Acute exacerbation of interstitial lung disease; subgroup analysis for causes, risk factors for mortality rate, and steroid responsiveness

( Seung Hyun Yong ),( Ah Young Leem ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Park ),( Hye Jin Jang ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Interstitial Lung Disease (ILD) has known as a poor prognosis disease, particularly idiopathic pulmonary fibrosis (IPF). Corticosteroid is widely used for treatment of acute exacerbation (AE)-ILD. This study aims to clarify efficacy of corticosteroid use, and compare the mortality rate depending on the subgroups of ILD. Materials and Methods: We collected the data from the patients who have diagnosed ILD and visited emergency room (ER) with the respiratory symptoms from January 1, 2016 to December 31, 2018. We classified AE-ILD patients into 3 groups depending on methylprednisolone dose per kilogram. Also, we compared the mortality of IPF patients to that of non-IPF patients. Results: A total case of AE-ILD visited ER from 2016 to 2018 was 209 cases, including IPF cases (n=122) and non-IPF cases (n=87). We divided total patients (n=209) into three groups depending on steroid use, and these include group 1 of 0-0.49 mg/kg (n=78), group 2 of 0.5-0.99 mg/kg (n=58), and above 1.0 mg/kg (n=41), each. We found poor prognosis from the cases of IPF compared to non-IPF cases (p=0.029, OR 2.463). Furthermore, there was significant differences of mortality rate according to steroid dose (p=0.036, OR 1.712), CRP elevation (p=0.016, OR 1.004), and intubated case (p=0.000, OR 8.152). Also, we categorized IPF (n=122) to non-IPF cases (n=87) and analyzed the mortality rate. Most of the patients were death from ILD itself (n=23, 63.9%), Pneumonia(n=8, 22.2%), and Lung cancer (n=5, 13.9%). Bacterial infection (n=26) was dominant cause of AE, followed by fungal infection (n=15), and viral infection (n=10). Conclusions: This retrospective analysis of corticosteroid treatment shows more fatal outcome when we use high dose steroid in AE-ILD cases, and there was significant difference in mortality rate depending on the subgroup of ILD and medical background, such as intubation status, higher CRP level, and IPF cases.

항암화학요법 관련 오심과 구토 완화를 위한 비약물요법에 관한 연구동향

소향숙,최자윤,조인숙,김영재,김지영,김애숙,김옥미,김춘심,김현오,설영애,안정옥,이애리,이영자 성인간호학회 2003 성인간호학회지 Vol.15 No.3

Purpose: Purposes of this study were to understand the current trends on complementary therapy in relieving chemotherapy-induced nausea and vomiting and to suggest the future research direction. Method: Subjects were selected on CINAHL, MEDLINE, Korean Academy Data Base from 1980 to 2001 which used nausea, vomiting, chemotherapy and complementary therapy as key words in experimental studies. Eight korean articles and twenty-one international articles were analyzed in terms of general characteristics, research methods, and types of complementary therapy. Data were analyzed by using descriptive statistical methods. Result: Since 2000, researchers have more actively used complementary therapy. In subject characteristics, mean age was 35.5 years old, 45% of the researchers were performed with high level of incidence of chemotherapy induced vomiting, 14% of them set limit of consecutive cycle during research, and 65% of them did not comment the selecting criteria of sample. About 60% of them were designed post-test only control group: 35% used INV by Rhodes, 31% used Likert scale, and 24% used VAS for dependent variable. Muscle relaxation therapy was mostly applied for relief of nausea and vomiting. Conclusion: Further studies will be needed to control extrinsic variables affecting nausea and vomiting in research design and to accumulate evidence with studies applying various complementary therapies.

『일년』의 검열과 개작

김영애(Kim, Young-Ae) 한국현대소설학회 2020 현대소설연구 Vol.- No.79

Park Young-joons “The One Year” is a double-deletion of the original work through two censorships. They include the deletion of the original copy by external censorship at the time of the first announcement in the Shindonga, and the revision by the author in the process of publishing the book after liberation. With the aim of exploring the reasons and backgrounds of double deletion due to external and self-censorship during the colonial period and after liberation, this paper tried to provide specific grounds through text comparison between the Shindonga edition in 1934 and the separate volume in 1974. Even in the prior study, which analyzed the text “The One Year” based on the keywords of censorship and reformation, the issue of rewriting by writers was not dealt with as important. The reason is that the publication of the book is very late and this may be partly due to the fact that the original work has already been censored and deleted. Based on the achievements and limitations of prior research, this study tried to discuss the overall censorship and rewriting aspects of the book by adding discussions on the revision of the book. “The One Year” is a work of double deletion, from the deletion during the colonial period to the revision and deletion by the author himself 40 years later. While the first deletion was compulsory by external censorship, the second was by the authors self-censorship. It is not a simple matter to extend beyond the level of refinement of the original work to the revision of narrative composition. Park Young-joon voluntarily declared his conversion right after the establishment of the of the independent government. It is possible to guess what purpose and background the self-censorship and conversion of “The One Year”. Park Young-joon, who was classified as a “middle-class” after liberation, was forced to choose his regime in 1949 due to his declaration of conversion, which forced him to erase his earlier literary identity, and his conversion can be estimated as a result of his self-censorship of his career in the Chosun Literary Union after liberation.

