18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

Synergistic effects of alkylated graphene oxide on the properties of polypropylene-based carbon nanocomposites.

Yun, Young Soo,Pyo, Hye-Ri,Lee, Jae Yun,Chin, In-Joo,Jin, Hyoung-Joon American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.10

<P>Polypropylene (PP)/carbon black (CB)-alkylated graphene oxide (AGO) hybrid nanocomposites were prepared via solution process and the synergistic effects of AGO on the properties of the PP/CB nanocomposites were investigated. AGO at a content of only 0.2 wt% formed an overlapped network structure in the PP matrix and affected the electrical, thermal and mechanical properties of the PP/CB nanocomposites. Specifically, PP/CB (5 wt%)-AGO (0.2 wt%) nanocomposites exhibited an electrical percolation threshold at lower CB contents than the PP/CB nanocomposites did, and the sheet resistance was decreased to 2.3 x 10(7) omega/sq. The thermal degradation temperature and recrystallization temperature of the PP/CB (10 wt%) nanocomposites were increased by 11.3 and 1.6 degrees C, respectively, by the addition of 0.2 wt% AGO. In addition, the Young's modulus of the PP/CB (10 wt%) nanocomposite was increased from 438.1 to 540.1 MPa.</P>

만성 B형 간염에서 라미부딘 치료중 발생한 Viral Breakthrough 예의 임상 결과

안수현,장윤정,오성남,최도원,백수정,정원석,최창원,김경오,임형준,조남영,박종재,김재선,박영태,이명석,연종은,변관수,이창홍 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.4

목적: 만성 B형 간염의 치료 중 발생하는 약제 내성 변이종은 임상적으로는 치료 중 음전되었던 혈청 HBV DNA가 다시 양전되는 viral breakthrough 로 진단할 수 있다. 현재 약제 내성 변이종이 발생했을 경우라도 라미부딘 치료를 계속 유지하는 것을 권장하고 있으나, viral breakthrough 발생 예들의 장기적 임상경과가 아직도 불명확하여 이것을 일반화하기는 어려운 상황이다. 이에 라미부딘 사용 중 viral breakthrough 가 발생한 예들을 대상으로 그 임상경과를 알아보고자 하였다. 대상과 방법: 9개월 이상 라미부딘을 투약한 만성 B형 간염 환자로 viral breakthrough가 발생한 74명을 대상으로 하였다(남/여 54/20, 평균연령 42세). Viral breakthrough 후 혈청 ALT치, 총 빌리루빈치, HBV DNA 역가, HBeAg, anti-HBe를 정기적으로 검사하면서 임상경과를 관찰하였다. Viral breakthrough 후 라미부딘의 투약기간은 평균 13개 월(1-41개월)이었다. 결과: Viral breakthrough 발생후 혈청 ALT치가 정상으로 유지되었던 환자는 8예(11%)에 불과했고 나머지 66예(89%)에서는 ALT치가 증가하였으며, 이중 30예(41%)에서 급성 악화(ALT 정상 상한치의 5배 이상 상승)를 보였다. 급성악화는 viral breakthrough 후 3개월 내에 19예 (63%)에서 발생하여 3개월 내에 발생한 예가 많았으나 12개월 이상 지나서 나타나는 예도 약 20%에서 있었다. 비대상성 악화는 6예에서 관찰되었다. Viral breakthrough 후 급성악화가 일어난 예와 없었던 예의 비교에서 급성악화를 예측할 수 있는 인자는 발견할 수 없었다. Viral breakthrough 후 발견할 수 없었다. Viral breakthrough 후 HBeAg이 음전된 예는 8예(11%)였으나 그 임상경과는 양호하지 않았다. 결론: 만성 B형 간염 환자 에서 라미부딘 투여 중 발생한 viral breakthrough 예 중 상당수에서 급성악화가 발생하였으며, HBeAg 이 소실되더라도 그 임상경과는 양호하지만은 않았다. Viral breakthrough 발생 후 주의 깊은 임상경과 의 관찰이 요구되며, 앞으로 viral breakthrough 후 급성악화 예에 대한 대규모 연구와 적절한 치료방향의 제시가 이루어져야 할 것으로 생각된다. Background/Aims: Long-term lamivudine therapy can induce the emergence of lamivudine resistant hepatitis B virus (HBV) mutants. Clinically emergence of the mutant is expressed by the reappearance of disappeared HBV DNA in serum. Continued lamivudine treatment has been usually recommended in cases of viral breakthrough. However, the clinical outcome in patients with viral breakthrough is not clear. The aim of this study was to investigate the clinical course of chronic hepatitis B patients after viral breakthrough during lamivudine therapy. Methods: A total of 74 patients with chronic hepatitis B who showed viral breakthrough after at least 6 months of lamivudine treatment were included in this study. They had positive HBeAg and HBV DNA before treatment. The median follow-up duration after breakthrough was 13 months. Results: After viral breakthrough, only 8 patients (11%) maintained normal ALT levels and 66 patients (89%) showed elevation of ALT. 30 patients (41%) showed acute exacerbation of hepatitis (ALT increase over five-times upper normal limit). These acute exacerbations occurred within three months after breakthrough in 19 patients (63%). In the cases of acute exacerbation, 6 patients showed decompensated progression such as elevation of serum total bilirubin. One of them died of hepatic failure. A predictive factor for acute exacerbation was not found. HBeAg seroconversion occurred in 8 patients after viral breakthrough but their clinical course was highly variable. Conclusions: Chronic hepatitis B patients who had viral breakthrough during lamivudine therapy should be followed carefully and regularly in mind of potential clinical deterioration. New strategies are needed to manage the cases of acute exacerbation after viral breakthrough.(Korean J Hepatol 2002;8:389-396)

