복시가 동반된 안와골절 환자의 임상양상

강효정,하명숙 대한안과학회 2009 대한안과학회지 Vol.50 No.7

conservative treatment group. Methods: The study comprised of 109 eyes of 109 patients with orbital wall fracture and diplopia. The patients were divided into two groups: the surgical treatment group (59 cases) and the conservative treatment group (50 cases). The groups were analyzed retrospectively according to age, gender, cause, CT, the period and severity of diplopia, and enophthalmos with time. Results: In the conservative treatment group, 38 cases (64.4%) had medial wall fracture, and the average fracture size was 26% of the inferior wall and 33% of the medial wall. In addition, at the first visit, the patients showed diplopia within 45.5 degrees, and diplopia disappeared completely within 17 days on average (57 cases, 96.6%). In the group that underwent the reconstruction of orbital wall fracture, 27 cases (54.0%) had inferior wall fracture, and the average fracture size was 41% of the inferior wall and 35% of the medial wall. Additionally, in the first visit, the patients showed diplopia within 20.3 degrees. The muscle incarceration occurred in 12 cases (24%). In the surgical treatment group, diplopia disappeared completely within 30 days on average (45 cases, 90.0%). Conclusion: In the group of conservative treatment, they showed diplopia within 45.5 degrees at the first visit. Diplopia disappeared completely within 17 days on average (57 cases, 96.6%). In the group of surgical treatment, they showed diplopia within 20.3 degrees at the first visit. Diplopia disappeared completely within 30 days on average (45 cases, 90.0%). 목적: 복시가 동반된 안와골절 환자에서의 수술적 치료와 보존적 치료를 시행한 경우의 임상양상을 각각 분석하고자 한다. 대상과 방법: 복시가 동반된 안와골절 환자 중 보존적 치료를 시행한 59명 59안과 수술적 치료를 시행한 50명 50안에 대해 나이, 성별, 발생원인, 전산화단층촬영 소견 및 시간에 따른 복시의 변화를 후향적으로 각각 분석하였다. 결과: 보존치료군은 내벽골절이 38명(64.4%)이고 평균 하벽의 26%, 내벽의 33% 크기의 골절을 보였고 초진 시 평균 45.5도의 복시를 보였으며 57명(96.6%)에서 평균 17일 이내 복시의 완전소실을 보였다. 수술치료군은 하벽골절이 27명(54.0%)이었으며 하벽의 41%, 내벽의 35% 크기의 골절을 보였고 초진 시 평균 20.3도의 복시를 보였다. 외안근 감돈은 12명(24%)이었고 45명(90%)의 환자에서 평균 30일 후 복시의 완전소실을 보였다. 결론: 보존치료군의 초기 복시각은 45.5도, 복시의 소실시기는 17일, 6개월 후 96.6%의 환자에서 복시의 회복을 보였고 수술치료군은 초기 복시각 35.0도, 복시의 소실시기 30일, 6개월 후 90%에서 복시가 회복되었다.

Progressive Familial Intrahepatic Cholestasis in Korea: A Clinicopathological Study of Five Patients

강효정,홍순억,오석희,김경모,유한욱,김구환,유은실 대한병리학회 2019 Journal of Pathology and Translational Medicine Vol.53 No.4

