부유형 해양 광생물반응기를 이용한 자외선과 초기 미세조류 접종 농도와의 상관관계 규명

김지훈,박한울,정성균,김수권,김희윤,박용성,홍한마루,이철균,Kim, Z-Hun,Park, Hanwool,Jung, Seong-Gyun,Kim, Su-Kwon,Kim, Hee-Yun,Park, Yong Sung,Hong, Han Ma Roo,Lee, Choul-Gyun 한국해양바이오학회 2015 한국해양바이오학회지 Vol.7 No.2

The purpose of this study was to investigate a relationship between ultraviolet radiation and initial cell density (ICD) of microalgae using a floating marine photobioreactor (PBR). To examine the effect of ultraviolet (UV) radiation in sunlight on biomass productivity as a function of ICD, 0.5-L floating PBRs covered with or without UV cut-off film were placed in an outdoor rectangular tank containing 200 L of water. At the lower ICDs, 0.01 and 0.05 g/L, biomass productivities in the PBRs without UV cut-off film decreased by $278{\pm}21%$ and $222{\pm}3%$ compared with those with the film, respectively. In contrast, the presence of UV cut-off film did not have a significant effect on biomass productivities at the higher ICDs, 0.25 and 1.25 g/L. When the differences in biomass productivity made by the UV cut-off film were plotted against the sum of cell projection area per light receiving area of the PBR, the results revealed that the inhibitory effect of UV on biomass productivity can be negligible when the sum of cell projection area is equal to the light receiving area of the PBR. These results show that photoinhibition caused by UV radiation could be eliminated via operating the PBR with a proper ICD.

인접전류패턴을 사용한 변형된 방향 대수적 영상복원법

김지훈,김찬용,김경연,최봉열,Kim, Ji Hoon,Kim, Chan Yong,Kim, Kyung Youn,Choi, Bong Yeol 대한전자공학회 2012 전자공학회논문지 Vol.50 No.8

전기 임피던스 단층촬영법(electrical impedance tomography, EIT)에서 관심 대상물 내부 영상을 복원하는 방법 중 하나인 방향 대수적 영상복원법(directional algebraic reconstruction technique, DART)은 삼각함수형태로 설계된 전류패턴을 외부 전극에 인가하고 이로부터 얻어지는 전압과의 상관관계를 이용하여 영상복원 알고리즘의 입력인 각 전극사이의 저항을 유도하게 된다. 이때, 저항유도 시간이 발생하고 이는 DART 알고리즘을 실시간 영상복원에 적용하는데 장애가 되고 있다. 이 논문에서는 저항유도 시간의 문제를 해결하기 위하여 기존에 사용하던 삼각함수형태의 전류패턴대신 인접전류패턴을 사용한 변형된 방향 대수적 영상복원법(modified directional algebraic reconstruction technique, mDART)을 제안한다. 제안한 방법은 주입한 전류와 측정된 전압으로부터 저항을 유도하지 않고 측정전압을 바로 복원 알고리즘의 입력으로 사용하기 때문에 DART의 영상복원시간의 대부분을 차지하는 저항유도 시간을 없앨 수 있을 뿐만 아니라 인접전류패턴을 사용하여 복원영상의 질도 향상시킬 수 있다. 이 논문의 타당성을 입증하기 위하여 모의실험을 수행하였으며 제안한 방법은 기존 방법보다 복원시간의 개선뿐만 아니라 영상오차 관점에서도 성능이 개선됨을 확인하였다. The directional algebraic reconstruction technique (DART) using the trigonometric current pattern is one of the image reconstruction algorithms in electrical impedance tomography (EIT). This method needs to compute resistances between electrode pairs as using relation between the injected currents and measured voltages for the reconstruction of the inner image. The delay time is incurred in this process. Therefore this paper proposes modified directional algebraic reconstruction technique (mDART) using the adjacent current pattern instead of the trigonometric current pattern to solve the delay time for initial resistance values. The proposed method uses measured voltages instead of computed resistances in the reconstruction algorithm. Hence this method can eliminate the delay time because it does not use the resistances. In conclusion, the proposed method improves image quality and image reconstruction time by using the adjacent current pattern. To prove performance of the proposed method, we carried on computer simulation of various cases.

