노인의료서비스정책의 발전방안에 관한 연구

심민수,정희선,심미연 원광대학교 대학원 2007 論文集 Vol.38 No.-

The population of the Aged in Korea is more rapidly growing, as compared with that of other countries, which raises serious intricacies in every walk of life, including politics, economy, society, and so forth. In particular, old-age medical service may be said to be one of the largest variables that produce a direct effect upon the good quality of old-age life. Furthermore, it functions as one of the most difficult impedi-ments in building an integration in society. The republic of Korea has made a great deal of efforts for old-age medical service but is now in an early stage. With this n view, this study puts its principal objective on groping for measures for the development of old-age medical service, and suggests some of them, as follows: First, from an environmental perspective, the Republic of Korea is greatly affected by its political influencing power, and so politics and economy need to be grow to a higher stage. And this study suggests changes in the overall age-group social structure and the eradication of a negative image of the aged, on a sociocultural side Second, it is recommended to boldly correct unreal or irrational laws and systems if any, on a legal system dimension. And this study suggests some strategies to establish old-age hospitals, to expand professional personnel, and to extend the range of medical allowances. Thirds, this study suggests measures to pay medical allowances for old-age health diagnoses for disease prevention is the national medical insurance system, to reduce the cost bearing in the use of high-priced medical equipments, to extend the application of administration of Oriental medicine and dental treatment in the old-age medical allowances. Fourth, this study suggests how to objectify the selection of subjects of the underprivileged, how to rationally calculate the amount of properties according to the standards of income, and how to reduce supporting obli-gators for beneficiaries of medical allowances for the underprivileged. Fifth, this study suggests the diversification and specialization of sanatoriums, the generation of subjects of home old-age welfare, and methods of rational fund-raising for long-term medical care. Sixth, this suggests the establishment of an old-age welfare police-making organization in the government, proper personnel allotment, the reestablishment of administrative functions among local governments, and the securement of officeholders in charge of social welfare. Finally, it is absolutely needed to augment the budget to expand the substrata of old-age medical services. In addition to it, to secure a budget on a proper scale for old-age medical services in consideration of the growing population of the aged.

스피로노락톤의 한국인 지원자에서의 약물속도론적 연구

심희옥,이선영,지웅길,김동출 충남대학교 약학대학 의약품개발연구소 2005 藥學論文集 Vol.20 No.-

A reversed phase HPLC method was developed and validated for the determination of spironolactone in human plasma. Fenoprofen was used as an internal standard. Calibration curves were linear in the concentration range of 2.5~200 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 100 ㎎ of spironolactone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(12hr) was 158.9±69.9 ngㆍhr/㎖, C_(max) was 42.2±14.9 ng/㎖, T_(max)was 1.79±0.60 hr, t_(1/2) was 2.72±0.87 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of spironolactone.

삼림토양의 미생물군집과 아밀라아제 활성에 관한 연구

이희선,심재국 西原大學校 基礎科學硏究所 1995 基礎科學硏究論叢 Vol.9 No.-

식생형이 다른 임상의 토양에서 토양요인과 총 세균수, 토양 amylase 활성 및 미생물량을 측정하고, 각 임상토양으로부터 분리된 세균에 대하여 상수리나무와 리기다소나무의 생잎 추출액의 타감효과를 검토하였다. 그 결과를 요약하면 1. 총 세균수는 서어나무림 토양이 소나무림보다 4~7배 많았으며, 이러한 차이는 발효층에서 가장 컸다. 2. 토양 아밀라아제 활성은 총 세균수, 토양유기물 함량과 매우 높은 양의 상관관계를 나타냈으며, 발효층은 부식층보다 4~5배, 부식층은 A층보다 2~4배 활성이 컸다. 3. 미생물량은 연중 여름철에 가장 많았으며, 토양의 깊이 증가에 따라 감소하는 수직분포를 나타냈다. 대부분의 경우 소나무림 토양이 졸참나무림 토양보다 큰 값을 나타냈다. 4. 리기다소나무와 상수리나무 생잎 추출액은 토양에서 분리된 세균들에 대하여 그들의 성장을 촉진 또는 저해하였다. 상수리나무 생잎 추출액의 경우 리기다소나무 추출액보다 많은 균종에 대하여 그 성장에 저해를 나타냈다. 리기다소나무림과 상수리나무림 토양에서 분리된 균주가 우점종의 생잎 추출액에 의해 저해받는 경우는 각각 4.2%, 25%로 나타났다. Soil condition, total number of bacteria, soil amylase activity and microbial biomass (CO₂-C) were measured at soil of different forest types. And the difference of the allelopathic effect was determined between fresh leaf extract of Quercus acutissima and Pinus rigida to the bacteria isolated from soil of different forest types. 1. Total number of bacteria in Carpinus laxiflora forest soil was 4~7 times larger than that in Pinus densiflora forest soil. 2. Soil amylase activity was positively correlated with total number of soil bacteria and soil organic matter content. The amylase activity at F layer was 4~5 times larger than that at H layer, and that at H layer was 2~4 times larger than that at A layer. 3. Seasonal changes of microbial biomass showed a peak in summer, and vertical distribution of microbial biomass decreased with increasing soil depth. The microbial biomass in Pinus densiflora forest soil was larger than that in Quercus serrata forest soil. 4. Fresh leaf extract of Pinus rigida and Quercus acutissima showed an acceleration or inhibition effect on the growth of soil bacteria, and that of Q. acutissima inhibited larger number of soil bacterial strains than that of P. rigida. 4.2% and 25% of soil bacterial strains isolated from soil of P. rigida and Q. acutissima forests were inhibited by fresh leaf extract of P. rigida and Q. acutissima, respectively.

