환경성 요인이 위암조직의 RUNX3 유전자 promoter 과메틸화에 미치는 영향

엄상용,윤효영,윤세진,강종원,장연위,송영진,현태선,박주승,우병완,김용대,김헌 대한임상건강증진학회 2008 Korean Journal of Health Promotion Vol.8 No.2

연구배경 RUNX3는 암억제 유전자로서, 위암의 40%이상에서 RUNX3 유전자 promoter의 과메틸화가 존재한다. 본 연구는 한국인에서 식이 요인을 포함한 환경적 요인과 RUNX3 유전자 promoter의 과메틸화의 관련성을 파악하고자 하였다. 방 법 확진된 위암 환자 142명을 대상으로 위험요인 노출에 대해 조사하였다. 위암 조직의 DNA에서 RUNX3 유전자 promoter 과메틸화를 조사하였다. 결 과 RUNX3 promotor 과메틸화가 없는 군과 있는 군의 일반적 특성은 유의한 차이가 없었다. 김치와 콩류, 찌개류, 잼과 초콜렛 등의 당류와 비타민 B6를 많이 섭취할수록 위암 조직의 RUNX3 promotor 과메틸화가 유의하게 많은 것으로 나타났다. 탄수화물과 비타민 C 섭취도 경계상 유의미성 정도로 RUNX3 promotor 과메틸화를 높이는 것으로 나타났다. 결 론 일부 식습관은 RUNX3 promoter 과메틸화와 유의한 관련성을 보여 위암 발생 기전에 관여할 가능성을 시사하였다. Background This study aimed to investigate the effects of environmental factors on hypermethylation of the RUNX3 gene promoter gastric cancer tissues in Korea. Methods 142 gastric cancer patients were enrolled. Exposure data to environmental factors were collected by interview. Hypermethylation of the RUNX3 gene promoters were analyzed in gastric cancer tissue. Results Kimchi, soybean foods, stews, jam, honey, candies, chocolate and vitamin B6 intake increased the risk of hypermethylation of the RUNX3 gene promoter. Conclusions Some dietary factors may be related with hypermethylation of the RUNX3 gene promoter in gastric cancer tissue.

예이츠의 시에 나타난 ‘책임’

엄상용 한국예이츠학회 2021 한국예이츠 저널 Vol.64 No.-

49세의 초로에 접어든 예이츠는 시인으로서의 ‘책임’을 통감하고 1914년 여섯 번째 시집 『책임』을 발행한다. 그는 아일랜드 상원의원으로서 사회적 책임, 일생 동안 사랑했던 모드 곤을 비롯한 주변 인물들에 대한 개인적인 책임, 아름다운 시를 쓰 고자 한 시인으로서의 심미학적 책임을 이 시집에서 시를 통하여 표현하고 있다. 이 시 집을 중심으로 전과 후의 시세계가 완전히 달라져서 예이츠 학자들은 이 시집을 매우 중 요한 전환점으로 평가한다. William Butler Yeats (1865-1939)’s sixth volume Responsibilities has 31 poems and was issued in 1914, in his age of 49. Many Yeats scholars thought Responsibilities as a crucial dividing point in Yeats’s poetic world. It is between the fifth section The Green Helmet and other Poems and the seventh section The Wild Swans at Cool and simultaneously and naturally evolves from The Green Helmet and other Poems into The Wild Swans at Coole in the poetic structure. Especially Yeats focused on the poet’s responsibilities in the past, present and future. John Unterecker classified the poems as five areas, like these, supernatural responsibilities, social responsibilities, personal responsibilities and aesthetic responsibilities. And he also classified the poems according to the responsibilities respectively.

Sean O'Casey Realism에 관하여

嚴相龍 成均館大學校 英語英文學會 1985 Academia Vol.7 No.-

리더십과 과학의 아름다운 하모니 KAIST 리더십 교육의 성과와 의의

엄상용,박정조,권소영,이호진 한국방위산업진흥회 2022 國防과 技術 Vol.- No.516

실리콘밸리1의 혁신적 사고방식, Moonshot thinking [Ⅰ] 불가능을 가능으로~

엄상용,김도영,전철영 한국방위산업진흥회 2015 國防과 技術 Vol.- No.440

실리콘밸리의 혁신적 사고방식, Design thinking [Ⅱ]

엄상용,김도영,최민식 한국방위산업진흥회 2015 國防과 技術 Vol.- No.441

미래 성장동력 ICT1의 세 가지 분야 : IoT, Wearable Device, Big Data

엄상용,김도영,문현호 한국방위산업진흥회 2016 國防과 技術 Vol.- No.443

Lead, Mercury, and Cadmium Exposure in the Korean General Population

엄상용,이영섭,이슬기,서미나,최병선,김용대,임지애,황명실,권호장,김유미,홍영습,손석준,박경수,표희수,김호,김헌,박정덕 대한의학회 2018 Journal of Korean medical science Vol.33 No.2