전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정

김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4

다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.

S-528 : The Clinical Characteristics of Angioedema with Eosinophilia

( Hyo Jung Cho ),( Hye Soo Yoo ),( Mi Ae Kim ),( Yoo Seob Shin ),( Young Min Ye ),( Dong Ho Nahm ),( Joo Hee Kim ),( Jeong Hee Choi ),( Sun Young Park ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Angioedema with eosinophilia (AE) is a very rare allergy disease, case reports of which have been published sporadically since 1984. Here, we retrospectively analyzed the clinical features of 10 AE patients in Korea. Nine of the 10 subjects were young females, ranging from 23 to 38 years old. Twenty percent of the subjects had episodic-type AE with high serum IgM and eosinophil counts, while 80% were non-episodic type with normal serum IgM levels but high eosinophil counts. All patients had used systemic corticosteroids to control AE. One patient with refractory EAE was treated with anti-IgE antibody. This is the first study to evaluate the clinical characteristics of AE in a Korean population.

노랫말 바꾸기 활동이 유아의 어휘력, 창의성에 미치는 영향

이효숙,심성경,백영애,김경의 이화여자대학교 사범대학 교육과학연구소 2004 교육과학연구 Vol.35 No.1

본 연구는 노랫말 바꾸기 활동이 유아의 어휘력과 창의성에 미치는 영향을 알아본 것이다. 본 연구대상은 만 5세 유아 40명이었고, 16주에 걸쳐서 통제집단은 일반적인 노래부르기 활동을, 실험집단은 노랫말 바꾸기 활동을 실시하였다. 검사도구는 김영태 등(1995)의 그림어휘력 검사와 전경원(2000)의 창의성 검사를 사용하였다. 검사결과, 1) 노랫말 바꾸기 활동은 유아의 어휘력 발달을 유의하게 증진시켰다. 2) 노랫말 바꾸기 활동은 유아의 창의성 발달에도 효과가 있었는 데, 상상력과 신체영역을 제외하고는 모든 척도별 창의성(유창성, 융통성, 독창성)과 영역별 창의성(언어, 도형)을 유의하게 증진시켰다. 따라서 노랫말 바꾸기 활동은 유아의 어휘력과 창의성 발달에 효과적인 활동임을 알 수 있다. This study investigated the effects of changing the verse of the song on young children's vocabulary and creativity. The activities were designed by researchers and constructed by 4 steps such as 1) learning a new song, 2) changing the words, 3) creating a song book, and 4) presentation. The subjects of this study were forty five-year old children from two classes at G kindergarten in K City. Twenty children were in the experimental group and twenty children were in the control group. The method of changing the verse of the song was used over a 16 week period. The vocabulary test(Kim Young Tae et al, 1995) and The creativity test(Jeon Gyeong-Weon, 2000) were administered and analyzed by t - test with SPSS/pc programs. The results were as follows: 1) Changing the verse of the song contributed to increasing young children's vocabulary significantly. 2) Changing the verse of the song contributed to increasing young children's creativity significantly. And the significant effects appeared in sub-scales of fluency, flexibility, and originality except imagination and in sub-areas of language and figure.

베체트병 환자에서 Azathioprine으로 유발된 급성 췌장염 1례

김기향,권민정,김동기,김애란,김윤정,박지훈,이영태,박보민,김동욱 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Although many drug are thought capable of initiating acute pancreatitis, following azathioprine administration represents the 5% incidence by far the highest recorded incidence to date. We report a 35-year-old male who developed acute pancreatitis in the course of treatment with azathioprine for Behcet's disease. He was admitted due to abdominal pain, diarrhea, and fever for 10 days. Serum amylase and lipase levels were 510U/L and 3702U/L respectively. The abdominal CT scan revealed diffuse enlargement of the pancreas. There was no history of alcohol use or gall bladder disease. We considered drugs, especially azathioprine, as the cause of acute pancreatitis. We diagnosed it as acute pancreatitis. The patient was treated conservatively with hydration and analgesics. The symptom subsided within four days. Five days later, azathioprine was resumed. And the patient complained of abdominal pain. The elevated levels of serum amylase and lipase confirmed the recurrence of pancreatitis. His symptom subsided when azathioprine intake the stopped, and the serum amylase and lipase levels returned to normal level within five days.

