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CC Chemokine CKβ8의 발현 조절 물질 탐색 및 저해활성 물질 분석
김탁용,이태훈,백남인,정대균,김지영 경희대학교식량자원개발연구소 2005 硏究論文集 Vol.24 No.-
CKβ8은 CC 케모카인의 부류에 속하는 사이토카인의 일종으로, 단핵구, 호염구, 호산구, T 림프구, 자연살해세포, 수지상세포 등의 화학주성물질로 작용하는 것으로 알려져 있다. CKβ8은 염증반응 및 혈관신생 등과 같은 여러 가지 생체 반응에 역할을 하는 것으로 알려져 있다. 본 논문에서는 사람 CKβ8 유전자의 전사저해 물질을 선별하기 위하여 CKβ8/Luc 유전자를 발현하는 세포주를 확립하였다. CKβ8 유전자의 전사시작점에서 -299 부터 +10 프로모터 부위를 PCR에 의해 얻은 다음 포유세포 발현 플라스미드에 클로닝하였다. CKβ8/Lvc 유전자는 U937 세포내에서 PMA에 의해 10배 이상 발현이 증가한다. CKβ8/Luc 발현 U937 세포주는 식물 추출물에서 전사 저해제를 탐색하는데 이용되었다. 46 개의 식물 추출물 중에서 6개가 90% 이상 CKβ8/Luc의 전사를 저해하였다. 이들 물질에 대해 세포 독성 실험을 수행한 결과 그 중 한 개만이 세포 독성이 거의 없는 것으로 나타났다. 이 추출물은 붉나무에서 얻은 추출물이며 이 식물 추출물은 염증관련 질환에 대한 가능성이 있는 치료제로 이용될 수도 있을 것으로 추측된다. Ckβ8 belongs to a family of CC chemokines, which is known to act as a chemoattractant for monocytes, basophils, eosinophils, T lymphocytes, NK cells, and dendritic cells. CKβ8 is known to play roles in various biological processes such as inflammation and angiogenesis. In the present study, we developed U937 cell line expressing CKβ8/Luciferase fusion gene for screening of transcriptional inhibitors for human CKβ8 gene. Genomic sequences that contain CKβ8 promoter region from 299 to+10 nucleotide from the transcription start site was amplified by PCR and cloned into mammalian episomal plasmid. The CKβ8/Luc fusion plasmid was introduced into human promonocytic U937 cells and selected for stable U937 cells expressing the fused reporter gene. The expression of the fusion gene was induced by more than 10 folds upon treatment of phorbol myristate acetate. The stable U937 transfectant cells were used for searching transcriptional inhibitors for human CKβ8 gene from plant extracts. Among 46 plant extracts tested, six extracts exerted more than 90% inhibition of PMA-induced CKβ8 transcription. Cytotoxic tests demonstrated that one of extracts, which was extracted from Rhus chinensis Mill, had little cytotoxic effect. The extract may be used for developing a potential therapeutic agent for inflammatory diseases.
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播種期 移動에 따른 차풀의 生育反應, 收量 및 粗成分 變化
玄京卓,趙南棋,吳恩敬,高志棅,趙英一 濟州大學校 亞熱帶農業硏究所 1999 亞熱帶農業硏究 Vol.16 No.-
ABSTRACT This study was conducted to determine influence of planting date, seeding rate and phosphate rate on main growth, characters, yield and chemical composition of senna from March 11, 1998 to December in Cheju Province. Days to flowering was lessened as planting date was delayed. The plant height of senna was the longest at 31 March planting (99cm) than at the other planting date. Stem diameter, number of leaves were increased at 31 March but number of branches was not affected by planting date. And number of withering leaves were increased as planting date was earlier. Fresh forage yield per lOa, for senna was the greatest (4,660kg) at 31 March planting, the second was 4,397kg at 1 April planting and the reduced the 3,473kg at 11 March planting. Also dry matter yield per lOa, crude protein yield and total digestable nutrient (TDN) yield was nearly the same tendency. Crude protein, crude fat percent was the greastest at 11 March planting and than decreased with further increased at planting date. Crude ash and crude fiber percent was decreased tendency as planting date was delayed. Nitrogen free extract (NFE), TDN percent was increased tendency as planting date was delayed. SPAD reading value of leaves had an efficiency increased as planting date was delayed.
