Graves 병 환자에서 항갑상선제 투여에 의한 TSH 수용체 항체의 변동에 관한 연구 : 치료 용량 및 기간에 따른 차이 및 임상상과의 관계 its relation to dose and duration of treatment~and clinical features

이문호,조보연,문대혁,고창순,민헌기,서교일 대한내과학회 1986 대한내과학회지 Vol.30 No.3

We undertook a prospective study of 59 patients with Graves' disease in order to clarify the influence of antithyroid drug on the immunological indices and to determine the association of the changes of TSH receptor antibodies activities with drug dosage, duration of treatment and clinical features according to mode of antitbyroid drugs treatment. Patients were divided into two groups. High dose group included 28 patients and conventional dose group 31 patients. We measured TBII activities, antimicrosomal antibodies, and the size of goiter every 3 months, comparing them with clinical features and laboratory findings. TBII activities declined from R months until 9 months following drug treatment. Therafter no significant change of TBII activities were observed. Antimicrosomal antibodies showed the same pattern of change. There was no statistically significant difference of declining rate of TBII activities, antimicrosomal antibodies, and reduction of size of thyroid between two treatment groups. TBII activities fell into normal range in 15 patients among those 44 patients who had been followed for more than 9 months (8 high dose group, 7 conventional dose group). In those 15 patients, TBII activities and frequency of exophthalmos were less than those whose TBII activity did not normalized. We conclude that TSH receptor antibodies activities and antithyroid autoantibodies are diminished by antithyroid drug treatment in patients with Graves disease and there is no relationship between dose of drug and declining of TBII activities. We suggest that changing levels of TBII activities might be secondary phenomenon which can be achieved by control of thyroid function by antithyroid drug rather than direct immunosuppressive effect of antithyroid drug per se.

Wechsler 記憶檢査(改訂版)의 妥當度 硏究

韓五洙,柳希姃,金晟倫,金昌潤,李楨敎,李哲,朴仁鎬 서울醫大 1997 精神醫學 Vol.22 No.1

유화 Chlorosulfonated Polyethylene Rubber (CSM)의 제조 및 특성 연구

이은경,최교창,최세영 한국고무학회 2005 엘라스토머 및 콤포지트 Vol.40 No.1

본 연구에서는 CSM 에멀젼의 물성을 향상시키고자 금속성 가교제인 magnesium carbonate 및 calcium hydroxide를 첨가하여 가교밀도, 열적특성, 표면자유에너지 그리고 인장강도, 파단신율 및 인열강도 특성을 고찰하였다, 금속성 가교제인 magnesium carbonate 및 calcium hydroxide 양이 증가함에 따라 CSM 에멀젼 필름은 가교밀도는 증가하였고, 이에 내수성과 T_(g) 값도 증가하였다. 금속성 가교제로 magnesium carbonate를 첨가하였을 때 calcium hydroxide에 비해서 다소 높은 가교밀도와 T_(g) 값을 보였다. 하지만 CSM 에멀젼 필름의 표면에너지 및 기계적 특성들은 다소 다른거동을 보였다 Magnesium carbonate 0.75% 그리고 calcium hydroxide 1.0% 첨가한 경우가 가장 높은 표면 자유에너지 값과 인장강도 및 인열강도를 보였으나, 그 이상의 양을 첨가하였을 경우에는 오히려 감소함을 확인하였다. 그러므로 본 연구에서 CSM 에멀젼의 물성을 향상시키는데 적용되는 금속성 가교제로서 calcium hydroxide 보다 magnesium carbonate가 더 적당하며, 0.75% 첨가하였을 때 보다 향상된 물성을 얻을 수 있었다. In this work. magnesium carbonate and calcium hydroxide as metallic crosslinking agent were added to chlorosulfonated polyethylene rubber (CSM) emulsion to enhance the mechanical properties of emulsion film such as tensile strength. elongation at break, and tear strength and crosslinking density. thermal features, and surface energy were also investigated. Crosslinking density of the CSM emulsion film with increasing the amount of magnesium carbonate and calcium hydroxide increased. leading to the enhancement of water resistance. It was shown that compared with calcium hydroxide, magnesium carbonate had a little higher crosslinking density and To value. The surface energy and mechanical characteristics of the CSM emulsion film, however, showed somewhat different behaviors. The highest surface energy. tensile strength. and tear strength were observed when 0.75° o for magnesium carbonate and 1.0° o for calcium hydroxide were added respectively. Therefore. it can be concluded that as metallic crosslinking agent to improve water resistance and mechanical properties of the CSM emulsion, magnesium carbonate is more preferable to calcium hydroxide

