Propolis 첨가에 의한 김치의 산패지연 효과

박인숙 배화여자대학 1999 培花論叢 Vol.18 No.-

We studied about propolis' effect on the prolongation of acidification of kimchi during its fermentation at 10℃. In the result of inhibitory effect of propolis on the growth of Lactobacillus plantarum in MRS broth, propolis didn't show the ability of the complet inhibition in growth but, showed the ability of bacteriostatic effect. All experimental groups such as 1.0, 1.5, and 2.0 % propolis-added kimchi produced propolis-specific and non-acceptible odors. In the experiment of 0.05, 0.1, and 0.5 % propolis-added kimchi fermentation, all experimental groups prolonged the acidification and showed better taste than that of control kimchi. Especially, 0.05 propolis-added kimchi showed the best taste among all of things. Microbial changes in propolis-added kimchi fermentation didn't show the strain-specific inhibitory effects of propolis, but showed that it caused the prolongation of acidification of kimchi by inhibition of lactic acid bacteria in the prior stages of kimchi fermentation. And the growth of yeast in kimchi fermentation was delayed by addition of propolis.

항암제에 대한 PK/PD 모델 설정 연구

박인숙,안미령,서수경,이선우,최흥석,안은주,진숙,손수정,구효정,양지선,유태무 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

약물에 대한 약동학(PK) 및 약력학(PD) 연구는 최적의 약물효과를 얻기 위한 약물툰여계획수립에 대한 기본데이타를 제공하띠 현대 약물요법에서 그 중요성이 더욱 강조되고 있다. PK-PD 모델링은 투여용량-혈중농도-약효간의 관계를 수학적으로 묘사하여 약동학 및 약력학 사이의 정량적이고 구체적인 상관성을 규명하고 이를 이용하여.투여용량으로부터 시간에 따른 약물의 동태 및 효력을 예측할 수 있다. 따라사 신약개발시에도 전임상단계 및 임상시험단계에서 PK-PD에 관한 정보가 제공되면 의다 적절한 약물요법을 결정하여 약물의 효과를 극대화할 수 있으므로 치료률 및 신약개발의 가능성을 높이는데 기여한다. 본 시험에서는 PK-PD 모델링에 대한 기본개념 및 방법을 연구하고자, 국내예서 개발된 캄토테신계 항암제인 CKD-6OB를 이용하여 약물의 약동학 및 약력학적 특성을 HT-29 cell에서 측정하였다. 항암제의 치료는 암세포로의 약물침투 및 효력발현 시점에 따라 투약을 조절함으로써 부작용을 최소화할 수 있다. 따라서 효력검색을 위하여 MTT 측정법을 사용하여 암세포의 증식정도를 측정하였으며, 투여시간에 판른 세포내외의 약물농도 측정을 통하여 약물동태를 연구하였다. 실험결과 CKD-602의 HT-29 cell에 대한 ICD는 250nbt로 나타났으며, 약물투여 24시간 후부터 세포로의 유입이 나타났파. 그러나 CKD-602의 쎄포내외의 농도비율이 거의 변화가 없으며 CKD-602의 려T-29 cell 에 대한 지연효과가 나폭나는 것으로 미루어 CKD-602의 항암효력이 약물농도 주입속도와 상관성이 있을 것으로 사료된다. Pharmacokinetic(PK) and pbarrnacodynamic(PD) information get from the scientific basis of modern iharrnacotheraDy PharrnacoEnetics describes ·the drug concentration- time courfes in body Huids resulting from administration of a cnfain drug dost and pharmacodynamics describes the observed effect resulting from a crrtain drug concentration. A Pf(/PD model is amathematical descfption of these relationships. The rationale for PK#PD-rnodelfng is to linkpharmacokinetics arid pharrnacofynamics In order to establish and evaluate dose-concentration-response relationships and subseauently describe and predict the effect-time courses resultingfrorrl a drug dose. The expanded use cf PK/PD-modeITing is assumed to be highly beneficialfor drug development as well as applied pharrnacotherfpy and will most likely improve thecurrent state of applied therapeutics. The anticancer drug therapy depends on the ability of the drug to penetrate on the solidtumor for the time-and concentraton-dependent drug. The present study examined thedeterminants of Pft/PD modeling of CKD-602 in HT-29 cel.Is. Anticancer effects of CKD-602by MTT assay was dependent on the time and the concentration. The concentration ofCKD-602 in both the cell and the medium was correlated with time and drug concentration.But pharmacodynamics of CKD-602 was not drug uptake limited and the relative importance ofdrug was exposure time. The knowledge of relative importance of a drug. in pbarrnacodynamicstudies will heTp to idendify the optimal dose resimens.

