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KHST와 각이 있는 트럭간의 충돌 후 틀림현상에 대한 해석
김승록(Kim Seung Rok),정현승(Jung Hyun Seung),박준서(Park Jun Soe),구정서(Koo Jung Soe),권태수(Kwon Tae Soo) 한국철도학회 2006 한국철도학회 학술발표대회논문집 Vol.- No.-
The purpose of this paper is to simulate the collision between a KHST 3D model and an oblique truck and to investigate zigzagging phenomenon. The used train model is the deformable KHST 3D model, its velocity is 110kph, and the angle of the truck is 30 degree. In order to check lateral forces between wheels and rails, the KEYWORDs that LS_DYNA provides, *RAIL_TRACK and *RAIL_TRAIN are used.
어린이의 일차성 단일 증상성 야뇨증에서 Imipramine과 Desmopressin 복합 약물치료의 효과 및 안전성
여지현,최정연,정효석,이경수,고철우,김교순,김기혁,김정수,남궁미경,박영서,배기수,유기환,박용훈,Yeo Ji-Hyun,Choi Jung-Youn,Chung Hyo-Seok,Lee Kyung-Soo,Ko Cheol-Woo,Kim Kyo-Sun,Kim Kee-Hyuk,Kim Jung-Soe,NamGoong Mee-Kyung,Park Young-Seo,Pai Ki 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.2
목적: 일차성 야뇨증에 여러 가지 치료법이 시도되고 있는데 이 중 일반적으로 사용되는 imipramine와 desmopressin 등의 약물요법은 치료효과가 빠르고 비교적 양호하기 때문에 선호하는 치료 방법이다. 그러나 효과가 매우 다양하고 때로는 약물에 의한 부작용으로 인해 사용이 어렵게 되는 경우도 있다. 본 연구에서는 이들 약물을 단독으로 투여한 경우에 비하여 복합투여 할 경우에 치료 효과와 안정성을 비교 평가하여 보다 나은 야뇨증 치료 방법을 제시하고자 하였다. 방법: 2002년 4월부터 2002년 12월까지 내원한 5-l5세 사이의 환자로서 1) 일차성 단일성 야뇨증, 2) 주 2회 이상의 야뇨증, 3) 5세 이상의 연령, 4) 비뇨기과적 이상이 없고, 5) 정신적 또는 신경학적인 증상이 없으며, 6) 내분비 질환이 없고, 7) 최근 2개월 동안 야뇨증 약물치료를 받지 않은 환아로서, 8) 부모의 동의를 받은 경우를 대상으로 하였으며 조건을 만족하는 환자들을 무작위로 선택하여 imipramine 단독투여군, desmopressin 단독투여군과 imipramine과 desmopressin 복합투여군의 3군으로 나누어 야뇨횟수, 부작용과 약물 중단 후 1개월 후 야뇨증 빈도를 확인하였다. 결과: 대상 환아들은 남, 녀 각각 78명과 90명이며, 5-10세가 119명이었고 11-16세는 49명이었다. 치료 시작 4주 이후에서부터 모든 군에서 유의하게 야뇨 횟수가 감소하였다. 치료 종료 시의 imipramine 단독투여군, desmopressin 단독투여군과 imipramine과 desmopressin 복합투여군의 치료율은 각각 68.6%, 74.4%와 86.1%로서 imipramine와 desmopressin 복합투여군의 치료율이 가장 높았으나 통계학적인 차이는 없었다. 치료 종료 후 4주의 야뇨 빈도는 imipramine 단독투여군은 주당 1.9회, desmopressin 단독투여군은 1.3회이고 imipramine와 desmopressin 복합투여군은 1.0회로 세군 사이에는 유의한 차이가 없었다. 약물에 의한 부작용은 imipramine 단독투여군은 20명, desmopressin 단독투여군은 12명, imipramine와 desmopressin 복합투여군13명에서 총 45례에서 나타났는데 이중 imipramine 투여로 인한 식욕 감퇴가 가장 많았다. 결론: 일차성 단일 증상성 야뇨증 치료를 위한 imipramine 단독용법, desmopressin 단독요법, imipramine과 desmopressin 복합요법의 치료효과와 단기간 동안 관찰한 재발 빈도에서는 의미있는 차이는 없어서, 두 약제의 복합요법이 desmopressin 단독 요법에 비해 치료효과, 재발정도와 부작용 빈도에서 차이가 없어 치료 효율성의 우월성을 발견하지 못하였다. 다만 약물 부작용 발생은 imipramine 단독요법이 다른 치료 방법에 비해 발생 빈도가 유의하게 높은 것으로 나타나서 imipramine 단독요법을 할 때에는 부작용 발생유무를 유의해서 관찰하여야 할 것으로 생각된다. Purpose : Nocternal enuresis is a common disorder. Tricyclic antidepressant and desmopressin have been accepted pharmacological treatment for this disorder We conducted a cooperative study to investigate the efficacy and adverse reactions of imipramine, desmopressin and combination treatment in children with primary monosymptomatic nocturnal enuresis(PMNE). Methods: Data from a large multicenter study were analysed. In the period of 8 months in 2002, the study comprised of 168 children(78 boys and 90 girls, 5 to 15 years old) with PMNE for imipramine, desmopressin or combination treatment. Before treatment a history, physical examination and laboratory tests were performed and the children were observed for 2 weeks. Response rate, adverse reactions and enuresis episodes after stopping drug administration were evaluated after 12-weeks of imipramine, desmopressin or combination of both. Results: After 4 weeks, the frequency of bed wetting in all treated