전립선 선암종에서의 p53 및 I-cadherin 단백의 면역조직 화학적 연구

맹이소,김원일,이교영,김영신,강창석,심상인 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.3

열처리 조건에 따른 Pt/SnO₂가스센서의 수소가스 감지특성

이재홍,김창교 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.3 No.3

A dry impregnation method was used for preparing pellet type Pt/SnO₂gas sensor. The crystal structure, the direction of crystal, and the crystal size were characterized with Electron Diffraction Analysis and Scanning Electron Microscopy. The characterization indicates that the hydrogen sensitivity of Pt/SnO₂ calcined at 400℃ was higher than that of Pt/SnO₂without calcination. After the reactor with a Pt/SnO₂sensor was run with a flow rate of 30sccm (a mixture of 0.5%H₂in N₂) for a while, the resistance of SnO₂was saturated, but the SnO₂continues to absorb H₂gas. This indicates that the surface state was saturated. The sensitivity of Pt/SnO₂sample calcind at 400℃ was about 93% for 14cc H₂at 300℃.

그레이브스 병 치료 후 재발 위험 인자에 관한 연구

이영창,유명희,윤석기,변동원,서교일,김극배 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

연구 배경 : 그레이브스 병에 대한 항갑상선제 치료후 적절한 치료 여부 평가 및 재발 위험성을 예측하기 위하여 여러 가지 예후 판정 인자들이 연구되어 왔으며, 이러한 인자들 중 TRH(thyrotropin-releasing hormone) 자극 시험이 가장 믿을 만한 검사중에 하나로 알려져 있다. 그러나 TRH 자극 검사가 정상으로 나와도 재발하는 경우가 많으며, 현재로는 이러한 경우에 재발을 예측하는 예후 인자에 대한 연구는 전무한 실정이다. 금번 연구에서는 TRH 자극 시험 후 TSH(thyroid stimulating hormone)가 정상적인 반응을 보인 환자를 대상으로 재발 및 관해여부를 예측할 수 있는 인자들을 찾고자 하였다. 대상 및 방법 : 항갑상선제제 치료 종료후 TRH 자극 시험을 시행하였던 그레이브스 병 환자 총 84명 중, 정상적인 TSH 반응을 보이면서 1년 이상 추적 관찰이 가능하였던 32명의 환자를 대상으로 하였다. 처음 진단 시와 치료 종료 시에 T3(triiodothyronine), T4(thyroxine), T3/T4 비, TSH, TRAb, Anti-TPO Ab(anti-thyroperoxidase antibody)를 측정하였으며, 치료 종료 2개월후에는 TRH 자극 검사를 하여 TSH 증가폭(△TSH) 및 유리 T_(3) 증가폭(△FT_(3))을 구하였다. 모든 측정치는 평균±표준편차로 표시하였으며, SPSS software를 이용하여 Student's paired t-test, chi-square test, Wilcoxon signed ranks test를 시행하였고, 유의 수준 0.05 이하를 통계적으로 유의하다고 판단하였다. 결과 1) 총 32명의 환자 중 재발한 환자(Group Ⅰ)는 22명(69%) 이었으며, 재발한 환자(Group Ⅱ)는 10명(31%) 이었다. 2) 진단 초기 총T3 치는 Ⅰ 군에서 342.0±126.2ng/dl, Ⅱ 군에서 493.0 ±142.2 ng/dl로 Ⅱ군에 비해 유의하게 증가되었다(p<0.05). 3) Anti-TPO Ab는 Ⅰ군에서 2.9±4.4, Ⅱ군에서 22.3±22.3 U/mL로 나타나 Ⅱ군에서 유의하게 증가되었다.(p<0.05) 4) 양군에서 치료 종료후 재발시 대부분의 환자가 1년 이내에 재발하였다. 5) TRH 자극· 검사후 유리 T3 증가폭 및 TSH 증가폭은 양군간에 차이가 업ㅅ었다(1.5±0.9 vs 1.2±1.0 pmol/L, 12.54±7.56 vs 11.23±4.21 mU/L, p>0.05) 결론 : TRH 자극 검사후 정상적인 TSH 반응을 보인 환자에서 재발 및 관해여부를 치료 초기 T3 및 치료 종료시 Anti-TPO Ab로 예측할 수 있었으며, 이들 측정치가 증가해 있을수록 재발의 가능성이 많음을 알 수 있었다. 또한 투약 중단후 초기 12개원의 추적기간 동안 관해가 유지되면 그 이후엔 재발의 가능성이 현저히 줄어 들었으며, 이 후 좀더 많은 환자들을 대상으로 하는 장기적인 추적연구가 진행 되어야 할 것으로 사료된다. Background : Many studies were undertaken to find parameters that could predict the clinical course of patients with Graves' disease after withdrawal of antithyroid drugs. In many parameters, TRH (thyrotropin-releasing hormone) stimulation test and T3 suppression test were considered to be one of the most reliable for predicting remission. But recently, some studies showed that the measurement of free T3 and FT3 are to be a more accurate than other thyroid function test. In this study, we measured T_(3), T_(4), T_(3)/T_(4), TSH (thyroid stimulating hormone), TRAb (TSH receptor antibody), FT3 and other known useful parameters to compare the factors influencing the relapse of Graves disease after antithyroid medication. Patients and methods : Among the 84 Graves' disease patients who had done the TRH stimulation test after withdrawal of antithyroid medication, we examined 32 patients who showed normal TSH response and followed up more than one year. T_(3), T_(4), T_(3)/T_(4), TSH and TRAb levels were measured at the time of diagnosis and at the end of therapy. Serum TSH and FT_(3) levels were measured after TRH stimulation, after two months of withdrawal of medication. Statistical evaluation was Performed by SPSS software in combination with Student's Paired t-test, chi-square test, Wlicoxon signed-ranks test. p-value less than 0.05 was considered to be significant. Results 1. In the 32 patients with Graves disease, 10 patients(31%) relapsed(Group Ⅰ) and 22 Patients(69%) remained in remission(Group Ⅱ). 2. Initial serum T3 level was significantly higher in group Ⅰ than group Ⅱ(342.0 ±126.2 vs. 493.0±142.2 ng/dl, p<0.05). 3. Anti-TPO Ab level was significantly higher in group Ⅰ than group Ⅱ(22.3±22.3 vs 2.9±4.4 U/mL, p<0.05). 4. In group Ⅰ and Ⅱ most patients showed relapse within 1 year after antithyroid medication. 5. After TRH stimulation test, serum FT_(3), and TSH level were not significantly different between group I and Ⅱ(p>0.05). 6. Serum T_(4), T_(3)/T_(4), TSH, TRAb levels were not significantly different from group Ⅰ and Ⅱ. Conclusion : In this study, we found increased relapse rate in the patients with Graves' disease whose initial serum T3 and anti-TPO Ab levels were high, so these parameters could be used to predict the relapse of Graves' disease. In the case of more than 12 months remission period after withdrawal of antithyroid medication, no relapse wsa observed in this study, but study should be done in the large population of patients with Graves' disease.

