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광주전남지역 정상신생아의 상부 구순 계측치와 형태에 대한 연구
조안영,양정열,이승찬,천지선 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1
Background and objectives : The face is the one of the most variable parts of the body and characterized not only by separated part but also by interrelation of the parts. Especially, in the case of bilateral cleft lip and palate, compared with unilateral case, it is necessary to establish the facial anthropometry in newborns, because of current trend of early intervention, such as fetal surgery, lip adhesion, and nasoalveolar molding device. Millard presented the concept of rotation advancement for unilateral cleft lip repair, and, thesedays, this method of cleft lip closure is acknowledged as the most optimal principle. However, it can produce a scar that crosses the upper one third of the philtrum obliquely. The purpose of this study is to determine the configuration of the vermillion tubercle, the Cupid's bow, and the philtrum, and to suppose that which anthropometric data and proportional index could be significant to determine the configulation of the philtrum in case of bilateral cleft lip and other deformity, which can't identify the philtral shape. Materials and Methods : 74 newborn infants, who were full-term normal infant In Gwangju-Jeonnam area were examined from April to June 2003. Mean gestational ages were 39 weeks. Mean birth weight was 3.3 Kg. Five anthropometric data, which were base of columella to tubercle, nasal base to Cupid's bow peak, Cupid's bow to commissure, philtrum, peak to peak, and mouth width were measured. And the proportional indexes of each data were evaluated. Morphologic parameter, which were the shape of vermillion tubercle, the Cupid's bow, the philtrum, were analized. Results : Mean values of five anthropometric data were 14.1±2.2, 10.5±2.7, 16.5±2.5, 6.9±1.8, and 26.7±4.9 each. And the one of these, Philtral width, peak to peak, and 7 proportional indexes which were ①/④, ②/④, ③/④, ⑤/④, ④/③, ④/②, ④/① have a significance according to 3 types of the philtral shape. The most common shape of vermillion tubercle is protrusion type (89.2%), and that of Cupid's bow is normal type (52.7) and that of philtrum is parallel from nostril base to vermilion border (70.7%). Conclusion : My study supplies the plastic surgeon and others with specialized interests in the craniofacial surgical area with fundamental normative population data that will help them decide what IS abnormal. And corrective surgery of the face and cranium is becoming so precise that the techniques and data detailed in this paper are essential to its further development.
( Seung-yong Lee ),( Narayan Chandra Paul ),( Won Park ),( Gyeong-dan Yu ),( Jin-cheon Park ),( Mi-nam Chung ),( Sang-sik Nam ),( Seon-kyeong Han ),( Hyeong-un Lee ),( San Goh ),( Im Been Lee ),( Jung 한국균학회 2019 韓國菌學會誌 Vol.47 No.4
A common post-harvest disease of sweetpotato tuber is root rot caused by Fusarium solani in Korea as well as the other countries. Storage root rot disease was monitored earlier on sweetpotato (Ipomoea batatas) in storehouses of different locations in Korea. In the present study, an isolate SPL16124 was choosen and collected from Sweetpotato Research Lab., Bioenergy Crop Research Institute, NICS, Muan, Korea, and confirmed the identification as Fusarium solani by conidial and molecular phylogenetic analysis (internal transcribed spacer ITS and translation elongation factor EF 1-α gene sequences). The isolate was cultured on potato dextrose agar, and conidiation was induced. The fungus was screened for Fusarium root rot on tuber of 14 different varieties. Among the tested variety, Yenjami, Singeonmi, Daeyumi, and Sinjami showed resistant to root rot disease. Additionally, the pathogen was tested for pathogenicity on stalks of these varieties. No symptom was observed on the stalk, and it was confirmed that the disease is tissue specific.
