Multiple Gastric Ulcers as a Manifestation of Cytomegalovirus Infection in a Patient with Adult-onset Still’s Disease

권미혜,이충섭,조성우,정청일 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.3

Cytomegalovirus (CMV) is a relatively common viral pathogen, and CMV infection is generally assumed asymptomatic in general hosts. In immunologically compromised patients, CMV infection can cause further serious diseases such as pneumonitis, retinitis, encephalitis, and enterocolitis. A 40-year-old man is being presented with acute fever, myalgia, and sore throat. Laboratory findings have revealed elevated ESR, CRP, and ferritin levels. The patient was being treated for adult-onset Still's disease (AOSD). Three weeks later, although AOSD activity was under control, the patient began to complain about oral soreness, epigastric pain, and diarrhea. Endoscopy revealed multiple round ulcers with white patches in the esophagus and the stomach, sparing the colon. Anti-fungal agent is being administered but failed to bring improvements after 2 weeks of therapy. CMV infection is confirmed with pathology, antiviral agents were initiated after the ulcers subsided. Currently, clinical associations between CMV infection and AOSD are suggested. CMV infection may be considered as a differential diagnosis when multiple upper gastrointestinal ulcerative lesions develop within patients whom have been treated AOSD with immunosuppressive agents.

특허정보를 활용한 교육용 건반악기 기술의 동향과 발전 방향 검토

권미혜 차세대컨버전스정보서비스학회 2019 차세대컨버전스정보서비스기술논문지 Vol.8 No.3

Keyboard instruments are the basic instruments for music education. As technology has advanced, so has the technology for educational keyboard instruments. In this study, the patent information was used to examine the trend of educational keyboard musical instrument technology and its direction. Technological advances have been made since 1999, and since 2003 there has been a greater increase in patents for educational acoustic keyboard instruments than for educational digital keyboard instruments. Most educational acoustic keyboard instruments used separate teaching aid and nearly half patents needed information processing device. Most of the educational keyboard instrument technology were classified for general education. Most of the keyboard instrument technology for early childhood education adopted the visual teaching principle, and most of the lecture delivery was done in the elementary and secondary education. Information processing technology will develop rapidly, but educational keyboard musical instrument technology is expected to develop in both acoustic and digital keyboard instruments. 건반악기는 음악교육의 기본적 악기이다. 기술이 발전함에 따라 교육용 건반악기에 대한 기술 역시 발전하고 있다. 특허정보를 활용하여 교육용 건반악기 기술의 동향과 그 발전방향을 검토하였다. 1999년 이후 기술 발전이 크게 이루어졌으며, 2003년 이후부터는 교육용 디지털 건반악기보다는 교육용 어쿠스틱 건반악기 특허의 증가가 더 컸다. 교육용 어쿠스틱 건반악기 특허는 대부분 별도의 교구를 함께 사용하였으며 절반에 가까운 특허는 정보처리기기를 필요로 하였다. 교육용 건반악기 기술의 대부분은 교육대상을 특정하지 않은 일반교육으로 분류되었다. 유아교육용 건반악기 기술은 시각적인 교육원리에 치우쳤으며, 초중등교육의 경우 강의전달이 대부분이라는 점은 아쉬운 부분이었다. 정보처리 기술이 급격히 발전할 것이나, 교육용 건반악기 기술은 어쿠스틱 건반악기와 디지털 건반악기 모두 고루 발전할 것으로 예상된다.

Functional and Immunofluorescence Evaluations of Vascular and Neural Integrities in Urinary Bladder of Streptozotocin-Induced Diabetic Mice

권미혜,최민지,Fang-Yuan Liu,Fitri Rahma Fridayana,Lashkari Niloofar,Guo Nan Yin,Ji-Kan Ryu 대한배뇨장애요실금학회 2022 International Neurourology Journal Vol.26 No.3

