근린환경과 주관적 정신건강의 관계에서 사회적 자본의 매개효과

( Jin Yinhua ),전희정 ( Jun Hee-jung ) 성균관대학교 국정전문대학원 2021 국정관리연구 Vol.16 No.3

본 연구는 근린환경이 주관적 정신건강에 미치는 영향에서 사회적 자본의 매개효과를 분석하였다. 해당 연구를 수행하기 위해 「2019년 지역사회건강조사」자료를 이용하였고 구조방정식 모형을 활용하였다. 독립변수인 근린환경은 쾌적성과 접근성으로 구분하고 종속변수는 주관적 정신건강으로서 설정하였다. 매개변수는 사회적 자본으로 설정하였다. 분석의 결과 사회적 자본은 근린환경과 주관적 정신건강 간의 관계에서 부분 매개역할을 하는 것으로 나타났다. 근린환경의 쾌적성은 사회적 자본과 연계하여 주관적 정신건강에 증진 효과를 갖고 있으며 근린환경의 접근성과 연계하여 주관적 정신건강을 감소하는 것으로 나타났다. 또한, 사회적 자본의 주관적 정신건강에 대한 영향은 근린환경 요인보다 큰 것으로 파악되었다. 해당 연구결과는 커뮤니티 수준의 정신건강을 향상하기 위한 도시정책 수립에 있어 사회적 자본과 근린환경의 쾌적성이 연계가 필요하며 국민의 전반적인 정신건강 수준을 제고시키기 위해 사회적 자본의 역할을 보다 중요하게 고려하여야 함을 시사한다. This study analyzed the mediating effect of social capital on the relationship between neighborhood environment and subjective mental health. This study used ‘2019 Community Health Survey’ and employed structural equation modeling. Neighborhood environment, the independent variable, was divided into pleasantness and accessibility and the dependent variable is subjective mental health. The mediating variable is social capital. The empirical analysis shows that social capital plays a partial mediating role in the relationship between neighborhood environment and subjective mental health. The pleasantness variable has an enhancing effect on subjective mental health in connection with social capital. Accessibility to neighborhood facilities was found to reduce subjective mental health in connection with social capital. The results of this study indicate that social capital and neighborhood pleasantness need to be linked for urban policies to improve mental health at the community level. Moreover, the study suggests that the role of social capital should be considered more important to improve the general mental health level.

High-Purity Amino-Functionalized Graphene Quantum Dots Derived from Graphene Hydrogel

Yinhua Jin,Hongyi Qin,김장아,김선영,김형우,임용택,김태성,Atul Kulkarni,김동빈 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.12

The unique properties of graphene quantum dots (GQDs) make them interesting candidate materials for innovative applications. Herein, we report a facile method to synthesize aminofunctionalized graphene quantum dots (AF-GQDs) by a hydrothermal reaction. Graphene oxide (GO) was synthesized by Hummer's method where ultra-small GO sheets were obtained by a prolonged oxidation process followed by sonication using an ultrasonic probe. Subsequently, graphene hydrogel (GH) was also obtained by a hydrothermal synthesis method. Proper care was taken during synthesis to avoid contamination from water soluble impurities, which are present in the precursor, GO solution. Following the treatment of GH in ammonia, ultra-small aminofunctionalized graphene fragments (AF-GQDs) were formed, which detached from the GH to eventually disperse evenly in the water without agglomerating. This modified synthesis process enables the formation of high-purity AF-GQDs (99.14%) while avoiding time-consuming synthesis procedures. Our finding shows that AF-GQDs with sizes less than 5 nm were well dispersed. A strong photoluminescence (PL) emission at ~410 nm with 10% PL quantum yield was also observed. These AF-GQDs can be used in many bio applications in view of their low cytotoxicity and strong fluorescence that can be applied to cell imaging.

