서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

짧은날개자루맵시벌속(벌목: 맵시벌과)의 분류학적 연구

李鐘郁,咸印皓,車晉烈 嶺南大學校附設 基礎科學硏究所 1987 基礎科學硏究 Vol.7 No.-

본 연구에서는 여러 형질을 종합 분석하여 한국산 Agrypon속의 분류학적 위치를 재검토, 확인하고 하위 분류군에서 유연관계를 밝혀 현재까지 여러 분류체계를 정리하고자 하였으며 이를 위해 한국산 및 구북구계에 분포하는 외국산 표본과 미동정종 10종(한국산 6종, 외국산 4종)을 포함하여 전산처리한 결과 다음과 같은 결론을 얻었다. 1. 한국산 Agrypon속은 미기록 2종(A. anomela, A. longipropodeum)이 추가되어 총 8종이 분포하게 된다. 2. 한국산 Agrypon 속 7종과 외국산 7종을 포함하여 14종의 검색표를 작성하였다. 3. 유연관계 추정을 위한 형질 선정은 Agrypon속에 있어서 형질의 수를 증가할수록 그 결과는 안정됨을 확인하였고, 질적형질 또는 실측치만을 사용하였을 때에는 뚜렷한 종간의 구분이 어려우므로 질적, 양적형질을 포함하여 80개 이상을 사용하는 것이 적당하였다. 4. 종수의 변화에 있어서도 동일한 현상선에서 묶이는 군의 수나 각 군의 구성 종에는 변화가 없었으므로 Agrypon속의 현상적 분류체계가 유효한 것으로 판명되었다. 5. 유집분석 방법에 있어서 Agrypon속의 분류체계를 분석하는데는 average 방법보다 ward 방법이 적합함을 알았다. 6. 현상적 수리 분석의 결과 Trichonotus 속이 Agrypon 속에 통합되는 것이 타당하다. 7. 한국산 Agrypon 속 7종은 다음과 같이 크게 3개의 group으로 나눌 수 있다. flaveolatum group: A. flaveolatum debilis group: A. anomelas, A. longipropodem, A. oyeyamense anxium group: A. anxium, A. suzukii In this study, various characters were analyzed synthetically. Taxonomic position of korean genus Agrypon was reviewed and ascertained, relationship in low taxo-nomic groups was clarified, and thus current taxonomic system was tried tobe rearran-ged. To do these, the increase and decrease of the number of species, that of the characters, and the variation of clustering analysis method were computerized, by using korean and eastern palearctic specimens and unidentified ten species. The results are as follow. 1. Two speciese(A. anomelas, A. longipropodeum) were newely recorded, and so eight specirs in genus Agrypon are distributed in korea. Keys was made, including seven korean species and seven foreign species among genus Agrypon. 2. In order to ascertain the relationship of species in genus Agrypon, using more than eighty characters was adquate. And it was confirmed that the more increasing the number of characters is, the more stable the result is. 3. It was proved that the phenetic taxonomic system is effective because the numbers of groups constructed by the same phenetic line and those of species n each group were not changed. Ward method was more suitable than average method, when analyzing taxonomic system of genus Agrypon. 4. It was validated that genus Trichonltus must be nuified in genus Agrypon as the result of phentic numerical analysis. Seven species in korean genus Agrypon were classified as the follwing three groups: flaveolatum group: A. flavolatum G. debilis group: A. debilis (W.), A. anomelas (G.), A. longipropodeum U., A. oyeyamense (U.) anxium guoup: A. anxium (W.), A. suzukii (M.)

