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      • 급, 만성 간염환자에서의 B 및 T림파구아형 변화에 관한 연구

        유진수,김현태,박애자 중앙대학교 의과대학 의과학연구소 1987 中央醫大誌 Vol.12 No.2

        The development of specific monoclonal antibodies to antigens present on all peripheral T cells(OKT 3), helper/inducer(OKT 4), and cytotoxic/ suppress(OKT 8) sudsets provides a simple means to dissect the immune cell populations. In patients with acute hepatitis virus(HBV) infection, OKT4/OKT88 ratio are known to be lower than normal control group. However. published data on the altreation of peripheral T cell subsets in chronic hepatitis(AVH) and chronic active hepatitis(CAH). Sera from 16 patients with AVH, 18 patients with CAH and 17 normal healthy control group were assayed for the evalution of total lymphocytes, helper/inducer,cytotoxic/ suppressor sbbsets and pan B lymphocytes(OKB 7). The resullts were as follows; 1. In patients with AVH, the value of OKT3 55.3±11.84%, OKT4 39.6±110.85%. OKB7 25.8 ±14.08%, T4/T8 ratio 1.49±0.31 were significantly decreased than normal control group that showed OKT3 66.5±10.6%, OKT4 47.2±15.02%, OKT8 25.3±7.30%, T4/T8 ratio 1.87±0.46 and OKB7 32.9 ±10.75%(p<0.05) and the value of OKT8 was not significantly different from that of normal control group. 2. In patients with CAH, OKT3 65.3±7.14%, OKB7 30.0 ±15.83%, were not significantly different from normal control group, but OKT4 30.0 ±12.69% was decreased and OKT8 37.9± 10.70% was increased than normal control group(p<0.05) 3. T-cell subset alterations during the course of AVH disclosed that OKT4 and T4/T8 ratio were decreased in early phase and gradually increased near normal level around 10 weeks later. But OKT8 was not changed significantly. According to the above results the regulation of immune mechanism in AVH and CAH appears to be different. In AVH, the percentage of T and B cells decreased. T4/T8 ratio decreased by decrement of T4 and then gradually normalized during the recovery of illness. In CAH, the percentage of T and B cells were normal. But, OKT4 were stilllower than normal control group. Thus the role of OKT4 would be important for the recovery from AVH and CAH.

      • KCI등재후보

        Monitoring of Mycophenolic Acid Trough Concentration in Kidney Transplant under Cyclosporine Is Beneficial in Reducing Acute Rejection within 1 Year

        유진수,이교원,박재범,김성주 대한이식학회 2018 Korean Journal of Transplantation Vol.32 No.4

        Background: This study was designed to analyze the clinical usefulness of mycophenolic acid trough concentration monitoring in kidney transplantation patients who were maintained with cyclosporine. Methods: The data of patients who underwent mycophenolic acid trough concentration monitoring after their first kidney transplant between November 2006 and August 2013 and were prescribed with cyclosporine, mycophenolate, and methylprednisolone were reviewed retrospectively. Cox analysis was used to analyze the risk factors for acute rejection within 1 year post-transplantation. Results: Among 90 patients, 41 (45.6%) achieved both the target levels of cyclosporine and mycophenolic acid, while three patients (3.3%) failed to achieve the target level of either cyclosporine or mycophenolic acid. Nine patients (10.0%) only achieved the mycophenolic acid target level and 37 patients (41.1%) only achieved the cyclosporine target level. While patients who achieved only the mycophenolic acid target concentration had no statistically increased risk compared to patients who achieved both target levels (hazard ratio [HR], 1.569; 95% confidence interval [CI], 0.316 to 7.778; P=0.581), patients who only achieved the cyclosporine target concentration showed an increased risk of rejection compared to the both achievement group (HR, 4.112; 95% CI, 1.583 to 10.683; P=0.004). Patients who had no achievement in the target levels showed significantly increased rejection risk compared to the patients who achieved both target levels (HR, 17.811; 95% CI, 3.072 to 103.28; P=0.001). Conclusions: Mycophenolic acid trough concentration monitoring combined with cyclosporine trough concentration monitoring is useful for avoiding acute cellular rejection if the first 1 year post-transplantation.

