간종양의 색도플러 초음파 소견

김창우 대한영상의학회 1996 대한영상의학회지 Vol.35 No.4

Purpose : To evaluate the color Doppler imaging patterns of hepatoma, hemangioma,and metastasis. Materials andMethods : The study comprised 37 patients with liver mass lesions: 12 patients had hepatoma,15 had hemangiomas and10 had metastatic liver cancers. All 37, who showed hepatic mass on gray scale ultrasonogrphy, were analyzedprospectively. Color mapping of tumors was performed for these patients, and the fastest or next fastest vesselwas spectrally analysed to show blood pattern and to measure peak velocity. Results : In all the 12 patients withhepatoma, spectral analysis revealed exteusive pulsating arterial blood flow within the tumor ; peak velocitieswere 7~65cm/sec(mean 34cm/sec). In ten hemangiomas(66%) color mapping revealed blood flow within the tumor andspectral analysis revealed this possibility in eight of the ten tumors. In none of these patients was a pulsatingcontinous wave observed ; peak velocity was 5~21cm/sec(mean 12.8cm/sec). In no mestastatic tumors was blood flowobserved. Conclusion : Color Doppler imaging is helpful in the differentiation of hepatoma,hemangioma, andmetastatic tumor in the liver.

外來 <武道身體文化>의 流入過程을 통해본 韓國 武道의 現代的 意義

김창우,이재학,송일훈 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.31

Introduction of Foreign Physical Culture andModernistic Significance of Korean Martial Arts

A selective morphosynthetic approach for single crystalline hematite through morphology evolution via microwave assisted hydrothermal synthesis

김창우,강명종,Thanh Khue Van,강영수 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-

Hematite single crystals are one of most promising materials which is able to apply for the field of catalyst industry. Even its prospective applicability, strategies for improving its catalytic performance are still not enough to meet the requirements for industrial application. In the present work, we demonstrate a morphology selective one pot reaction for a hematite single crystal by microwave-assisted hydrothermal synthesis. The microwave-assisted hydrothermal route, taking advance of the exposed crystal facetbased activity of the material, is suggested to crystal facet controlling synthesis of the hematite crystal. The dispersant and capping agents such as sodium carboxymethyl cellulose and N2H4, respectively, play a very important role in controlling the exposed crystal facet and morphological uniformity for a selective morphology of hematite crystal. In addition, systematically experimental examination of the wellexposed facet is interestingly giving an insight into the crystal growth and morphological evolution of single crystalline hematite from plate to tetrahexagonal bipyramid, octahedral and oblique cubic shape. Physicochemical techniques were used to characterize and evaluate the photoactivity of the material in detail. In here, a well-defined crystal facet is obtained and expected to be applied as an efficient catalysts and its synthetic methodology is applicable to other metal oxide photocatalyst.

한국 현대사의 증언 남로당 지방당 조직의 활동상을 밝힌다-면당위원장 출신 전북도당 산하 4도(전북,전남,경남,충남)연락책을 맡았던 김문현의 증언

김창우 역사문제연구소 1988 역사비평 Vol.- No.5

microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish

김창우,한지혁,Ling Wu,최재영 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.1

Purpose: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiationin various organs by silencing specific RNAs and regulating gene expression. In the present study, we show that the microRNA(miR)-183 cluster is upregulated during hair cell regeneration and that its inhibition reduces hair cell regeneration followingneomycin-induced ototoxicity in zebrafish. Materials and Methods: miRNA expression patterns after neomycin exposure were analyzed using microarray chips. Quantitativepolymerase chain reaction was performed to validate miR-183 cluster expression patterns following neomycin exposure (500 μM for 2 h). After injection of an antisense morpholino (MO) to miR-183 (MO-183) immediately after fertilization, hair cell regenerationafter neomycin exposure in neuromast cells was evaluated by fluorescent staining (YO-PRO1). The MO-183 effect also was assessed in transgenic zebrafish larvae expressing green fluorescent protein (GFP) in inner ear hair cells. Results: Microarray analysis clearly showed that the miR-183 cluster (miR-96, miR-182, and miR-183) was upregulated after neomycintreatment. We also confirmed upregulated expression of the miR-183 cluster during hair cell regeneration after neomycin-induced ototoxicity. miR-183 inhibition using MO-183 reduced hair cell regeneration in both wild-type and GFP transgenic zebrafishlarvae. Conclusion: Our work demonstrates that the miR-183 cluster is essential for the regeneration of hair cells following ototoxic injuryin zebrafish larvae. Therefore, regulation of the miR-183 cluster can be a novel target for stimulation of hair cell regeneration.

