Anti-Inflammatory Effect of By-Products from<i>Haliotis discus hannai</i>in RAW 264.7 Cells

Rho, Ho-Seok,Kim, Hyang,Kim, Jung-Ae,Karadeniz, Fatih,Ahn, Byul-Nim,Nam, Ki-Ho,Seo, Youngwan,Kong, Chang-Suk Hindawi Limited 2015 Journal of chemistry Vol.2015 No.-

<P>Several reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents. Pacific abalone,<I>Haliotis discus hannai</I>viscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory. In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste of<I>H. discus hannai</I>was evaluated using RAW 264.7 mouse macrophage cell model. Results indicated that presence of<I>H. discus hannai</I>mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-<I>α</I>, IL-1<I>β</I>, and IL-6 and enzymes iNOS and COX-2. Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1. Presence of AM also scavenged the free radicals<I>in vitro</I>. In conclusion, by-products of<I>H. discus hannai</I>are suggested to possess notable anti-inflammatory potential which promotes the possibility of utilization as functional food ingredient.</P>

Effects of pyridoxine on a high‐fat diet‐induced reduction of cell proliferation and neuroblast differentiation depend on cyclic adenosine monophosphate response element binding protein in the mouse dentate gyrus

Yoo, Dae Young,Kim, Woosuk,Yoo, Ki‐,Yeon,Nam, Sung Min,Chung, Jin Young,Yoon, Yeo Sung,Won, Moo‐,Ho,Hwang, In Koo Wiley Subscription Services, Inc., A Wiley Company 2012 JOURNAL OF NEUROSCIENCE RESEARCH - Vol.90 No.8

<P><B>Abstract</B></P><P>In this study, we challenged pyridoxine to mice fed a high‐fat diet (HFD) and investigated the effects of pyridoxine on HFD‐induced phenotypes such as blood glucose, reduction of cell proliferation and neuroblast differentiation in the dentate gyrus using Ki67 and doublecortin (DCX), respectively. Mice were fed a commercially available low‐fat diet (LFD) as control diet or HFD (60% fat) for 8 weeks. After 5 weeks of LFD or HFD treatment, 350 mg/kg pyridoxine was administered for 3 weeks. The administration of pyridoxine significantly decreased body weight in the HFD‐treated group. In addition, there were no significant differences in hepatic histology and pancreatic insulin‐immunoreactive (‐ir) and glucagon‐ir cells of the HFD‐treated group after pyridoxine treatment. In the HFD‐fed group, Ki67‐positive nuclei and DCX‐ir neuroblasts were significantly decreased in the dentate gyrus compared with those in the LFD‐fed mice. However, the administration of pyridoxine significantly increased Ki67‐positive nuclei and DCX‐ir neuroblasts in the dentate gyrus in both LFD‐ and HFD‐fed mice. In addition, the administration of pyridoxine significantly increased the protein levels of glutamic acid decarboxylase 67 (GAD67) and brain‐derived neurotrophic factor (BDNF) and the immunoreactivity of phosphorylated cyclic AMP response element binding protein (pCREB) compared with the vehicle‐treated LFD‐ and HFD‐fed mice. In contrast, the administration of pyridoxine significantly decreased HFD‐induced malondialdehyde (MDA) levels in the hippocampus. These results showed that pyridoxine supplement reduced the HFD‐induced reduction of cell proliferation and neuroblast differentiation in the dentate gyrus via controlling the levels of GAD67, pCREB, BDNF, and MDA. © 2012 Wiley Periodicals, Inc.</P>

中風病辨證診斷標準에 의한 臨床的 硏究

任長信,文祥官,高昌男,權正男,曺基湖,金永錫,裵亨燮,李京燮 경희대학교 1997 慶熙醫學 Vol.13 No.3

울금(鬱金)에서 분리된 demethoxycurcumin이 백서의 혈관재협착에 미치는 효과

길인호,정명수,신창호,배현옥,정헌택,이기남,Kil, In-Ho,Chong, Myong-Soo,Shin, Chang-Ho,Pae, Hyun-Ock,Chung, Hun-Taeg,Lee, Ki-Nam 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.3

The pathobiologic process of arterial stenosis following balloon angioplasty continues to be an enigmatic problem in clinical settings. This study investigates the ability of demethoxycurcumin, a curcuminoid isolated from Radix Curcumae, to attenuate balloon injury-induced neointima(NI) formation in the rat carotid artery. It was found that demethoxycurcumin induced inducible heme oxygenase(HO-1) expression and inhibited dose-dependently cellular proliferation in rat vascular smooth muscle cells. Perivascular application of demethoxycurcumin immediately following injury significantly reduced NI area and NI thickness 2 weeks post-injury. Interestingly, treatment with tin-protoporphyrin IX, a HO inhibitor, reversed the effects of demethoxycurcumin on NI formation. These results implicate demethoxycurcumin as a potent new therapeutic agent that is capable of reducing post-angioplasty arterial stenosis through induction of the HO-1 expression.