韓國産 夜行性 맵시벌科(벌目: 벌亞目)의 分類學的 硏究

이종욱,정종철,김기범,김정한,배지득,남상호 대전대학교 기초과학연구소 2002 自然科學 Vol.13 No.2

영남대 생물학과에 소장되어 있는 표본과 2001년 4월~2002년 6월 사이에 채집한 표본을 대상으로 하여 한국산 야행성 맵시벌의 분류학적 연구와 출현 현황 및 숙주 관계의 분석을 실시하였다. 분류학적 연구 결과 Gauld(1970)가 영국산 야행성 맵시벌을 대상으로 한 연구에서 기록한 Mesochorinae아과, Tryphonin-ae아과, Ctenoplematinae아과, Ophioninae아과의 4아과외에 Metopinae (Metopius속)를 추가하여 한국산 야행성 맵시벌류는 총 5아과 13속을 기록하였다. 또한 한국산 야행성 맵시벌의 출현 현황을 분석한 결과 야행성으로 잘 알려진 Mesochorinae아과의 Mesochorus속, Tryphoninae아과의 Netelia속과 Ophioninae아과가 전체 야행성 맵시벌 증 95%를 차지하였다. 속별 출현현황을 살펴보면 Netelia속이 393개체가 출현하여 가장 많은 수를 나타내었으며 Ophi-on속, Mesochorus속, Enicopilus속도 전체 출현 분류군 중 높은 비중을 차지하였다. 월별 현황을 살펴보면 전반적으로 4월에서 11월 사이에 걸쳐 나타나는데, Op-hioninae아과는 5월과 7월에, Tryphoninae아과는 6월에 집중적인 출현 빈도를 보였다. 숙주의 분류군에 따른 야행성 맵시벌의 기생 양상을 살펴보면 대부분이 나비목을 대상 숙주로 하고 있으며 Mesochorinae아과와 Ctenopelmatinae아과는 벌목에도 많은 종이 기생하는 것으로 나타났다. 특히 Mesochorinae아과의 Cidaphus속은 위생 해충으로 분류되는 기생파리과(Tachinidae)에도 기생하는 것으로 나타나 위생 해충을 구제할 수 있는 천적 분류군으로 연구될 수 있는 가능성을 보였다. 숙주의 식성에 따라 살펴보면 부식성의 먹이를 섭식하는 부식성(saprophagus) 숙주, 곤충의 유충을 섭식하는 식충성(entomophagus)인 숙주가 소수 출현하였고 기생생활(parasite)을 하는 숙주도 다수 출현하였으나 대부분의 야행성 맵시벌의 기생 대상 숙주는 주로 식물을 해하는 식식성 곤충(phytophagus)으로 나타났다. Nocturnal Ichneumonidae, which was called yellow-brown ichneumonoid, included several subfamilies adapted for nocturnal activity. Taxonomic study of nocturnal ichneumonoid has been investigated by Gauld(1975) but examination of Korean nocturnal ichneumonoid has not been provided until now. This present study: the taxonomic revision, Appearance state and Host-parasite relation analysis of nocturnal ichneumonoid, were examined using Korean peninsula specimens. As the result. approximately 13 genera referable to 5 subfamilies appeared regularly in light trap. Genus MetopiudSubfamily Illetopinae) were newly recorded in nocturnal ichneumonoid. Tryphoninae and Ophioninae, which were dominant in appearance taxa! occupied 96% of total numbers of individuals, and majority of them were taken from May to November. Nocturnal ichneumonoid are parasitoids of part of immature holometabolous insects(Coleoptera, Diptera, Hymenoptera, Lepidoptera). Lepidoptera is the most common hosts of nocturnal group except Mesochorinae and Ctenopelmatine. In large number of Mesochorinae are koinobiont hyperparasitoids of ectoparasitic or endoparasitic BraconiddHymenoptera), and, less frequently, of Tachinidae(Diptera1. Also, Ctenopelmatinae are koinobiont endoparasitoids of Symphyta and, rarely, Lepidoptera. Majority of nocturnal ichneumonoid hosts are phytophagous, feeding plant taxa, and many host of Mesochorinae taxa are parastoids, and a few host are saprophagus or entomophagus.

월경주기 증상의 요인 분석

이수일,유태혁,강종선,안석철,이병욱,김헌,석재호 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1

404 nurses and nurse-aids rated their experiences of 45 symptoms(Moos' Menstrual Distress Questionnaire) of the menstrual, premenstrual and intermenstrual phase on a 4 point scale separately. The 45 symptoms were inter-related and factor analyzed separately for each phase. six common clusters of symptoms emerged from 3 phases, which were labeled concentration, motor tension, pain, pleasurable affect, autonomic reactions and water retention. Four clusters of symptoms emerged from premenstrual phase. These clusters were labeled instabillity, withdrwal reactions, depression and headache. The factor named unpleasurable affect emerged from intermenstrual and menstrual phase. Above findings were differed from the results of Moos' study in which eight basically replicated clusters of symptoms emerged from three phases. Through discussion of validity of this scale, and differences between results of Moos' and this study, we came to the conclusion that sampling of subjects, prospective longitudinal symptoms reporting, amount of variance in a symptom over the course of menstrual cycle and proper choice of factor analysis method would be salient variables to construct valid scale for measuring menstrual cycle symptoms.

