상지 체중부하 운동 프로그램이 무정위 운동성 뇌성마비유아의 이동운동에 미치는 영향

김중선 대한물리치료학회 1996 대한물리치료학회지 Vol.8 No.1

The present case study has a object to investigate the changes in locomotion patterns of infant with athetoid cerebral palsy would be occurred by the program when it is applied with upper extremity weight bearing. The subject has been limited to one infant over one year of age, selected from the patients in the physical therapy clinic, Rehabilitation Center, Taegu University. Subject is normal in the visual and auditory sense, but he is unable to walk on his own. Subject weighted 2.9㎏ at birth and underwent severe postnatal kernicterus, always on the baby-walker at home. He disliked supine position characteristic in moving in athetoid type before he was under the program. The program was applied 7 months. Each session of the program is composed of 7 stages : (1) prebriefing between the therapist and the parents (2) pretherapy amusement time of the infant (3) warming-up (4) upper extremity weight bearing (5) cooling-down (6) post-therapy amusement time (7) postbriefing. The locomotion of the subject is proved to be influenced by the program. He showed a leftward circular movement as a result of the exercise, reducing the involuntary movement of his head when he was positioned for crawling. Later he proceeded to develop into creeping. crawling; kneeling and finally cruising. In conclusion, it appeared evident that the locomotive abilities of the subject is improved by the program explored in this study: The higher locomotive patterns could be achieved such as crawling, sitting, kneeling d cruising with enable the upper extremities weight bearing.

기관지 천식에서 Impulse Oscillometry(IOS)의 유용성

김중선,서정훈,허애정,정혜원,김철우,윤영연,박중원,홍천수 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

포스타 전시 발표 : 감염, 알레르기, 류마티스 ; 벌독 아나휠락시스성 쇼크가 의심된 환자에서 벌독 특이 IgE 항체 측정의 유용성

김중선,허애정,서정훈,김철우,윤영연,박중원,홍천수 대한내과학회 1999 대한내과학회 추계학술대회 Vol.57 No.-

Neurophysiological and Clinical Features of the Pusher Syndrome: Review Article

김중선,남석현 대한물리치료학회 2010 대한물리치료학회지 Vol.22 No.3

Patients with the pusher syndrome show severe misperception of their own upright body orientation although visual vestibular processing is almost intact. They recognize their body as oriented upright when it is actually tilted nearly 20 degrees to the affected side. These patients resist any attempts to assively correct their tilted body posture towards an earth vertical upright orientation. They use the non-affected side arm and/or leg to actively push towards the affected side. Pusher syndrome patients have different prognoses and symptoms than general stroke patients without pusher syndrome. Pusher syndrome patients have a poor prognosis, so they need a long duration of treatment. Therefore, accurate diagnosis and proper treatment are important. In this study, we reviewed the symptoms, causes, evaluation, and treatment for pusher syndrome.

온열 자극에 따른 심혈관계 반응:전신욕과 반신욕의 비교

김중선,이왕수,경희두,장혁재,조영석,연태진,정우영,채인호,최동주 대한심장학회 2004 Korean Circulation Journal Vol.34 No.12

Background and Objectives:The beneficial effects of systemic thermal therapy such as taking a hot tub or sauna have been described for patients with cardiovascular disease. Despite such positive effects, there is still concern over the safety of these procedures. Half-body immersion has recently been widely used as an alternative to achieve the same benefit, and it is better tolerated than conventional whole-body immersion (WBI). However, there has been no study that has clarified the cardiovascular effect of half-body immersion (HBI). Subjects and Methods:We asked 13 healthy men (age:20 to 27 years) to immerse themselves to the shoulder level on day 1) and to the umbilical level on Day 2 for 20 minutes in a hot tub, respectively (temperature:39.0 to 41.0℃). Changes of skin (TSk) and esophageal temperature (TEo), hemodynamic and autonomic responses, and symptom scale were measured during the immersion. Results:All the volunteers were compliant and there were no adverse events. During immersion, the TEo increased continuously with each methods, but 10 minutes after immersion the TEo for the WBI patients was higher (p=0.03). The heart rate (HR) increased and the diastolic blood pressure decreased for both conditions. In contrast to HBI, the ejection fraction (EF) (p=0.10), and cardiac output (CO)(p=0.005) increased continuously for WHI. Among the HRV parameters, the values for the low-to-high frequency ratio (p=0.03) increased significantly with WHI after 10 minutes. The symptom scale during (p=0.01) and immediate after immersion in the hot tub (p=0.005) was better for HBI. Conclusion:Core temperature, echocardiographic systolic parameters and sympathetic activity were increased more slowly for HBI compared to WBI. This suggests that HBI could be a safer alternative for systemic thermal therapy for the patients with cardiovascular disease. 배경 및 목적: 심장 질환 환자에서의 온열 치료는 혈역학적 지표, 임상적인 증상, 심장 및 혈관 내피세포 기능을 향상시킬 수 있다고 알려져 있다. 이러한 잇점에도 불구하고 환자에서의 적용은 안전성에 대한 우려가 있는 상태로, 최근 반신욕의 경우는 전신욕과 비슷한 효과를 가지면서 보다 안전하고 편안하게 이용할 수 있는 방법으로 생각되고 있다. 하지만 현재까지 반신욕의 혈역학적 및 심장 기능에 변화에 대한 연구는 없었고 이에 본 저자들은 반신욕과 전신욕의 심장 기능 및 자율 신경계의 변화를 살펴 봄으로써 반신욕의 유용성과 안전성에 대해 알아보고자 하였다. 방 법: 대상군은 13명의 지원자(age range, 20 to 27 years;mean BSA 1.7 m2, mean BMI 22.5 kg/m2) 였고, 전신욕은 어깨 높이로 반신욕은 배꼽 높이로 시행하였다. 검사 중 물의 온도는 39~41℃로 유지하였고 20분 입수 시간 동안 피부 및 식도 중심 온도, 혈역학적인 변화, 심초음파를 통한 심장 기능의 변화, 증상의 변화 및 자율 신경계의 변화를 5~10분 간격으로 측정하였다. 결 과: 식도 중심 체온은 두 군 모두 지속적으로 상승하는 양상이었으며 전신욕 군의 경우 10분 이후 급격한 양상으로 증가되었다. 입수 동안 심 박동수는 증가되었으며 이완기 혈압은 감소되었다. 증상은 전신욕 군의 경우가 반신욕 군에 비하여 심하게 나타났으며 p=0.01) 입수 직후 기립시 증상도 전신욕 군에서 많이 나타났다(p=0.005). 심초음파를 통한 수축기능의 변화에서는 반신욕 군의 경우 심구혈율(p=0.10), 심박출량(p=0.005)이 10분까지 증가되다가 10분 이후 유지되었지만 전신욕 군은 지속적으로 상승하였다. 자율 신경 기능 평가를 위한 심박동 변이 분석상 저주파수에 대한 고주파수의 빈도의 비율이 전신욕 군에서 높았다(p=0.03). 결 론: 결론적으로 반신욕은 전신욕에 비해 혈역동학적 변화가 완만하며 교감신경계의 항진 정도가 낮아 심혈관계 부하가 적은 방법이었고 심혈관계 질환의 재활 치료에 도움이 된다고 알려져 있는 온열 치료 중 하나로 보다 안전한 방법으로 생각된다.

