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      • KCI등재후보

        Usefulness of for BI-RAD Category 4 or Higher Lesions

        변준석,오현화,이혜윤,김금원,김진숙,윤대성 대한종양외과학회 2017 Korean Journal of Clinical Oncology Vol.13 No.1

        Purpose: As an alternative to core-needle biopsy in confirming the diagnosis of breast cancer, the usefulness of 99mTc-sestamibi scintimammography (MIBI scan) has been rarely reported. Thus, we aimed to evaluate a direct comparison between general diagnostic modalities and breast MIBI scan, which may be revealed as a potential diagnostic alternative. Methods: In a retrospective study, 301 patients with 801 lesions, who underwent breast MIBI scan, ultrasonography, and mammography simultaneously between January 2013 and February 2015, were reviewed. All data were analyzed by McNemar and Kappa test for statistical significance. Results: Mean age was 49.2±9.37 years old (range from 26 to 85 years old). Results of Breast MIBI scan were divided into three categories: 236 positive intensity uptakes (29.5%), 565 negative intensity uptakes (70.5%), and 67 suspicious abnormal intensity uptakes (8.4%). Pathologic reports were also allocated into four subgroups: 122 invasive cancers (15.2%), 44 non-invasive cancers (5.5%), 194 proliferative benign lesions (24.2%), and 441 non-proliferative benign lesions (55.1%). The sensitivity, specificity, positive predictive value, and negative predictive value of MIBI scan were 83.5%, 55.6%, 59.1%, and 95.2%, respectively. Specificity of MIBI scan plus general diagnostic modalities increased dramatically, up to 85.2%, compared to general modalities (6.8%). Conclusion: In general diagnostic modalities, such as mammography and ultrasound, BI-RAD category 4 or higher lesions were performed by needle biopsy rather than observation. The outstanding specificity and negative predictive value of MIBI scan provided confident results on non-proliferative benign lesions. MIBI scan may offer an alternative diagnostic tool for “invasive” biopsy procedures.

      • KCI등재

        Pressure-induced Resonance Raman Effect of InAsxP1−x Alloy Films on InP

        변준석,김영동,박타령 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.10

        We have studied the effect of hydrostatic pressure on the Raman spectra of the InAs<I><SUB>x</SUB></I>P<SUB>1-<I>x</I></SUB> alloy films that were grown on InP substrates. The high-pressure Raman scattering provides very useful information on the microscopic properties of the materials because electronic transition can be controlled by the pressure. The samples with intermediate compositions (0 < x < 1) exhibit both InAs-like and InP-like mode at all the pressures (up to ~80 kbar) we tried. It is well known that pressure increases the magnitude of E1 band gap whose magnitude is responsible for the Raman scattering efficiency of the related materials such as InP and GenSim multiple quantum wells. Using 457.9 nm (2.708 eV) line of argon ion laser we could observe enhanced Raman scattering efficiency for the three x = 0.7, x = 0.75, and x = 0.8 alloys at certain pressures, which indicates that the three samples have E1 band gap below 2.708 eV at ambient pressure. (Notice that both InAs-like and InP-like mode show resonance features). This result is consistent with the measurement of the electronic structure by ellipsometry. The shift-rates of E1 band gap of the three samples are comparable to that of InP. The resonance of ternary alloys with wider widths than InAs indicates that they have spatially fluctuating E1 band gaps, although good electronic band structures are maintained.

      • KCI등재후보

        고요산혈증과 Triglyceride Glucose Index의 연관성: 국민건강영양조사(2016년)