조건부수급자의 자활사업 참여와 불참간 의사결정 요인분석

이성희,원종욱 한국사회복지정책학회 2004 사회복지정책 Vol.20 No.-

본 연구는 조건부수급자증 자활사업 불참자의 특성을 자활사업 참여자와 비교하여 분석함으로써 어떠한 요인들이 이 두 집단을 구분짓게 마는지 실증적으로 규명하는데 그 목적이 있다. 조건부수급자중 정당한 사유 없이 자활사업에 불참한 사람들의 특성에 대한 과학적인 분석은 자활사업이 안고 있는 참여율 저조 문제에 대한 원인을 이해하고, 향후 성공적인 자활사업 시행을 위한 정책수립에 기초자료가 될 것으로 사료된다. 이를 위해 『2003 자활정책평가와 개선과제 실태조사』 의 자료를 이용하여 조건 부수급자증 자활사업 참여자와 불참자에 대찬 설문분석과 함께 자활사업 참여결정에 영향을 미치는 요인을 계량적으로 분석하였다. 설문분석 결과 자활사업 불참자는 참여자에 비해 상대적으로 남성의 비율이 높고, 연령은 낮고, 동거 가구원수가 많으며, 학력이 높고, 소득수준이 놓으며, 담당공무원이 자신의 소득수준을 정확히 파악하지 못한다고 생각하는 편으로 나타났다. 자활사업 참여결정에 영창을 미치는 요인을 probit model로 추정한 결과 역시 설문분석 결과의 타당성을 뒷받침하였다. 그리고 자활사업 불참자의 소득 추정식을 분석한 결과 수급자 가구가 근근이 생활하는데 필요하다고 생각하는 금액이 클수록, 즉 기본적인 생활수준을 높이고 싶은 욕구가 강할수록 민간 노동시장에서 얻는 소득수준도 높아지는 것으로 나타났다. The main purpose of the study is to identify the differences in socio-economic variables between participants and non-participants of the public self-reliant program. Under the 『Law of the Guaranteeing Basic Livelihood』, those who are physically fit to work, are classified as conditional recipients. One of the condition applied to them is to participate in the public self-reliant program when they can't find job. By analyzing the survey data of 2003, we found out that there are differences in socio-economic variables between two groups. Other things controlled, men are more likely to not to participate in public self-reliant program rather they chose to work in private labor market. Age is another factor influencing decision on participation of the program. The younger recipients are more likely to work in private labor market rather than public self-reliance program. We also found out that those who believe that real incomes are less likely to be revealed by government social workers are more likely to participate private labor market rather than government program. Finally, we predicted income level that non-participants could earn in the private labor market by utilizing Heckman selection model(two-stage). Even though average income of the non-participants' of the public program was about to 420,000 Won the predicted private market income of the total conditional recipients are close to only 200,000 Won. It implies that public self-reliant program is vital source of income for the recipients who possess labor capacity but are unfit to competitive private labor market.

수중 가청음에 의한 쏨벵이의 청각능력 : 2. 청각 임계비

이창헌,박용석,문종욱,강창익,김고환,서두옥 제주대학교 해양연구소 1999 해양자원연구소연구보고 Vol.23 No.-

수중 가청음은 어군의 행동 제어와 해양목장화에서 음향 순치에 많이 이용되고 있다. 수중 가청음에 의한 어류반응 해석을 하기 위해서는 물고기의 청각능력을 정확히 파악할 필요가 있으며,오래전부터 여러물고기의 청각능력을 관련된 연구가 수행되었다.

인슐린 비의존성 당뇨병에 동반된 심상성 천포창 1 례

이상준,박진용,임태형,윤영호,권순대,남창욱,허규찬,박근용,구본식,김상표,장종억 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

저자들은 인슐린 비의존형 당뇨병 환자에서 통증성 구강내 미란 및 전신성 수포성 미란을 동반한 심상성 천포창 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Various skin conditions such as diabetic dermopathy, necrobiosis lipoidica diabeticorum, bullosis diabeticorum, granuloma annulare occur frequently in diabetes, although common lesions may be associated by chance. Pemphigus vulgaris(PV) is a blistering skin disease seen predominantly in elderly patients. This disorder is characterized by the loss of cohesion between epidermal cells with the resultant formation of intraepidermal blisters. These blisters rupture easily, leaving denuded areases that may crust and enlarge peripherally. In half or more of patients, lesions begin in the mouth: approximately 90% of patients have oromucosal involvement at some time during the course of their disease. But the relationship of this disorder with diabetes is not clear. We experienced a case of pemphigus vulgaris associated with NIDDM in 67 years old woman who was admitted due to painful oral ulcer and control of blood glucose, so we present this case with a review of literatures.