarvil, Yuyu Co.). Methods: The study population consisted of 33 postmenopausal healthy female volunteers, aged 50 to 70 years (mean age, 58 ± 5) without gastrointestinal symptoms and with normal baseline endoscopic findings. Esophagogastroduodenoscopy was performed at baseline and was repeated 2 weeks later after daily intake of Maxmarvil (n = 17 subjects) or alendronate only (n = 16 subjects). Mucosal injury scores were reported by an endoscopist after 2 weeks of treatment with each medication schedule. Results: Esophageal mucosal injuries developed in two of 16 subjects in the alendronate only group and 0 of 17 in the Maxmarvil group. Gastric mucosal injuries developed in eight subjects in the alendronate group and four subjects in the Maxmarvil group; this difference was statistically significant. Conclusions: The mucosal damage scores for the alendronate group (total score 24) were significantly higher than those for the Maxmarvil group (total score 9) in the esophagus and stomach. Therefore, this study suggested that enteric-coated Maxmarvil is less harmful to gastrointestinal mucosa than alendronate, and may improve the tolerability of osteoporosis medication in clinical practice.
기관지천식 환자에서 기도 염증의 증등도에 따른 치료 반응 비교
목지오,오제호,박성우,기신영,임건일,문승혁,정성환,김현태,어수택,김용훈,박춘식 대한천식알레르기학회 1997 천식 및 알레르기 Vol.17 No.4
Objectives.' Chronic asthma has a number of characterist,ic feature', the increased airway responsiveness and bronchial inflammation. Although these mechanisms are not clear, activated T-cell has had an important role in migration and activation of inflammatory cells. In order to evaluate the role of T-lymphocyte and T-cell subsets in the development of asthmatic symptoms and the posibility for predicting the therapeutic response, we performed bronchoalveolar lavage from asymptomatic and symptomatic asthmatic subjects and inflammatory cell count, T-cell subset, activated T-lymphocyte were analysed and they were compared with healthy controls. Method: 76 bronchial asthmatics and 54 healthy controls were enrolled in this study. Asthmatic patients were classified into symptomatic and asymptomatic group according to symptom severity. Symptomatic group was divided into two groups according to therapeutic response, early responder(ER) and late responder(LR). Lymphocytes(T- lymphocytes subsets and activation marker) in bronchoalveolar lavage(BAL) cells were analyzed using a flow-cytometry. Results.' The counts of eosinophil and neutrophil in BAL fluid were significantly higher in both asymptomatic and symptomatic asthmatic patient than those of healthy controls (p<0.05). The number of T3, T4, and T8 lymphocytes were significantly higher in symptomatic asthmatic patient than those of healthy controls, and the counts of T3-ILR', T4-IL,R', and TS-IL,R lymphocytes were significantly higher in symptomatic subsets than in healthy con- trols (p<0.05). Although there were no significant differences in the number of lymphocyte, eosinophil and neutrophil between t,he ER and LR of symptomatic patients ( p >0.05). The numbers of T3 and T4 lymphocyte subsets were significantly higher in LR than in healthy controls, and the number of T3-ILR, T4-ILR+ lymphocytes were sig- nificsntly higher in ER than in healthy controls (p<0.05)- Conelusion.' We could conclude that the infiltration and activation of T-lymphocytes might be associated with the development of asthmatic symptoms and responsiveness to therapy.
각종 조혈모세포 근원별 CD34+ 양성세포율 및 혈구 집락배양의 비교
목지오,변재호,김숙자,전진우,원종호,백승호,서원석,홍대식,박희숙 대한조혈모세포이식학회 1996 대한조혈모세포이식학회지 Vol.1 No.1
목적: 각종 조혈모세포의 근원인 말초혈액(PB), 고용량 항암요법과 조혈성장인자 투여후 얻은 말초혈액(MPB), 골수(BM) 및 제대혈 (UB)의 단핵구를 이용하여 CD₃₄+ 세포양성율 및 각종 조혈전구 세포의 집락 형성능을 비교 관찰하고자 한다. 방법: flow cytometry와 anti-CD₃₄+ 단세포항체를 이용하여 각종 조혈모세포 근원의 CD₃₄+ 양성세포함유 정도를 측정하였고, 분리된 단핵구를 집락배양하여 CFU-GM, BFU-E, CFU-GEMM 및 HPP-CFC의 집락형성능을 관찰하였다. 결과: 1) 각 조혈모세포의 근원별 CD₃₄+ 양성세포의 분리 전후의 비교 CD₃₄+ 양성세포의 양성률은 고용량 항암요법과 조혈성장인자 투여후 얻은 말초혈액에서 3.46±0.72%로 가장 높았으며 골수와 제대혈에서 각각 1.78±0.86%과 1.53±0.43%으로 비슷하였으며 말초혈액에서 0.14%로 가장 낮았다. CD₃₄+ 세포를 분리하였을 때, 분리후 CD₃₄+ 양성세포는 제대혈액에서 96.99±1.95%로 가장 높았으며 고용량 항암요법과 조혈성장인자 투여후 얻은 말초혈액에서 72.54±14.06%, 골수에서 60.6±1.9%, 그리고 말초혈액에서 54%로 나타났다. 2)각 조혈모세포의 근원별 조혈전구세포의 집락형성 CFU-GM, BFU-E, CFU-GEMM 그리고 HPP-CFC를 사용한 집락배양결과 CD₃₄+ 양성세포 분리군에서 비분리군에 비해 집락수가 많았으며, CFU-GM의 경우 그 비는 말초혈액, 골수, 그리고 제대혈액에서 각각 112배, 10배, 5배, 26배 또한 CFU-GEMM은 각각 136배, 8배, 12배가 높았다. 