사구체 기저막 비박화 소견을 보인 미세변화 신증후군에 관한 고찰

김창우,조민현,고철우,구자훈,곽정식,Kim, Chang-Woo,Cho, Min-Hyun,Ko, Cheol-Woo,Koo, Ja-Hoon,Kwak, Jung-Sik 대한소아신장학회 2002 Childhood kidney diseases Vol.6 No.1

목 적 : 비박화 사구체신증은 대개 혈뇨의 가족력이 있고 우성유전하며 소아 및 성인의 무증상성 혈뇨의 가장 흔한 원인중의 하나로 알려져 있다. 사구체 기저막의 비박화는 정상 성인에서도 보고되고 있고 또한 Alport 증후군의 초기, IgA 신병증 및 메산지움 증식성 사구체 신염등과 같은 다른 사구체 신장질한 시에도 나타난다고 한다. 그러나 사구체 기저막의 비박화와 미세변화 신증후군이 동반된 보호는 극히 희소하여 이에 본 연구는 사구체 기저막의 비박화와 미세변화 신증후군과의 여관관계를 살펴보고자 시행되었다. 대상 및 방법 : 대상환아는 1997년부터 2001년까지 5년간 경북대학교병원 소아과에 입원하여 신조직 검사상 미세변화 신증후군으로 확진된 49예로 하였으며 환아들은 모두 스테로이드 의존성 이든가 빈번한 재발형 이었다. 이중 8예에서 사구체 기저막의 현저한 비박화(사구체 모세혈관의 $50\%$이상)가 관찰되었으며 이를 제1군으로 하고 나머지 41예를 제2군으로 하여 이들 환아의 발병연령, 신조직 검사까지의 기간, 신질환의 가족력 및 혈뇨의 동반여부, 그리고 24시간 요단백 배설량, 혈청 알부민, 콜레스테롤등의 각종 검사실 성적을 비교 관찰하였다. 결 과 : 대상환아의 발병연령 및 성별분포는 제1군 $7.l{\pm}3.5세$, 제2군 $4.8{\pm}2.9세$로 제1군에서 다소 연령이 높았으나 통계적으로 유의하지 않았으며(P=0.056) 남녀비는 3:1로 양군에서 차이가 없었다. 혈뇨의 가족력은 제2군에서 2예에 있어서 관찰되었고 혈뇨의 빈도는 제1군에서 8예중 2예($25\%$)였고 제2군에서는 41예중 7예($17\%$)로 제1군에서 다소 높은 비율을 보였으나 통계적으로 유의하지는 않았다. 그외 BUN, creatinine, 24시간 뇨단백 배설량, 혈청단백, 혈청 알부민 및 T4/T8 비등의 각종 검사실 소건은 양군에서 유의한 차이는 없었다. 신조직검사 소견도 양군에서 의미있는 차이를 발견할수 없었고 제1군에서 사구체 기저막의 두께는 평균 $188{\pm}30nm$였다. 결 론 : 8예의 MCNS 환아들에게서 TGBM의 소견이 보였으며 같은 기간중 신생검 소견상 MCNS로 진단된 49예의 $16.3\%$에 해당되는 높은 빈도로서 이는 TCBM과 MCNS가 우연히 공존한다기 보다 서로 연관성이 있음을 시사한다고 하겠다. 또한 TGBM이 동반된 MCNS 8예 모두에서 전형적인 TGBMN의 임상상을 보여주지 않았음으로 TCBM이 MCNS를 유발한다기 보다는 MCNS에 나타나는 TGBM은 MCNS 그 자체로 초래되는 이차적인 소견일 것으로 생각된다. Purpose: Thin glomerular basement membrane nephropathy (TGBMN) is recognized as the leading cause of microscopic hematuria in both children and adults. However thinning of glomerular basement membrane (TCBM) has been found in healthy adult and also is known to be associated with various renal diseases such as Alport syndronh, IgA nephropathy and mesangial proliferative glomerulonephritis. The association of TGBM with minimal change nephrotic syndrome (MCNS) has been very rare so that the present study was undertaken to determine the relationship between TGBM and MCNS. Methods: The study population consisted of 49 children with biopsy- proven MCNS who have been admitted to the pediatric department of Kyungpook University Hospital during the past 5 years from 1997 to 2001. Group I consisted of 8 children associated with TGBM and Group II 41 children without TCBM. Various parameters such as age of illness, duration from discovery of illness to the time of biopsy, family history of hematuria and other laboratory tests were compared between these two groups and the following results were obtained. Results: Age distribution showed slightly older age in Group I ($7.1{\pm}3.5$ years) compared to Group II ($4.8{\pm}2.9$ years). However this was not statistically different (P=0.056). Family history of hematuria was noted in 2 cases in Group II. Though statistically not significant, hematuria was seen in 2 out of 8 cases ($25\%$) in MCNS children with TGBM, compared to 7 out of 41 cases ($17\%$) with MCNS children without TGBM. Other parameters such as BUN, creatinine, 24 hours urine protein excretion, serum protein, albumin, cholesterol, and T4/T8 ratio, showed no difference. Also renal biopsy finding showed no significant difference and the thickness of glomerular basement membrane in Croup I was $188{\pm}30nm$. Conclusion: TGBM was found in 8 out of 49 children with MCNS ($16.3\%$). And this high frequency of occurrence indicates that these association is not an incidental findings. Typical clinical findings of TCBMN was not noted in all of the 8 children with MCNS associated with TGBM, suggesting that thinning of glomerular basement membrane (TCBN) is secondary to rather than the cause of MCNS. (J Korean Soc Pediatr Nephrol 2002;6: 48-55)