소아 궤양성 대장염의 수술적 치료 성적

김지훈,김현영,정성은,박귀원,김우기,Kim, Ji-Hoon,Kim, Hyun-Young,Jung, Sung-Eun,Park, Kwi-Won,Kim, Woo-Ki 대한소아외과학회 2005 소아외과 Vol.11 No.2

Ulcerative colitis, an inflammatory bowel disease, is primarily managed medically with a combination of 5-ASA and steroids. However, this chronic disease requires surgical management if symptoms persist or complications develop despite medical management. The clinical course, indications and outcome of surgical management of 21 patients under the age of 15 who were endoscopically diagnosed with ulcerative colitis at the Seoul National University Children's Hospital between January, 1988 and January, 2003 were reviewed. Mean follow up period was 3 years and 10 months. The mean age was 10.3 years old. All patients received medical management after diagnosis and 8 patients (38 %) eventually required surgical management. Of 13 patients who received medical management only, 7 patients (53 %) showed remission, 4 patients are still on medical management, and 2 patients expired due to congenital immune deficiency and hepatic failure as a result of sclerosing cholangitis. In 8 patients who received surgical management, the indications for operation were, 1 patient sigmoid colon perforation and 7 patients intractability despite medical management. The perforated case had a segmental colon resection and the other 7 patients underwent total colectomy with ileal pouch-anal anastomosis. One patient expired postoperatively due to pneumonia and sepsis. and 1 is still on medical management because of mild persistent hematochezia after surgery. Six other operated patients are doing well without medical therapy. Pediatric ulcerative colitis patients can be surgically managed if the patient is intractable to medical management or if complications such as perforation are present. Total colectomy & ileal pouch-anal anastomosis is thought to be the adequate surgical method.

혈액질환에 속발하는 이차성 위암

김지훈,지성배,허훈,진형민,김욱,김동욱,이종욱,민우성,김춘추,전해명,Kim, Ji-Hoon,Jee, Sung-Bae,Huh, Hoon,Chin, Hyung-Min,Kim, Wook,Kim, Dong-Wook,Lee, Jong-Wook,Min, Woo-Sung,Kim, Choon-Choo,Jeon, Hae-Myung 대한위암학회 2007 대한위암학회지 Vol.7 No.4

Purpose: Patients with hematologic diseases such as chronic myeloid leukemia (CML) or chronic lymphoid leukemia (CLL) are known to have an increased chance of acquiring a secondary neoplasm. Stomach cancer is one of the most common malignant diseases in Korea, and we investigated whether the incidence of secondary stomach cancer in patients with a hematologic disease increases, in order to determine if a more intensive screening program for detecting secondary gastric cancer was required. We also investigated the safety of performing a gastrectomy in hematologic disease patients. Materials and Methods: From 1992 to 2006, the medical records of 8376 patients diagnosed with one of the six common hematologic diseases were reviewed. Results: Nine secondary stomach cancers were found among the 8376 patients during the 15-year observation period. No surgical-related complications occurred, and there was no recurrence of stomach cancer if detected early. Conclusion: It seems that a more intensive screening program for detecting secondary gastric cancer in hematologic disease patients is not required, and surgery is not risky in these patients. 목적: 만성 골수성 백혈병이나 말성 림프구성 백혈병에서 이차성 암의 위험은 증가하는 것으로 알려져 있다. 백혈병을 비롯한 혈액질환을 가진 환자에서 우리나라에서 가장 흔한 암 가운데 하나인 위암의 위험이 증가하는지 조사하여 혈액질환 환자를 대상으로 위암에 대한 보다 적극적인 검진이 필요한지 알아보고자 하였다. 또한 응고장애나 면역저하와 같은 수술에 관련된 위험인자가 있을 수 있는 혈액질환 환자에서 위암 수술이 안전하게 이루어질 수 있는지에 대해 조사하고자 하였다. 대상 및 방법: 지난 15년가 성모병원에서 백혈병 및 다발성 골수종, 재생불량성 빈혈로 진단받은 8,376명의 환자를 대상으로 의무기록을 후향적으로 조사하였다. 결과: 총 9예의 이차성 위암이 확인되었다. 감염이나 출혈등 수술관련 합병증은 발생하지 않았으며, 조기에 발견된 경우 재발도 관찰되지 않았다. 결론: 위암의 빈도가 일반인에 비해 크게 증가하지 않아 혈액질환 환자에서 이차성 위암의 감시를 위한 집중적인 프로그램이 따로 도입되어야 할 필요성은 없는 것으로 생각되며, 혈액질환 환자의 위암 수술에 있어 합병증도 크게 증가하지는 않는 것으로 생각된다.

