수은 고노출지역 주민의 수은노출요인과 노출량 변화에 관한 연구

김대선,권영민,정희웅,최경희,KIM, Dae Seon,Kwon, Young Min,Chung, Hee-Ung,CHOI, Kyunghee 한국환경보건학회 2015 한국환경보건학회지 Vol.41 No.5

Objectives: The 2007 Korea National Survey for Environmental Pollutants in the Human Body found the highest blood mercury levels nationwide among residents in Seoksan-ri, Goro-myeon, Gunwi-gun, Gyeonsangbuk-do. With the aim to reduce the blood mercury levels of residents in this region, we conducted this study to identify the association between mercury exposure levels and shark meat consumption. Methods: This survey was conducted with 118 participants in Seoksan-ri before the Chuseok festival and 113 residents were added afterwards. Information on participants was collected via questionnaires. Total mercury concentrations in biological samples were measured using a mercury analyzer with the gold-amalgam collection method. Results: To identify this, we conducted mercury exposure level analysis before and after the Chuseok festival and found that blood and urinary mercury levels after Chuseok (GM of $6.9{\mu}g/L$ in blood and $1.68{\mu}g/g$_cr in urine) were higher than those before (GM of $5.29{\mu}g/L$ in blood and $1.44{\mu}g/g$_cr in urine). This area maintains a custom of using shark meat as one of the ancestral rite foods, and the performance of such rites and shark meat consumption have been identified as main sources of mercury exposure. Other than this, smoking, dental amalgam treatment and residential period in the area also contributed to an increase in mercury exposure levels. On the other hand, recent consumption of oriental medicine and vaccination did not have a significant influence on mercury levels. Conclusion: The results were attributed to the local custom of consuming shark meat with high mercury concentrations during rituals taking place during the festival and ancestral rites. Given that the blood mercury levels in 23.2% of the residents exceeded the HBM II values recommended by the German Commission on Human Biological Monitoring, it is suggested that further appropriate actions and follow-up measures be taken to reduce the mercury exposure levels of the residents that exceeded the reference values.

Mobile IPv4/Mobile IPv6 통신을 위한 모바일 해더 변환 메커니즘

김대선,홍충선 한국통신학회 2007 韓國通信學會論文誌 Vol.32 No.1

폐금속광산 주변지역 주민의 체내 카드뮴 농도 수준 평가

김대선,류정민,박충희,안승철,유화연,유승도,최경희 환경독성보건학회 2013 한국독성학회 심포지움 및 학술발표회 Vol.2013 No.10

병렬 처리 구조 터보 부호에서 라틴 방진 행렬로 구성된 충돌 방지 인터리버

김대선,오현영,송홍엽 한국통신학회 2008 韓國通信學會論文誌 Vol.33 No.2

일개 농촌지역의 초등학생과 주민에서 다환성 방향족 탄화수소와 톨루엔 노출이 요중 Thiobarbituric Acid Reactive Substance 농도에 미치는 영향

김대선,이철호,엄상용,강택신,김용대,김헌,Kim, Dae-Seon,Lee, Chul-Ho,Eom, Sang-Yong,Kang, Tack-Shin,Kim, Yong-Dae,Kim, Heon 대한예방의학회 2008 예방의학회지 Vol.41 No.1

Objectives : Polycyclic aromatic hydrocarbons (PAH) and toluene have been reported to induce reactive oxygen species and oxidative stress. This study was performed to investigate the effects of low level exposure to PAHs or toluene on the lipid peroxidation level in elementary school children and the elderly in a rural area. Methods : Forty seven elementary school children and 40 elderly people who were living in a rural area and not occupationally exposed to PAH or toluene were the subjects of this study. Information about active or passive smoking and diet was obtained using a self-administered questionnaire. The urinary 1-hydroxypyrene (1-OHP), 2-naphthol, hippuric acid and thiobarbituric acid reactive substance (TBARS) concentrations were measured, and these values were corrected with the urinary creatinine concentration. Results : In school children, the geometric means of the urinary 1-OHP, 2-naphthol, hippuric acid and TBARS levels were $0.02\;{\mu}mol/mol$ creatinine, $0.47\;{\mu}mol/mol$ creatinine, 0.14 g/g creatinine and $0.95\;{\mu}mol/g$ creatinine, respectively. Those values for the elderly were $0.07{\mu}mol/mol$ creatinine, $1.87{\mu}mol/mol$ creatinine, 0.11 g/g creatinine and $1.18\;{\mu}mol/g$ creatinine, respectively. The mean levels of urinary 1-OHP, 2-naphthol and TBARS were significantly higher in the elderly subjects than in the children. The urinary TBARS level was not correlated with the urinary 1-OHP, 2-naphthol and hippuric acid, but they were correlated with the age of the subjects. Conclusions : These results suggest that low level inhalation exposure to PAH or toluene does not markedly increase lipid peroxidation, and age is a significant determinant of lipid peroxidation.

