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Novel dentin phosphoprotein frameshift mutations in dentinogenesis imperfecta type II
Lee, K‐,E,Kang, H‐,Y,Lee, S‐,K,Yoo, S‐,H,Lee, J‐,C,Hwang, Y‐,H,Nam, KH,Kim, J‐,S,Park, J‐,C,Kim, J‐,W Blackwell Publishing Ltd 2011 Clinical genetics Vol.79 No.4
<P>Lee K‐E, Kang H‐Y, Lee S‐K, Yoo S‐H, Lee J‐C, Hwang Y‐H, Nam KH, Kim J‐S, Park J‐C, Kim J‐W. Novel dentin phosphoprotein frameshift mutations in dentinogenesis imperfecta type II.</P><P>The dentin sialophosphoprotein (<I>DSPP</I>) gene encodes the most abundant non‐collagenous protein in tooth dentin and DSPP protein is cleaved into several segments including the highly phosphorylated dentin phosphoprotein (DPP). Mutations in the <I>DSPP</I> gene have been solely related to non‐syndromic form of hereditary dentin defects. We recruited three Korean families with dentinogenesis imperfecta (DGI) type II and sequenced the exons and exon–intron boundaries of the <I>DSPP</I> gene based on the candidate gene approach. Direct sequencing of PCR products and allele‐specific cloning of the highly repetitive exon 5 revealed novel single base pair (bp) deletional mutations (c.2688delT and c.3560delG) introducing hydrophobic amino acids in the hydrophilic repeat domain of the DPP coding region. All affected members of the three families showed exceptionally rapid pulp chambers obliteration, even before tooth eruption. Individuals with the c.3560delG mutation showed only mild, yellowish tooth discoloration, in contrast to the affected individuals from two families with c.2688delT mutation. We believe that these results will help us to understand the molecular pathogenesis of DGI type II as well as the normal process of dentin biomineralization.</P>
남녀 고등학생의 자궁경부암, HPV 및 HPV 예방 백신에 대한 지식 정도
남영선,류수진,백송,송가람,이윤진,정혜진,최지은,JINGUOHUA 이화여자대학교 간호과학대학 2012 이화간호학회지 Vol.- No.46
Purpose: This research is to determine the degree of knowledge about cervical cancer, Human Papillomavirus(HPV), HPV vaccination of boy and girl high school students in Republic of Korea, and aimed to provide a basis of the education and policies which are for the reduction of HPV infection risks. Methods: The research subjects consisted of 132 boy students and 142 girl students. The data were collected using self-reported questionnaires composed of 10 questions about cervical cancer, 10 questions about HPV, and 5 questions about HPV vaccination. The collected data were analyzed with frequency, percentage, average, standard deviation, t-test and ANOVA by using SPSS version 19.0. Results: As a result, the degree of knowledge about cervical cancer, HPV, HPV vaccination of the research subjects was very low, and each average was 4.47±2.98, 2.79±2.91, and 1.20±1.46 points. There were statistically significant differences in the degree of knowledge about cervical cancer, HPV, and HPV vaccination depending on the research subjects’ sex (p<0.01), school types (p<0.05), majors (p<0.05), whether they had heard about cervical cancer or not (p<0.01). Conclusion: Concrete educational programs about cervical cancer, HPV, and HPV vaccination for high school students should be developed considering the students’ sex, school types, and majors.
남윤성,김현주,이숙환,곽인평,윤태기,차광열,Nam, Y.S.,Kim, H.J.,Lee, S.H.,Kwak, I.P.,Yoon, T.K.,Cha, K.Y. 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.2
Different Y mutation in Yq11 occurring de novo in sterile males were first described 19 years ago. Since the phenotype of the patients was always associated with azoospermia or severe oligospermia, it was postulated that these mutations interrupt a Y spermatogenesis locus in the euchromatic Y region (Yq11) called azoospermia factor (AZF). Recently, it became possible to map AZF mutations to different subregions in Yq11by molecular deletion mapping. This indicated that azoospermia is possibly caused by more than one Y gene in Yq11 and the Yq11 chromatin structure. The frequency of AZF mutations in idiopathic sterile males $(5{\sim}20%)$ may indicate a need for a general screening programme for its analysis in infertility clinic. We have experienced a case of deletion distal to Yq11 region in azoospermic patient. So we report this case with a brief review of literatures.
남지우,김동욱,배미영,박강순,김정현,노상률,최영일,김희종,장동욱,최소명,권영준,Hikita, S.,Yu, C.,Yoshimura, Y.,Kichimi, H. 성균관대학교 기초과학연구소 1998 論文集 Vol.49 No.-
We investigated the properties of BELLE Time Of Flight(TOF) counter using the data taken in Jan 98 beam test at Pi2 beam line at KEK 12 GeV proton synchrotron. Charge distributions from readout PMT were analysed in comparison with dE/dx distributions predicted by GEANT full simulation. Experimental setup of the beam test is described, then procedures of data analysis, Monte Carlo simulation and analysis results are also described.