德裕山 森林群落의 植物社會學的 硏究

李喜銑,沈載國 西原大學校 基礎科學硏究所 1988 基礎科學硏究論叢 Vol.1 No.-

Mt.Dukyoo is 1,594m high, located in latitude 35。51'N and longitude 127。45'E, and very famouse mountain in Korea. The vegetation, soil and topographical factors of the mountain were investigated, and discussed on the continuous changes of the vegetational structures and species compositions according to the elevational changes. The vegetation of Mt.Dukyoo was changed continuously along with elevational increase. Below of 1,100m of the sea level was dominated by Quercus serrata and Q.mongolica and the upper parts of the level was dominated with Q.mongolica almost absolutely. The top part of the mountain was covered with dwarfed Q.mongolica, Betula platyphylla var.japonica and Taxus cuspidata. These continuous changes of vegetation coincide with vertical distribution of Kira's Warmth Index and didn't affected by soil factors such as soil pH, organic content and water content. In the point of view of climatic factors and species composition, the vegetation of the Mt.Dukyoo is assumed to be cool temperate broad leaved forest in lower part of the sea level 1,300m and the beginning of subalpine coniferous forest in upper of the level. On the order hand, species diversity and eyeness for each diversity index were very in all plots sampled, so that the plant communities of Mt.Dukyoo seems to be mature and very stable.

여성들의 자기효능감과 건강증진행위에 관한 연구

정숙희,하안례,심선녀,이용환,김광혁 고신대학교보건과학연구소 2003 보건과학연구소보 Vol.13 No.-

The results were as follows : The higher the degree of self-efficacy feeling, one of the recognition factor was the more did they do health-promoting activities (γ=0.48, p=0.00). The conducting degree of health-promotion activities resulted in 3.79 points in the perfect score of 6point, which was a quiet high result. The subordinate areas under the health-promoting activity were adjustment of personal relationshiP (4.42), nutrition (3.93), stress control (3.87), self-realization (3.64), alcoholic drink/smoking (3.38), and responsibility for health. As for the differences of self-efficacy feeling according to subjects general characters, significant differences were found in the areas of age, occupation, whether or not they have taken healthrelated lectures, family and geriatric diseases of family members or relatives. The above study results tell that the self-efficacy feeling has a great effect on their putting the health-promoting activities into practice, in daily life.

경연 대회를 통한 초ㆍ중고생의 창의력 신장 효과에 관한 연구

이희복,육근철,류해일,김현섭,김희수,박달원,유병환,김선효,김여상,서광수,변두원,서명석,배성효,박종석,심규철,이성희 공주대학교 과학교육연구소 2001 과학교육연구 Vol.32 No.1