김제시 간척지역 천부 지하수내 철 환원작용 특성에 대한 고찰

김지훈,정태진,류종식,김락현,Kim, Ji-Hoon,Cheong, Tae-Jin,Ryu, Jong-Sik,Kim, Rak-Hyeon 대한자원환경지질학회 2013 자원환경지질 Vol.46 No.1

간척지를 포함하고 있는 연구지역에서 육지에서 해안지역으로 근접할수록 측정된 지하수의 산화환원 전위 (Eh)와 용존 산소량 (DO)은 낮게 관찰되었다 (Eh: 0.57 V ${\rightarrow}$ 0.13 V, DO; 9.7 mg/l ${\rightarrow}$ 1.3 mg/l). 이는 연구지역 지하수의 산화환경이 육지에서 해안가로 근접할수록 호기성 환경에서 아혐기성/혐기성 환경으로 변화한다는 것을 의미한다. 또한 지하수 수질 분석 결과에 의하면 철이온 (Fe)이 지하수에 많이 포함되어 있으며 (> 20 mg/l), 대부분의 2가 철로 존재한다. 이러한 연구지역 해안가 지하수들의 특징들은 지하수들이 철의 환원작용 (Fe reduction)이 일어날 수 있는 혐기성 환경에 위치하고 있음을 지시해준다. 철 환원작용이 일어나기 위해서는 3가 철의 공급원이 필요한데, 관측정 퇴적물의 철이온 추출실험에 의하면 연구지역의 퇴적물은 철 환원작용에 필요한 3가 철이온에 대한 충분한 공급원 역할을 할 수 있다. 따라서 분석한 지하수 및 퇴적물의 결과들을 종합해석하면, 연구지역에서 일어나는 철 환원작용은 갯벌의 간척활동과 많은 관련을 가지고 있는 것으로 추정된다. The study area is located on the western coastal region of Korea, partly had been reclaimed lands. Groundwaters of the coastal area show lower Eh and DO values (Eh: 0.57 V ${\rightarrow}$ 0.13 V, DO; 9.7 mg/l ${\rightarrow}$ 1.3 mg/l), and higher Fe concentrations (> 20 mg/l) than those of the inner land (< 0.3 mg/l), indicating that the redox condition of groundwater changes from oxic into suboxic/anoxic conditions as it flows from the inland toward the coastal area. In addition, Fe speciation of groundwater from the coastal area demonstrates that the most dissolved Fe exist as $Fe^{2+}$, reflecting that groundwater is under the anoxic condition to sufficiently occur Fe reduction. According to the result of Fe extraction with the sediment samples from three wells (A, B, C), the sediments provide enough $Fe^{3+}$ to occur the Fe reduction in the groundwater. Integrated all results of the groundwater and sediment, we infer that the Fe reduction to occur in groundwater is associated with the reclamation processes of the study area.

자동 클럭 보정 기능을 갖춘 크리스털리스 클럭 합성기 설계

김지훈,김호원,이강윤,Jihun Kim,Ho-won Kim,Kang-yoon Lee 반도체공학회 2024 반도체공학회 논문지 Vol.2 No.3

본 논문은 32, 72, 80MHz 의 주파수에서 작동하는 블루투스 저에너지(BLE) 스마트 태그 애플리케이션용으로 설계된 보정 기능이 있는 레퍼런스 클럭 합성기(CR)에 대해 설명합니다. 기존 주파수 합성기와 달리 제안된 설계는 외부 소자가 필요하지 않습니다. 단일 종단 안테나를 사용하여 2.4GHz 신호에서 - 36dBm 의 최소 입력 전력을 수신하는 클럭 합성기(CR)는 저잡음 증폭기(LNA)를 통해 수신된 RF 신호를 처리하여 클럭을 합성합니다. 이 방식을 통해 시스템은 크리스털에 의존하지 않고 레퍼런스 클럭을 생성할 수 있습니다. 수신된 신호는 LNA 에 의해 증폭된 이후 16 비트 ACC(자동 클럭 보정) 회로에 입력됩니다. ACC는 수신된 신호의 주파수를 발진기 출력 주파수와 비교하여 주파수 계산 방법을 통해 32MHz 레퍼런스 클럭 합성을 용이하게 합니다. 발진기는 주파수 분배기가 있는 링 발진기(RO)를 사용하여 구성되며, 다양한 시스템 구성 요소에 대해 세 가지 주파수(32/72/80MHz)를 제공합니다. 제안된 주파수 합성기는 55nm CMOS 공정을 사용하여 구현되었습니다. This paper presents a crystal-less reference clock recovery (CR) frequency synthesizer with compensation designed for Bluetooth Low Energy (BLE) Smart-tag applications, operating at frequencies of 32, 72, and 80MHz. In contrast to conventional frequency synthesizers, the proposed design eliminates the need for external components. Using a single-ended antenna to receive a minimal input power of -36dBm at a 2.4GHz signal, the CR synthesizes frequencies by processing the RF signal received through a Low Noise Amplifier ( L N A ) . This approach allows the system to generate a reference clock without relying on a crystal. The received signal is amplified by the LNA and then input to a 16-bit ACC (Automatic Clock Compensation) circuit. The ACC compares the frequency of the received signal with the oscillator output signal, using the synthesis of a 32MHz reference clock through a frequency compensation method. The oscillator is constructed using a Ring Oscillator (RO) with a Frequency Divider, offering three different frequencies (32/72/80MHz) for various system components. The proposed frequency synthesizer is implemented using a 55-nm CMOS process.

