조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

기독교 교역자들이 주장하는 귀신들림에 대한 정신의학적 고찰

신형균,손진욱,우성일 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.6

Opinions and experiences about demon possession and mental disease were collected from clergymen in the western area of Gyeongsangnamdo by the mail questionnaire and direct interview. The results can be summarized as follows. 1) The majority of respondents thought that demons were fallen angels(92.3%) and existing at that time(96.6%). Many of them(63.2%) thought that the incidence of demon possession was increasing. 2) The majority of respondents(94.9%) had seen individuals possessed by demons and they believed in the existence of demon possession firmly. Those who were possessed by demons were mainly females, in their 20th and 30th, with short academic career, in low SES and with shamanistic beliefs. 3) Many respondents thought that mental diseases were different from demon possession(94.0%) and it was possible to distinguish between them(67.5%). Violent behavior, soliloquy, avoidance of eye contacts with clergyman, bizarre voice, social withdrawal and auditory hallucination were regarded as features of demon possession. 4) As the cause of demon possession, many respondents regarded non-religious factors such as psychological conflict or trauma(59.0%) and personality(10.3%), while smaller number of them regarded religious factors such as own sin or unbelief(35.0%) and divine providence(12.8%). Many respondents(76.2%) had treated individuals possessed by demons with religious healing techniques only, but many respondents(61.5%) also thought that medical treatments must be combined. 5) Many respondents(72.6%) never studied mental diseases and their knowledge about mental diseases were mainly from the Bible. 6) Cases of demon possession collected by mail questionnaire can be diagnosed as follows : 37.5%, schizophrenia, 34.4%, atypical psychosis and schizophreniform disorder, and the remainder, dissociative disorder, mood disorder and delirium tremens. 7) Symptomatic features of demon possession were not different from the symptoms of mental illness, and the cases of demon possession were not essentially different from mental diseases. Through mutual understanding and cooperation, both clergymen and psychiatrists can find better ways of treating the individuals possessed by demons and get deeper insights about human psyche.

여성 복압성 요실금에서 질전벽슬링수술의 효과

신홍석,유진욱,정희창,박동춘 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: The purpose of this study was to determine the efficacy and safety of the anterior vaginal wall sling in the management of women with stress urinary incontinence. Materials and Methods: From January 1998 to December 1999, 42 patients(31 with genuine stress urinary incontinence and 11 with mixed urinary incontinence, 38 with anatomical incontinence and 4 with intrinsic sphincteric deficiency) underwent anterior vaginal wall sling at Yeungnam University Hospital were studied retrospectively. The mean age was 49.3 years(ranging from 34 to 66 years of age) and the mean follow-up period was 29.4 months(ranging from 16 to 40 months). Intra- and postoperative complication, success rate and patient's satisfaction were evaluated. Results: The mean operation time was 79 minutes(ranging from 65 to 124 minutes) and the mean hospital stay was 5.1 days(ranging from 4 to 10 days). Mean postoperative Foley catheter drainage was 2.1 days(ranging from 1 to 5 days). As a complication, bladder perforation occurred in one patient(2.4%), residual urine sensation developed in seven patients(16.7%), and suprapubic pain was complained in five patients(11.9%), which improved gradually. Vaginal epithelial inclusion cyst occurred in one patient(2.4%) at postoperative 31 months. Four(9.4%) patients with de novo instablility were improved by anticholinergics medication. The success rate was 92.9% and 38 patients(90.5%) were satisfied with this procedure. Conclusion: We consider that the anterior vaginal wall sling to be a safe and effective surgical procedure for the treatment of female stress urinary incontinence, but a longer follow-up is necessary to determine long term effect.

