Plasminogen kringle (angiostatin) 분획의 유효부분 분석

최영기,서원덕,이종수,신광순,김철중 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

In order to inhibit the growth of the malignant tumor, the development of various drugs against the malignant tumors has been archived. The combination of these drugs made the tumor therapy possible, but in many cases, secondary matastasis of the tumor to the other organs after its removal has been frequently reported. The angiostain, recently purified and cloned, not only promtes the angiogenesis of the tumor itself in the primary tumor but also inhibits the angiogenesis and metastasis of the secondary tumors. In this study, the nucleic acid sequences of the angiostatin was investigated. And the angiostain gene was expressed in a prokayotic expression system(E. coli) and a eukayotic expression system(Pichia pastoris). The angiostain gene was futher subcloned into 6 clones to characterize its biological activity. In the near future the biological activity and the biochemical property of the protein encoded by each clone will be elucidated.

개에서 관찰된 모기질세포종의 증례보고

조성환,손화영,김혜성,최종윤,류시윤,박배근,윤원기,홍성혁,김덕환 충남대학교 수의과대학 동물의과학연구소 2002 動物醫科學硏究誌 Vol.10 No.-

Pilomatricoma was histopathologically diagnosed in a 2.5-year-old male Alaskan malamute. The patient was referred to Chungnam National University, Veterinary Medical Teaching Hospital with solitary, firm and well-circumscribed mass at shoulder. Grossly, the mass was dome shaped to tumor like and 10 x 8 x 5㎝ in size. Some lesions had gritty or bony consistency and was chalky when sectioned Histopathologic feature included mumerous clusters of tightly arranged, basaloid cells with evenly distributed chromatin and ghost cells were characterized by a central unstained zone. The ghost cells often become calcified and osseous metaplasia was also present.

뇌의 미만성 축삭 손상 정도, 지능 지수 그리고 예후와의 상호관계

양승민,김영백,권정택,박승원,황성남,최덕영 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.2

Diffuse axonal injury (DAI) is defined as posttraumatic coma for over 24 hours without intracranial mass lesion. the purpose of this study was to examine the neurologic state of the patient and to evaluate the psychiatric sequela after DAI by psychometric analysis.Twenty eight patients with DAI were analyzed by a psychoanalyzer. Electroencephalography and magnetic resonance(MR) imaging were performed on eighteen patients. The ratio of male to female was about 6 to 1 and the major cause was traffic accident followed by fall down. Radiologic abnormality in MR image was predictors of poor outcome and early neurologic state was one of the most significant prognostic factor. Psychometric anlysis revealed that lntelligence Quotient was correlated with outcomes and most of patients with DAI were in normal range of lntelligence Quotient(67.9%) but they have suffered from variable psychologic problems, such as depression, anziety, phobia and dementia. Previous studies in DAI have been based principally on the prognostic factors and treatment without a systemic apporach to their meurologic and psychologic problems. Psychometric analysis can reveal psychologic symptom in the patients with DAI and appropriate management of their psychiatric problems may carry important implications for management of patients with moderate or servere DAI and improve rehabilitation outcomes.

수면량과 집중력의 상관관계

김병우,류지근,박우진,박계원,김미정,임지은,백대현,최재덕,최윤호,이가현,이관,김덕수 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

수면, 기억 그리고 학습의 연관성은 실제 매우 복잡하다. 많은 연구에도 불구하고 명확한 연구결과는 아직 없다. 우리는 이 연구에서 평소와는 달리 시험 전날 수면 변화 양상이 집중력에 어느 정도 영향력을 미치는지 알아보고자 하였고, 이를 이용해 효율적인 수면 관리를 할 수 있는 기초자료로 삼고자 하였다. 동국대 의대 본과 1학년생 중 지원자 30명과 본과 2학년생 10명을 대상으로 평상시 상태와 시험 직후 수면이 부족한 상태에서 각각 K-PES TEST를 실시하여 총 8항목에 걸쳐 암기력, 판단력, 단순반응의 변화정도를 검사하였다. 또 설문조사를 병행하여 결과에 영향을 미칠 수 있는 다른 인자들도 파악하였다. 수면량에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 인간의 최대 생리학적 기능은 꼭 수면부족에 의해 좌우되는 것은 아니다. 그러나, 수면감소는 피로를 증가시키고, 동기부여를 감소시키나 단, 새로운 사실을 학습하는 데에는 큰 영향을 끼치지 않는다. 즉, 수면부족으로 장시간 깨어있는 것은 정확성과 반응성을 떨어뜨린다. 흡연에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 니코틴의 수면에 대한 상호관계는 알려지지 않았고, 인간의 감정이나 의식, 인식에 영향을 주는 것으로 알고있지만, 장기적은 측면에서 흡연이나 알코올은 인식능력과 무관한 것 같다. 카페인에 대한 숫자 외우기(암기력)검사 결과, 카페인은 spacial selective attention에는 특별한 영향을 주지 않지만 지각과정이나 주의 집중에 큰 효과를 주며, 인간의 의식 수행에 긍정적인 효과를 준다. 즉 카페인은 활력, 혼란, 피로상태를 변화시키고 visual analog scales에서 휴식상태에 가까운 양상을 나타낸다. 또 48시간 동안 수면을 취하지 않은 사람에게 카페인은 집중력과 장시간의 좋은 기분을 유지하게 하였다. 그러나 규칙적, 비규칙적으로 먹는 사람간에는 인지수행력의 차이를 보이지 않으며 상용자에서는 상당한 내성이 보인다. 수면패턴에 대한 숫자 더하기(순간 판단력)검사 결과, 집중력은 수면패턴에 의해서도 영향을 받고, 수면패턴이 바뀌게 되면 순간판단력을 저하시킨다. This study was performed to evaluate relationship of sleep and attention, and to control sleep effectively. We conducted a K-PES test of 40 medical students. K-PES contains eight elements, for example, simple response, selective response, color pairing, OddEven discrimination, number addition, number-symbol matching, memory, right-tapping, left tapping. Through these, we tested changes of memory, judgement, simple response. And we conducted a questionnaire survey to exclude bias. Results are as follows. As a results of number-symbol matching test, we know that sleeplessness is not complete responsible for physiologic function for humans. But, decreased sleep increases fatigue and decreases motivation, but no influence on learning new materials. So, long term sleeplessness decreases precision and responsibility. As a results of number-symbol matching test on smoking, a relationship of nicotine and sleep is not certain. A point of view in long term period, smoking and drinking is not related cognition, even if we know that those influence mood, consciousness and cognition. As a results of memory work test on caffeine, caffeine does not influence spacial selective attention, but mainly does perception, attention and consiousness process. Namely caffeine changes energetic activities, chaos, fatigue states and shows resting state in visual analog scales In sleeplessness for 48 hours, caffeine produced attention and good mood for a long time. But, in case of cognitive process no significance shows in regular or irregular diet. Regular diet shows high resistance. As a results of number addition test on sleep patterns, seep patterns influence attention, changes of sleep patterns decrease a moment judgement.

