급성 골수성 백혈병에서의 병적 비장파열 1 예

이순남,한운섭,경난호,성연아,손현주,박응범,임양희,박이갑 대한내과학회 1987 대한내과학회지 Vol.33 No.3

Spontaneous splenic rupture is a rare complication of hematologic malignancies. A case of spontaneous rupture of spleen in 31-year-old man with acute myelacytic leukemia, M2 is presented, Splenectomy was carried out successfully and he is alive in remission status without any complication.

당뇨병성 케톤산 혈증에서의 대사장애에 관한 연구

이순남,경난호,박이갑 대한당뇨병학회 1985 Diabetes and Metabolism Journal Vol.9 No.1

진행성 비소세포폐암 환자의 Ifosfamide, Etoposide와 Cisplatin(IEP) 복합화학요법

이순남 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4

To evaluste the efficacy and toxicity of IEP chemotherapy in locally advanced and metastaticnon-small cell lung cancer, nineteen previously untreated patients with non-small cell lungcancer were studied. Patients received ifosfamide 1000mg/m^2 with mesna, 20% of ifosfamide dose at 0,4, 8 hoursafter ifosfamide, etoposide 100mg/m^2, and cisplatin 20mg/m^2 with full hydration and mannitoldiuresis intravenously on days 1-3 every 4 weeks. Eighteen male and one female, two stage ⅢA, 10 stage ⅢB and 7 stage Ⅳ patients havebeen treated. The response rate of IEP was 26% with no complete remission, 53% of stable disease, and23% of progressive diasease. The overall median survival was not reaced yet and 20 month survival rate was 51.4%, The duration of remission was at the range of 4^+ to 40 weeks. The toxicities were alopecia (100%), nausea and vomiting(47%), leukopenia(14%), infection(6%), renal dysfunction(6%) and oral mucositis(5%). This phase Ⅱ study of IEP in advanced non-small cell lung cancer is not superior to another combinatiori regimens in terms of response but toxicity was tolerable. Other new chemothera-peutic drugs and newer trials should be developed further.

악성종양 환자에서 A. Port Implantation의 유용성과 합병증

이순남,김광호 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4

Reliable venous access is increasing serious problem in cancer chemotherapy Patients. Thiry six implantable second generation catheter system(A. Port) were placed subcutaneouslyin 35 patients with cancer. A Port were in place f3r an ave.age of 158 days(range 10-731^+ days). Complicationsincluded infections in 3 cases, thrombosis in 1 case, skin laceration in 1 case and pneurnothoraxin 1 case. Five ports were removed due to complication. One pneumothorax was managedconservatively; It is concluded that A. Port implantation constitute a safe and convenient access with alow rate of complication for long term intravenous chemotherapy in cancer patients.

장티푸스에 동반된 Hypoplastic Anemia의 1예

이순남,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.3

The authors experienced a 29 year old female patient with hypoplastic anemia during her illness of typhoid fever. Because that is very rare and unreported, we are reporting this patient. She was promptly recovered from hypoplastic anemia with antibiotics for typhoid fever.

쥐의 Adriamycin에 의한 점막염에 대한 Sucralfate의 예방효과

이순남 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

연구목적 : 항암제 치료에 의한 점막염의 예방에 경구 sucral-fate의 예방효과에 대한 이견이 있어 이를 임상응용하기 전에 쥐에서 adriamycin 투여 후 점막염을 유발하고 sucralfate를 경구투여하여 그 예방효과를 확인하여 임상응용에 이용하고자 실험을 수행하였다. 연구방법 : 예비실험에는 250~300gm 의 Sprague Dawley쥐를 10mg/kg의 adriamycin을 복강내 주사하고 2일간격으로 4마리씩 12일까지 희상시켜 관찰하였다. 본 실험에서는 각 군당 4마리씩 adriamycin 10mg/kg 단독투여군(제1군), sucralfate 100mg/kg/day(제2군), 50mg/kg/day(제3군), 병용투여군과, sucral-fate 100mg/kg/day(제4군), 50mg/kg/day(제5군) 단독투여군으로 하고 제 10일에 희생시켜 육안 및 he-matoxilin과 eosin 염색 후 광학현미경으로 관찰하였다. 연구결과 : 제10일에 adriamycin에 의한 점막염이 관찰에 가장 적당하였다. 경구 sucralfate의 병용투여는 10mg/kg/day 또는 50mg/kg/day에서 모두 점막염 예방효과가 있었고, sulcrafate 단독투여에 따른 부작용은 없었다. 결론 : 경구 sucralfate의 투여는 쥐에서 adriamycin에 의해 유발된 점막염의 예방에 효과적이었으며 이는 암환자에서 항암제치료나 방사선치료에 의한 잠막염의 예방을 위한 sucralfate의 임상시험도 가능할 것으로 생각된다. Objective : Mucositis is a threatening complication of chemotherapy and/or radiotherapy. To evaluate the prophylactic effect of sucralfate on adriamycin induced mucositis in the rat for the basis of application of sucralfate in cnacer patients, the experiments were performed. Methods : In preliminary study 250 ~ 300gm Sprague Dawley rats were injected 10mg/kg of adriamycin intraperitoneally and 4 rats were dissected every other day till 12 days. The sucralfate were applied per os with aqueous portion of 100mg/kg and 50 mg/kg just after intraperitoneal injection of adriamycin 10mg/kg. On Day 10, 4 rats on each group were dissected and oral, esophageal and gastric mucosa were obtained and histologocally examined. Results : On day 10, adriamycin induced mucositis was most severe. The application of sucralfate significantly lessened the adriamycin induced mucositis was most severe. The application of sucralfate significantly lessened the adriamycin induced mucositis compared to that of control without sucralfate on the dose of 100mg/kg or 50mg/kg, respectively. And there was no ad-verse effect by sucralfate itself. Conclusion : Oral sucralfate could prevent the adriamycin induced mucositis in the rats without any adverse effect. This result supports that sucralfate can be used in the clinical trials on chemotherapy and/or radiotherapy induced mucositis for prophylaxis.

