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방광 이행상피세포암의 병리학적 병기에 따른 Osteopontin과 Clusterin 단백의 발현
윤종현,이주환,염범우,원남희,윤덕기 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.4
Purpose: This study was performed to evaluate the expressions of osteopontin(OPN) and clusterin in a transitional cell carcinoma(TCC) of the urinary bladder, and then compare their expression rates with the tumor invasiveness. Materials and Methods: Twenty-five superficial and 25 invasive TCC were used for immunohistochemical staining. Results: All 25 non-invasive TCC showed a strong positive reaction for OPN. Twenty of the invasive TCC showed a strong positive reaction for OPN, but 5 showed only a weak positive reaction. OPN expression was significantly decreased in the invasive TCC(p=0.02). Eighteen superficial TCC showed a weak positive reaction for clusterin, with 7 showing a negative reaction. Nine invasive TCC showed a strong positive reaction for clusterin, and 11 showed only a weak positive reaction. Five invasive TCC showed a negative reaction for clusterin. Clusterin expression was significantly increased in the invasive TCC(p=0.001). Conclusions: These results may suggest that OPN and clusterin could be used as markers to predict the biological behavior of a TCC.
전자적 시민참여 활성화를 위한 정부활동과 시민참여정도 간의 경로분석 연구
윤종현 한국거버넌스학회 2007 한국거버넌스학회보 Vol.14 No.1
통하여 시민참여를 위한 정부의 다양한 노력들의 발견 즉, 변수들을구성하였다.둘째, 설문지에 대한 전문가들의 내용타당성을 확인하고, 실무자들을 대상으로 예비조사와 본 조사를 실시하였다.셋째, 수집된 설문자료에 대하여 신뢰도 분석(내적 일치도)과 타당성 분석을 실시하였다. 타당성 분석을 위하여 탐색적 요인을 하였다. 이를 통하여 변수와 하위항목 간의 가설적 요인구조가 얼마나 일치하는지를 살펴보았다. 넷째, 경로분석을 통하여 모형의 적합도를 살펴보고, 연구가설을 검증하였다. 다섯째, 자료의 분석결과들을 토대로 전자정부 시민참여의 양적질적 향상을 위한 제안을 하였다. 2) 변수의 설정 및 측정방법시민참여 설명모형과 선행연구 그리고 정부실무자들과의 인터뷰(정보공개 요청)를 토대로 변수에 따른 하위 문항들을 설정하였고, 이에 대하여 전문가 의견조사를 통하여 설문 문항을 확정하였다. This study aims to uncover the extent of government activities in the ICT & participation perspective, which enhance citizens' E-participation, and to analyze the causal relationship between government activities and their results by path analysis using the AMOS 5.0 computer program. For this study, 18 Ministries in the Korean government, which are relatively active in providing pertinent services, are selected as the target group of this study. Specific findings are as follows: Firstly, government activities have various sides, which are the function of homepage, characteristics of cyber space, responsive government service and administrative supports. This findings give a good direction for government specific activities. Secondly, it is confirmed that the relationships between government activities and the degrees of citizens' E-participation aries in statistical significance along with the impact factors. This implies that a strategic approach to enhancing degrees of citizens' E-participation is required.
성기능 저하를 호소하는 성인남성에 대한 보원단(保元丹)의 효과 -IIEF와 Rigiscan을 이용한 발기능의 변화-
윤종현,이경진,이종훈,안세영,장원만,Yoon, J.H.,Lee, K.J.,Rhy, J.H.,Ahn, S.Y.,Jang, W.M. 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4
Objectives : To improve decreased erectile function as well as impotence, caused by physical fatigue, psychologic stress, too much alcohol and smoking, medication like antihypertensives, and geriatric change, by the prescription of BOWONDAN. Methods : 18 male-volunteers with decreased erectile function who are married 30 to 59 years old, were studied about the difference of a sexual function between before and after taking BOWONDAN 3 pills a day for a month. The results of IIEF(International Index of Erectile Function) and AVSS(Audio-Visual Sexual Stimulation) were reviewed statistically with paired samples t-test. Results : Based on the IIEF, 13(81.25%, p<0.01), 9(56.25%, p<0.05), 9(56.25%, p<0.05), 9(56.25%, p<0.05), 7(43.75%, p<0.05) and 15(93.75%, p<0.01) volunteers were improved in erectile function, orgasmic function, sexual desire, intercourse satisfaction, overall satisfaction and total score respectively, among 16 volunteers excluding 2 due to a false measurement. Through the Rigiscan of AVSS, 11 (68.75%, p<0.1)volunteers were improved in base tumescence, among 16 volunteers excluding 2 due to a false measurement. Conclusions : As a result of our work, BOWONDAN is expected to take effect to treat or improve both impotence and decreased erectile function.