결론: 각종 조혈모세포의 근원별 CD₃₄+ 양성세포의 양성세포율 및 조혈전구세포 집락배양비교시 CD₃₄+ 양성세포와 조혈전구세포가 말초혈액이나 골수보다 MPB나 제대혈에서 훨씬 많은 것을 관찰하였다. Background: Classically bone marrow is the major source of hemopoietic stem cells of the allo/autologous hemopoietic stem cell tansplantation. Recently, hemopoietic stem cells circulate in peripheral blood, "mobilized" with cytokines and/or cytotoxic chemotherapy and umbilical cord blood stem cells, are widly used for high dose chemotherapy with hemopoietic stem cells support. The aim of this study is to investigate the possibility of clinical applications of selected CD34+ cells with source of hemopoietic stem cells such as, peripheral blood(PB), mobilized PB(MPB), bone marrow(BM), and umbilical cord blood(UB) Methods: We evaluated the comparison of the clonogenicithy and percentage of CD₃₄+ cells according to each source of hemopoietic stem cells in before and after separation of CD₃₄+ cells through in vitro colony assay and flow cytometry with anti-CD₃₄+ monoclonal antibody. Results: 1) CD34+ cells were detected in PB, MPB, BM, and UB at incidences of 0.14%, 3.46 ±0.72%, 1.78±0.86%, and 1.53±0.43% of total mononuclear cells. And the most CD34+ cells were detected in UB after seperation of CD₃₄+ cells. 2) The colony counts revealed more in CD₃₄+ isolating group. Clonogenicity of CD₃₄+ cells in PB, MPB, BM, and UB was 112-fold, 10-fold, 5-fold, and 26-fold in colony forming unit-granulocyte and macrophage(CFU-GM), and 136-fold, 8-fold, 3-fold, and 12-fold in colony of forming unit-granulocyte, erythrocyte, monocyte, megakaryocyte(CFU-GEMM). The colony counts of UB and MPB were large numbers more than PB and BM. Conclusion: Clonogenicity and percentage of CD₃₄+ cells are superior MPB and UB than in PB and BM.
응급수술후 발생한 당뇨병성 케톤산증 및 고중성지방혈증으로 인한 급성췌장염 1예
목지오 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Severe hypertriglyceridemia in diabetic ketoacidosis are rarely observed in acute pancreatitis which usually occurred when serum triglyceride levels are above 1,000㎎/dl. Auther report a case of diabetic ketoacidosis and hypertriglyceridemia-induced acute pancreatitis after emergency operation. A 14 year old female was presented with right lower abdominal pain. She was diagnosed acute appendicitis and received appendectomy. After emergency operation, she showed polydipsia, dry mouth and drowsiness. Blood gas analysis showed severe acidosis and serum ketone body was positive. The laboratory finding showed serum glucose 412㎎/dl, HbA1C 16.9%, total cholesterol 586㎎/dl, triglyceride 1,333㎎/dl, amylase 1,942U/L, lipase 2,251IU/L. She was diagnosed as having diabeteic ketoacidosis and hypertriglyceridemia-induced acute pancreatitis. Findings of her abdominal CT was acute pancreatitis with formation of pseudocyst. She treated with continuous intravenous insulin infusion and fluid replacement without feeding. After conservative management of 15 days, general condition gradually improved and her serum glucose, amylase, lipase and triglyceride levels ware normalized. After 13weeks, findings of abdominal CT showed improved pancreatitis and pseudocyst.
부갑상선 선종에 의해 발생된 극심한 고칼슘혈증을 동반한 갈색종 1예
목지오 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2
Most of primary hyperparathyroidism results from parathyroid adenoma, and is characterized by hypercalcemia, reduced bone density, frequent renal stone, gastric ulcer, duodenal ulcer, muscle weakness, depression, hypertension, anemia, and rarely brown tumor. We had a case of an 80-year-old man having brown tumor caused by primary hyperpara- thyroidism on the right 10th rib confirmed by CT guided bone biopsy. The patient presented with decreased level of consciousness, acute gastric ulcer, acute duodenal ulcer, GB stones, renal insufficiency, depression, and osteoporosis. Serum calcium level was 16.7 mg/dL and the intact parathyroid hormone level was 3901 pg/mL. A parathyroid mass was detected by neck CT and 99%-tetrofosmin parathyroid scan. The parathyroid tumor was removed and confirmed as a parathyroid adenoma by pathology. After operation, the patient was treated with vitamin D and calcium in response to the resulting hungry bone syndrome. The intact PTH level returned to a normal range after the removal of the parathyroid adenoma (J Kor SOC Endocrinol 18:153-158, 2003).