http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 김기웅 (검색결과 754 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
-
Cytochrome P-450 의존성 radical 전달에 의한 Benzene, Toluene, Xylene의 대사기전 연구
김기웅,장성근,김양호,문영한 한국독성학회 1995 Toxicological Research Vol.11 No.2
This study was undertaken to investigate the effects of organic solvents on xenobiotic metabollzing enzyme system in vivo by meaas of experimental conditions i.e. (1) single group which was treated by benzene (B), toluene (T) and xylene (X), respectively, (2) combination group which was treated by mixture of benzene+toluene (BT), benzene+xylene (BX), and toluene+xylene (TX), respectively, (3) mixture group which was treated by benzene+ toluene+xylene mixture (M), and to interpreat the interaction between the organic solvents metabolizing enzymes. 1. The contents of cytochrome P-450 in liver microsomes were increased (p < 0.01) in organic solvents treated groups, and the contents of cytochrome P-450 were increased by following order of B < T < M < BT=BX < X < TX. 2. The activity of cytochrome P-450 dependent AHHase was significantly higher in organic solvents treated groups than in control group (p < 0.01), and the activity of AHHase was increased by following order of B < T < BT=BX=TX=xylene < M. 3. The activity of NADPH P-450 reductase was significantly higher in organic solvents treated groups than in control group (p < 0.01), and the order of M < combinated group < X < T <B, however, the activity of NADH b5 reductase was the reverse order of NADPH P-450 reductase activity. 4. The activity of superoxide dismutase (SOD), and generation of hydroxyl radical and lipid peroxide were significantly higher in organic solvents treated groups than in control group (p < 0.01), and the order of M < T=X=combinated group (BT=BX=TX) < B. These results suggested that the first step of biotransformation pathway of organic solvents(benzene, toluene and xylene) may be proceeded by a different metabolic reaction. Because benzene was metabolized by radical reaction through cytochrome P-450 dependent radical intermediates, meanwhile toluene and xylene were hydroxylated by cytochrome P-450 dependent AHHase.
-
혈장(血漿) MHPG와 HVA 농도(濃度)의 24시간(時間) 주기성(週期性) 변화(變化)에 관한 연구(硏究)
김기웅,이정희,우종인,Kim, Ki-Woong,Lee, Jung Hie,Woo, Jong Inn 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2
We invesigated whether the circadian rhythms of plasma MHPG and HVA concentrations exist in 11 healthy young adults, and analyzed the patterns of their circadian rhythms. The results were as follows : 1) The change in the mean plasma MHPG concentrations analyzed by repeated measures ANOVA was not statistically significant. Five subjects showed significant circadian rhythms of plasma MHPG concentrations of each individual, and 4 of those had the acrophases between 17PM and 24PM. 2) The change in the mean plasma HVA concentrations analyzed by repeated measures ANOVA was not statistically significant. Six subjects showed significant circadian rhythms of plasma HVA concentrations of each individual, and 4 of those had the acrophases between 21PM and 6AM. In conclusion, the circadian rhythm pattern of plasma HVA concentrations in our result is consistent with the previous study. It was suggested that plasma MHPG and HVA concentrations should be measured more frequently, and the physical activities of subjects be controlled more strictly for the following study.
-
-
Dimethylformamide가 사람 혈청의 과산화지질 농도와 Superoxide dismutase 활성도 변화에 미치는 영향
김기웅,최정근,김태균,송문기,고경선,손남석,조영숙,김소연,김희곤 한국독성학회 1996 Toxicological Research Vol.12 No.1
The variation in the enzyme activities of human liver usually represents the particular physiological conditions of each individuals. Thus, we investigated the variation in the activities of SOD, HR and LPO of (1) non-exposed workers (56 subjects), and (2) exposed workers to DMF (43 subjects) in synthetic leather process. Serum levels of enzyme activities of exposed workers (AST:$30.26{\pm}20.041$U/L, ALT:$32.72{\pm}23.393$U/L, GGT:$28.47{\pm}18.635$ U/L, ALP:$81.77{\pm}34.879$ U/L)were slightly higher than those in nonexposed workers (AST:$24.00{\pm}9.441$ U/L, ALT:$23.89{\pm}18.305$U/L, GGT:$21.95{\pm}17.970$U/L, ALP:$70.84{\pm}24.678$U/L), but only the level of ALT was statistically significant (p< 0.05). Serum levels of LDH, TRF and CHOL in non-exposed workers were slightly higher than those of exposed workers. However, they were not statistically significant (p > 0.05). Serum levels of HR and LPO of the exposed workers appeared to be reduced, but not those of the non-exposed workers. The SOD activities of exposed workers were also slightly higher than those of non-exposed workers, but the results were not statistically significant (p > 0.05). The level of HR was increased with age, but the SOD level was not. These results suggest that the intermittent exposure to DMF at time-weighted average (TWA) level (10 ppm/$m^3$) has affected on the activities of enzymes such as AST, ALT, TRF, but not on the generation of HR, activity of SOD. However, if high dose of DMF was used, there would be severe effects for the generation of HR and LPO.
-
-
Ethanol이 Trichloroethylene 대사효소의 활성도와 유도성에 미치는 영향
김기웅,강성규,조영숙,이세휘,문영한,최병순,박상신,Kim, Ki-Woong,Kang, Seung-Kyu,Cho, Young-Sook,Lee, Sei-Hui,Moon, Young-Hahn,Choi, Byung-Soon,Park, Sang-Shin 대한예방의학회 1995 예방의학회지 Vol.28 No.1
This study was performed to find out the influences of ethanol on the metabolism of trichloroethylene(TRI) in rats. TRI in corn oil at the dosage of 150, 300, 600 mg/kg was injected peritoneally once a day for two days to two groups. In one group ethanol(4 g/kg) was taken orally 30 minutes before TRI injection, and the other group ethanol was not. The results of experiments are as follows: 1. The contents of cytochrome P-450 and $b_5$ had inverse relationship with in-jected TRI amounts in both groups. 2. The activity of NADPH P-450 reductase was decreased slowly in TRI injected group related with TRI amount, but decreased drastically in the group pretreated with ethanol. 3. The activity of NADH $b_5$ reductase had relationship with injected nt amount , but the statistical significance was found only in the groups of 300 and 600 mg/kg of TRI injected without relevance to ethanol when compared with the group that was not injected. 4. The activity of ADH was more decreased and ALDH activity was more increased in groups that TRI injected and ethanol was pretreated with ethanol groups than in group without any treatment. These results suggest that ethanol may inhibit epoxide formulation, the first step of TRI metabolism, and change from TCE-OH to TCA also.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