patients decreased during treatment significantly Even though a 30-50%, reduction in the number of wet nights were 68.6%, 74.4% and 86.1% during 12 weeks treatment by imipramine, desmopressin and both of them respectively, there was no significant difference between them. The most common adverse reaction was decreased appetite from imipramine administration. But no serious drug-related adverse events were reported. Conclusion: Efficacy of the combination therapy of imipramine and desmopressin in PMNE appears not to be better than either drug alone. It is necessary to pay attention on account of adverse reactions during imipramine treatment even though imipramine and desmopressin were generally well tolerated.
( Eun-jung Ko ),( Bo Hye Kim ),( Hye Yun Jeong ),( Sung Un Soe ),( Dong Ho Yang ),( So-young Lee ) 대한신장학회 2016 Kidney Research and Clinical Practice Vol.35 No.1
Background: Vitamin D has pleiotropic effects important for the proper functioning of multiple organ systems. We investigated whether serum 25- hydroxyvitamin D [25(OH)D] levels influenced hospitalization-free survival in patients with chronic kidney disease (CKD). Methods: In this prospective study, serum levels of 25(OH)D were measured in 210 patients with CKD in the winter of 2009. Data regarding hospitalizations were collected over the subsequent 3 years. Results: Vitamin D deficiency, as defined by a serum 25(OH)D level below 15 ng/ mL, was observed in 76.7% of the patients. The mean 25(OH)D serum level was 13.6 ± 7.8 ng/mL in predialysis patients (n ¼ 62) and 11.3 ± 6.7 ng/mL in dialysis patients (n ¼ 148). During the follow-up, 107 patients (28 predialysis and 79 dialysis) were hospitalized because of infectious (33.6%) or cardiovascular diseases (23.4%). Predialysis and dialysis groups were divided into 2 subgroups based on the median 25(OH)D serum level. KaplaneMeier analysis revealed that the risk of hospitalization was significantly lower in both predialysis and dialysis patients with above-median serum 25(OH)D levels (log-rank test; P ¼ 0.043 and 0.002, respectively). Multivariate Cox proportional hazards models also demonstrated that the risk of hospitalization was significantly lower for patients with higher serum 25(OH)D levels in both the predialysis (hazard ratio, 0.963; 95% confidence interval, 0.93e0.99) and dialysis groups (hazard ratio, 0.955; 95% confidence interval, 0.91e0.99). Conclusion: A lower serum 25(OH)D level predicted poorer hospitalization-free survival in both predialysis and dialysis CKD patients.
Guidance Application for Drivers" Safety at Moving to Work
Eunji Jung,Jimi Kim,Seowoo Jeong,Seoyu Soe,Mingu Lee 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2
The aim of the research is suggesting safety light in the highway/roads to provide useful information simultaneously and safely. Real-time safety light system request users to prevent secondary vehicle accident, to detour busy road, or to select alternative transportation matters. For these objects, App(mobile application) connecting with open API is important for providing information. Development of application represents three way like: (1)“Different way to work”, (2)“Wise way to work”, (3)“Refresh way to work”. This application allows city workers to develop your personal commute and recommend your service system “to select variables using causal inference”. It provided users with satisfactory commutes.