Background: Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of autosomal recessive liver diseases that present as neonatal cholestasis. Little is known of this disease in Korea. Methods: The records of five patients histologically diagnosed with PFIC, one with PFIC1 and four with PFIC2, by liver biopsy or transplant were reviewed, and ATP8B1 and ABCB11 mutation status was analyzed by direct DNA sequencing. Clinicopathological characteristics were correlated with genetic mutations. Results: The first symptom in all patients was jaundice. Histologically, lobular cholestasis with bile plugs was the main finding in all patients, whereas diffuse or periportal cholestasis was identified only in patients with PFIC2. Giant cells and ballooning of hepatocytes were observed in three and three patients with PFIC2, respectively, but not in the patient with PFIC1. Immunostaining showed total loss of bile salt export pump in two patients with PFIC2 and focal loss in two. Lobular and portal based fibrosis were more advanced in PFIC2 than in PFIC1. ATP8B1 and ABCB11 mutations were identified in one PFIC1 and two PFIC2 patients, respectively. One PFIC1 and three PFIC2 patients underwent liver transplantation (LT). At age 7 months, one PFIC2 patient was diagnosed with concurrent hepatocellular carcinoma and infantile hemangioma in an explanted liver. The patient with PFIC1 developed steatohepatitis after LT. One patient showed recurrence of PFIC2 after 10 years and underwent LT. Conclusions: PFIC is not rare in patients with neonatal cholestasis of unknown origin. Proper clinicopathologic correlation and genetic testing can enable early detection and management.

삼채 부위별 항산화 활성

강효정,박수진,정도연,송근섭,김영수 한국식품영양과학회 2013 한국식품영양과학회 학술대회발표집 Vol.2013 No.11

지방 도시 일반철도 역사 활용방안에 관한 연구

강효정 한국실내디자인학회 2022 한국실내디자인학회논문집 Vol.31 No.5

In South Korea, the railway facilities were once a symbol of modernization and a driving force behind urban growth, however, they encounter a period of decline as the occurrence of the overall changes in the transportation system. In particular, the number of passengers who use the rapid transit railway stations other than KTX stops has been significantly lowered, thus the plans to utilize those stations were sought continuously. Under the circumstance, the plan for utilizing the idle spaces of those stations as public rental housing for young people has recently been announced in the metropolitan area, but it is still a challenge to generalize the plan to local cities. In that regard, this study examined the rapid transit railway stations in Gwangju, thereby suggesting measures to utilize idle spaces around the stations. This study can be a reference when utilizing the stations of the urban outskirts, which are difficult to develop as a tourism resource because they are not combined with urban railways among the rapid transit railway stations of local cities with a small number of passengers and have no sufficient value as modern cultural heritage. In other words, it would be possible to utilize those railway stations by analyzing the characteristics of the wide-area and local-area for the places of the relevant station and inserting a strategic program suitable for the idle spaces of the station.

유치원 3세반 급식시간에 나타난 교사의 역할갈등에 관한 문화기술적 연구

강효정,최윤정 한국육아지원학회 2018 한국육아지원학회 학술대회지 Vol.2018 No.11

공간분석이론을 활용한 국립아시아문화전당 건립 후 광주 구도심의 공간구조 변화 예측

강효정,최재필 대한건축학회 2007 대한건축학회논문집 Vol.23 No.6

This study aims for analyzing the current urban structure of Gwangju’s historic urban center and the locational properties of building-use program before the construction of Asian Culture Complex, and based on the analysis result, the future distribution of building-use program is to be estimated and applied to the existing plan in order to suggest a more effective urban plan for Gwangju’s historic urban center. For this study offers understandings in the spatial properties of commercial districts in the downtown areas, and the location patterns for different building programs, it becomes a framework for future urban planning or redevelopment in the central districts of contemporary cities. And if further researches are conducted in understanding the detailed relationship between urban space structure and it’s phenomena, these analysis models can be more actively utilized in estimating and evaluating urban plans.

