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        정신분열병에 대한 리스페리돈의 효과 및 안정성

        이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

        연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

      • 다공성 세라믹에 의한 중금속 이온의 흡착거동에 관한연구

        윤동준,권이열,홍성자 漢陽大學校 環境科學硏究所 1989 環境科學論文集 Vol.10 No.-

        본 연구는 다공성 세라믹을 이용하여 수용액중의 중금속 이온(Cu(Ⅱ),Pb(Ⅱ)의 흡착특성을 회분석(Batch Test) 실험으로 고찰하였다. 다공성 세라믹(porous ceramics)의 흡착능을 비교하기 위하여 Sand와 활성탄(Activated Carbon)을 비교흡착제로 사용하였으며, 실온에서 중금속 이온농도가 20mg/ι인 용액 50ml에 대하여 pH(2.0±0.5, 3.0±0.5, 6.0±0.5), 접촉시간(0.5hr, 1hr, 2hr,3hr) 및 흡착제양을 변화시키면서 각 인자에 대한 특성을 관찰하였다. 흡착제양이 4.0g이고 접촉시간이 3hr, pH6.0±0.5일 때 Sand는 Cu(Ⅱ), Pb(Ⅱ) 및 Zn(Ⅱ)의 제거율이 7.8%, 18.6% 및 7.1%로 나타났다. 활성탄 (0.3g)은 Cu(Ⅱ), Pb(Ⅱ) 및 Zn(Ⅱ)의 제거율이 99.5% , 99.5% 및 73.8%로 나타났다. 이에 대하여 다공성 세라믹은 Cu(Ⅱ)가 97.8%, Pb(Ⅱ)가 99.0% over 및 Zn(Ⅱ)가 38.3%로서 Cu(Ⅱ)와 Pb(Ⅱ)에 대하여 좋은 제거율을 보였다. This investigation was carried out to study on the sorption characteristics of heavy metallic ions (Cu(Ⅱ), Pb(Ⅱ), Zn(Ⅱ)) by porous ceramics in batch type experiment. To compare the sorption ability of porous ceramics, sand and activated carbon were used as comparative adsorbents. At room temperature the sorption characteristics were observed by factors-pH(2.0±0.5, 3.0±0.5, 6.0±0.5), contact time(0.5hr, 1hr, 2hr, 3hr), amounts of adsorbents for 50ml solution of 20mg/ιof each heavy metallic ions.

      • KCI등재후보

        개에서 이중 결찰법을 통한 동맥관 개존증의 완치 예

        윤헌영,정순욱,박희명,박철,정만복,김준영,한현정,황민,노병국,박상혁,장하영,박정윤 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1

        A ten months old, female Yorkshire terrier weighing 2.88 kg referred to veterinary teaching hospital of college of veterinary medicine, Konkuk University because of syncope, cough and dyspnea. First hematological and serum chemical test revealed thrombocytopenia, mild anemia, and increase of concentration of ALP (195 U/L). On 57 days later, second hematological and serum chemical test revealed polycythemia, increase of concentration of ALP (211 U/L), and Tchol (387 mg/dl). Right atrium enlargement, main pulmonary artery bulge and cardiomegaly (VHS = 11.5) were observed in radiographic findings. Ultrasonographic images showed both right and left ventricular dilation and turbulent flow between the descending aorta and the main pulmonary artery in color Doppler imaging. ECG showed left ventricular enlargement, SA block, and electrical alternant. Thoracotomy was performed through left fourth intercostal incision under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. Cough and dyspnea disappeared on 5 days after operation. Turbulent flow was not found in color doppler imaging of ultrasonography on 10 days after operation. Ten months later after the operation, syncope could not exist any more.

      • KCI등재
      • 西海岸 綜合開發計劃 樹立을 爲한 關聯計劃 分析

        윤준상 公州大學校 産業開發硏究所 1997 産業開發硏究 Vol.5 No.-

        This study aims to investigate the related planning for the establishing of integrated development of west coast area and to suggest more efficient planning and policies to archive balanced regional development. In detail, this study reviewed the central and local government policies and planning. The major findings and suggestions of this study could be follows; 1) Recently, the west coast of chungnam, one of the typical lagging regions in the country draws a nationwide attraction for a base of West-Sea Rim. Thus, many a projects are being suggested and attempted. However, the region has serious limitations in structural rather than quantitative terms to be tackled. Those are concerned with ① poor endowment of hard and soft infrastructure, ② increasing intraregional disparity. 2) The top-down development strategy employed by the central government, in which development effects of centers has not contributed much to improving inequality structure. Since chungnam has been always least benefited from the fruit of high economic development and SOC development. 3) By the plannings and reports, the development potential of west coast of chungnam is very high and varius. So, planning and ploicy of this area must be setting up many-sided diversity. The development plan could be seperately presented as follows: ① west-north part of this area(Chonan, Asan, Tangjin, Soesan) - manufacuring industry area ② west coast area(Seochon, Hongsung, Taechon) -tourist area ③ west-south part of this area(Seochon, Janghang) - large industrial complex. 4) The central government as a coordinator and a cooperator with local governments provides directions of each region's development and assists large scale projects through financial supports, while local government prepares and implements its plans as a main body of regional development. And people's participation of planning should be widen.