      • KCI등재후보

        정신지체학교 교사의 과학교육에 대한 이해와 교과용 도서 활용실태 분석

        유진수,정동영 한국특수교육교과교육학회 2015 특수교육교과교육연구 Vol.8 No.3

        The purpose of this study is to figure out how special teachers understand science education and use science textbooks which developed on 2011 according to the special education curriculum. To accomplish this research, we practice the questionaries to 95 special school teachers who work in the schools for the mental retardation and emotional disturbance. The result of survey is as following. First of all, science specialists understand contents better than classroom teachers on the science textbook’s contents in the schools for the mental retardation. Specially, as in the contents, science specialists figure out better than classroom teachers in the Biology, Chemistry, Physics. Second, middle school teachers utilize textbooks more than high school teachers, and science specialist use textbooks more than classroom teachers. An aspect of application of science textbooks, elementary school teachers prefer to utilize specific unit for students. Third, it shows that the teachers who understand the science contents higher use textbooks more. In light of these findings, science specialists understand contents better than classroom teachers on the science textbook’s contents, and the teachers who understand the science contents higher use textbooks more. So, it is important to understand science textbook’s contents in the utilization of the science textbooks. 이 연구는 2011 특수교육 기본 교육과정 과학과 교육과정을 적용하고 있는 정신지체학교 교사들이 과학교육을 어느 정도 이해하고 있는지와 과학과 교과용 도서를 활용하고 있는 실태는 어떠한지 및 그 관계는 무엇인지를 파악하는데 목적을 두고 있다. 이를 위하여 본 연구는 정신지체학교 교사 95명을 대상으로 조사를 실시한 결과, 정신지체학교 교사들은 학교급별로 과학교육에 대한 이해에 큰 차이를 나타내지 않았으나, 과학과 전담교사들은 비전담교사들보다 과학교육을 더 많이 이해하고 있는 것으로 밝혀졌다. 그리고 정신지체학교 교사들은 초등학교와 중학교 과정의 교사들이 고등학교 과정의 교사들보다 교과용 도서를 더 많이 활용하고 있으며, 과학과 전담교사들이 비전담교사들보다 교과용 도서를 더 많이 활용하고 있는 것으로 밝혀졌다. 그리고 정신지체학교 교사들의 과학교육에 대한 이해는 교과용 도서 활용에 영향을 미치는 변인이 되는 것으로 밝혀졌다. 따라서 정신지체학교 교사들의 과학과 교과용 도서 활용을 지원하기 위해서는 교사들의 과학과 교육내용에 대한 이해를 높이는 것이 중요한 과제라고 할 수 있다.

      • KCI등재

        안전 영역 기반 자율주행 차량용 주행 경로 생성 및 추종 알고리즘 성능평가 연구

        유진수,강경표,이경수,Yoo, Jinsoo,Kang, Kyeongpyo,Yi, Kyongsu 한국자동차안전학회 2019 자동차안전학회지 Vol.11 No.2

        This paper describes the tracking algorithm performance evaluation for autonomous vehicle using a safety envelope based path. As the level of autonomous vehicle technologies evolves along with the development of relevant supporting modules including sensors, more advanced methodologies for path generation and tracking are needed. A safety envelope zone, designated as the obstacle free regions between the roadway edges, would be introduced and refined for further application with more detailed specifications. In this paper, the performance of the path tracking algorithm based on the generated path would be evaluated under safety envelop environment. In this process, static obstacle map for safety envelope was created using Lidar based vehicle information such as current vehicle location, speed and yaw rate that were collected under various driving setups at Seoul National University roadways. A level of safety was evaluated through CarSim simulation based on paths generated with two different references: a safety envelope based path and a GPS data based one. A better performance was observed for tracking with the safety envelop based path than that with the GPS based one.

      • KCI등재

        장기이식의 역사와 주요 면역억제제의 발전

        유진수 대한의사협회 2020 대한의사협회지 Vol.63 No.5

        The history of organ transplantation is limited to the last century. To overcome the barrier of the host immune system, which results in transplant rejection, the pioneers of transplantation achieved their first success by performing a kidney transplantation between identical twins. This achievement led the transplant clinicians to perform transplantations with immunological barriers present. Strategies such as whole-body irradiation combined with steroids yielded success in kidney transplantation between non-identical twins and siblings. However, owing to the toxicity related to irradiation, the paradigm shifted to the use of immunosuppressants. Azathioprine, steroids, and anti-lymphocyte globulin became the first multiple immunosuppressive regimens. With the introduction of cyclosporine, the 1-year survival rate increased by more than 80%. Cyclosporine, azathioprine, and steroids became the new standard maintenance regimens until the introduction of tacrolimus and mycophenolate mofetil, which replaced cyclosporine and azathioprine, respectively. The most recent change in immunosuppressants was the development of monoclonal antibodies with specific binding sites, such as CD20 (rituximab) and CD25 (basiliximab). With the innovation of molecular engineering and new insights into the costimulatory pathways, new molecules are under investigation in the field of transplantation.

      • KCI등재

        구매 프로젝트 학습이 지적장애학생의 경제개념 및 자기결정력에 미치는 영향

        유진수,정동영 대구대학교 특수교육재활과학연구소 2013 특수교육재활과학연구 Vol.52 No.2

        본 연구는 구매 프로젝트 학습이 지적장애학생의 경제개념 및 자기결정력에 미치는 영향을 알아보는데 그 목적이 있다. 이러한 목적을 달성하기 위해 중학교에 재학하고 있는 지적장애학생 30명을 선정하여 실험집단과 통제집단에 각각 15명씩 배치하고, 실험집단에 주1~3회씩 총 20회기에 걸쳐 구매 프로젝트 학습 프로그램을 시행하고, 통제집단에는 같은기간 동안 교사 주도의 ‘경제’관련 교육을 실시하였다. 본 연구에서 실험집단과 통제집단을대상으로 사전 및 사후 검사를 실시하고, 공분산 분석을 통해 효과 차이를 검증한 결과, 구매프로젝트 학습은 지적장애학생의 경제개념 습득에 유의한 효과가 있었고, 지적장애학생의 자기결정력 향상에도 유의한 효과가 있는 것으로 나타났다. 따라서 구매 프로젝트 학습은 중학교 지적장애학생들의 경제개념 습득과 자기결정력 향상에 효과적인 교수방법이라고 할 수있다.

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