기업의 "핵심역량 집중도"와 "IT 아웃소싱 성숙도"가 IT 아웃소싱 성과에 미치는 영향에 관한 연구

남기찬,오승호 서강대학교 경영연구소 2004 서강경영논총 Vol.15 No.2

생활체육 동호인조직의 운영 실태와 전망

남일호,이기세 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.6

The physical environment of korea came to conclusion, without scattering accumulation of long history 80 years, at the base of advanced sports of advanced sports as following in order to make its frame which fixation and management of sports club. 1) Laws f the national sport promotion must be amended to use the unified title of various projects. 2) Fixations of "sports club" need to reform of administration for using existing facilities efficiently. 3) Methods of not only induce joining sports club, but also induce people where the place of sport For el[ need to reform of system as like "tax cut" 4) As demand of sport For a[[ increase, occurrence Frequency of safety accident also become increase, So "sports safety insurance" have to activate by mutual-aid-center of the national sport for all. 5) Teenagers ratio who participating formation of sports club, new member of collective joining each event, unit activity have to enlarge over twenty percents. 6) KOC, which carrying out Function attars of IOC, is separated as a independence corporation and the national council of sport for all & the korea sports council must be equipped with advanced system through "unity". 7) Political supports from the korea broadcasting advertising corporation by authorities, 3-broadcasting station participation of the campaign sport For all and expansion of budget related of sport for all. 8) It is demanded for creation "the ministry of athletics" to make peaceful settlement about main projects of athletics.

조혈모세포이식환자에서 조혈기능의 회복과 관련된 인자들에 관한 연구

정기주,강명수,권기두,김경하,이상철,김현정,배상병,김찬규,이남수,이규택,원종호,홍대식,박희숙 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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아급성 연합성 변성의 선경전도 검사

권기한,선우일남,정근호 대한신경과학회 1999 대한신경과학회지 Vol.17 No.2

고등학교 지구과학 실험실습 내용의 선정 및 개선 연구

남기상,이광호,이영범,김광호 全北大學校 敎育大學院 1984 敎育論叢 Vol.4 No.-

Based on the opinions of earth science teachers obtained by questionnaire methods(Nov.1983-Feb.1984) and, the analyses of curricula and textbooks (domestic and foreign), 44 laboratory activities for high school earth science were selected as main or important items, among which 21 were proposed as essential ones. Some items were application-tested in the attached high school. Selection was filtered through the seven criteria of selection, two most important ones of which are as follows: laboratory activities should be 1) free of temporal and spatial restrictions, and 2) directed to real objects (earth and universe), not to models, if possible. Domain of concern of earth science was divided by four main fields such as geology, atmospheric science, oceanography and geophysics,and astronomy, so that laboratory activities were grouped accordingly. For 44 items short remarks are tabulated of the methods of implementation, while for ten essential ones detailed description is presented. Situations in high schools and some propositions in relation to the laboratory activities are discussed.

부산 황령산의 개미 분포상

임남기,문두호 釜山大學校 師範大學 2003 교사교육연구 Vol.42 No.-

부산의 도심에 위치한 황령산의 개미상을 조사하기 위하여 2002년 5월부터 2002년 9월까지 3개의 사면(동북사면, 남사면, 서북사면)으로 나누어 각 사면별로 4회씩 총 12회를 채집하였으며, 발견된 총 콜로니 1176개를 관찰·동정하여 아래와 같은 결과를 얻었다. 1. 황령산 일대의 총 종 구성은 4과 19속 33종이었고, 우점종으로는 주름개미(Tetramorium caespitum)로서 상대풍부도가 27.9%로 가장 많았다. 아과별로는 두마디개미아과(MYRMICINAE)의 개미가 10속 15종으로 가장 많이 서식하고 있었다. 2. 황령산 개미의 수직적 종 분포를 살펴보면 총 19속 33종 중에서 하층부(70m-219m)에서 15속 19종, 중층부(220m-319m)에서 8속 11종, 상층면에서 15속 23종이 채집이 되었으며, 상층부(320m-428m)에서 상대적으로 종이 풍부하였다. 3. 황령산의 남사면과 서북사면에서 왕주름개미(Tetramorium bicarinatum)가 이번 조사에서 채집되어 우리나라에 서식하고 있는 것이 확인되었다. 또한 경상남도 미 기록종인 북방왕개미(Camponotus herculeanus sachalinensis)와 황장다리개미(Aphaenogaster famelica)가 동북사면에서 채집이 되었다. 4. 황령산의 개미군집의 종 다양도 지수는 3.48 이었고, 종 풍부도는 4.53 이었고, 종 우점도는 0.42로 나타났다. 한편 종 유사도는 동북사면과 남사면간이 0.94로 가장 높게 나타났다. This thesis intends to investigate the ants' faunas of Mt. Hwangryeong located in downtown Busan. For this purpose, samples were collected twelve times in total, four times for the three different slopes(north-east, south and north-west) respectively from May 2002 through September 2002. In addition, samples were classified three different levels(upper, middle and bottom) in terms of vertical altitudes according to each relevant slopes. The observation and classification of 1176 colonies found from the different slopes of the mountain are as following; 1. It turns out that there are 4 families, 19 genus and 33 species in total throughout the mountain, and Tetramorium caespitun as a dominant is relatively abundant up to 27.9 percent. Ants belonging to the family of MYRMICINAE are distributed in the highest density of 10 genus and 15 species. 2. From the perspective of vertical distribution to the altitudes of the mountains, there are 19 genus and 33 species, among them 15 genus and 19 species in the bottom level(70m-219m), 8 genus and 11 species in the middle 1evel(220m-319m) and relatively abundant 15 genus and 23 species in the upper level(320m-428m). 3. The fact that Tetramnrium bicarinatum was found both in the southern and north-west slopes of the mountains was identified as the ant living in Korea. Besides both Camponotus hercuteanus sachalinensis and Aphaenogaster fametica which were not collected in the Kyungnam province are found in the north-east slope of Mt. Hwangryeong. 4. An analysis on the community's structures shows that diversity index is 3.48, richness index is 4.53 and dominant index is 0.42, while the similarity index is the highest(0.94) both in the north-east and southern slopes.