뽕잎분말 섭취가 혈청지질에 미치는 영향

김영숙,김애정,김선여,김순경 순천향대학교 기초과학연구소 1999 순천향자연과학연구 논문집 Vol.5 No.1

This study was conducted to investigate the effect of mulberry leaves on lipid metabolism in adult females. The subjects(n=13) intake 1.8g mulberry leaves powdered per day with the common diet. To conduct this study, anthropometric measurements, daily nutrients intake, and serum lipids(total-cholesterol, HDL-cholesterol, triglycerides, LDL-cholesterol) were measured 3 times(before, after 2week and 4week during the experimental periods). The results are as follows: Serum LDL-cholesterol contents were significantly(P<0.05) decreased with treatment of mulberry leaves powder. And serum total-cholesterol and triglycerides were decreased, but did not show significant differences.

김치담금재료의 미생물 오염상태와 오존처리효과

김미정,김미경,오영애,김미향,김순동 대구효성가톨릭대학교 식품과학연구소 1992 식품과학지 Vol.4 No.-

배추김치 담금재료의 미생물 오염상태를 조사하고 동시에 ozone처리에 의한 청정화 효과를 검토하였다. 배추, 고추 마늘 및 생강의 오염정도를 부위별 또는 생태별로 조사해 본 결과 세균수는 24.67-334.96×10 exp (4)범위였으며, 곰팡이+효모는 17.89-274.50×10 exp (4) 범위이었다. 미생물 오염 정도는 배추의 경우 겉부분 보다 속부분과 상부에서 높았다. 또 고춧가루는 무포장이 포장한것 보다 8-9배의 높은 오염도를 나타내었다. 마늘은 깐마늘의 경우가 까지않은것 보다 6-7배의 높은 오염도를 보였다. 고추의 미생물 오염도는 숙도가 높을 수록 높았으며 표면보다 내부의 오염도가 높았다. 배추를 흐르는 수돗물로 세척한 결과 세척 20분 동안에 총균의 46%가 제거되었으나 그 이상의 세척효과는 없었다. 오존수에 의한 세척은 오존농도 6㎎/ℓ/sec에서 0.5-1시간 처리시 총균의 92-95%가 제거되었으며, 개스상의 오존을 동일 동도로 처리하였을 때는 86-89%가 제거되었다. 오존을 처리시에 생존한 미생물은 유도기가 연장되었으며, 생육도도 현저하게 낮았다. This study examined the microbial contamination in the soaking materials of Chinese cabbage kimchi and cleaned effect by ozone treatment. of the kimchi. In Chinese cabbage, red pepper powder, garlic and ginger, the mumber of bacteria was 24.67-334.96×10 exp (4) and that of mold and yeast was 17.89-247.50×10 exp (4). Microbial contamination was higher in the outer and upper part of cabbage than in the inner part. The contamination was 8-9 times higher in unpackaged red pepper powder than in packaged one. That was 6-7 times higher in peeled garlic than in unpeeled one. As a result of washing by tap water for 20min, 46% of the total number of microbe in Chinese cabbage was eliminated. 92-95% of that was eliminated by treatment of ozone water 6㎎/ℓ/sec for 0.5-1.0 hour whereas 86-89% of that was eliminated by treatment of ozone gas. The lag phase of survival microbes was extended but the growth of the microbes inhibited by the treatment of ozone.

전문대학 간호과 통합교과과정 개발에 관한 연구

김영희,김정수,김정애,방숙명,배경진,이애경,장은정,정안순,주미경,최나영 경복대학 1998 京福論叢 Vol.2 No.-

교과과정의 조직은 체계적이고 뜻이 있는 순서로 학생들을 가르치기 위해 지식을 어떻게 조직화할 것인지와, 과목들 사이에서 공통된 내용은 통합시켜 중첩되는 일이 없도록 조정할 필요가 있다. 이에 현재 본 대학 간호과에서 운영되었던 97학년도의 17개 전공과목들의 교과과정의 내용을 비교, 분석하여 중복을 줄이며 순차적 지식의 습득을 도모하는 새로운 통합교과과정의 틀을 개발, 제시함으로써 보다 나은 전문직 간호교육이 이루어지도록 하고자 하였다. Most curricula are considered how to teach the student in systematic and meaningful orders. And it is necessary to coordinate the duplicate contents in major subjects in nursing. So this study was designed to set up a new comprehensive curriculum through comparing and ananlyzing each seventeen major subjects in Nursing Department of Kyung-Bok College. Therefore, the purpose of this study is to present the new comprehensive curricula for promoting the efficiency and effectiveness in diploma degree course of nursing education.