Tailoring the defects and carrier density for beyond 10% efficient CZTSe thin film solar cells
Li, J.,Kim, S.,Nam, D.,Liu, X.,Kim, J.,Cheong, H.,Liu, W.,Li, H.,Sun, Y.,Zhang, Y. North-Holland ; Elsevier Science Ltd 2017 Solar energy materials and solar cells Vol.159 No.-
The defects states and carrier density of CZTSe absorber layers are two of the crucial factors that decide the photovoltaic performance of CZTSe thin film solar cells. Fine tailoring the defects and carrier density is a key to push the power conversion efficiency of CZTSe solar cells to a more competitive level. In this work, the phase properties, defect states, and carrier density of CZTSe thin film are well controlled by fine tuning the ratio of Zn/Sn in the range from 0.75 to 1.27. Capacity-Voltage measurements and Admittance Spectroscopy are used to characterize the carrier density, depletion region width, and defect states of the CZTSe solar cells. The results indicate that the defects states and carrier density of CZTSe layer are very sensitive to the ratio of Zn/Sn. Combining experimental results and numerical simulation, the statistic regularities of the photovoltaic parameters of the CZTSe solar cells with different ratios of Zn/Sn is well explained. The increase of V<SUB>OC</SUB> of CZTSe solar cells with the ratio of Zn/Sn is related to both the increased carrier density and the decreased deep level defects states. The decline of J<SUB>SC</SUB> of the Zn-rich solar cells is caused by both the shrunken depletion region width and a large barrier caused by ZnSe phase. This barrier is the cause for a low fill factor in the Zn-rich solar cells. Overall, the CZTSe solar cells with a stoichiometric ratio of Zn/Sn=1.02 have favorable defects property and carrier density, thus resulting in the highest photovoltaic efficiency of 10.21%.
윤진일,남재철,홍석영,김준,김광수,정유란,채남이,최태진 한국농림기상학회 2004 한국농림기상학회지 Vol.6 No.3
Evapotranspiration (ET) is a critical component of the hydrologic cycle which influences economic activities as well as the natural ecosystem. While there have been numerous studies on ET estimation for homogeneous areas using point measurements of meteorological variables, monitoring of spatial ET has not been possible at landscape - or watershed - scales. We propose a site-specific application of the land surface model, which is enabled by spatially interpolated input data at the desired resolution. Gyunggi Province of South Korea was divided into a regular grid of 10 million cells with 30m spacing and hourly temperature, humidity, wind, precipitation and solar irradiance were estimated for each grid cell by spatial interpolation of synoptic weather data. Topoclimatology models were used to accommodate effects of topography in a spatial interpolation procedure, including cold air drainage on nocturnal temperature and solar irradiance on daytime temperature. Satellite remote sensing data were used to classify the vegetation type of each grid cell, and corresponding spatial attributes including soil texture, canopy structure, and phenological features were identified. All data were fed into a standalone version of SiB2(Simple Biosphere Modell) to simulate latent heat flux at each grid cell. A computer program was written for data management in the cell - based SiB2 operation such as extracting input data for SiB2 from grid matrices and recombining the output data back to the grid format. ET estimates at selected grid cells were validated against the actual measurement of latent heat fluxes by eddy covariance measurement. We applied this system to obtain the spatial ET of the study area on a continuous basis for the 2001-2003 period. The results showed a strong feasibility of using spatial - data driven land surface models for operational monitoring of regional ET.
액체금속로 증기발생기에서 대규모 누출 소듐-물 반응 사고시 중후반기 압력거동특성 연구
정지영,어재혁,정경채,김병호,김태준,남호윤,박남국 한국공업화학회 2005 응용화학 Vol.9 No.1
In order to investigate the pressure transient at the later phase of a large leak sodium-water reaction event in KALIMER(Korea Advanced Llquid MEtal Reactor), an experimental study has been carried out. The experiment was performed to simulate the long-term system transient response of a large leak sodium-water reaction event due to double ended guillotine failure of three tubes in a 1/10 scale-down mock-up test facility with sufficient considerations of the quasi-steady state features of the SWR event.
대학생 자녀를 둔 중년여성의 자아존중감, 자녀와의 관계, SNS 이용강도가 우울에 미치는 영향
우지원,김가은,김경미,남주희,박지인,범준희,이나경,조소연,조은경,최영윤,김석선,길민지 이화여자대학교 간호과학대학 2017 이화간호학회지 Vol.- No.51
Purpose: This study aims to identify the effects of self-esteem, relationship with children, Social Networking Services(SNS) use intensity on depression in middle-aged women with college-age children, and to provide basic data for the health promotion of middle-aged women. Method: A sample of 133 middle-aged people was purposely selected from parents of university students. Questionnaires used for this study were CES-D(The Center for Epidemiological Studies-Depression Scale), Self-esteem Scale, Relationship with Children Scale, SNS Intensity Scale. The collected data was analyzed by SPSS 21 with descriptive statistics, independent t-test, ANOVAs, Pearson correlation, multiple regression. Result: Self-esteem was correlated with relationship with children (r=0.385, p<0.01) and depression (r=-0.440, p<0.01). Relationship with children was correlated with depression(r=-0.402, p<0.01). As a result, a factor having the greatest influence on the subject's depression degree was self-esteem(β=-0.335), followed by relationship with children(β=-0.274). Conclusion: The result of this study suggested that depression in middle-aged women is closely related to self-esteem and relationship with children. This result can be used in Nursing by developing the theoretical basis for education program related to enhancing self-esteem and relationship with children.