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허현,유현덕,서승석,김영창,최장석,이영구 인제대학교 1995 仁濟醫學 Vol.16 No.3
소아 고관절 골절은 대부분 심한 외력에 의해 초래되므로 동반 손상이 많고, 치료 후에도 합병증이 빈발하므로 치료에 많은 어려움이 따르지만, 조기에 해부학적 정복 및 견고한 내고정을 함으로써 좋은 결과를 기대한다고 하였다. 이에 저자들은 1년이상 추시관찰이 가능했던 소아 고관절 골절 38례를 대상으로 그 치료 결과를 분석 하였다. The femoral neck fracture in the children is a rare injury and occurreda by severe trauma in the most cases. This accounts for the high frequency of serious associated injuries. Since the femoral neck in children has many anatomic and physiologic differences, there are many difficulties during the treatment period and complications such as coxa vara, avascular necrosis of the femoral head, and premature epiphyseal closure are commonly encountered following treatments. 38 cases treated at Paik Hospital from Jan. 1979 to Aug. 1992 were analyzed both clinically and radiologically. The following results were obtained 1.The commonest age group was between 10 and 15 years and the ratio of boys to girls was approximately 1.5 : 1. 2.According to the classification of Delbet and Colonna, the cervicotrochanteric fracture was the most common type (50% of the cases) and displaced fracture was 30 cases(79%). 3.The main cause of fracture was traffic accidents, which occurred in 17 cases (45%). 4.Associated injuries were long bone fracture and pelvic bone fracture and genitourinary injury. 5.In type I, II, III fracture by early reduction and internal fixation, and in type IV fracture by conservative treatment, we gained satisfactory results. 6.Complications were developed in 16 cases(42%) The commonest complication was coxa vara, 7 cases(17%) and other complications was avascular necrosis, 5 cases(13%) and premature epiphyseal closure, 4 cases(11%).
Hepatoprotective Effects of GongJin-dan on Ethanol-mediated Experimental Liver Damage in Rats
허현,김희준,박경,곽민아,김대준,변준석 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Background : A traditional Oriental medicine, GongJin-dan (GJD), is one of the most well-known tonic agents in Korea. Among 6 types of GJD components, antler, red ginseng, and Cornus fructus have shown antioxidant effects, while EtOH-induced tissue damage may be a consequence of oxidative stress. Objectives & Methods : The hepatoprotective effects of GJD were evaluated on EtOH-mediated experimental liver damaged rats at 50, 100, 250 and 500mg/kg comparing with 100mg/kg of silymarin as a reference drug in the present study. Test substances were dosed once a day for 60 days with oral administration of 20% ethanol 2.5ml/100g body weight twice a day (equivalent to 7.9g ethanol/kg/day). Each of 8 rats per group was selected using body weight at 10 days after acclimatization. Experimental animals were sacrificed after 60 days of continuous oral treatment of test substances with 20% ethanol treatment, and changes on the body weight, liver weight, and serum AST and ALT were observed. Results : There were dramatic decreases of body weight and increases of liver weight and serum AST and ALT. Similar inhibition effects on the EtOH-induced hepatic damages were detected between equal dosages of GJD and silymarin. Conclusion : Based on these results, it is concluded that GJD showed clear hepatoprotective effects on EtOH-induced hepatic damage. Background : A traditional Oriental medicine, GongJin-dan (GJD), is one of the most well-known tonic agents in Korea. Among 6 types of GJD components, antler, red ginseng, and Cornus fructus have shown antioxidant effects, while EtOH-induced tissue damage may be a consequence of oxidative stress. Objectives & Methods : The hepatoprotective effects of GJD were evaluated on EtOH-mediated experimental liver damaged rats at 50, 100, 250 and 500mg/kg comparing with 100mg/kg of silymarin as a reference drug in the present study. Test substances were dosed once a day for 60 days with oral administration of 20% ethanol 2.5ml/100g body weight twice a day (equivalent to 7.9g ethanol/kg/day). Each of 8 rats per group was selected using body weight at 10 days after acclimatization. Experimental animals were sacrificed after 60 days of continuous oral treatment of test substances with 20% ethanol treatment, and changes on the body weight, liver weight, and serum AST and ALT were observed. Results : There were dramatic decreases of body weight and increases of liver weight and serum AST and ALT. Similar inhibition effects on the EtOH-induced hepatic damages were detected between equal dosages of GJD and silymarin. Conclusion : Based on these results, it is concluded that GJD showed clear hepatoprotective effects on EtOH-induced hepatic damage.
기관 내관의 기낭을 팽창시키는 방법의 비교: 수동적 배출법과 최소 기낭 팽창법
허현,김경환,신동운,박준석,김훈,전우찬,신희준,김민정,박준민 대한응급의학회 2013 大韓應急醫學會誌 Vol.24 No.1
Purpose: Inflation of an endotracheal tube cuff with adequate pressure is an important procedure. Passive release technique (PRT) is a useful and convenient method for inflating the cuff. To date, no study comparing this method with minimal occlusive volume technique (MOVT), one of the most commonly used methods for inflating the cuff, has been reported. We conducted this study for comparison of effectiveness, difficulty, and preference between the two methods. Methods: We conducted a prospective, crossover, randomized study in which participants used each technique,one at a time. Participants inflated the cuff of an endotracheal tube inserted into a manikin after receiving brief education on use of the two methods. After inflating the cuff using each method, pressure and volume of the inflated cuff were measured using a portable manometer and syringes, respectively. Then, difficulty of each method was investigated using the visual analogue scale (VAS) and preference for each method was investigated. Results: A total of 47 participants were enrolled in the study. The mean pressure between the two methods was not statistically different (p=0.27). However, adequate pressure was achieved in 37 (78.7%) and 16 (34.0%) of participants in PRT and MOVT, respectively (p<0.01). The mean volume was 6.0±0.4 ml in PRT and 5.7±0.6 ml in MOVT (p<0.01). The VAS score for diffculty was 17.7±15.8 in PRT and 76.0±15.8 in MOVT (p<0.01). Preference for PRT was 46(97.9%) and that for MOVT was 1 (2.1%). Conclusion: PRT is an easier, more preferred, and more effective method for cuff inflation than MOVT.
허현,김재우,Hyun Heo,M,D,Jae Woo Kim,M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.10
Purpose: To investigate the effect of amniotic membrane extract (AME) on the survival, nitric oxide production by cultured human Tenon`s capsule fibroblasts (HTCF) and contraction of collagen gels. Methods: After exposure to 5~20 ?g/ml AME for 5 days, the survival and nitrite production of the primarily cultured HTCF were assessed with MTT and Griess assays respectively. Acridine orange/Hoechst 33342 double staining and flow cytometric analysis using FITC-Annexin/propidium iodide double staining were done to evaluate AME-induced apoptosis of HTCF. The effect of AME on the contraction of collagen gels cultured with fibroblast was also evaluated. Results: AME decreased cellular survival in a dose-dependent manner and did not affect the production of nitric oxide. AME caused apoptotic death of HTCF in a dose-dependent manner and caused necrosis at high concentration (20 ?g/ml). AME did not affect on the contraction of collagen gel. Conclusions: AME decreased cellular survival of HTCF by apoptosis and did not affect the contraction of collagen gels. Thus AME could modulate conjunctival wound healing by suppressing the cellular survival and activity of HTCF.