女記者가 보는 女記者

朴仁淑 관훈클럽 1984 관훈저널 Vol.- No.38

지각된 간호사의 의사소통 스타일이 입원 환아 어머니의 스트레스 및 대처노력에 미치는 영향

박인숙,오재우,김양신 한국디지털정책학회 2014 디지털융복합연구 Vol.12 No.6

일부 종합병원 외래응급환자에 대한 조사 연구

박인숙 中央醫學社 1979 中央醫學 Vol.37 No.5

中南美의 공산주의 침투현황과 문제점

박인숙 세계평화교수협의회 1982 廣場 Vol.104 No.-

Serratia sp. B-7가 생산하는 단백질 분해 효소에 대한 연구

朴仁淑 배화여자대학 1991 培花論叢 Vol.10 No.-

A number of strains producing alkaline-protease isolated from soils and among them, the strain of Serratia sp.B-7 was selected as amost powerful strain to producing the enzyme. The optimal culture conditions for the production of protease of the strain were studied, and it was found that almost all protease activity was produced in the extracellular. The maximum enzyme activity was obtained when the strain was cultured at 30℃, 180 rpm, for 35 hr in a medium containing 1% of casein, 0.5% of Na₃PO₄7H₂O, 0.1% of NaCl, 0.05% of KCI, 0.02% of MgSO₄7H₂O, 0.02% of CaC1₂2H₂O, 0.02% of ZnSO₄7H₂O, 0.02% of MnCl₂4H₂O and 0.5% of soybean oil, and the initial p^(H) of culture broth was adjusted to 7.0. The enzyme was prepared from the culture supernatant through ultrafiltration, ammonium sulfate precipitation and DEAE-Sephascel chromatography. The specific activity of purified. enzyme was 12459U/mg. The enzyme showed maximum activity at p^(H) 9.0 and 37℃ and was stable under the p^(H) from 6.0 to 10.0 at 4℃ Molecular weight of purified enzyme was 54000 dalton and the isoelectric point was 6.6.

안까타운 기형, 소중한 생명 살리기 - 대한 선천성 기형 포럼

박인숙 인구보건복지협회 2004 가정의벗 Vol.37 No.6

선천성 기형의 종류는 매우 다양하며 완치가 가능한 기형도 많다. 그러므로 선천성 기형이 있다고 무조건 자랑할 필요는 없으며 전문가의 상담이 필요하다. 감기약 한번 잘못 먹어서, 또는 임신인 줄 모르고 한번 찍은 가슴 X-선 사진으로 인공임신중절을 하는데 이는 고쳐져야 할 관행이다.

