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비효소적 핵산 분해 반응 : DNA에 대한 몇가지 Organometallointercalator Some Organometallointercalator for DNA
고동성,박미경,류형원,서일환 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-
Cu^(2+) -nalidixate 또는 Cu^(2+) -pipemidate 시스템을 H_2O_2 및 아스코르빈산 존재하 방사능-표지된 DNA와 함께 37℃에서 배양시키므로써 산-용해성 분해산물들이 생성되었다. 본성 DNA 대신 변성 DNA를 기질로 쓸 경우 금속-drug 시스템의 DNA 절단활성은 현저하게 감소되었다. 또한 본성 DNA에 대한 절단활성은 DNA에의 전형적 intercalator이며 metalloquinolones의 DNA에의 결합에 대한 경쟁적 방해제가 될 수 있는 ethidium bromide에 의하여 저하되었다. Quinolone 항생제가 금속이온과의 킬레이트 복합체 형성을 통하여 DNA의 두가닥 나사선 염기쌍 사이에의 삽간결합(intercalation)을 할 수 있으며 이와 같은 결합을 이룬 금속복합체는 DNA 가닥에 대한 산화성 절단활성을 가질 수 있음을 시사한다. Incubation of Cu^(2+)-nalidixate or Cu^(2+)-pipemidate system with DNA at 37℃ in the presence of H_2O_2 and ascorbic acid resulted in the production of acid-soluble counts from dadioactively labeled DNA. With denatured DNA as substrate, the cleavage activity of the metalloquinolone systems was far less than with the native DNA. The DNA cleavage activity of metalloquinolones was also decreased by the addition of ethidium bromide, which was known to be a typical intercalator of DNA and was shown to be a competitive inhibitor for the metalloquinolone binding to DNA. The data here suggest the DNA cleavage activity of quinolone antibiotics intercalated into DNA as metal chelate complexes.
12주간의 유산소성 운동이 비만 초등학생의 신체조성과 혈액성분에 미치는 영향
윤미수,최건식,고성경,정소봉 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5
[Purpose] The purpose of this study was to investigate the effect of aerobic exercise training on the body composition and blood components in obese elementary children after 12 weeks. [Methods] Subjects of this study were composed of 20 male students ranging in age from 9 to 12 years who were classified into two groups, obese exercise group(n=10) and normal control group(n=10). For 12 weeks, obese exercise group performed the aerobic exercise training that the program was composed by Yoon. The blood samples were taken before and after 12 week Paired t-Test was adopted to analyse the difference between before and after aerobic exercise training. [Results] body fat of obese exercise group was decreased 4.8% after aerobic exercise training(p<.01) and that of normal control group was decreased 0.1% during same time(NS). Among the blood lipoprotein, total cholesterol(p<.01), LCL-C(p<.01), and triglycerides(p<.05) of obese exercise group were decreased after aerobic exercise training, but not changed HDL-C of same group. Red blood cell, Hemoglobin(p<.65) of obese exercise group were increased after aerobic exercise training. Glucose of obese exercise group were decreased after aerobic exercise training(p<.05), but not changed in Ca and P. [Conclusion] In conclusion, aerobic exercise training for 12 weeks seems to reduce body might and body fat, and to change the profiles of blood Component in obese elementary children.
노치권(외 6명) 신라대학교 자연과학연구소 2012 自然科學論文集 Vol.22 No.-
To study fauna of Silla University located in Mt. Baek-yang, we conducted six surveys from 29 May 2011 to 28 April 2012. We found five phyla 41 orders 197 species of animals inhabiting in this area: four phyla 27 orders 163 species of invertebrates and in vertebrates one order six species of fishes, three orders nine species of amphibians and reptiles, six orders 14 species of aves, and four orders five species of mammals. Of these species, some Korean endemic species were included: a fish of Rhodeus uyekii in a pond near main gate of this university, a frog of Rana coreana in a creek near a dormitory, and a rabbit of Lepus coreanus and a water deer of Hydropotes inermis in a grass region near a main stadium. A kind of hawk, Falco tinnunculus as a natural monument (animal) of no. 323-8, was observed on a building of medical and life science. A blue frog of Hyla japonica as a variation was found near a spring resort. Therefore, this area is considered an ecologically important area having a high animal diversity.
Ko, In Ok,Jung, Ki-Hye,Kim, Mi Hyun,Kang, Kyeung Jun,Lee, Kyo Chul,Kim, Kyeong Min,Noh, Insup,Lee, Yong Jin,Lim, Sang Moo,Kim, Jung Young,Park, Ji-Ae Hindawi 2017 Contrast media and molecular imaging Vol.2017 No.-
<P>The thymidine analogue 3′-deoxy-3′-[<SUP>18</SUP>F]fluorothymidine, or [<SUP>18</SUP>F]fluorothymidine ([<SUP>18</SUP>F]FLT), is used to measure tumor cell proliferation with positron emission tomography (PET) imaging technology in nuclear medicine. FLT is phosphorylated by thymidine kinase 1 (TK1) and then trapped inside cells; it is not incorporated into DNA. Imaging with <SUP>18</SUP>F-radiolabeled FLT is a noninvasive technique to visualize cellular proliferation in tumors. However, it is difficult to distinguish between [<SUP>18</SUP>F]FLT and its metabolites by PET imaging, and quantification has not been attempted using current imaging methods. In this study, we successfully acquired<I> in vivo </I><SUP>19</SUP>F spectra of natural or nonradioactive 3′-deoxy-3′-fluorothymidine ([<SUP>19</SUP>F]FLT) and its monophosphate metabolite (FLT-MP) in a tumor xenograft mouse model using 9.4T magnetic resonance imaging (MRI). This preliminary result demonstrates that <SUP>19</SUP>F magnetic resonance spectroscopy (MRS) with FLT is suitable for the<I> in vivo</I> assessment of tumor aggressiveness and for early prediction of treatment response.</P>
고혜정,김혜정,민숙영,박선미,박은영,서혜경,오미애,이경례,정현정,제영미 연세대학교 생활과학대학 1987 婦學 Vol.20 No.-
The purpose of this study was to examine the relationship between the child rearing attitudes of parents and the social development of their children and to examine the sex difference in those relationship. The subjects were 60 5-year-old children and their parents. The instruments for this study were the Diagnostic Examination of the Relationship between Parents and Children for Parent by Oh(1965), and the Examination of Social Maturity by Kim and Kim(1985). The data were analyzed with ANOVA. The results showed that the correlation between the type of parents' rearing attitudes and the children's social development was not statistically significant and that there were no difference in the social development between boys and girls.