Purpose: To assess functional and structural changes in vascular and neural structures associated with diabetic bladder dysfunction (DBD) in the bladders of streptozotocin (STZ)-induced diabetic mice. Methods: Eight-week-old C57BL/6 mice were injected with STZ at 50 mg/kg daily for 5 consecutive days. Catheters were inserted 12 weeks later, and 5 days after catheter placement bladder functions were assessed by conscious cystometry. Neurovascular and extracellular matrix marker changes in harvested urinary bladders were investigated by immunofluorescent staining. Body weights and fasting and postprandial blood glucose levels were measured 12 weeks after STZ injection. Results: STZ-induced diabetic mice had significantly lower body weights and significantly higher blood glucose levels. Assessment of bladder function in STZ-induced diabetic mice revealed a nearly 3-fold increase in bladder capacity and intercontractile interval compared to controls. However, basal pressure, maximal bladder pressure, and threshold pressure were not significantly different. Morphological and structural analysis showed that STZ-induced diabetic mice had significantly reduced microvascular density in lamina propria (33% of the nondiabetic control values), and severely decreased nerve contents in the detrusor region (42% of the nondiabetic control values). Conclusions: STZ-induced diabetic mice exhibit functional and structural derangements in urinary bladder. The present study provides a foundation and describes a useful means of evaluating the efficacies of therapeutic targets and exploring the detailed mechanism of DBD.

포스터 전시 : 간 ; 패혈증 및 대둔근 농양을 동반한 간농양 1예

권미혜,임대승,김용석,김선문,이태희,임의혁,허규찬,강영우,최용우 대한소화기학회 2006 대한소화기학회 추계학술대회 Vol.2006 No.-

녹색 소비를 위한 광고 바로 보기 : TV 광고를 중심으로

권미혜,권송희,김성희,박은서,박지혜,안태인,임현주 한국환경교육학회 2010 한국환경교육학회 학술대회 자료집 Vol.2010 No.12

A Case of Neck Abscess Caused by Salmonella Serotype D in a Patient with Liver Cirrhosis

권미혜,강미일,천지영,임현우,염윤식,강영우,김영근,김영진 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.1

Non-typhoidal salmonellosis, which is increasing nowadays in Korea as well as in the developed countries, is manifested as enteritis in most cases, but it also encompasses bacteremia, intraabdominal infections, and bone, joint and soft tissue infections. These rare diseases are known to result from primary gastrointestinal infection and subsequent bacteremia with or without symptoms. We experienced a case of neck abscess caused by Salmonella serotype D, which is a rare but important differential diagnosis of neck abscess. We herein report it.

삼차신경통 태음인 환자의 만성 설사 치험례

권미혜,장하림,이혜리,이의주,Kwon, Mi Hye,Jang, Halim,Lee, Hyeri,Lee, Eui Ju 사상체질의학회 2021 사상체질의학회지 Vol.33 No.4

Objectives This study was aimed to report a significant improvement of chronic diarrhea patient, diagnosed as 'Taeeum type liver heat-lung dryness pattern' based on Sasang medicine. Methods The patient had treatment with Sasang constitutional medicine. The treatment was executed three times everyday from August 27th to September 3rd and two times everyday from September 3rd to September 16th of 2021. Clinical improvement was evaluated with Bristol stool form scale, the degree of abdominal discomfort and nausea compared to the day of hospitalization and the number of defecations and nocturia per day. Results The symptoms of diarrhea, abdominal discomfort and nausea were improved. The number of night urination was decreased from 3-4 times to once a night. Conclusion After the treatment with Sasang constitutional medicine, diarrhea, abdominal discomfort, nausea and the general condition of the patient also improved.

Quantitative and Rapid Analysis of Transglutaminase Activity Using Protein Arrays in Mammalian Cells

권미혜,정재완,정세희,Jin-Young Park,김영명,Kwon-Soo Ha 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.3

We developed a novel on-chip activity assay using protein arrays for quantitative and rapid analysis of transglutaminase activity in mammalian cells. Transglutaminases are a family of Ca2+-dependent enzymes involved in cell regulation as well as human diseases such as neurodegenerative disorders, inflammatory diseases and tumor progression. We fabricated the protein arrays by immobilizing N,N′-dimethylcasein (a substrate) on the amine surface of the arrays. We initiated transamidating reaction on the protein arrays and determined the transglutaminase activity by analyzing the fluorescence intensity of biotinylated casein. The on-chip transglutaminase activity assay was proved to be much more sensitive than the [3H]putrescineincorporation assay. We successfully applied the on-chip assay to a rapid and quantitative analysis of the transglutaminase activity in all-trans retinoic acid-treated NIH 3T3 and SH-SY5Y cells. In addition, the on-chip transglutaminase activity assay was sufficiently sensitive to determine the transglutaminase activity in eleven mammalian cell lines. Thus, this novel on-chip transglutaminase activity assay was confirmed to be a sensitive and high-throughput approach to investigating the roles of transglutaminase in cellular signaling, and, moreover, it is likely to have a strong potential for monitoring human diseases.