인지적종결욕구 군집유형에 따른 휴리스틱 정보처리 단서 효과 비교 온라인 여행사(OTA)를 중심으로

강효정,박상원 한국관광학회 2024 한국관광학회 국제학술발표대회 Vol.96 No.-

GATA1: a novel target for gene therapy in major depressive disorder

강효정 한국통합생물학회 2014 Animal cells and systems Vol.18 No.5

Major depressive disorder is the most common psychiatric disorder in the world, affecting 350 million people worldwide. According to the World Health Organization (WHO), it is expected to become the second greatest cause of illness by 2020. For individuals in the age group of 15–44 years, major depression is already considered as the first cause of disease in the2012 WHO survey. Thus, as the social burden continues to increase worldwide, the need to study the causes and treatmentof major depression has been rapidly growing. Due to the limited efficacy of chemical-based antidepressants, which havebeen used for the treatment of major depression, new antidepressants and gene targeting therapies are garnering moreattention in treatment of major depressive disorder. To identify the genes responsible for major depressive disorder, manygene-profiling studies have been performed on various regions of postmortem human brains with major depression andcompared to control brains. In this review, it is examined gene expression changes in the prefrontal cortex of patients withmajor depression compared to that in the normal population using high throughput analysis and bioinformatics. It is alsodiscussed how this altered gene expression can contribute to structural and functional losses in the brain of patients withmajor depression. In the concluding part, it is considered the possibility that GATA1 – a newly identified transcriptionalrepressor for synapse-related genes under stressed condition, which induced depressive behavior by high copy expression inthe dorsolateral prefrontal cortex of rodents – can be developed as a new therapeutic target for major depressive disorder.

C형 간염 바이러스 감염 간암 세포주와 T 림프구의 상호작용에 대한 연구

강효정,조효선,Kang, Hyojeung,Cho, Hyosun 한국미생물학회 2014 미생물학회지 Vol.50 No.2

Recently, Hepatitis C virus (HCV) replication system has been established using human hepatoma cells (huh cell) and a variety of HCV clones. In this study, we established an infectious HCV replication system using huh7.5 cells and J6/JFH1 clone (genotype 2a). In addition, we investigated the antigen presentation capability of HCV-infected huh7.5 cells to HCV-specific T cells. Interestingly, HCV-infected huh7.5 cells were not capable of activating HCV-specific T cells. However, huh7.5 cells stimulated by exogenous HCV peptide were able to activate HCV-specific T cells, which was shown to produce TNF-${\alpha}$ and IFN-${\gamma}$. We further examined if HCV infection has an inhibitory effect on the expression of MHC class I molecule of huh7.5 cells. We found that HCV infection did not change the expression level of MHC class I molecule on huh7.5 cells.

동작관찰과 시각적 되먹임 융합 운동이 머리전방자세와 둥근어깨의 정렬, 통증과 기능에 미치는 영향

강효정,양회송 한국융합학회 2018 한국융합학회논문지 Vol.9 No.12

The aim of this study was to determine the effects of the action observation and visual feedback on the alignment, pain and function of forward head posture(FHP) and round shoulder(RS). A total of 24 participants with FHP and RSP were randomly assigned to general exercise(GE, n=8), action observation(AO, n=8), and visual feedback(VF, n=8). All subjects were exercised three times a week for four weeks. The groups were assessed for craniovertebral angle(CVA), round shoulder posture(RSP), visual analog scale(VAS), and neck disability index(NDI) before and after exercise, There was a significant difference in CVA in the GE, AO and RSP, VAS and NDI were significantly different in all groups. AO was more effective than GE, VF for VAS. The results of this study suggest that action observation may be effective to improve the FHP and RS. 본 연구는 머리전방자세와 둥근어깨자세에 대한 일반 운동과 동작관찰, 시각적 되먹임의 효과를 알아보고자 한다. 머리전방자세와 둥근어깨자세를 가진 24명으로 하였으며, 일반 운동군(8명), 동작관찰군(8명), 시각적 되먹임군(8명)으로 무작위 배분하였다. 모든 운동군은 주 3회, 총 4주간 운동하였다. 운동 전․후 머리척추각(CVA), 둥근어깨자세(RSP), 시각적상사척도(VAS), 경부장애지수(NDI)를 평가하였다. 연구결과 CVA는 일반 운동군과 동작관찰군에서 유의한 변화를 보였으며, RSP, VAS, NDI의 경우 모든 운동군에서 유의한 변화를 보였다. 운동군 간 변화량 비교에서는 VAS에서 동작관찰군이 일반 운동군과 시각적 되먹임군보다 큰 변화량을 보였다. 본 연구결과 동작관찰이 머리전방자세와 둥근어깨자세의 개선에 효과가 있을 것이라고 사료된다