강릉지역 주민의 체내 중금속 농도 추적조사

김대선,안승철,윤영삼,정희웅,유승도 대한보건협회 2011 대한보건협회 보건종합학술대회 Vol.2011 No.-

[연구배경] 지난 2003년부터 국립환경과학원에서 추진 중인 「산단지역 주민 건강영향 감시사업」결과의 정확한 해석 및 객관적인 비교를 위해 비산단지역 중 산단지역과 지리적, 인구학적, 환경 조건이 비슷한 강릉을 비교지역으로 선정하여 격년으로 조사를 시작하였다. [연구목적] 본 연구의 목적은 대규모 국가산단이 없는 강릉지역 주민을 지속적으로 추적조사하여 혈액 및 요중 중금속 농도의 변화정도를 파악하고 산단지역 주민의 혈액 및 요중 중금속 농도 수준과 비교할 수 있는 자료를 축적하는 데 있다. [연구방법] 조사기간은 2010년 4월부터 7월까지였으며, 2006년부터 본 연구에 참여한 대상자를 중심으로 건강검진을 위해 지역 의료기관을 방문한 주민의 혈액 및 소변을 채취하여 중금속 농도를 분석하였다. 혈중 납과 요중 카드뮴은 GF-AAS로, 요중 수은은 Hg Analyzer를 사용하여 분석하였다. 요중 카드뮴과 수은의 경우에는 분석 후 요중 크레아티닌 농도로 보정하였으며, 크레아티닌 농도가 0.5~2.0g/L 범위를 벗어나는 시료에 대해서는 최종 통계처리에서 제외하였다. [연구결과] 강릉지역 주민 총 1,007명의 혈중 납, 요중 카드뮴 및 수은을 분석한 결과, 각각 1.57 ㎍/dL, 0.82 ㎍/g-cr, 0.98㎍/g-cr(이하 기하평균) 이었으며, 혈중 납을 제외하고는 남자보다 여자가 높았다. 2009년의 산단지역 및 국민환경보건기초조사 결과와 비교한 결과, 혈중 납은 전국 평균(1.81 ㎍/dL)과 유사하였으며, 광양만(2.19 ㎍/dL) 및 포항(2.65 ㎍/dL)에 비해 약간 낮은 수준이었다. 요중 카드뮴과 수은은 전국 평균(각각 0.80 ㎍/g-cr, 0.68 ㎍/g-cr)과 유사하였다. 조사에 참여한 1,007명 중 509명은 `06년, `08년, `10년 3개년도 모두 조사에 참여하였으며, 이들의 혈중 납 농도는 `06년 1.38 ㎍/dL, `08년 1.66 ㎍/dL, `10년 1.67 ㎍/dL로 약간 증가하는 경향을 보였다. 요중 카드뮴은 각각 1.01 ㎍/g-cr, 1.20 ㎍/g-cr dL, 0.96 ㎍/g-cr로 큰 변화는 없었으며, 요중 수은의 경우에는 각각 1.80 ㎍/g-cr, 1.34 ㎍/g-cr, 1.06 ㎍/g-cr로 감소하는 경향을 나타내었다.

Health Impacts of Climate Change and Natural Disaster

김대선,이철우,Jase Vatukela 적정기술학회 2019 적정기술학회지(Journal of Appropriate Technology) Vol.5 No.2

Climate change is one part of 17 Sustainable Development Goals (SDGs). According to the Fifth Assessment Report by the Inter- governmental Panel on Climate Change(IPCC) published in 2014, global warming is caused by greenhouse gas (GHG) emissions. The most important GHG is carbon dioxide (CO2), which is released by the burning of fossil fuels and, to a lesser extent, by land use practices, followed by nitrous oxide and methane. IPCC predicts that global temperatures will rise 3.7℃ and sea level will rise 0.63 m by 2099 in the case of no strong restraint. According to the report, we can expect a massive species extinctions, changes in storm and drought cycles, altered ocean circulation, and redistribution of vegetation by global warming. However, climate changes, especially global warming, are the largest potential threat to human health and the source of a number of diseases globally. If climate changes are continued uncontrolled, human health will be adversely affected by the accelerating climate change and the natural disaster induced by climate change. It means we will face more serious conditions of injury, disease, and death related to natural disasters such as flood, drought, heat waves, malnutrition, more allergy, air pollution and climate change related infections related to morbidity and mortality. This review emphasizes on the relationship between global climate changes and human health and provides some suggestions for improvement.