터널 변위 거동 및 수치 모의실험의 결합 해석

정윤영 ( Yun Young Jeong ),한희수 ( Heui Soo Han ),이재호 ( Jae Ho Lee ) 대한지질공학회 2010 지질공학 Vol.20 No.1

이 연구는 터널설계의 안정성을 예측하기 위한 터널거동분석에 초점을 맞춘 것이다. 3차원 수치해석, 현장계측 후 최대변형 및 사쿠라이에 의해 제안된 터널변형에 관한 경험적 안정성 평가방법들을 결합한 평가기법을 사용하였다. 사쿠라이가 사용한 계측자료들은 새로운 해석기법을 도입하여 재해석되었다. 터널안정해석을 위한 사쿠라이의 경험적 추세선은 이론적 추세선으로 새로이 도입되었으며, 이는 안정, 불안정 및 파괴영역으로 구분되었다. 터널 현장자료의 새 해석기법을 평가하기 위한 현장의 적용 예로, 김포의 지하철 9호선으로 연결되는 인천공항의 지하철터널을 이용하였다. 그 결과 터널보강후 인천공항 지하철의 상부 및 하부터널 모두 충분한 안정성을 보였다. 마이크로 실리카 그라우팅과 엄브레라방법에 의한 지반보강 후 겉보기 영계수가 상당히 증가하는 것을 볼 수 있었다. 그러므로, 제안된 새 해석기법을 이용하면, 터널변형과 지반조건에 따른 최적의 보강기법 선정에 활용할 수 있다. This study is focused on the analysis of tunnel behavior to estimate the stability on tunnel design. An estimation method was proposed as a hybrid consideration, which contains the displacement analysis by 3D numerical simulation, the maximum displacement obtained after field measurement, and an assessment of tunnel stability using a deformation analysis proposed by Sakurai(1988, 1997). The points of case study by Sakurai(1988, 1997) were replotted considering his analysis. From the new analysis of the tunnel case study, the trend line for analyzed points is analogized, which curve is divided into stable, unstable and failure zone. To evaluate the estimation method, a special shape of railway tunnel was selected, which are the Inchon international airport rail way connected to subway line 9 in Gimpo, Korea. The point s of upper and below track on the Inchon international airport rail way were satisfied to the stability of tunnel after reinforcing. Also the points shows the higher apparent Young`s modulus, which resulted from improvement on shear strength by the micro silica grouting and the supporting of umbrella method. Therefore, if new analysis used, proper tunnel reinforcing method could be selected according to tunnel strain and geological property.

물질남용 치료프로그램 후 재범여부에 대한 예비적 추적조사 연구

김현수,조선미,오은영,임기영,정영기,윤웅장,이영미 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 본 연구는 물질사범에게 시행되는 수강명령 프로그램의 효과를 재범률을 중심으로 살펴보고자 한 것이다. 방 법: 이 연구의 대상집단은 보호관찰소에서 의뢰받은 물질남용자집단이다. 이들은 법원으로부터 보호관찰, 수강명령, 치료명령, 사회봉사 등을 부과받았다. 총 104명의 대상자집단을 치료프로그램을 이수한 수강군과 비수강군으로 나누었으며 이들에 대한 재범률을 조사하였다. 결 과: 프로그램을 이수한 수강군이 비수강군에 비해 재범률이 낮았다(p<.05). 또한 단기 수강군과 장기수강군의 재범률의 차이를 조사하였는데 대상자 집단의 수가 적기 때문에 장기 수강군의 효과가 통계적으로 입증되지는 않았다. 결 론: 우리는 물질남용자에 대한 정책이 보다 교육적으로 변화할 것을 본 논문을 통하여 제시하려 하였으며 정부 및 법무부는 물질남용자에게 교육과 치료를 제공해주어야만 한다. Objectives: Using recidivism rate, we investigated the outcome after our substance abuse treatment program had been implemented. Methods: Our target population was substance abuse criminals referred by probational office. They either received the parole and probation order, treatment order or social service order from the court. We divided 104 substance abuse criminals into treatment group and non-treatment group. We examined their recidivism rate. Results: We reached a conclusion that treatment group had lower recidivism rate than non-treatment group(p<.0.5). We examined the effectiveness of short-term and long-term programs. However, no effectivess of long-term program was found because the sabject number was too small. Conclusion: We suggest that the strategies for substance abuse should be changed to more educative ones. The Government and Ministry of Justice must provide education and treatment to the substance abuse criminals.

