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청미래덩굴 잎 및 뿌리 추출물의 항산화, α-Glucosidase 억제 및 항염증 활성비교
김경곤,최면,강윤환,김대중,김태우 한국영양학회 2013 Journal of Nutrition and Health Vol.46 No.4
This study was conducted in order to compare the biological activities of leaf and root water extracts of Smilax china L. (SC) by measuring the total polyphenol and flavonoid contents, anti-oxidant activity, inhibitory effect on α-glucosidase, and anti-inflammatory gene expression. The total polyphenol and flavonoid contents of SC leaf (SCLE) and root (SCRE) water extracts were 127.93 mg GAE/g and 39.50 mg GAE/g and 41.99 mg QE/g and 1.25 mg QE/g, respectively. The anti-oxidative activities of SCLE and SCRE were measured using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity assay and reducing power assay. Both SCLE and SCRE scavenged radicals in a concentration-dependent manner, and SCLE showed stronger radical scavenging activity and reducing power than SCRE; however, both SCLE and SCRE exhibited lower activities than ascorbic acid. Compared to the anti-diabetic drug acarbose, which was used as a positive control, SCLE and SCRE exhibited low α-glucosidase inhibition activities; nevertheless, the activity of SCLE was 3.7 fold higher than that of SCRE. Finally, SCLE caused significantly decreased expression of the LPS-induced cytokines, iNOS, and COX-2 mRNA in RAW264.7 cells, indicating anti-inflammatory activity. These results indicate that SCLE might be a potential candidate as an anti-oxidant, anti-diabetic, and anti-inflammatory agent.
국내에서 현재 장기간 사용목적으로 선택할 수 있는 비만 치료약제의 작용기전과 임상응용
김경곤 대한의사협회 2019 대한의사협회지 Vol.62 No.11
Over the last 5 years, the Korean Ministry of Food and Drug Safety has approved four anti-obesity drugs for long-term weight management. In this review, the mechanisms of action and clinical applications of lorcaserin, naltrexone/bupropion, liraglutide, and phentermine/topiramate have been clarified. Lorcaserin stimulates proopiomelanocortin/cocaine- and amphetamine-regulated transcript neurons in the arcuate nucleus. Naltrexone/ bupropion reduces body weight by controlling the hedonic reward system of food intake. The hypophagic effect of liraglutide depends on the direct activation of the proopiomelanocortin/cocaine- and amphetamine-regulated transcript neurons and indirect suppression of neuropeptide Y/agouti-related peptide neurons through gammaaminobutyric acid-dependent signaling, with an additional thermogenic effect. Phentermine/topiramate induces weight loss by elevating the norepinephrine levels in the hypothalamus, reducing energy deposition in the adipose tissue and skeletal muscle, and elevating the corticotropin-releasing hormone in the hypothalamus. In patients with high cardiovascular risks or type 2 diabetes mellitus, lorcaserin and liraglutide are appropriate. In patients with mood disorders, naltrexone/bupropion could be considered as the first choice of therapy. Notably, lorcaserin and liraglutide are neutral in the aspect of sleep disorder. In case of obese individuals with obstructive sleep apnea, liraglutide or phentermine/topiramate would be selected as the treatment option. These four drugs should be used after considering the patients’ co-morbidities of obesity.
지역사회 바탕 의학교육 및 외래 진료 환경의 새로운 교육 방법인 Wave 모델에 대한 일차 진료의의 관심도
김경곤,강희철,김찬경,조희정,윤방부 한국의학교육학회 2005 Korean journal of medical education Vol.17 No.3
Purpose: In order to expand and improve community-based medical education(CBME), we attempted to delineate the characters of the primary care physicians interested in medical education and their opinions on the new medical teaching method for ambulatory care settings, Wave model. Methods: Through mailed questionnaires, we asked the Seoul members of the family physician association and the internal medicine physician association about their interest and opinions of CBME and the Wave model. Results: We received 186 replies from the total 1088 questionnaires(17.1%) sent out. Many of the primary care physicians(141/186; 75.8%) had no experience with CBME. However, 127 (68.7%) were interested in CBME and 121(65.4%) answered that they were interested in teaching students in their clinic. There were 128(69.2%) affirmative responses to the Wave model, which was much higher than that to the observation-centered method, 53(30.3%)(p<0.0001). Primary care physicians who have affirmative attitudes to adopting the Wave model would select this model as their CBME program(p<0.0001). Primary care physicians willing to teach students tend to be males(p=0.0085) and younger in age(p=0.0003), have examination rooms for student-patient contact(p<0.0001), and possess positive attitude to adopting the Wave model(p= 0.0018). Conclusion: There are many primary care physicians eager to participate in CBME. They view the Wave model as an effective teaching method. Factors associated with the desire to work as a preceptor include being male and younger in age. having examination rooms for student-patient contact, and possessing a positive attitude to adopting the Wave model.