        변준석,김주노,송유신,노용균,최민규 대한가정의학회 2019 Korean Journal of Family Practice Vol.9 No.3

        Background: Hyperuricemia refers to an excess of uric acid in the blood and is associated with gouty arthritis, hypertension, metabolic syndrome, atrial fibrillation, kidney stones, insulin resistance (IR), and type 2 diabetes mellitus. Previous studies have used the homeostatic model assessment of IR (HOMA-IR), a well-known index of IR, to investigation the correlation between serum uric acid levels and IR. However, difficulty with measuring insulin levels limits the clinical applicability of the HOMA-IR index. This study investigated the correlation between hyperuricemia and the triglyceride glucose (TyG) index. Methods: We used data from the Seventh Korea National Health and Nutrition Examination Survey, 2016. The study population included adults without diabetes aged >19 years. The TyG index, which serves as an indicator of IR, was calculated using fasting serum glucose and triglyceride levels to investigate the correlation between the TyG index and hyperuricemia. Pearson’s correlation coefficient and analysis of covariance were used for statistical analysis, which was performed using IBM SPSS software. Results: Astatistically significant correlation was observed between serum uric acid levels and the TyG index. After adjustment for factors that may affect IR (age, body mass index, waist circumference, and systolic and diastolic blood pressures), we observed that the TyG index was significantly higher in the hyperuricemia than in the non-hyperuricemia group (8.96 vs. 8.54, P<0.001). Conclusion: Serum uric acid levels were significantly correlated with IR assessed using the TyG index in adults without diabetes aged >19 years. 연구배경: 고요산혈증은 통풍성 관절염, 고혈압, 대사증후군, 심방세동, 신장결석, 인슐린 저항성, 제2형 당뇨병과 연관이 있다. 인슐린저항성의 유용한 지표로 소개되고 있는 TyG index로 고요산혈증과인슐린 저항성의 상관관계에 대해 알아보았다. 방법: 국민건강영양조사 제7기 2016년도 자료를 이용하여 19세 이상 당뇨병으로 진단받지 않은 성인을 연구 대상으로 시행하였다. 공복혈당과 중성지방을 이용하여 인슐린 저항성의 지표인 TyG index를 계산하여 고요산혈증과의 관계를 알아보았다. 통계적 방법으로는 IBM SPSS를 이용하여, Pearson 상관분석과 공분산분석을 실시하였다. 결과: 요산과 TyG index는 유의한 상관 관계(r=0.31)를 가지고 있는것으로 나타났다. 요산과 TyG index 값의 독립적인 연관성을 보기 위해 인슐린 저항성에 영향을 줄 수 있는 요소들(나이, 체질량지수, 허리둘레, 수축기 혈압, 이완기 혈압)에 대해 보정한 후에도 고요산혈증군에서 정상 요산수치 군에 비해 유의하게 TyG index 값이 높게나타났다(8.96 vs. 8.54, P<0.001). 결론: 당뇨병이 없는 19세 이상 성인에서, 혈청 요산 수치는 TyGindex로 평가한 인슐린 저항성과 유의한 양의 상관 관계를 보였다.

      • KCI등재

        도시환경정비사업의 집행 지연요인 도출 및 관리적 시사점 분석

        변준석,이주형 디자인융복합학회(구.한국인포디자인학회) 2013 디자인융복합연구 Vol.12 No.5

        본 연구는 도시환경정비사업을 대상으로 사업의 지연에 영향을 미치는 여러 요인들 가운데 사업지연에 보다 큰 영향을 미치는 주요 요인들을 분석하였으며, 관리적 시사점을 제시하였다. 연구방법은 도시환경정비사업 집행 지연요인 도출 및 계층화 분류, AHP방법을 활용한 지연요인들 간 중요도 분석을 수행하였다. 분석결과, 총 21개의 사업 지연요인이 도출되었으며, 그 중 ‘행정절차 오류’, ‘조합의 정치적 분쟁’, ‘사업계획 변동’, ‘소유자 이해부족 갈등’, ‘세입자 보상가 불만족’, ‘사업성에 대한 불확실성’, ‘주민의견 반영 미흡’, ‘부정행위’, ‘정비계획 수립 지연’, ‘세입자 이주대책 미흡’, ‘주택경기 침체에 따른 사업성 저하’, ‘과도한 기반시설’ 의 12개의 요인이 주요 지연요인으로 분석되었다. This study analyzed main factors affecting project delay among the several factors and suggest managerial implications about urban renewal project. The method of study is as in the following. First of all, we deducted action delay factors of urban renewal project and classified hierarchy. And then, we carried out Analysis of Importance among factors of delay using the AHP(Analytic Hierarchy Process). As a result of this study, total twenty-one factors of project delay are deducted and twelve factors(administrative procedures mistake, political conflict of association, change of project plan, conflict of owner, dissatisfaction of compensation price for tenant, business value, insufficiency of resident opinion reflect, cheating, delay of maintenance plan establishment, insufficiency of migration measure, feasibility decline of depression housing economy, excessive infrastructure) are analyzed that it is important to delay project.

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