한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

생보사 약관대출 수요에 대한 계량분석적 연구

박상범,마승렬 한국보험학회 2003 保險學會誌 Vol.64 No.-

약관에 보험계약자가 보험증권을 담보로 보험자에 대하여 해지환급금의 범위 내에서 대부를 청구할 수 있도록 구정하고 있는 것이 약관대출이다. 약관대출은 계약자에게는 긴급자금원 등이 될 수 있다. 반면 보험자에게는 자금운용의 한 수단이 될 수 있으나 실제로 현금흐름을 왜곡시킬 수 있다. 따라서 약관대출 수요를 파악하는 것은 투자 등 자금운용에 매우 중요하다고 하겠다. 본 연구에서는 약관대출 수요를 결정짓는 변수에 대한 연구를 시행하였으며 특히 IMF구제금융 요청으로 시작된 경제침체기를 전후하여 각각의 결과를 비교하여 보았다. 결과는 전체적으로 실업률, 물가상승률 그리고 계약준비금이 영향을 미치는 것으로 나타나고 있다. IMF사태 이전에는 계약준비금만이 약관대출에 영향을 주는 것으로 나타나고 IMF이후에는 실업률과 물가상승률이 주요변수임을 보여주고 있다. Policy loans can cause a form of disintermediation and distortion of cash flow for life insurers. Also, when investment market is booming, policy loans impose opportunity cost to life insurers. This study investigates policy loan demands for the years 1991.7∼2002.6, which encompasses period of the IMF shock. The results show that overall unemployment rate and inflation arte are main factors influencing policy loan demands. Before IMF period, policy reserve is the only main factor while after IMF period unemployment rate and inflation rate are the factors that are related to policy loan demands.

폴리프로필렌 섬유보강 콘크리트(PFRC)의 역학적 특성 및 내구성에 관한 실험적 연구

박승범,김부일,윤준석 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

The result of an experimental study on the mechanical properties and durability of polypropylene fiber reinforced concrete are presented in this paper. This study has been performed to obtain the properties of PFRC such as strength toughness and durability. The test variables are fiber content fiber types, W/C ratio. PFRC shows the highest strength when the polypropylene fiber content is about 0.2% in concrete, flexural toughness of PFRC was increased remarkably as polypropylene fiber contents were increased to 2.0 vol.%. Also, freeze-thaw resistance and carbonation were somewhat more improved than plain concrete.

流動化 콘크리트의 物理的 特性에 關한 基礎的 硏究

朴承範,玄錫訓 忠南大學校 産業技術硏究所 1986 산업기술연구논문집 Vol.1 No.1

Superplasticizers(Melamine sulphonate, Naphthalene sulphonate) has been used to aid the placement of high quality, high strength concrete in other country. The purpose of this study was to examine the effect of superplasticizers in the manufacture of high quality concrete(especially durability). This paper describes the results of hydration, X-ray diffraction of cement paste and setting time, strength, drying shrinkage, freeze-thaw resistance of concretes by the use of admixtures(Melamine sulphonate, Naphthalene sulphonate, Lignosulphonate). As a result, superplasticizers(Naphthalene sulphonate, Melamine sulphonate) can be used at high dosage levels than Lignosulphonate without the problems of concrete.

외부 프리스트레스 도입에 의한 노후된 콘크리트 거더교의 보강성능평가

박승범,홍석주,이봉춘,장석호,권혁준 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

One of the promising methods to enhance the flexural strength of a externally prestressed girder is to place the tendons with large eccentricities. The analysis and design of composite girders prestressed by external tendons involve difficulties related mainly to the position of anchorages and the construction sequences. This study was conducted on the concrete bridges reinforced by the continuous girders and the external prestressing. The test results in this study showed that the external prestressing of a composite girder increased the range of the elastic behavior, reduced deflections, increased ultimate strength, and added to the redundancy by providing the multiple stress paths.

構造用 流動化 콘크리트의 長期變形 特性에 關한 硏究 : 크리프 및 건조수축 변형을 중심으로

박승범,이보성,임창덕 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.1

In order to discuss the properties of Superplasticized Concrete for Civil engineering structure at long terms, this report carried out the experiment that Superplasticized concrete compare with control concrete of Compressive Strtength, Drying-Shrinkage, Creep deformation and Creep recovery as follow condition ; ① Kinds of superplasticizer(Naphthalene, Melamine, Lignin base), ② Stress eovel(15%, 30%), ③ Curing Condition (moisture, air) As a results, Superplasticized Concrete has a good results in comp. strength more than 20%, in drying-shrinkage less than 15%, in creep deformation less than 11% of control concrete and creep recovery are also less than control concrete in 28 days. There are some difference in property between superplasticizers, but It has good results to reduce the drying-shrinkage and creep deformation using the proper superplasticizer and its dosage.

상온재생 유화아스팔트 개질 혼합물의 배합방법 및 특성에 관한 실험적 연구

박승범,권혁준,이봉춘,김선용 충남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.14 No.2

Recently, the quantities of waste asphalt concrete at construction sites have much increased greatly, but maintaining a filling-up and final disposal place is a difficult problem. Therefore, we are faced with a worsening environmental problem brought about present illegal measures. One of the most effective recycling method is cold recycling. This method will satisfies treatment and recycling of construction waste is a very important question in the preservation of environmental and natural resources. So, in this paper, we dealt cold recycling modified mixtures using emulsified asphalt to concern the effect of adding reclaimed asphalt concrete 30, 40, 50%, and using SBR Latex for modified mixtures.

기질재를 혼입한 재생아스팔트의 물리적특성에 관한 실험적 연구

박승범,조청휘,김정환,채용주 충남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.14 No.2

This paper present the results of an experimental study on the mechanical properties of reclaimed asphalt using modified additives. This study has been performed to obtain the properties of recovered asphalt such as penetration, softening point and ductility, weight change ratio, penetration change ratio after thin film oven test according to contents of modified additives(3∼5%). Recovered-modified asphalt has improved in the temperature sensitivity, which is ductile at higher temperature and brittle at lower temperature compared to virgin one. Penetration, softening point, ductility test and mass and weight changing rate and thin film oven test of recovered-modified asphalt satisfied the standard fir the modified asphalt II. Therefore, it could be possible to produce a recovered-modified asphalt mixture similar to those of virgin-modified asphalt mixture.