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반코마이신 내성 장구균 감염에 대한 quinupristin-dalfopristin 치료 경험
추은주,최상호,조영환,정선미,김백남,김남중,김미나,김양수,우준희,류지소 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.1
VRE 감염이 중환자에서 급속히 증가하고 있으나 이에 대한 확실한 치료제가 없어 새로운 항생제에 대한 활발한 연구가 있는데 그 중 하나가 quinupristin/dalfopristin이고, 저자들은 중증 환자들의 VRE 감염에 대해 quinupristin/dalfopristin를 투여하여 치료한 임상적 경험을 하였기에 문헌고찰과 함께 보고하는 바이다. Vancomycin-resistant enterococci (VRE) was first recognized in 1992 in Korea. VRE infection have been increasingly reported in immunosuppressed patients over the past decade and have become one of major nosocomial pathogens. Clinicians carings for patients with VRE infections face severe constraints in the selection of treatment. Quinupristin/dalfopristin is active in vitro againt vancomycin-resistant E. faecium (VREF), with a MIC_(90) of 1.0㎍/mL. We studied the clinical efficacy and safety of this agent in the treatment of VREF infection. Patients were included if they had signs and symptoms of active infection including bacteremia, intra-abdominal infection, and wound infection. A total of 13 patients with VREF infection were enrolled. A favorable clinical response (cure or improvement) occured in 10 of 11 evaluable patients. The only adverse events related to quinupristin/dalfopristin were arthralgia and myalgia, which occurred in 2 of 13 patients. These results suggest that quinupristin/dalfopristin is effective and safe as treatment for VREF infections in critically ill patients with serious underlying conditions.
김창희,양승순,김연자,손연정,유미애,송주은 대한간호학회 간호행정학회 2009 간호행정학회지 Vol.15 No.4
Purpose: The purpose of this study was to construct and test a structural equation model of nurses' turnover intention. Method: The participants were 716 nurses at 4 university hospitals. Data were collected by a self-report questionnaire in 2008 and analyzed using SPSS 12.0 and AMOS 4.0 Win program. Results: The fit indices of modified model were x²=285.928(p<.001),x²/df=1.958GFI=0.964, RMSEA=0.037, AGFI=0.944, NFI=0.947, NNFI=0.961, CFI=0.973, PNFI=0.658 and showed high compatibility with the empirical data. In the final model, job stress and satisfaction were found to have significant direct effects on nurses' turnover intention, while organizational culture and emotional labor were very important factors to have indirect effects on turnover intention via job stress and satisfaction. Nurses' turnover intention was accounted for 41.2% of covariance by these factors. Conclusions: Comprehensive nursing interventions for decreasing nurses' turnover intention should be focused on reducing job stress and increasing job satisfaction. Also, Nursing strategy for enhancing positive organizational culture and decreasing emotional labor would be helpful for decreasing nurses' turnover intention, too. Further studies are needed to prospectively conduct to verify these causal relationships with larger sample.
Son, Mi Ju,Kim, Young-Eun,Song, Young Il,Kim, Yun Hee Elsevier 2017 COMPLEMENTARY THERAPIES IN MEDICINE Vol.35 No.-
<P><B>Abstract</B></P> <P><B>Introduction</B></P> <P>This systematic review aimed to assess the clinical evidence for the widespread use of herbal medicines in treating acute otitis media.</P> <P><B>Methods</B></P> <P>Eleven electronic databases, including MEDLINE, EMBASE, and the CENTRAL were searched, without language limitations. All randomised controlled trials involving the use of herbal medicines, alone or in combination with conventional therapies, for acute otitis media were included.</P> <P><B>Results</B></P> <P>We identified 4956 studies, of which seven randomised clinical trials met the inclusion criteria. The overall risk of bias of the included trials was relatively high or unclear. Treatment with Longdan-xiegan decoction or Shenling-baizhu powder, combined with antibiotics, appeared to be more effective than treatment with antibiotics alone in terms of the proportion of patients with total symptom recovery. Moreover, combination treatment of Sinupret<SUP>®</SUP> and antibiotics facilitated the recovery of middle ear conditions and hearing acuity.</P> <P><B>Conclusions</B></P> <P>Despite some indications of potential symptom improvement, the evidence regarding the effectiveness and efficacy of herbal medicine for acute otitis media is inconclusive due to the poor quality of trials included. Moreover, we only analysed seven trials in this review. Therefore, to properly evaluate the effectiveness of herbal medicine for acute otitis media, systematic reviews based on more rigorously designed randomized trials are warranted in the future.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Longdan-xiegan decoction or Shenling-baizhu powder with antibiotics synergistically enhanced the total symptoms in acute otitis media patients. </LI> <LI> Combination of Sinupret and antibiotics facilitated the recovery of middle ear conditions and hearing acuity. </LI> <LI> Eryanling decoction was superior in terms of the symptom-recovery initiation time. </LI> <LI> More rigorous and larger studies are needed to confirm the therapeutic efficacy of herbal medicines for acute otitis media. </LI> </UL> </P>