성인애착이 심리적 안녕감에 미치는 영향: 마음챙김과 영성의 매개효과

박인숙,김은하 한국상담심리학회 2018 한국심리학회지 상담 및 심리치료 Vol.30 No.1

This study aimed to verify the mediating effects of mindfulness and spirituality on the relationship between adulthood affect and psychological well-being. Correlation analysis was utilized to confirm the relationship between variables, structural relation model to examine validity, and optimum model to analyze the mediating effect. Results: (1) Mindfulness, spirituality, and psychological wellbeing significantly correlated with each other, but negatively correlated with attachment in adulthood (2) The structure equation model affirmed the appropriateness of the measurement model utilized as well as the research model used to configure relations between each variable (3) Verification of the mediator effect between adulthood affect and psychological wellbeing showed that attachment anxiety has a positive mediating effect on both mindfulness and spirituality, while attachment avoidance positively mediating mindfulness, exclusively. (4) The dual mediating effect of mindfulness and spirituality positively correlated with attachment in adulthood and psychological well-being. 본 연구의 목적은 성인애착과 심리적 안녕감의 관계에서 마음챙김과 영성의 매개효과를 검증하는 것이다. 이를 위해 서울, 경기, 대전, 광주 지역에 거주하는 만 20세부터 만 65세까지의 성인남녀 397명을 대상으로 하여 자료를 수집하였다. 수집된 자료를 바탕으로 연구 변인 간 상관관계를 살펴보고, 성인애착이 심리적 안녕감에 미치는 영향에서 마음챙김과 영성의 매개효과에 대한 모형이 타당한가를 검증하여 최적의 모형을 도출해 확인한 결과를 요약하면 다음과 같다. 성인애착은 마음챙김, 영성, 심리적 안녕감과 부적 상관을 보였고, 마음챙김, 영성, 심리적 안녕감은 유의미한 정적상관을 보였다. 구조 방정식 모형을 적용하여 자료를 분석한 결과 측정모형은 자료에 적합한 것으로 나타났고, 모든 변인 간 경로를 설정한 연구모형이 마음챙김에서 영성을 설정하지 않은 경쟁모형에 비해 더 적합한 것으로 나타났다. 성인애착과 심리적 안녕감의 관계에서 마음챙김과 영성의 매개효과를 검증한 결과, 애착불안의 경우 마음챙김과 영성 모두 유의미한 매개효과가 나타났으나, 애착회피의 경우 마음챙김의 매개효과는 유의미하였으나 영성은 유의미하지 않았다. 성인애착과 심리적 안녕감과의 관계에서 마음챙김과 영성의 이중매개 효과가 유의미한 것으로 나타났다. 마지막으로 주요 결과에 대한 시사점을 논의하고 연구의 의의와 제한점 및 추후 연구를 위한 제언을 덧붙였다.

환자, 간호사, 의사가 지각하는 교육요구도와 교육제공정도에 관한 연구

박인숙,문영숙,조미경,최은숙,이경숙,정길수 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

The purpose of this study was to provide the basic data for the planning of education of patients by exploring and comparing patients', nurses' and doctors' perception of the educational needs and degree of providing education. 66 hospitalized patients undergoing chemotherapy and 44 nurses, 42 doctors assigned for the direct care were sampled in 1 university hospital in Taejon from August 30, 1993 to September 30, 1993. For the comparing patients', nurses' and doctors' perecption of the educational needs and degree of providing education, the researcher used Kims' Educational need scale which is composed of 20 item Likert type 5 point scale. Data were analyzed by means of percentile score, SPSS, t-test, ANOVA, Pearson correlation. The result were as follows 1. Comparision of total Mean score patients', nurses' and doctors' perception of the educational need ordering nurses(M=4.0465), patients (M=3.9803), doctors (M=3.8309). The difference between the three group's total Mean score is showed no statistical significant difference. 2. Comparision of total Mean score patients' educational need, patients' percetion of nurses' and doctors' degree of providing education, patients' educational need is scored 3.9803, patients' perception of nurse is scored 2.3431, patients' perception of doctor is scored 2.5022. The difference between the patients' educational need and medical teams' degree of providing education is showed statistical significant difference(P<.001). 3. Comparision of total mean score nurses' educational need is scored 4.0465, nurses' perception of nurses' degree of providing education is scored 2.9920, patients' perception of nurses' degree of providing education is scored 2.3431. The difference of between the nurses' educational need and nurses' perception of nurses' degree of providing education is showed statistical significant difference(P<.001) 4. Comparision of total mean score doctors' educational need is scored 3.8309, doctors' perception of doctors' degree of providing eduation is scored 3.1726, patients' perception of doctors' degree of providing education is scored 2.5022. The difference of between the doctors' educational need and doctors' perception of doctors' degree of providing education is showed statistical difference(P<.001).