Composite Nanofilm of Polypyrrole and Mycosporine-like Amino Acids for UV sensor

Yinhua Jin,Atul Kulkarni,Hongyi Qin,Dae-hwan Kim,Yeong Wook Yu,Joon Chul Lee,Taesung Kim,Sang Hun Moh 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.2

공임대주택과 주거급여 제도의 효과성에 관한 연구 2016년과 2021년 비교를 중심으로

( Jin Yinhua ),전희정 한국행정학회 2022 한국행정학회 학술발표논문집 Vol.2022 No.2

본 연구는 주거급여 제도 및 공공임대주택을 중심으로 주거복지정책의 효과성에 대해 분석하였다. 주거만족도의 전후 차이를 비교· 분석하기 위해 2016년과 2020년 주거실태조사를 사용하였으며 다음과 같은 연구질문을 제시하였다. “주거급여 수급자와 공공임대 거주가구의 주거만족도는 실제로 향상되었는가?‘, ”공공임대주택 거주가구와 주거급여 수급가구의 주거만족도 영향요인에는 변화가 있는가?“ 따라 연구질문에 대해 실증분석을 하기 위해 본 연구에서는 t-test, x² test 및 다중회귀분석을 실시하였다. 연구결과 주거급여제도는 개편 후 주거만족도가 제고되었으며 공공임대주택 거주가구와의 차이가 감소되었다. 둘째, 공공임대주택과 주거급여 수급가구의 주거만족도 주택 및 근린특성 영향요인에는 모두 변화가 나타났다. 셋째, 시간에 따른 주거복지정책의 효과성이 나타났다. 이에 각 집단의 주거만족도 변화를 바탕으로 본 연구는 주거복지정책의 실태를 파악함과 동시에 미래 주거복지정책의 방향성을 제시하고자 한다.

Preparation of nano scale crumpled CVD graphene

Yinhua Jin,Hyeong-U Kim,Jang Ah Kim,Hyunjae Chung,Taesung Kim 한국진공학회 2017 한국진공학회 학술발표회초록집 Vol.2017 No.2

주거급여 수급 및 공공임대주택 거주 가구의 주거만족도 및 영향요인 변화에 관한 연구: 2016년과 2020년 주거실태조사 자료 비교를 중심으로

JIN YINHUA,전희정 한국도시행정학회 2023 도시 행정 학보 Vol.36 No.1

This study aims to examine the level of residential satisfaction and contributing factors of housing benefit recipients and public housing residents by comparing the 2016 and 2020 Housing Survey Data. We ask two research questions: 1) Did the levels of residential satisfaction among housing benefit recipients and public housing residents change between 2016 and 2020?; 2) Did the contributing factors on residential satisfaction among housing benefit recipients and public housing residents change between 2016 and 2020? For empirical analysis, we used 2016 and 2020 Housing Survey Data and employed t-test, chi-squared test and multiple regression analyses. The results show that residential satisfaction among housing benefit recipients significantly improved between 2016 and 2020 while that among public housing residents did not. Next, compared to that in 2016, residential satisfaction among housing benefit recipients in 2020 is affected by more diverse factors. More specifically, in 2020, all of housing structure, lighting conditions, residential area, and neighborhood characteristics affect residential satisfaction among housing benefit recipients. 본 연구는 2016년과 2020년 주거실태조사 자료를 활용하여 주거급여 수급 및 공공임대주택 거주 가구들의 주거만족도 및 영향요인을 분석하고 시기별 차이를 비교하여 주거복지정책의 효과성을 분석하는 것을 목적으로 한다. 이에 대한 연구질문은 “2016년과 2020년 사이 주거급여 수급 및 공공임대주택 거주가구의 주거만족도는 변화하였는가?”, “2016년과 2020년 사이 주거급여 수급 및 공공임대주택 거주가구의 주거만족도 영향요인은 변화하였는가?”로서 제시하고 실증분석을 위해 본 연구에서는 t-test, chi-squared test 및 다중회귀분석을 실시하였다. 연구결과 첫째, 주거급여 수급가구들의 주거만족도가 제고되었으며 공공임대주택 거주가구들과의 주거만족도 차이가 감소되었다. 둘째, 공공임대주택 거주가구들의 주거만족도 영향요인에는 큰 변화가 없었으나 주거급여 수급가구의 주택 및 근린특성 영향요인에는 모두 변화가 나타났다. 2020년 주거급여 수급가구는 주택 특성의 집의 구조물, 채광상태, 주택면적과 근린 특성의 모든 요인이 주거만족도에 영향을 미치는 것으로 2016년에 비해 다양한 요인의 영향을 받고 있었다. 이에 각 집단의 주거만족도 변화를 바탕으로 본 연구는 주거복지정책의 실태를 파악함과 동시에 향후 주거복지정책의 방향성을 제시하였다.