자모의 이름을 보고

김창우 한글학회 1935 한글 Vol.3 No.7

항공사 조직구성원의 항공안전과 항공보안에 대한 상충적 태도가 조직효과성에 미치는 영향 연구

김창우,김기웅,박성식 한국항공운항학회 2020 한국항공운항학회지 Vol.28 No.2

This paper has studied the effect of airline staff’s perception on both aviation safety andaviation security to their organizational effectiveness. Airline staff’s perception on aviationsafety is different from that on aviation security due to organizational difference in an airline. Through an empirical analysis, it was analyzed the effect of such perceptional difference onairline’s organizational effectiveness. According to the analysis, it was found the perception ofaviation safety has a significant positive effect on organizational effectiveness. Airline staffbelieved the safety is a core value of an airline and emphasizing the safety never impeded theairline’s operation including service quality. Secondly, it was proven the perception on abidingby aviation security rules had a significant negative effect on organizational effectiveness. However, emphasizing aviation security had a very significant positive contribution on airline’sphilosophy of aviation safety. Following the research results, it was suggested an airline lookfor improving the process and regulations to deal with aviation security in the organization.

교육감의 행정행위와 책무성에 대한 국가의 관여 방식과 기제에 관한 쟁점 분석

김창우,김규태 한국교육정치학회 2014 敎育政治學硏究 Vol.21 No.3

본 연구는 교육감의 행정행위와 책무성에 대한 국가의 관여 방식과 기제에 관한 쟁점을 분석하기 위해 수행되었다. 이와 같은 목적을 달성하고자 교육감과 교육부장관 사이에 가장 쟁점이 된 아홉 가지 사례를 분석하였다. 본 연구의 결론은 다음과 같다. 교육감의 행정행위와 책무성에 대한 쟁점은 교육감의 행정행위에 대한 불명확한 법규 내용과 그에 따른 국가와 교육감의 인식 차이에서 비롯되었다. 교육감의 행정행위에 대한 국가의 관여는 행정적 관여가 주류를 이루었지만 행정적 관여로 쟁점이 해결되지 않으면 사법적・입법적 관여를 통해 교육감의 행정 행위에 관여하고 있는 것으로 나타났다. 또한 교육감을 평가하는 책무성에 대한 국가와 교육감의 인식의 차이에 의해서 쟁점이 발생하였다. 그리고 이러한 양상은 지역주민의 여론에 의해 가장 큰 영향을 받고 있었다. 본 연구의 결론을 바탕으로 몇 가지 제언을 한다면 다음과 같다. 첫째, 교육감의 권한에 관한 모호한 법규 내용 정비가 필요하다. 둘째, 자치사무와 재량행위의 범위및 내용과 방식 등을 담고 있는 관련 법령 개정을 위한 후속연구가 필요하다. 셋째, 고객지향적 책무성에 초점을 두는 국가의 관여 방식을 재고할 필요가 있다. The purpose of this study was to analyze the educational issues on the State’s involvement and Mechanisms of the Administrative Acts and Accountability of Superintendents of Education. The findings were as follows. First, the educational issues of the administrative acts and the accountability types of the superintendents of education were derived from ambiguous provisions in the concerned rules and regulations resulting in different points of view between the state and the superintendents of education. Second, These conclusions set the course for further study clarifying the role of superintendents as prescribed in educational laws. Follow-up studies are needed to determine steps to reduce conflict between the state and the superintendents. Such work could examine the administrative acts in line with customer-driven accountability for superintendents.

열상장비용 직병렬주사광학계

김창우,김현숙,홍석민,김재기 한국광학회 1994 한국광학회지 Vol.5 No.2

원적외선 영역인 $8-12.\mu$m 대역의 열상장비 주사광학계를 설계 제작하였다. 검출기로 5개 소자의 SP-RITE HgCdTe를 사용하는 직병렬 주사를 위해 수평 및 수직주사에는 각각 회전다면거울과 진동평면거울을 사용하였으며, 주사연결거울로는 구면거울을 사용하여 주사거울의 크기 및 입사동에서의 동수차를 최소화 하였다. 주사광학계는 $40^{\circ}\times26.67^{\circ}$의 넓은 주사시야를 갖는다. 회절 변조전달함수의 계산결과 회절한계의 성능을 만족하였으며 제작 및 시험 결과 고분해능의 열영상을 얻을 수 있었다. We have designed and constructed a scanner optics for thermal imaging system operating in 8 - 12 /lfll band. The scanner consists of rotating polygon and oscillating mirror for serial-parallel scan using 5 elements SPRITE HgCdTe. A spherical mirror is used for scan relay mirror to minimize size of the scan mirrors and pupil aberration. The scanner has $40^{\circ}\times26.67^{\circ}$ wide scan field of view and the calculated diffraction MTF shows diffraction limited performance. As a result we have obtained high resolution thermal image. image.