비대면 비실시간 대학 피아노 전공실기 수업의 만족도 분석과 개선방안 연구

권미혜 차세대컨버전스정보서비스학회 2021 디지털예술공학멀티미디어논문지 Vol.8 No.3

After conducting non-face-to-face non-real-time college applied music piano lessons for two semesters in 2020, 74 students responded to the survey. In this survey, piano playing video recording locations, lesson video learning locations, the satisfaction of the non-face-to-face non-real-time lessons, and the pros and cons of the non-real time non-face-to-face class were investigated. It is confirmed that there were many students who take the lesson video without a piano and the satisfaction score was 6.06. As an positive opinion by students, being able to check their skills voluntarily and objectively through their performance records, being able to freely choose the learning location and time, and repeated learning through repeated playback of lesson videos are confirmed. As an negative opinion, the limitation of musical expression, lack of tension and concentration due to free choice of the learning location and time, and difficulties in immediate communication with the instructor are confirmed. By the thought of instructor, there is the additional advantage that of increasing the time of lessons per person and there is the disadvantage of not being able to observe the performance and development of other students. As a way to improve non-face-to-face non-real-time piano lessons, conducting non-face-to-face non-real-time lessons with non-face-to-face real-time lessons, changing the format of assignment videos for smoother communication, and learning from each other through Havruta teaching method is suggested. 2020년도 두 학기 동안 비대면 비실시간 방식으로 피아노 전공실기 수업을 진행한 후, 74명의 수강생을 대상으로 과제 영상의 촬영 장소, 레슨 영상의 학습 장소, 비대면 비실시간 수업의 만족도, 비대면 비실시간 수업의 장단점 등을 조사하였다. 피아노 없이 레슨 영상을 수강하는 학생이 다수 있는 것으로 조사되었으며, 만족도는 6.06점으로 조사되었다. 학생이 체감하는 비대면 비실시간 수업의 장점 의견으로, 자신의 연주 기록을 통해 자발적이고 객관적인 실력 검증, 자유로운 레슨 시간과 장소, 레슨 영상 반복 재생을 통한 반복 학습이 확인되었으며, 단점 의견으로 음악적 표현 전달의 한계, 자유로운 레슨 시간과 장소에 의한 긴장감과 집중력 부족, 교수자와의 즉각적 소통 어려움이 확인되었다. 교수자는 학생 1인당 레슨시간이 증가한다는 장점과 학생들 서로의 연주 및 발전 과정을 관찰하지 못한다는 단점이 더 있다고 판단하였다. 비대면 비실시간 피아노 전공실기 수업의 개선방안으로, 비대면 비실시간 수업을 중심으로 수행하되 비대면 실시간 수업을 접목하는 방안, 보다 원활한 소통을 위한 과제 영상 형식을 변경하는 방안, 하브루타 교습을 통한 서로 배우기 방안을 제안한다.

피아노 교습을 위한 융합 기술의 발전 동향 연구 -특허 분석을 중심으로-

권미혜,이재홍 차세대컨버전스정보서비스학회 2022 디지털예술공학멀티미디어논문지 Vol.9 No.4

특허 분석을 통하여 최근 20년 동안의 피아노 교습 융합 기술 발전 동향을 검토하고 미래의 기술 발전 방향을 전망하였다. 2016년 내지 2017년 이후부터 스마트기기를 함께 사용하는 어쿠스틱 피아노 교습 기술에 대한 특허 출원의 증가 추세가 확인되었으며 전자피아노 교습 기술에 대한 특허 출원 감소가 확인되었다. 2015년까지는 다양한 추가 기기를 활용하는 피아노 교습 기술이 개발되었으나, 2016년 이후부터 스마트기기를 활용하는 피아노 교습 기술이 점진적으로 증가하여 2020년에는 전체 특허의 약 60%에 이르렀다. 또한, 2016년부터 자가 테스트 방식으로, 소프트웨어를 이용한 자동 평가 목적의 피아노 교습 기술 특허의 증가 추세가 확인되었다. 미래에는 스마트기기의 기술 발전과 더불어 어쿠스틱 피아노를 활용하는 교습 기술이 계속 발전할 것이며, 전자피아노를 활용한 교습 기술은 크게 증가하지 않을 것으로 전망된다. 또한, 스마트기기의 정보처리능력 발전과 더불어 피아노 연주 능력을 자가 테스트하는 소프트웨어 기술 발전도 계속될 것으로 전망된다.