Son, Dong Ju,Jung, Yu Yeon,Park, Mi Hee,Lee, Hye Lim,Song, Min Ji,Yoo, Hwan-Soo,Hwang, Dae Youn,Han, Sang Bae,Hong, Jin Tae Neoplasia Press 2017 Neoplasia Vol.19 No.7
<P>A protective effect of allergy for cancer has been suggested, but the results are somewhat conflicting, and the mechanism remains elusive. Interleukin-4 (IL-4) signaling has been identified as a potentially important pathway in the development of allergies and the suppression of cancer development. To evaluate the allergy responses in IL-4–mediated tumor development, we compared the growth of B16F10 melanoma cells in 4% phthalic anhydride (PA)-treated <I>IL-4/Luc/CNS-1</I> transgenic mice (IL-4 mice) and acetone-olive oil (AOO)–treated IL-4 mice as a control for 3 weeks. Much higher allergic responses and natural killer (NK) and STAT6 activation were found in PA-treated IL-4 mice compared with AOO-treated IL-4 control mice. Tumor volume and weight showed an inverse association with the higher allergic response and were significantly reduced in the PA-treated IL-4 mice when compared with those of AOO-treated IL-4 control mice. Significantly higher activation of STAT6, as well as IL-4 and NK cell activation, was found in the tumor tissues of PA-treated IL-4 mice. Infiltration of immune cells and cytokine levels were also higher in the tumor tissues of PA-treated IL-4 mice. We further found that IL-4–activated NK-92MI cells showed increased anticancer effects in human melanoma cells. Overall, these results showed that allergy responses further accelerated the IL-4–induced inhibition of tumor development through the activation of STAT6 pathways.</P>
`실버케어 전문가` 미래직업 연계형 STEAM 프로그램이 초등학생의 미래지향 시간관, 진로인식 및 과학적 태도에 미치는 영향
유미현 ( Mi Hyun Yoo ),최정진 ( Jung Jin Choi ),박문숙 ( Mun Sook Park ),채수진 ( Su Jin Chae ),김보라 ( Bo Ra Kim ),손미현 ( Mi Hyun Son ),임은경 ( Eun- Kyong Lim ),유화수 ( Hwasoo Yu ),서종원 ( Jong Won Seo ),김주미 ( Ju Mi Kim 경북대학교 과학교육연구소 2017 科學敎育硏究誌 Vol.41 No.1
이 연구의 목적은 `실버케어 전문가` STEAM프로그램을 개발하고 초등학교에 적용하여 효과를 알아보는 것이다. 이 연구를 위해 경기도 소재 초등학생 110명이 참여하였다. 54명은 실험 집단으로, 56명은 비교집단으로 배치하였으며 프로그램 적용 전후에 미래지향 시간관, 진로인식, 과학적 태도 검사를 실시하였다. 본 연구에서 얻어진 결과는 다음과 같다. 첫째, `실버케 전문가` STEAM 프로그램을 적용한 실험집단 학생의 미래지향 시간관 전체 점수와 2개 하위영역 모두에서 비교집단에 비해 유의미하게 향상되었다(p<.05). 둘째, `실버케어 전문가` STEAM 프로그램을 적용한 실험집단 학생의 진로인식 전체 점수와 4개 하위영역 점수가 비교 집단에 비해 유의미하게 향상되었다(p<.05). 셋째, `실버케어 전문가` STEAM 프로그램을 적용한 실험집단 학생의 과학적 태도 전체 점수와 7개 하위영역 점수가 비교집단에 비해 유의미하게 향상되었다(p<.05). 넷째, `실버케어 전문가` STEAM 프로그램에 대한 실험집단 학생의 만족도를 조사한 결과 `나는 과학기술 분야와 관련된 직업에 대한 관심이 생겼다`라는 항목에서 가장 높은 긍정적 인식을 보여주었다. 결론적으로 본연구에서 개발 적용한 STEAM 프로그램이 초등학생의 미래지향 시간관, 진로인식, 과학적 태도를 향상시키는 데 효과적임을 시사한다. The purpose of this study was to develop `Silver Care Expert` STEAM Program for the elementary students and investigate the effects of the program on creative thinking activity, scientific attitude and leadership. Participants were 110 elementary school students. Before and after the program, the participants were asked to take the test about future time perspective, career awareness and scientific attitude. The major results of this study were as follows. First, the total score of experimental group`s future time perspective and all 2 sub-domains was significantly improved than those of comparative group(p<.05). Second, total score of experimental groups` career awareness and all 4 sub-domains were significantly increased than those of comparative group after the STEAM program(p<.05). Third, the total score of experimental groups` scientific attitude and all 7 sub-domains were significantly improved than those of comparative group(p<.05). Fourth, according to students` post-program opinions, experimental group students showed very positive perception like that science class was very interesting and they became interested in science and technology. In conclusion, `Silver Care Expert` STEAM Program was very effective to improve elementary students` future time perspective, career awareness, scientific attitudes.