와이브로(WiBro) Model frame mapper Hardware 구조 설계

윤창중,임웅철,김진상,조원경,김영수,서덕영 경희-다반 ASIC 설계교육센터 2005 경희-다반 ASIC센터 논문집 Vol.6 No.-

WiBro는 하향 링크와 상향 링크를 시간으로 구분하는 TDD방식이 사용되며 다중접속 방식으로는 OFDMA가 사용된다. WiBro 서비스의 특징들은 frame Mapping 과정에서 잘 나타난다 frame은 하나의 frame당 42개의 symbol 단위로 mapping 되며 TFFT Block에서는 하나의 symbol 단위로 frame mapper에서 Data를 불러와 처리한 후 CP insertion, windowing 과정을 거쳐서 단말에 전송한다. 본 논문에서는 WiBro 서비스를 위하여 TTA에서 제정한 표준안을 토대로 모뎀부분을 VHDL 언어를 이용하여 하드웨어로 설계 하였고 Xilinx Vertex 8000을 Target Device로 이용하였다.

토양 과습 조건하에서 수수의 생육특성

윤민헌,권수정,주영환,최주영,우선희 忠北大學校 農業科學硏究所 2021 農業科學硏究 Vol.37 No.2

본문참고

전단보강근량에 따른 초고강도 콘크리트를 사용한 고층형 내력벽의 이력거동

윤현도,연길환,정수영,윤석천,이창갑 忠南大學校 産業技術硏究所 1995 산업기술연구논문집 Vol.10 No.1

Three one fourth scale models using ultra high-strength concrete(f' =704 kg/㎠) are tested under the combined action of a constant axial and a horizontal load cyclically to failure. Such specimens are considered to represent the critical 3-story of low part in 60-story tall building of a structural wall system in area of high seismicity. The amount of vertical reinforcement and the level of applied axial stress are identical for the three wall tested. The cross-section of all walls is barbell shape. The aspect ratio(h /l ) of test specimen is 1.8. The primary objectives of this paper are to investigate the influence of the amount of horizontal reinforcement on the lateral resistance, failure mechanism, ductility and energy-dissipation capability of walls with ultra high-strength concrete. In contrast to what is widely believed, the horizontal web reinforcement does not appear to have a significant effect on shear capacity. Certainly, since the reduction of the web horizontal reinforcement to almost half the value specified by building codes doesn't affect the failure load, this effect in not accounted for by the truss analogy concept. The results obtained have helped to identify the causes of wall failure and have demonstrated that the concepts underlying current ACI Building Code provisions for the design of walls conflict with the observed structural behavior. It has been found that shear resistance is associated with triaxial compressive stress conditions that develop in the compressive zone of the section at the base of the wall.

구조적 설계문제 최적화를 위한 혼합유전알고리즘

윤영수,이상용 한국경영과학회 1998 한국경영과학회지 Vol.23 No.3

Genetic algorithms(GAs) are suited for solving structural design problems, since they handle the design variables efficiently. This ability of GAs considers them as a good choice for optimization problems. Nevertheless, there are many situations that the conventional genetic algorithms do not perform particularly well, and so various methods of hybridization have been proposed. Thus, this paper develops a hybrid genetic algorithm(HGA) to incorporate a local convergence method and precision search method around optimum in the genetic algorithms. In case study, it is showed that HGA is able consistently to provide efficient, fine quality solutions and provide a significant capability for solving structural design problems.

복강경하 질식 자궁적출술 30예의 임상적 고찰 : A Review of 30 Cases

윤병일,김소정,정두용,김수녕,손인숙,이지영 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Hysterectomy is the most common gynecologic operation. Traditionally, hysterectomy was performed either through an abdominal approach or through a vaginal approach. Recently, laparoscopic hysterectomy is quite often tried. To evaluate the effectiveness and value of LA VH(Laparoscopy Assisted Vaginal Hysterectomy), and to evaluate the possibility whether to rep;ace abdominal hysterectomy to LAVH, we analyzed our clinical cases. This clinical study is a retrospective review of 30 cases of LAVH from May 2002 to February 2003 at the department of Obstetrics and Gynecology, Chung- Ju hospital, Konkuk University. We evaluated age, parity, previous abdominal operations, indications of hysterectomy, combined operation, operating time, hemoglobin change, weight of uterus, hospital stay and postoperativeThe average operating time was 146 ± 42 minutes, the uterine weight was 239 ± 126 grams, and the mean postoperative hemoglobin loss was 1.7 ± 1.4 g/dl. The most common pathologic finding was myoma uteri(37%), and the second most pathologic finding was adenomyosis(20%) and myoma uteri with adenomyosis (20%). Serious complications were not appeared. LAVH provides a shorter hospital stay, quicker recovery, and the acceptable complication rate except incerased operating time than abdominal hysterectomy. This study suggests that LAVH appears more useful than TAH(Total Abdominal Hysterectomy) and could replace abdominal hysterectomy.