중년 직장 남성의 피로도와 심박동변이

송상욱,신진희,Findley, Thomas 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.1

목적: 이 연구는 중년 직장 남성의 피로도와 심장 자율 신경 기능과의 관련성을 심박동변이의 분석을 통해서 알아보고자 하였다. 방법: 대학 부속 병원에서 종합건강검진을 받은 자동차 생산 공장의 중년 남성 근로자 중 특이 병력이 없는 82명을 연구 대상으로 하여 연령, 키, 체중, 혈압, 음주 및 흡연력, 규칙적인 운동 여부 등과 함께 피로도 및 심박동변이를 평가하였다. 피로도 평가는 Krupp 등에 의해서 개발된 자가-보고 형식의 Fatigue Severity Scale(FSS)을 이용하였으며, 피로도 점수에 따라 연구 대상을 저피로군(N=31), 중등도 피로군(N=33), 고피로군(N=18)으로 분류하였다. 심박동변이의 평가는 안정 상태에서의 5분 동안 심전도 기록을 시간 범주인 Standard Deviation of NN intervals(SDNN), Root-Mean-Square of Successive Differences(rMSSD)와 주파수 범주인 Total Power(TP), Low Frequency(LF: 0.04∼0.15 Hz) power, High Frequency(HF: 0.15∼0.4 Hz) power, LF/HF비로 나누어 분석하였다. 결과: 피로 정도에 따라 분류한 세 군의 평균 피로도 점수는 저피로군이 2.1±0.7, 중등도 피로군이 3.7±0.4, 고피로군이 5.2±0.4 이었다(p<0.001). 세 군간의 인구사회학적 특성 비교에서 흡연 유무에 있어서는 차이를 보였지만 이외에 나이, 수축기 및 이완기 혈압, 심박수, 체질량지수, 음주 유무, 규칙적인 운동 여부에 있어서는 통계적으로 유의한 차이를 나타내지 않았다. 세 군간의 심박동변이 값의 차이는 시간 범주 분석 항목에서는 통계적으로 유의한 차이를 나타내지 않았지만 주파수 범주 분석 함목 중에서는 In(natural logarithm) LF 및 HF 값이 고피로군에서 저피로군에 비해 유의하게 감소하는 것으로 나타났다(p=0.009. p=0.0015). 그 외 In TP 및 LF/HF ratio 값은 세 군간에 통계적으로 유의한 차이를 나타내지 않았다. 흡연 유무에 따른 심박동변이 값은 시간 및 주파수 범주 분석 항목 모두에서 유의한 차이가 없었으며, 심박동변이 값에 대한 피로도와 흡연 유무와의 유의한 교호 작용 또한 관찰되지 않았다. 결론: 중년 직장 남성의 극심한 피로 상태가 심박동변이 분석에서 교감 및 부교감 신경 기능의 감소와 관련이 있음을 알 수 있었다. 이는 심장에 대한 자율신경 조절의 이상을 반영하며, 아직까지 정확한 기전을 알 수는 없지만 이들에게서 심혈관 질환의 발생 위험이 증가할 수 있음을 시사한다. 아울러 향후에는 잘 계획된 전향적 연구를 통하여 이에 대한 추적 관찰이 필요할 것이다. Objectives: This study investigated the relationship between the severity of fatigue and the cardiac autonomic function by analyzing the heart rate variability on middle-aged male workers. Methods: The severity of fatigue and heart rate variability were assessed with the control measures of age, body mass index, blood pressure, alcohol consumption, smoking history, regular exercise on 82 healthy middle-aged male workers in an annual health checkup. The severity of fatigue was evaluated by the Fatigue Severity Scale (FSS), which was developed by Krupp. The 5-minute electrocardiographic recordings were analyzed as a function of the time and the frequency domain methods of the heart rate variability (HRV). Standard Deviation of the NN intervals (SDNN), Root-Mean-Square of Successive Differences (rMSSD), Total Power (TP), Low Frequency (LF: 0.04∼0.15 Hz) power, High Frequency (HF: 0.15-0.4 Hz) power, LF/HF ratio were used as the indices of the HRV. For a comparison of autonomic nervous functions and other variables, the subjects were divided into three fatigue groups based on the FSS score as follows: low (N=31), moderate (N=33), high (N=18) fatigue groups Results: There were no significant differences in age, blood pressure, heart rate, body mass index, alcohol consumption, or regular exercise except for the smoking history among the groups. In addition, there were no significant differences in the time domain analysis (SDNN, rMSSD) of HRV among the groups. Spectral analysis of the HRV showed that the mean amplitudes of the HF and LF component were lower in the high fatigue group, whereas there was no significant difference in the LF/HF ratio among the fatigue groups. There were no significant differences in the HRV indices between the smoking and non-smoking groups. No significant interacting effects between the severity of fatigue and smoking on the HRV were observed. Conclusions: The association between severe fatigue and the reduced high and low frequency components of the HRV in middle-aged male workers reflects a dysregulation of the cardiac autonomous control. Although the pathophysiological mechanism of this association remains unclear, these results might explain their increased risk for cardiovascular disease. However, these effects need to be confirmed through a well-designed prospective study.