민간부문 건설사업관리 활성화방안

이정희,장홍진,구교진,김옥규,현창택,김양현 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1

Since, korean government introduced Construction Management system by the law in 1997, only a few public construction projects have been adopted the system Nevertheless there are many laws which are related in public construction projects, Construction Management is positively carried out by non-government. About the activation plan of Construction Management questionnaire was inquired by experts in construction. The purpose of this study is to give a solution by finding out the problem of the laws, reconstructions remodelings.

설계추진단계별 설계VE의 효율적 적용 방안

이승훈,서용칠,구교진,현창택 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study is to propose an efficient design-VE job plan and applicable methods in each phase of design process. This is for more effective and practical use of VE in design phase. This study focuses on differences of the VE target selection phase and function analysis phase in each phase of design process. In the phase of preliminary design, conceptual sketch, size, use, or major spaces of project are selected for VE target and function assessment step is skipped because present cost and function cost cannot be produced easily in early in early phase of design. At the end of preliminary design phase, function review phase is added which consists of function satisfactory indices review step and unsatisfactory function removal step.

Turbo-PROLOG를 이용한 전문가시스템 쉘의 원형개발

이동만,서창교,이영숙 慶北大學校出版部 1993 經商論集 Vol.21 No.3

새로운 LacZ Gene Fusion 및 Gene Cartridge Vector의 개발에 관한 연구

박교선,이영훈,박충웅,최창진 圓光大學校 基礎自然科學硏究所 1987 基礎科學硏究誌 Vol.6 No.2

In this study, a new lacZ gene vector, plasmid PGEM3-lacZ was constucted, which could be used for the study of the gene regulation and the function of proteins. Plasmid pMC1871 was digested with restriction endonuclease Pst I and Sma I to obtain a DNA fragment with the lacZ-gene(3091 bp). Recombinant plasmid pGEM3-lacZ was constructed by inserting the lacZ gene DNA(Pst I-Sma I cut DNA; 3091 bp) of pMC1871 into the Pst I and Hinc Ⅱ sites of plasmid pGEM3. After then, Recombinant plasmid pGEM3-lacZ DNA was transformated into E. coli HB 101. pGEM3-lacZ DNA/HB 101 was screened on the NZY plate with ampicillin and X-gal(5-Bromo-4-Chloro-3-Indolyl-β-D-Galactoside) by selecting blue colonies. The restriction map of pGEM.3-1acZ DNA was constructed by the following restriction enzymes :Bgl I, Xbal I, Bam HI, EcoR I, Hind Ⅲ, Kpn I, Pst I, Sma Ⅰ, Sal Ⅰ. From the restriction map, the lacZ DNA was confirmed to be present at the expected position in the plasmid pGEM3-lacZ. pGEM3-lacZ/HB101 gives about 10 times more lacZ DNA than pMC 1871/HB101.