Preparation of high purity graphene quantum dots for bio imaging

Yinhua JIN,Hongyi QIN,Sun-Young KIM,Yong Taik LIM,Taesung KIM 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of <i>Cyfip2</i> -Null Embryonic Mice

Zhang, Yinhua,Kang, Hyojin,Lee, Yeunkum,Kim, Yoonhee,Lee, Bokyoung,Kim, Jin Yong,Jin, Chunmei,Kim, Shinhyun,Kim, Hyun,Han, Kihoon Frontiers Media S.A. 2018 Frontiers in molecular neuroscience Vol.11 No.-

<P>Cytoplasmic FMR1-interacting protein 2 (CYFIP2) is a key component of the WAVE regulatory complex (WRC) which regulates actin polymerization and branching in diverse cellular compartments. Recent whole exome sequencing studies identified <I>de novo</I> hotspot variants in <I>CYFIP2</I> from patients with early-onset epileptic encephalopathy and microcephaly, suggesting that CYFIP2 may have some functions in embryonic brain development. Although perinatal lethality of <I>Cyfip2</I>-null (<I>Cyfip2</I><SUP>−/−</SUP>) mice was reported, the exact developmental time point and cause of lethality, and whether <I>Cyfip2</I><SUP>−/−</SUP> embryonic mice have brain abnormalities remain unknown. We found that endogenous <I>Cyfip2</I> is mainly expressed in the brain, spinal cord, and thymus of mice at late embryonic stages. <I>Cyfip2</I><SUP>−/−</SUP> embryos did not show lethality at embryonic day 18.5 (E18.5), but their body size was smaller than that of wild-type (WT) or <I>Cyfip2</I><SUP>+/−</SUP> littermates. Meanwhile, at postnatal day 0, all identified <I>Cyfip2</I><SUP>−/−</SUP> mice were found dead, suggesting early postnatal lethality of the mice. Nevertheless, the brain size and cortical cytoarchitecture were comparable among WT, <I>Cyfip2</I><SUP>+/−</SUP>, and <I>Cyfip2</I><SUP>−/−</SUP> mice at E18.5. Using RNA-sequencing analyses, we identified 98 and 72 differentially expressed genes (DEGs) from the E18.5 cortex of <I>Cyfip2</I><SUP>+/−</SUP> and <I>Cyfip2</I><SUP>−/−</SUP> mice, respectively. Further bioinformatic analyses suggested that extracellular matrix (ECM)-related gene expression changes in <I>Cyfip2</I><SUP>−/−</SUP> embryonic cortex. Together, our results suggest that CYFIP2 is critical for embryonic body growth and for early postnatal survival, and that loss of its expression leads to ECM-related gene expression changes in the embryonic cortex without severe gross morphological defects.</P>