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( Ji Young Tak ),( Gun Oh Chong ),( Ji Y. Park ),( Seung Jeong Lee ),( Yoon Hee Lee ),( Dae Gy Hong ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.5
Adult granulosa cell tumors (AGCTs) presenting with massive ascites and elevated serum CA-125 levels have rarely been described in the literature. An ovarian mass, massive ascites, and elevated serum CA-125 levels in postmenopausal women generally suggest a malignant ovarian tumor, particularly advanced epithelial ovarian cancer. AGCT has low 18F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography due to its low metabolic activity. In the present report, we describe a case of an AGCT with massive ascites, elevated serum CA-125 level, and low 18F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography.
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( Ji Yeon Kim ),( Young Hwan Kwon ),( Young Yi Kim ),( Se Jin Kim ),( Jung Gil Park ),( Soo Young Park ),( Min Kyu Jung ),( Won Young Tak ),( Young Oh Kweon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background/Aims: Sustained virologic response (SVR) has been regarded as therapeutic end point in chronic hepatitis C (CHC). But, ideal follow-up time for these patients still remains undefined. In analyses of SVR durability, the incidence of late relapse is extremely low (<1%) and patients with SVR have significantly fewer liver related complications, less hepatocellular carcinoma (HCC), and liver-related deaths. We investigated the durability of SVR and development of HCC to assess the clinical outcome in chronic hepatitis C (CHC) patients who achieved SVR after combination therapy of pegylated interferon (PEG-IFN) and ribavirin. Methods: The study was conducted on 293 CHC patients who achieved an SVR after PEG-IFN and ribavirin combination treatement. Liver function tests, qualitative HCV RNA assays and imaging study (USG or CT) were performed every 6 or 12 months during the follow-up period. Results: Among the 293 patients, 285 (genotype 1, 136; genotype non-1, 149) were followed up for more than 6 months after SVR. These 285 patients were aged 51.2 ± 11.0 years (mean ± SD), and 169 (59.3%) of them were male. The median follow-up duration was 29.4 months (range 6-81 months). The reappearance rate of HCV RNA during follow-up was 2.1% (n=6). Among 6 relapsers, five patients were genotype 1 , three had dose reduction of PEG-IFN or ribavirin (1:2) during combination therapy and the rest of them were treated with shorter duration (24wks). The median follow up duration of relapse was 5 months (range 3 -9). Six patients (2.1%) developed HCC during the follow-up period and the median follow up duration was 23.3 months (range 3 -74). Conclusions: These results suggests that even though, the relapse rate is low, the relapse could occur after SVR achievement, and all cases of relapse occurred within one year after SVR. Furthermore, periodic surveillance for HCC should be done because risk of HCC development was same with rate of relapse and still exist even after SVR achievement.
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Case Reports : Lemierre Syndrome: A Case of Postanginal Sepsis
Young Tak Seo,Mi Jin Kim,Ji Hoon Kim,Byung Wook Ha,Hyo Sun Choi,Yong Tai Kim,Young Hwan Ham 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.3
Lemierre syndrome is a rare disease that`s characterized by internal jugular vein thrombosis and septic emboli. These symptoms typically develop after acute oropharyngeal infection by Fusobacterium necrophorum. Although this syndrome is less frequently seen in modern times due to the availability of antibiotics, physicians must be aware of the syndrome in order to initiate prompt antibiotics therapy, including coverage of the anerobic organisms. We discuss here the case of an 18-year-old female with Lemierre syndrome and we review the relevant literature on this syndrome.
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Spontaneous restoration of missed uterine inversion
( Ji Young Tak ),( Hyun Hwa Cha ),( Won Joon Seong ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
Uterine inversion is easily detected during physical examination but its diagnosis can be missed in a case of partial inversion or when ob-stetricians` experiences are insufficient. Also, the management of uterine inversion can be a trouble to obstetricians in a delayed diagnosing case. Here, we wish to present a case of missed partial uterine inversion which managed with uterine artery embolization successfully and resulted in spontaneous restoration at 8 weeks of postpartum. A postpartum woman was admitted due to acute postpartum bleeding and treated by uterine embolization with a diagnosis of uterine atony. However, partial uterine inversion was detected during scheduled pelvic examination performing at three weeks after discharge. Since she did not have significant vaginal bleeding and did not want surgical intervention, we decide to observe in-stead of laparoscopic surgery. Fortunately, her uterus was completely repositioned without any intervention at 4 weeks after the detection of missed uterine inversion.
