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Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례
김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-
Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).
金俊榮,金淙澤 경북대학교 산업기술연구소 1987 産業技術硏究誌 Vol.15 No.-
The crystallinity and the thermal property of four graphites produced in Korea were studied by x-ray and DT/TGA. The sample OR exhibited to be most well graphitized crystal whereas the TH and GA were relatively well crystallized. The amorphous graphite SW had shown little crystallinity by x-ray diffractogram. DTA and TGA study of these graphite show significant difference in ignition temperature and heat of combustion according to the crystallinity.