비산단지역 환경오염 수준 및 주민의 생체지표 모니터링

김대선,안승철,류정민,유승도,Kim, Dae-Seon,Ahn, Seung Chul,Ryu, Jung Min,Yu, Seung Do 한국환경보건학회 2012 한국환경보건학회지 Vol.38 No.6

Objectives: The main purpose of this study is to produce background data which can be compared with data on vulnerable areas such as industrial complexes in Ulsan, SihwaBanwol, Gwangyang, Yeosu, Pohang, Cheongju and Daesan in Korea. Methods: This study was performed on 1,007 local residents in Gangneung using personal questionnaires and medical check-up. Environmental pollutants including heavy metals in blood and urine were analyzed and the results are as follows. Results: According to the results of medical check-up, 705 subjects were "Normal (A and B)", 232 subjects were "Disease doubtful (R1)" and 70 subjects were "High blood pressure or Diabetes doubtful (R2)". Regarding geometric mean concentration, blood lead was 1.57 ${\mu}g/dL$, urine cadmium was 0.82 ${\mu}g/g-cr$, urine mercury was 0.98 ${\mu}g/g-cr$ and urine arsenic was 15.78 ${\mu}g/g-cr$. In the analysis of 11 kinds of VOCs in blood, vinyl chloride, 1,3-butadiene and dichloroethylene were not detected, while the detection rate of other chemicals was above 70% except chloroform(49.7%) and trichloroethylene(19.0%). In analysis of 16 kinds of PAHs in blood, 10 kinds showed more than 80% in detection rate. Also, detection rate of 4 kinds of PCBs in blood ranged 52 to 78%. Conclusions: Compared with industrial compelxes, the concentration of blood lead was lower, while urine cadmium and mercury levels were similar. Also, urine arsenic ranged at a significant level. Further study is required to find the cause of regional differences in concentrations of environmental pollutants.

시공간통계를 이용한 천리안 위성산출물의 품질관리방안

김대선,조재일,이양원 건국대학교 기후연구소 2013 기후연구 Vol.8 No.1

The CMDPS(COMS Meteorological Data Processing System) provides 16 meteorological products by processing satellite data obtained from 1 visible and 4 infrared channels. It is expected that the COMS(Communication, Ocean and Meteorological Satellite) products will contribute to numerical weather prediction and climate change monitoring. For more active utilization of the products, we first need a scheme for the quality management based on outlier detection. This paper describes a method for detecting spatial and temporal outliers from the COMS products using Moran scatterplot and wavelet transform. The applicability of our method was made sure through the tests for seven products such as sea surface temperature, land surface temperature, aerosol optical depth, total precipitable water, upper tropospheric humidity, cloud top height, and cloud top temperature. Their quality was estimated very good in terms of our spatio-temporal statistical approach. For future work, we need more comprehensive study on the outlier detection, particularity focusing on the threshold setting in accordance with physical characteristics of each product.

Candida sp. 변이주에 의한 Glutathione 생산

김대선,유재홍,윤성식,신원철 한국산업미생물학회 1993 한국미생물·생명공학회지 Vol.21 No.5

Glutathione 생산균주를 돌연변이시켜 변이주의 생산 최적조건 및 glutathione의 분리, 정제를 행하였다. Glutathione 생산을 위한 Candida sp. mutant의 배지조성은 glucose 1.5%, yeast extract 4.0%, KH_2PO_4 0.04%, biotin 5 ㎍/㎖ 및 L-cysteine 0.04%이었으며 온도는 25℃, pH 6.0에서 48시간 배양하였을 때 glutathione 생산이 가장 좋았다. Glutathione 생산을 위한 최적배지에서 Candida sp. mutant 균주에 의한 glutathione 생산량은 175 ㎍/㎖로 원균주보다 1.9배 정도 증가하였다. 표준 glutathione과 정제된 glutathione의 TLC, UV 및 IR spectrum을 비교하여 본 결과 동일한 구조를 가지고 있는 것으로 판단되었다. c For the overproduction of glutathione, Candida sp. mutant was isolated by the treatment with U.V. light. The highest glutathione production of Candida sp. mutant was obtained after shaking culture for 48 hours in the culture medium containing glucose 1.5%(W/V). yeast extract 4.0%(W/V), KH_2PO_4 0.04%(W/V), biotin 5 ㎍/㎖, and L-cysteine 0.04%(W/V). The optimal pH and temperature for the glutathione production were pH 6.0 and 25℃, respectively. The glutathione production of Candida sp. mutant under the optimal culture condition was 175 ㎍/㎖. The purified glutathione was identified to be the same as the authentic glutathione by TLC chromatogram, UV and IR spectrum.