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( Ji Yeon Kim ),( Young Hwan Kwon ),( Young Yi Kim ),( Se Jin Kim ),( Jung Gil Park ),( Soo Young Park ),( Min Kyu Jung ),( Won Young Tak ),( Young Oh Kweon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background/Aims: Sustained virologic response (SVR) has been regarded as therapeutic end point in chronic hepatitis C (CHC). But, ideal follow-up time for these patients still remains undefined. In analyses of SVR durability, the incidence of late relapse is extremely low (<1%) and patients with SVR have significantly fewer liver related complications, less hepatocellular carcinoma (HCC), and liver-related deaths. We investigated the durability of SVR and development of HCC to assess the clinical outcome in chronic hepatitis C (CHC) patients who achieved SVR after combination therapy of pegylated interferon (PEG-IFN) and ribavirin. Methods: The study was conducted on 293 CHC patients who achieved an SVR after PEG-IFN and ribavirin combination treatement. Liver function tests, qualitative HCV RNA assays and imaging study (USG or CT) were performed every 6 or 12 months during the follow-up period. Results: Among the 293 patients, 285 (genotype 1, 136; genotype non-1, 149) were followed up for more than 6 months after SVR. These 285 patients were aged 51.2 ± 11.0 years (mean ± SD), and 169 (59.3%) of them were male. The median follow-up duration was 29.4 months (range 6-81 months). The reappearance rate of HCV RNA during follow-up was 2.1% (n=6). Among 6 relapsers, five patients were genotype 1 , three had dose reduction of PEG-IFN or ribavirin (1:2) during combination therapy and the rest of them were treated with shorter duration (24wks). The median follow up duration of relapse was 5 months (range 3 -9). Six patients (2.1%) developed HCC during the follow-up period and the median follow up duration was 23.3 months (range 3 -74). Conclusions: These results suggests that even though, the relapse rate is low, the relapse could occur after SVR achievement, and all cases of relapse occurred within one year after SVR. Furthermore, periodic surveillance for HCC should be done because risk of HCC development was same with rate of relapse and still exist even after SVR achievement.
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의인성 쿠싱 증후군과 동반하여 발생한 말초 신경 병증 및 스테로이드 근병증
김지훈 ( Ji Hoon Kim ),김미진 ( Mi Jin Kim ),서영탁 ( Young Tak Seo ),김광현 ( Kwang Hyun Kim ),박아영 ( A Young Park ),함영환 ( Young Hwan Ham ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1
Myopathy is a well known side effect of corticosteroid therapy. We report a case of iatrogenic steroid therapy induced myopathy in a 79-year-old female who had taken steroids for more than three years due to treatment for degenerative osteoarthritis. She complained of severe proximal muscle wasting and lower extremities weakness. Also, she had typical features of Cushing syndrome such as moon face, buffalo hump and easy bruising. Needle electromyogram showed no abnormal spontaneous activities in both lower extremities, but peripheral nerve conduction study showed motor conduction defect of both deep peroneal and tibial nerves. And, low SNAP (sensory nerve action potential) of both superficial peroneal and sural nerves, which were compatible with peripheral polyneuropathy in both lower extremities. The muscle biopsy revealed a pronounced muscle fiber atrophy, fatty degenerative change and selective type 2 fiber depletion on ATPase staining in pH 9.4 buffer. She was treated isotonic exercise physical therapy and slowly improved. After three months later, she complained sudden onset of chest discomfort and died due to congestive heart failure.(Korean J Med 71:103-107, 2006)
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국내 노인전문시설 옥외공간 평가를 위한 외국도구(AGAT)의 적용 후 평가
탁영란 ( Young Ran Tak ),안지연 ( Ji Yeon An ),정소영 ( So Young Jung ) 한국의료복지건축학회 2013 의료·복지 건축 Vol.19 No.1
Purpose : The aging population is the quickly increasing in Korea. Since 2008, the National Long term Care Insurance, a number of long term care facilities have established during short time in Korea. Especially, the environmental assessment tool is important for managing healing environment in a long term care facility for the elderly. Alzheimer`s Garden Audit Tool (AGAT) is used to assess whether a garden incorporates those elements and qualities as healing outdoor space. In this paper, we discuss the benefits, limitations, and future directions of the assessment tool for long-term care facilities. Methods : The AGAT audit was done through content analysis by 5 experts from diverse discipline as post occupancy evaluation of a long term care facility located in suburban area. The expert group was asked to describe their comments for modification and improvement in application of AGAT. Results : The results of this study show that it is necessary to refine the instrument`s items to better meet the needs of the criteria and items for Korean culture-friendly tool. Especially, greenhouse elements (various plants, birds etc.), multisensory experiences, users-oriented space, programmed activities in garden, and hazards on pathway has somewhat limitation as measurement to assess outdoor of long-term care facilities in Korea. Implications : Consequently, AGAT could be applicable to evaluate the outdoor space of long term care facility in Korea with culturally sensitive revision.
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