절단 위치에 따른 족부 절단술의 치료 결과

김지훈,고형탁,서진수,Kim, Ji Hoon,Ko, Hyeong Tak,Suh, Jin Soo 대한족부족관절학회 2015 대한족부족관절학회지 Vol.19 No.1

Purpose: The purpose of this study is to evaluate the incidence and cause of reamputation with respect to the location of foot amputation. Materials and Methods: Eighty-six patients who received amputations below the ankle level from March 2002 to September 2012 with at least 1 year follow-up were enrolled in this study. We stratified the site of the initial amputation from first to fifth ray and into either the phalanx or metatarsal bone, and investigated the cause of reamputation. Results: The reamputation rate below the ankle level was 53.5%. It was highest (62.1%) in patients with first ray amputations without statistical significance. Rays were divided into two columns, first to third rays as the medial column and others as the lateral column, and reamputation was performed in 61.2% of patients with medial column amputation. Comparing the results between phalanx and metatarsal amputations, reamputation was performed in 62.1% of patients with metatarsal bone amputation. The rate of reamputation was statistically significant in both the medial column and metatarsal amputations. The most common reamputation site, in accordance to the initial site of amputation, was the adjacent ray (57.4%), which was without statistical significance. Moreover, the most common cause of reamputation was osteomyelitis and focal infection in all rays. Conclusion: This study showed that reamputation after amputation below the ankle level was relatively common with highest rate in medial column and metatarsal amputations. Hence, surgeons should be aware of the risk of reamputation and put more preventive effort during medial column and metatarsal amputations.

백부자산(白附子散)이 자외선 조사된 피부 손상과 색소침착에 미치는 영향

김지훈,홍승욱,Kim, Ji-Hoon,Hong, Seong-Ug 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.1

Objective : The purpose of this study is to examine the effects of Baickbujasan(BB) on the skin damage and depigmentation. Method : The inhibition of tyrosinase activity, melanogenesis and cell viability in cultured B16 melanoma cells were measured. In order to test effects of reduction of melanogenesis, B16 F-10 mouse melanoma stem line was employed to extract melanin from cultured cell, where BB was added or not, and was dissolved in alkali for colorimetric analysis. Also, in order to test skin alteration in C57BL/6 after UV irradiation, the animals were grouped into a UV urradiation group and UV irradiation after BB application group. Dopa oxidase tissue staining was excuted to invesitage the change in the distribution of active melanin cell. The distribution of active melanin cell in inner skin of iNOS after damage from UVB irradiation and the manifestation condition of P53 which takes part in natural death of keratinocyte were examined. Result : The results indicate that BB has significant effects on tyrosinase activity, and melanogenesis in vivo test. BB seems to reduce C57BL/6, external dermatological damage, for instance, erythematous papule, eczema, loss of keratinocyte, reduction in pus, and relieves dermatological damages. Conclusion : BB can be applied externally for UV protection and depigmentation.

$La_2CuO_4$ 구조를 갖는 $(C_4H_9NH_3)_2PbI_4$의 합성 및 분석

김지훈,박성훈,최동식,Kim, Ji Hoon,Park, Sung Hoon,Chair, Tong Seek 대한화학회 1998 대한화학회지 Vol.42 No.5

기존한약서 수재 처방 Database 구축 연구

김지훈,이대중,윤성중,안상우,김윤경,Kim, Ji-Hoon,Lee, Dae-Jung,Yun, Sung-Joong,Ahn, Sang-Woo,Kim, Yun-Kyung 대한한의학방제학회 2015 大韓韓醫學方劑學會誌 Vol.23 No.2

Objective : The main purpose of this study is to find a reasonable solutions for utilization of herbal formulas based on the medical classics. Methods : We used official Ten 'Selected Korean Medical Classics(SKMC)'. For input of formulas from SKMC, we had to select proper editions of them. After consultations with experts of 'The Korean Medicine Society for the Herbal Formula Study' and 'Korean Society of Medical History', we chose the proper editions of SKMC, and according to those books, we built formulas database using microsoft office excel sheets, respectively. Results : After whole input procedures, we requested several experts to inspect the results and also, to correct errors in them. Input categories were name of formula, name of classic, classification, original source, composition herb, weight, unit of weight, weight conversion index, converted weight, basic formula, indications, reason for modification, preparing method, taking method and contraindications. Final number of whole formulas in DB was 32,882. Conclusions : We used SKMC and built database using excel program. Through this procedure, we can provide a developmental ways to make a foundation for herbal formulas from the medical classics, so that we can make herbal formulas be standardized or industrialized more efficiently.