      • 忠南地域住民의 開發要求分析에 關한 硏究

        윤준상,이창식 公州大學校 産業開發硏究所 1997 産業開發硏究 Vol.5 No.-

        This study aims to analyze the need assessment of development in Chungnam west-coast people and to search implication of ploicy and planning that induses inter-regional balanced development. The major findings of this study could be follows; 1) The most positive development in industry of all researching area was tourist business. And the most negative industry was forestry. 2) The most positive Social Overhead Capital(SOC) business was education, and the most negative business was electric. 3) The most positive development method was the sustainable development and the third sector types. 4) The lack of capital was the most important factor of barrier of development. The followings implications were suggested for more efficient inter-regional balanced development; 1) making the development circumstance of the low developed area 2) planning of development from bellow, 3) getting rid of the barrier of development, 4) selecting the sustainable development method and the third sector, 5) investing inter-regional balanced development.

      • 급성 호흡곤란 증후군으로 발현된 폐결핵 1례

        윤여준,박성우,이준혁,장안수,박춘식 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

        Pulmonary tuberculosis as a cause of the acute respiratory distress syndrome is quite rare. The diagnosis of acute respiratory distress syndrome due to pulmonary tuberculosis is difficult because of the diversity of radiological patterns. The ability to identify patients at risk for the acute respiratory distress syndrome is important if therapies are to be developed to prevent the disorder. We experienced a young female compliants with mild fever, dyspnea who diagnosed pulmonary tuberculosis 1 months ago. She stoped anti-tuberculosis medication 2 day because confirmation of drug fever and after then sudden aggravated dyspnea. The clinical course of this case is similar with presentaion of ARDS. We started antituberculosis medication with steroid, which result in good prognosis.

      • 유도선수들의 개인별 특성에 따른 성취동기에 미치는 영향 : mainly university students

        윤익선,김진표,권성준 龍仁大學校 武道硏究所 2002 武道硏究所誌 Vol.13 No.1

        This investigation used questionnaire which amended and made up for TSMI(Taikyo Sport Motivation Inventory) to verify what effect judo champions personal trait has on accomplishment motive. The subject of the study was 406 men, women judo champion's in Seoul and Kyung-Ki province. The personal trait which is an independent variation was set up as sexual distinction, grade, athlete career, economic standard, record of winning a prize and weight. According to this, the dependent variable for accomplishment motive to find out about accomplishment motive was foxed as competition, ambition, effort and self-confidence and the result of the research is followed as below. Firstly, there seemed to exist a significant difference in competition(p<.001), standard of ambition(p<.006) and self confidence(p.006) in accomplishment motive according to sexual distinction. Secondly, a significant difference in standard of ambition(p<.001) existed among the dependent variable of accomplishment motive according to grade. Result of Scheffe's pre-verification was that significant difference seemed to exist in 4th grade with the 1st and 3rd grade. Thirdly, all of the dependent variable; competition(p<.001), standard of ambition(p<.001), effort(p<.003) and self confidence(p.006) showed significant difference in accomplishment motive according to athlete's career. Scheffe's pre-verification showed that significant difference in competition existed in between 5-8 years and 8-10 years, and significant difference in standard of ambition in between 3-5 years and 8-10 years and also 3-5 years and 5-8년 and over 10 years group existed. Also significant difference in effort showed in 5-8 years and 8-10 years. Fourthly, the accomplishment motive according to the economic levels showed significant difference only in standard of ambition(p<.05) which is a dependent variable. Fifthly, The accomplishment motive according to the career of winning a prize showed a significant difference in competition(p<.01), ambition(p<.01) and effort(p<.05) among the dependent variable, and also Scheffe's pre-verification showed a significant difference in more than 7 times, less than 3times and less than 7 times in ambition. Sixthly, the accomplishment motive according to weight showed a significant difference in competition(p<.001) and effort(p<.05) among the dependent variable, and Scheffe's pre-verification showed significant difference in middle weight class with the lightweight and middle lightweight class in competition.

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