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Catechol-tethered chitosan as a tissue-adhesive material
류지현 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Recently, catechol-tethered chitosan has attracted much attention as promising adhesive biomaterials applicable for hemostasis and surgical tissue adhesive in surgical procedures. Herein, we have synthesized and processed chitosan-tethered chitosan materials in various physical forms including hydrogels, (thin) films, sponges, and nanoparticles. The variety of physical states of catechol-tethered chitosan are expected to be usefully exploited for injectable drug delivery depots, tissue engineering hydrogels, underwater adhesives, tissue culture platforms, and anti-bleeding materials.
류지현,박혜진,정이영,한선규,신정혜,이수정,강민정,성낙주,강다원 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.4
Lipopolysaccharides (LPS) activate nuclear factor kappa B (NF-κB), a transcription factor that is involved in inflammatory response. The pathways that activate NF-κB can be modulated by phytochemicals derived from garlic. We recently demonstrated that aged red garlic extract (ARGE), a new formulation of garlic, decreases nitric oxide (NO) generation by upregulating of heme oxygenase-1 (HO-1) in RAW 264.7 cells activated by LPS. However, the effects of ARGE on LPS-induced NF-κB activation are unknown. This study was performed to evaluate whether ARGE regulates LPS-induced NO production by modulation of NF-κB activation in macrophages. The inhibition of NF-κB by Bay 11-7085, an inhibitor of NF-κB, decreased LPS-induced NO production. ARGE treatment markedly reduced LPS-induced NO production and NF-κB nuclear translocation. ARGE downregulated expression of inducible nitric oxide synthase (iNOS) and upregulated expression of HO-1, a cytoprotective and anti-inflammatory protein. However, Bay 11-7085 only reduced iNOS expression. The NO production and iNOS expressions upregulated by suppression of HO-1 were suppressed by treatment with ARGE and Bay 11-7085. These results show that ARGE reduces LPS-induced NO production in macrophages through inhibition of NF-κB nuclear translocation and HO-1 activation. Compared to Bay 11-7085, ARGE may enhance anti-inflammatory effects by controlling other anti-inflammatory signals as well as regulation of NF-κB.