UV 센서를 위한 Spiroxazine LB 단분자막 특성에 대한 연구

최성욱,박은진,장지훈,김재호,강신원 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

9-12%Cr강의 첨가원소 및 열처리에 따른 미세조직거동과 경도변화

주성욱,유정훈,신기삼,허성강,이재현,석진익,김병훈,김정태 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

9-12%Cr steel are getting increasing attention for expanded application as high temperature materials applicable for gas turbine compressors, steam turbine rotors, blade and casing. For efficient and extensive application of 9-12%Cr steel, the data in addition to the improvement of mechanical properties on the correlation of microstructural evolution and mechanical properties are inevitable and thus the investigation in this study is performed for the determination for the specimens heat-treated at 600, 650 and 700℃ for 1000, 3000 and 5000hrs. The microstructure of as-received specimen was tempered martensite, with a high dislocation density and secondary phases. Upon high temperature heat-treatment, the martensite lath got larger and dislocation density decreased resulting the reduction of the strength. In addition, sharp growth of secondary phases was observed in the specimen heat-treated at 700℃ for 5000hrs. A specimen aged at 600℃ and 650℃ Laves phase was observed. The hardness showed close relationship with the secondary phase particle and dislocation density.

모듈간의 유사성 분석을 통한 시스템 규모 축소 및 재사용에 대한 연구

최신형,허경욱,진광윤 三陟大學校 1999 論文集 Vol.32 No.1

소프트웨어에서 유사한 모듈의 분석으로 소프트웨어 시스템 규모를 축소하거나 재사용 여부를 판단할 수 있다. 본 논문에서는 모듈간 유사성을 나타내는 방법으로 모듈 유사성률과 복잡성을 측정하는 사이크로매틱 그래프를 이용하여 유사한 모듈들을 하나로 통합해서 새로운 모듈을 만들어서 사용하는 방안을 제시한다. 이는 시스템 규모 축소와 모듈 재사용을 위해서 유사한 모듈을 찾아내어 구조화하는데 유용하다.

스쿠알렌 합성 유전자를 도입한 형질전환 가시오가피

서진욱,정재훈,최용의,이학성,신차균 중앙대학교 유전공학연구소 2003 遺傳工學硏究論集 Vol.16 No.1

The enzyme, squalene synthase, represents a branch point in the isoprenoid pathway capable of diverting carbon flow specifically to the biosynthesis of phytosterol and Triterpenoid. Transgenic Eleutherococcus senticosus plants were prepared by introducing the genes for squalene synthase derived from Panax ginseng (PgSS1), hygromycin phosphotransferase (HPT) and green fluorescent protein (GFP) through Agrobacterium-mediated transformation. Establishment of transgenic plantlets were confirmed by the presence of PgSS1 and HPT bands in the genomic DNA preparation using a PCR method and a Southern blotting. In addition, expression of the introduced GFP DNA was confirmed by observing green fluorescence of GFP from the embroyos. In the in vitro analysis of the PgSS1 enzymatic activities the transgenic plants showed to have 1.5 to 3 times higher than wild type plant, indicating that the PgSS1 genes was well over-expressed in the transgenic plants. Especially the PgSS1 acivities of embroyogenic cell was 120 times higher than those of plantlet.

鬱血症을 同伴한 파킨손氏病에 對한 電氣痙攣療法 治驗 1例

朴哲秀,姜東佑,申瑩均,孫鎭旭,韓圭熙 서울醫大 1990 精神醫學 Vol.15 No.1

RAW 264.7 세포에 대한 중국산 천연 광물성 섬유 TAFMAG의 독성효과

임영,한진구,김지홍,김현욱,김은경,김경아,장황신 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3

Objectives : This study was designed to evaluate cytotoxicity of TAFMAG, which is a trade name of natural mineral fiber mined and produced in China. Methods : The cytotoxicity of TAFMAG was evaluated by measuring iron content, lipid peroxidation, erythrocyte hemolysis, and cytotoxicity in vitro. These results were compared with the data of chrystotile and wollastonite as a positive and negative control, respectively. Results : There was significant increase of Fenton activity in TAFMAG and chrysotile with dose-response pattern. The iron chelating agent, desferrioxamine, significantly decreased Fenton activity of the particulates except wollastonite. TAFMAG and chrysotile fibers significantly increased malondialdehyde concentration from lipid peroxidation of the red blood cell membrane. In erythrocyte hemolysis test, TAFMAG & chrysotile had stronger effect on erythrocyte hemolysis than wollastonite with the concentration of 1,000g/ml. Furthermore, TAFMAG was more hemolytic than chrysotile with the concentration of 5,000g/ml. There was a significant cytotoxic effect in TAFMAG and chrysotile on RAW cell compared with wollastonite. Conclusions : In vitro study suggested that TAFMAG may have a similar health hazard as usual asbestos.