Cheon, Seung Hoon,Park, Joon Suck,Jeong, Seon Hee,Chung, Byung Ho,Choi, Bo Gil,Cho, Won Jea,Kang, Boo Hyon,Lee, Chong Ock 전남대학교 약품개발연구소 1997 약품개발연구지 Vol.6 No.1
5-Aryl-2,3-dihydroimidazo[2,1-a]isoquinolines were reported to have strong antitumor activity and one of the derivatives such as 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1-a] isoquinoline (1, SDZ 62-434) was found to be more effective than the clinical cytostatic agent edelfosine (2) in in vitro and in vivo assays. Currently SDZ 62-434 is in clinical trials in Europe. The structure-activity relationship studies of SDZ 62-434 showed that compounds with substitution on ring A were less active than the lead compound. Ring Bin SDZ 62-434 was essential for the activity because compounds without B ring had no antitumor activity. Among the 3-arylisoquinolin-1-one derivatives, 3-[4'-(piperidinomethyl)phenyl] substituted analog had no antitumor activity but simple phenyl substituted compound, such as 4, showed the most potent antitumor activity in various human tumor cell lines.
Cheon, Seung-Hoon,Park, Joon-Suck,Jeong, Seon-Hee,Chung, Byung-Ho,Choi, Bo-Gil,Cho, Won-Jae,Kang, Boo-Hyon,Lee, Chong-Ock The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.2
5-Aryl-2,3-dihydroimidazo[2,1-a]isoquinolines were reported to have strong antitumor activity and one of the derivatives such as $5-[4^{l}$ -(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1-a] isoquinoline (1, SDZ 62-434) was found to be more effective than the clinical cytostatic agent edelfosine (2) in in vitro and in vivo assays. Currently SDZ 62-434 is in clinical trials in Europe. The structure-activity relationship studies of SDZ 62-434 showed that compounds with substitution on ring A were less active than the lead compound. Ring B in SDZ 62-434 was essential for the activity because compounds without B ring had no antitumor activity. Among the 3-arylisoquinolin-1-one derivatives, $3-[4^{I}$-(piperidinomethyl)phenyl] substituted analog had no antitumor activity but simple phenyl substituted compound, such as 4, showed the most potent antitumor activity in various human tumor cell lines.
Poster Session : PS 1259 ; Pulmonology : A Case of Primary Mediatinal Choriocarcinoma
( Seung Hyeun Lee ),( Young Min Koh ),( Yong Won Park ),( Mi Ju Cheon ),( Seon Bin Yoon ),( Byung Woo Yoon ),( Yong Geon Song ),( Sae Han Kang ),( Byung Wook Jung ),( Jun Gyu Song ),( Hyeon Sik Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Primary mediastinal choriocarcinoma is an extremely rare disease most of which occurs in young men. Here, we present a case of primary mediastinal choriocarcinoma with multiple metastases. A 31-year-old Korean man presented to pulmonary department complaining of progressive dyspnea (MRC Grade III) and pleuritic chest pain for 1 month. There was no history of exposure to any occupational or inorganic dusts. Chest x-ray showed widened upper mediastinum with multiple lung masses scattered in both lungs. Chest computed tomography (CT) scan showed a 10cm-sized huge mass at anterior mediastinum and multiple variable-sized lung masses with peripheral contrast enhancement. With suspicion of germ cell tumors or sarcomas we checked human chorionic gonadotropin (hCG) and alpha-fetoprotein, and markedly elevated hCG level was found (>225,000 mIU/mL). Scrotal ultrasonography revealed no lesion. CT-guided percutaneous needle biopsy on a lung mass showed large multinucleated cells representing syncytiotrophoblast admixed with medium-sized cells, often with clear cytoplasm, similar to cytotrophoblasts or intermediate trophoblasts, which is compatible with choriocarcinoma. Immunohistochemically, the tumor cells were reactive for hCG. 18FDG-PET showed no hypermetabolism except thorax suggesting primary mediastinal choriocarinoma. He underwent combination chemotherapy with bleomycin, etoposide and cisplatin. At 5 months follow up, the patient is alive in good condition and the hCG level actually reduced. Primary mediastinal choriocarcinoma is a rarest form of extragonadal germ cell tumors. It is characterized by distractively poorer prognosis than its testicular counterpart although recently-introduced combination regimen prolonged survival in some patients. Clinician should keep in mind that serum hCG level can help early diagnosis of this aggressive disease. In addition, establishment of more effective chemotherapy regimen is necessary for this condition.