열공성 경색 환자의 경동맥 초음파소견 및 혈청지방의 분포

여상준,민병국,황성남,석종식,김영백,박승원,권정택,최덕영 중앙대학교 의과대학 의과학연구소 2001 中央醫大誌 Vol.26 No.1

Notes : Lysophosphatidylcholine Suppresses the Expression of Phr1p and Pra1p, Surface Proteins Involved in the Morphogenesis of Candida albicans

( Duck Hyang Shin ),( Won Young Choi ),( Yung Joon Yoo ),( Min Kyoung Kim ),( Won Ja Choi ) 한국미생물 · 생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.4

Effects of Kokja as a Fermentation Starter on Sponge-and-Dough Bread Properties

Choi, In-Duck,Choi, Won-Seok The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1

Kokja, referred to Nuruk (Korean Koji), was used as a fermentation starter for sponge-and-dough breads. Sponge prepared with wheat flour, water and Kokja was fermented, and the fermented sponge at 0 h (FS0), 8 h (FS8), 16 h (FS16) and 24 h (FS24) was added to dough mixture. A significant pH decrease from 6.01 to 4.50 in sponge is closely related to the increased lactic acid bacteria viable cells of 2.9, 3.1, and 3.6 (log cfu/g) in FS8, FS16, and FS24, respectively. An increase in $CO_2$ content was observed in the dough with FS16, consistently increasing $CO_2$ production up to 90 min of dough fermentation. The bread with FS16 appeared to be high in loaf volume and medium in bread firmness. Adding the longer fermented sponge in bread dough resulted in blighter color on the bread crumb. Sensory ratings on overall acceptance were higher for the breads with FS0 and FS16, indicated as there was no significant difference statistically.

F-F18 : 실시간 이온화 방법을 이용한 수질 미량물질의 초고속 정성,정량방법

최원석 ( Won Seok Choi ),김윤덕 ( Yoon Duck Kim ),장제헌 ( Je Heon Jang ),최재원 ( Jae Won Choi ) 한국물환경학회(구 한국수질보전학회) 2013 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2013 No.-

낮은 바렉터 제어 전압을 이용한 광대역 주파수 합성기 설계

원득호(Duck-Ho Won),최광석(Kwang-Seok Choi),윤상원(Sang-Won Yun) 한국전자파학회 2010 한국전자파학회논문지 Vol.21 No.1

본 논문에서는 클랩형 전압 제어 발진기 회로를 바탕으로 UHF 대역에서 광대역 주파수 합성기를 설계하는 방법을 제시하였다. 전압 제어 발진기의 동작 조건 중 부성 저항 회로와 부하 회로의 위상 변화 특성을 해석하여 동작 범위를 증가시킬 수 있는 방법을 제안하였다. 이러한 방법을 적용하여 광대역 전압 제어 발진기를 설계하고, PLL 기반의 광대역 주파수 합성기를 설계하고 제작하였다. 제작된 주파수 합성기는 0~5 V의 버랙터 제어 전압에서 740~1,530 ㎒의 발진 주파수 범위를 갖고, 2~-6 ㏈m의 출력 전력을 얻었다. 또한 위상 잡음은 10 ㎑에서 -77 ㏈c/㎐, 100 ㎑에서 -108 ㏈c/㎐로 측정되었다. In this paper, with using the clapp type VCO(Voltage Controlled Osillator) configuration a wideband frequency synthesizer in UHF band is proposed. In order to design a wideband frequency synthesizer, the variation of phase in the negative resistance circuit as well as the load circuit was analyzed. Based on this result we propose a method to widen the operation range of the VCO. A frequency synthesizer using the proposed wideband VCO was designed and fabricated. It is shown that the synthesizer has the operating frequency range of 740~1,530 ㎒ by 0~5 V varactor tuning voltage, and it had the output power of 2~-6 ㏈m. Moreover, the phase noise mesaured as -77 ㏈c/㎐ at 10 ㎑ offset, and as -108 ㏈c/㎐ at 100 ㎑ offset from the oscillation frequency.

Food Science/Microbiology : Effects of Kokja as a Fermentation Starter on Sponge-and-Dough Bread Properties

In Duck Choi,Won Seok Choi 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1

Kokja, referred to Nuruk (Korean Koji), was used as a fermentation starter for sponge-and-dough breads. Sponge prepared with wheat flour, water and Kokja was fermented, and the fermented sponge at 0 h (FS0), 8 h (FS8), 16 h (FS16) and 24 h (FS24) was added