미래 사회를 대비하기 위한 개인의 개성을 존중과 창의적인 능력을 지닌 인간을 양성을 목적으로 충청남도 지역의 초 ㆍ 중고등학생들을 대상으로 한 창의력 경연대회가 공주대학교 과학교육연구소에서 개최되었다. 충청남도 초 ㆍ중 ㆍ 고등학생들을 대상으로 실시한 창의력 경연대회는 창조적 아이디어를 내어 스스로 문제를 해결해 나갈 수 있는 교육 프로그램을 제공하는 좋은 기회였음이 확인되었으나, 일부의 팀에서만 참신하고 재미있는 아이디어들이 제안되었다. 여학생의 참가자 수가 상당히 증가하였으며, 대체적으로 입상권의 학생들의 상당 부분이 여학생이라는 것이 특이할만하다. 학년이 올라감에 따라서 창의적인 아이디어를 내는 양이나 질에 있어서 뒤떨어지는 것으로 분석되었으며, 토론 학습의 적응력이 미흡하고 발표력 및 청취력에 있어서도 떨어지는 것으로 나타났다. 따라서 중 ㆍ고등학교의 학교교육에서도 학생들에게 프로젝트형 탐구학습 프로그램의 적용은 물론 토론식 수습을 통한 학생들의 사고의 전환의 기회를 제공해야 할 것으로 사료된다. The creativity competition was held to foster the creativity of elementary and secondary school students in the Institute of Science Education, Kongju national University. It was found that the creativity competition effected on the improvement of inventing creative ideas and problem solving activities. But, only some competitors participated in semifinal and final contests, presented original and interesting ideas. More female students participated in competition than last year. More female participants were awarded a prize than males. Totally, participants were defective in discussion and communication, and presentation and listening ideas. Increasing grades correlated inversely with creativity and originality. There is need of inquiry project teaming programs and presenting opportunities of conversion of thinking by discussing instructions in school

소집단 책 만들기 활동이 유아의 창의성과 사회적 기술에 미치는 영향

조순자,심성경,변길희 이화여자대학교 교과교육연구소 2015 교과교육학연구 Vol.19 No.4

The purpose of this study is to examine the effect of book making activities in small groups devised and practiced by the researcher on young children’s creativity, and social skills. The study was conducted with a total of 43 five-year-old children in two classes of K Kindergarten in the city of J, Jeonbuk. The children were randomly divided into an experimental group(n=20) and a control group(n=23). Test tools for young children’s comprehensive creativity designed by Jeon Kyung Won(2010), rating scale tools for young children translated by Jeong Young Sun(2005) based on the social skills Rating Scales designed by Elliott and Gresham(1990) were used. Collected data were analyzed by using SPSS 20.0 program and a t-test was conducted to find out the difference between the experimental group and the control group. The results of the study are as follows. First, book making activities in small groups generally improved young children’s creativity such as originality, fluency, flexibility, and imagination. Second, book making activities in small groups generally improved young children’s Social Skills such as cooperation/ compliance, assertiveness, and self-control. 본 연구의 목적은 소집단 책 만들기 활동을 고안, 실시하여 유아의 창의성과 사회적 기술에 미치는 영향을 밝히는 것이다. 이를 위해 전라북도 J시에 소재한 K유치원의 만 5세 2개 학급의 유아 43명 중 1학급의 유아 20명을 실험집단, 다른 1학급의 유아 23명을 통제집단으로 임의 배정하였다. 또한, 유아의 창의성을 측정하기 위하여 Jeon(2010)이 만 4세에서 6세까지 유아를 대상으로 표준화한 ‘유아 종합 창의성 검사(K-CCTYC)와 유아의 사회적 기술을 측정하기 위하여 Eliott와 Gresham(1990)에 의해 고안된 사회적 기술 척도 중 유아용 척도를 Chung(2005)이 번역한 것을 사용하였다. 본 연구는 교사훈련, 검사자 및 평정자 훈련과 예비 검사, 사전검사, 실험처치, 사후검사 순으로 총 16주에 걸쳐 이루어지며 사전에 4주간의 예비연구를 진행하였다. 수집된 자료는 SPSS/PC 20.0 프로그램을 이용하여 실험집단과 통제집단의 사전-사후 점수 증가분에 대한 독립표본 t-검증을 실시하였다. 본 연구에서 얻어진 결과는 다음과 같다. 첫째, 소집단 책 만들기 활동은 유아의 창의성 발달을 전반적으로 증진시킨다. 즉, 유아의 독창성, 유창성, 융통성, 상상력의 4가지 하위영역 모두에서 긍정적인 효과가 있다. 둘째, 소집단 책 만들기 활동이 유아의 사회적 기술 행동을 전반적으로 증진시킨다. 즉, 협동/순응, 자기주장, 자아통제의 3가지 하위영역 모두에서 증진효과가 있다.

신원방우황청심원의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

신원방우황청심원액의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

신우황청심원액의 심혈관계에 관한 약효연구

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

In order to investigate the pharmacological properties of New Woohwangchungsimwon Liquid (NCL), efects of Woohwangchungsimwon Liquid (CL) and NCL were compared. In isolated rat aorta, NCL and CL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^6M) without regard to intact endothelium or denuded rings of the rat aorta. Furthemore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxation of NCL and CL. NCL and CL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dosedependent manner. In conscious spontaneously hypertensive rats (SHRs), NCL and CL significantly decreased heart rate. NCL and CL, at high doses, had a negative inotropic effect that was a decrease of LVDP and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NCL and CL had no efects on parameters of action potential at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NCL and CL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between two preparations.