악성종양환자의 호중구기능에 관한 연구

이순남,박이갑 梨花女子大學校 醫科大學 醫科學硏究所 1989 EMJ (Ewha medical journal) Vol.12 No.4

It has been recognized for a long time that human malignant diseases are associated with immune deficiency states. Impaired phagocytic function, low levels of plasma opsonins, impaired bactericidal activity of granulocytes and macrophages, deficiency of myeloperoxydase, reduced migration of polymorphonuclear leukocytes and granulocytopenia have all been found in malignant condition primarily or secondarily. Especially neutrophils are crucial to the body's defenses against infection. Defects in phagocytes can contribute to the local establishment and systemic spread of serious bacterial infection. The authors studied neutrophil function in 40 control and 15 patients with acute myelogenous leukemia, 10 with non-Hodgkin's lymphoma, 40 with stomach cancer, 10 with hepatoma, 10 with pancreas cancer and 25 with other organ tumor to prove the mechanism of increased risk and the severity of infection using a battery of simple and reproducible neutrophil function tests as adherence to nylon wool fiber, migration under agarose method and nitrobule tetrazolium reduction test. The results obtained are as follows; 1) On adherence to nylon wool fiber, the adherence was significantly decreased in patients with acute myelogenous leukemia, but increased in patients with lymphoma. In patients with other solid tumors, there were no significant differences from those of controls. After chemotherapy with Cisplatin and 5-FU, the adherence was significantly decreased than that of prior to therapy. 2) On migration under agarose, the chemotactic differential was significantly decreased in patients with acute myelogenous leukemia but increased in patients with hepatoma and pancreas cancer. Presence of factors of those increment was suspected. After infusion of Cisplatin, chemotactic differential was decreased significantly but after infusion of 5-FU, it was decreased but there was no significance. 3) On NBT reduction test, NBT reduction was diminished in patients with acute myelogenous leukemia but increased in patients with hepatoma and pancreas cancer. It is assumed that some unidentified factors would be present to enhance chemotaxis and NBT reduction in patients with hepatoma and pancreas cancer. After infusion of Cisplatin, NBT reduction was significantly decreased, but after infusion of 5-FU it was decreased but not significantly. In patients with acute myelogenous leukemia, neutrophil functions were much impaired but in patients with solid tumors, there were no neutrophil function defects. After chemotheraphy with Cisplatin and 5-FU, neutrophil functions were much compromised and this would predispose to increased risk of infection.

당뇨병환자에서의 Treadmill Exercise Test의 임상적 의의

이순남,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.4

The maximum exercise testing using treadmill walking was performed in 36 patients of diabetes mellitus who were admitted to the Ewha Womans University Hospital from March, 1983 to August, 1983 and 30 normal control subjects to evaluate the efficacy of significance to detect latent coronary artery disease in diabetes mellitus as a chronic complication. Among 36 patients of diabetes mellitus, ten(27.8%) were treadmill exercise test positive, of whom two had ST depression in resting electrocardiogram but eight didn't have any changes in resting electrocardiogram. Since treadmill exercise test can be a useful sensitive diagnostic tool for early detection of latent coronary artery disease in the patients of diabetes mellitus as a chronic complication.

생물학에서 진화론의 역할에 관한 현직 과학 교사들의 인식

이순남,차희영 韓國生物敎育學會 2011 생물교육 Vol.39 No.2

Many biologists and various educational associations define evolution as an unifying theme as well as a central idea in biology. This research investigated how well the in-service science teachers perceive the role of evolution as an unifying theory in biology. Subjects were 92 in-service science teachers. Utilized tools were a questionnaire developed, a test for the conceptions of evolutionary mechanisms and a test to identify association between evolution and personal religious belief. They had perceived that evolution was one of the important concepts in biology; however, they judged evolution as relatively low value when they compared it with other concepts in biology because it was they had not perceived evolution as an unifying theory in biology. According to results, only about 50% of in-service science teachers had an understanding evolution as an unifying theory in biology and only about 36% of them had applied this idea to teaching biology. Despite of these results, the teachers perceiving the role of evolution theory in biology had more experiences, higher evolutionary belief as well as better understandings of evolutionary mechanism comparing to them of not perceiving it. This result means that a special teacher education program focusing on the role of evolution as an unifying theory in biology and effective teaching strategies is required.

급성백혈병과 고형종양 환자에서 피하 중심정맥포트의 비교

이순남,김광호 大韓血液學會 1994 大韓血液學會誌 Vol.29 No.3