KIKO는 과연 수출기업에게 적절한 환위험관리 수단이었나? 효율적 시장가설 검증을 중심으로

김은화(Yinhua Jin),김태중(Tae-Joong Kim),이재호(Jae-Ho Lee) 한국무역연구원 2016 무역연구 Vol.12 No.2

This paper focuses on how foreign exchange risk management of a company, particularly through foreign exchange derivatives, influences the company’s stock price. Based on 2008 biannual reports of KOSPI and KOSDAQ listing companies reflecting a loss from derivatives trading and using the event study method, this study analyzes the impact of existing derivatives contracts as well as types of derivatives on the company’s stock prices. It also examined how foreign exchange rate change influences these companies’ stock values. Derivatives loss has any impact to company stock price. Results show that disclosure of derivatives loss causes a significant negative impact on stock prices of these companies. Moreover, findings reveal that the higher the hedge ratio of a company is, the larger the losses. As for KIKO (Knock In, Knock Out) trading, results exhibit a significantly negative impact on stock prices while foreign exchange rate fluctuations do not reflect any significant impact on the company’s stock values.

Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in <i>Shank3</i> -Overexpressing Mice

Jin, Chunmei,Kang, Hyojin,Ryu, Jae Ryun,Kim, Shinhyun,Zhang, Yinhua,Lee, Yeunkum,Kim, Yoonhee,Han, Kihoon Frontiers Media S.A. 2018 Frontiers in molecular neuroscience Vol.11 No.-

<P>Variants of the SH3 and multiple ankyrin repeat domain 3 (<I>SHANK3</I>) gene, encoding excitatory postsynaptic core scaffolding proteins, are causally associated with numerous neurodevelopmental and neuropsychiatric disorders, including autism spectrum disorder (ASD), bipolar disorder, intellectual disability, and schizophrenia (SCZ). Although detailed synaptic changes of various <I>Shank3</I> mutant mice have been well characterized, broader downstream molecular changes, including direct and indirect changes, remain largely unknown. To address this issue, we performed a transcriptome analysis of the medial prefrontal cortex (mPFC) of adult <I>Shank3</I>-overexpressing transgenic (TG) mice, using an RNA-sequencing approach. We also re-analyzed previously reported RNA-sequencing results of the striatum of adult <I>Shank3</I> TG mice and of the prefrontal cortex of juvenile <I>Shank3<SUP>+/</SUP></I><SUP>Δ</SUP><I><SUP>C</SUP></I> mice with a 50–70% reduction of Shank3 proteins. We found that several myelin-related genes were significantly downregulated specifically in the mPFC, but not in the striatum or hippocampus, of adult <I>Shank3</I> TG mice by comparing the differentially expressed genes (DEGs) of the analyses side by side. Moreover, we also found nine common DEGs between the mPFC and striatum of <I>Shank3</I> TG mice, among which we further characterized ASD- and SCZ-associated G protein-coupled receptor 85 (<I>Gpr85</I>), encoding an orphan <I>Gpr</I> interacting with PSD-95. Unlike the mPFC-specific decrease of myelin-related genes, we found that the mRNA levels of <I>Gpr85</I> increased in multiple brain regions of adult <I>Shank3</I> TG mice, whereas the mRNA levels of its family members, <I>Gpr27</I> and <I>Gpr173</I>, decreased in the cortex and striatum. Intriguingly, in cultured neurons, the mRNA levels of <I>Gpr27</I>, <I>Gpr85</I>, and <I>Gpr173</I> were modulated by the neuronal activity. Furthermore, exogenously expressed GPR85 was co-localized with PSD-95 and Shank3 in cultured neurons and negatively regulated the number of excitatory synapses, suggesting its potential role in homeostatic regulation of excitatory synapses in <I>Shank3</I> TG neurons. Finally, we performed a gene set enrichment analysis of the RNA-sequencing results, which suggested that Shank3 could affect the directional expression pattern of numerous ribosome-related genes in a dosage-dependent manner. To sum up, these results reveal previously unidentified brain region-specific and broad molecular changes in <I>Shank3</I>-overexpressing mice, further elucidating the complexity of the molecular pathophysiology of <I>SHANK3</I>-associated brain disorders.</P>