Background: Lead (Pb), mercury (Hg), and cadmium (Cd) are well-known environmental pollutants. They are unnecessary in the biological processes of humans. This study was performed to estimate the representative background exposure levels to the metals by measuring concentrations in whole blood of the Korean general population. Methods: This population-based cross-sectional study included 4,000 subjects (1,886 males and 2,114 females) 0–83 years of age in 2010 and 2011. Adult subjects (≥ 19 years of age) were collected by sex- and age-stratified probability method, and preschool- and school-aged subjects were recruited by a cluster sampling method. Written consent was provided prior to blood sampling. Pb and Cd blood concentrations were determined by a flameless atomic absorption spectrophotometry, and blood Hg was analyzed by a direct Hg analyzer. Results: The geometric mean, median and 95th percentile of blood Pb was 1.82 µg/dL, 1.83 µg/dL, and 3.78 µg/dL, respectively. The respective values were 2.92 µg/L, 2.87 µg/L, 9.12 µg/L for Hg, and 0.56 µg/L, 0.59 µg/L, 2.20 µg/L for Cd. Blood Pb and Hg were higher in males than in females, but no sex difference was observed, respectively, in subjects 0–4 years of age for Pb and in subjects less than 20 years for Hg. However, blood Cd was higher in females than in males and no sex difference was observed in subjects < 30 years of age. Conclusion: This study provides representative data of human exposure to Pb, Hg, and Cd covering whole age groups of the general population in Korea.

예이츠의 시에 나타난 현실과 이상의 충돌 — 비잔티움 시편을 중심으로 —

엄상용 한국예이츠학회 2022 한국예이츠 저널 Vol.67 No.-

예이츠에게 비잔티움은 충격 그 자체였다. 아폴로니아 성당의 모자이크 벽에서 만난 황금새는 금세공사가 만든 인공적인 예술작품이지만, 시간과 이미지를 초 월한 영원한 이상세계의 아름다움을 간직하고 있고 동시에 생성과 변화를 반복하는 현 실세계의 정화되지 않은 이미지들과 충돌하여 파괴하는 것으로 보았다. 예이츠는 비잔 티움으로의 항해 와 비잔티움 의 두 시를 통하여 현실세계와 이상세계와의 충돌을 넘 어 조화와 일치를 이루고자 무던히도 노력했음을 알 수 있다. Yeats said if he were to choose a city where he would live for a month, he would pick up Byzantium. His meeting with ‘the golden bird’ in Byzantium was the collision, reconciliation, and the unity of being between the real and ideal world, even if it is an artificial artwork. The reality and the ideal coexist for Yeats in both “Sailing to Byzantium” and “Byzantium.” What Yeats said about Byzantium as a symbolic city was that religious, aesthetic and practical life were one in the place and at that time.

Yeats의 신비주의 : 'Daimon'과 'the Thirteenth Cone'의 관계를 중심으로 Focused on 'Daimon' and 'the Thirteenth Cone'

엄상용 한국 예이츠 학회 1992 한국예이츠 저널 Vol.2 No.-

W.B. Yeats' works have made most of us disconcerted because his thoughts were so profound. Deeply interested in Irish Literature, folklre, philosophy and the genius of his nation, Yeats had been naturally absorbed in the occutism. He has also been influence dby Indian philosophy and the activities of 'the order of Golden Dawn' as well as by his father's motto that a poet should hammar his thoughts into unity. The important principles of the occultism were supported by Yeats whose beliefs were derived from his interests in the Irish legend and tradition as well as from his various readings. Yeats belived the cyclic movement of history and that of individual life representing itself in succeeding forms both in this 재4깅 and beyond. He believed that life always holds a dramatic tension between warring 'opposites'. More important, he agreed with William Blake that 'Without Contrary is no progression. Attraction and Repulsion Reason and energy, Love and Hate, are necessry to Human Existence'. It is the very tension between opposite that creates the movement of the cycles. Yeats found that for every cyclic movement, there is its opposite, a counter-cycles such as the sun and the moon, male and female, life and death, subjective and objective. It is significant that Yeats found an elaborate series of correspondences between the two of these antinomies. He also believed the combination between the opposites could reach the real state of 'Unity of Being'. Yeats had sturggled to combine these opposing elements to give the 'Unithy of Being' to his works. For this purpose he set up a great scheme to give them an organic unity. In the effort of doing so, he used to rearrange the order of the poems in his anthologies so that they mingy have a harmonious unity and sometimes dropped some of his poems which were not suitable to his plan. Doubtless, the basic thought that tempted him to rearrange all his works was the idea of occultism based on the 'Diimon' thought. Yeats accepted 'Daimon' as 'an attendent spirit', or 'a geius' which gives an artist 'a supernatural help'. Yeats had a spiritual contact with the spirit of Leo Africnus, which he reckoned as a 'Damon.' The contack eventrually enabled him to produce the body of his Occultism and 'Daimon' thought which exerted a crucial influence on his developments as a poet. Yeats suggested that there is 'the Thirteenth Cone' which is to havit of 'the daimons'. He thought 'the Thirteenth cone' is the ultimate reality 솟 is the poet's goal to reach. "The Thirteenth Cone' is the symbol fo perfection completeness as a phaseless sphere. He claimed all souls could be set free from the cycles of time and space, from the conflict between death and life, love and hate and so on, in 'the Thirteenth Cone'. So within it, it is possible for all the arists, like Yeats, to reach their ultimate goal, that is "Unity of Being'.