A study of the effect of sequential injection of 5-androstenediol on irradiation-induced myelosuppression in mice

김중선,장원석,이선주,손영훈,박선후,이승숙 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6

Herein, we aimed at examining the therapeuticeffects of 5-androstenediol (5-AED), a natural hormoneproduced in the adrenal cortex, on radiation-induced myelosuppressionin C3H/HeN mice. The mice were subjectedto whole-body irradiation with a sublethal dose of5 Gy gamma-irradiation to induce severe myelosuppression,and 5-AED (50 mg/kg) was administered subcutaneously. 5-AED was administrated 1 day before irradiation(pre-treatment) or twice weekly for 3 weeks starting from1 h after irradiation (post-treatment). Treatment with5-AED significantly ameliorated the decrease in theperipheral blood neutrophil and platelet populations inirradiated myelosuppressive mice, but had no effect on thelymphocyte population. It also ameliorated hypocellularityand disruption of bone marrow induced by irradiation andled to rapid recovery of myeloid cells. Further, it attenuatedthe decrease in spleen weight and megakaryocyte andmyeloid cell populations in the spleen and promoted multilineagehematopoietic recovery. We found that a singleinjection of 5-AED produced only a temporary therapeuticeffect, while sequential injection of 5-AED after irradiationhad a more pronounced and prolonged therapeutic effectand reduced myelosuppression by irradiation. Thus,sequential injection of 5-AED after irradiation hastherapeutic potential for radiation-induced myelosuppressionwhen administered continuously and can be a significanttherapeutic candidate for the management of acuteradiation syndrome, particularly in a mass casualty scenariowhere rapid and economic intervention is important.

In vitro and in vivo protective effects of granulocyte colonystimulating factor against radiation-induced intestinal injury

김중선,양미영,이창근,김성대,김정기,양광모 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.10

Intestinal injury is a major cause of death afterhigh-dose radiation exposure. The use of granulocyte-colonystimulating factor (G-CSF) to treat radiation injury hasfocused on enhancing recovery from hematopoietic radiationsyndrome. We evaluated G-CSF for its ability toprotect against radiation-induced intestinal injury in ratintestinal epithelial cells (IEC-6) and BALB/c mousemodels. For in vitro tests, pre-radiation addition of G-CSFto IEC-6 prevented cytotoxicity and the loss of cell viability. Pre-radiation G-CSF treatment also reduced radiation-induced cleavage of caspase-3 and p53 in IEC-6. Forin vivo tests, examination 12 h after abdominal irradiationshowed that G-CSF-treated mice were protected againstapoptosis of the jejunal crypts. G-CSF-treated mice alsoshowed attenuated intestinal morphological changes3.5 days after abdominal radiation (10 Gy). G-CSF alsoreduced the levels of proinflammatory cytokines interleukin-6 and tumor necrosis factor-a after radiation. Thisstudy showed that G-CSF may protect against radiationinducedintestinal damage through its anti-apoptotic andanti-inflammatory effects. These results suggest thatG-CSF is promising candidate for protection againstintestinal mucosal injury following irradiation.

Differential patterns of nestin and glial fibrillary acidic protein expression in mouse hippocampus during postnatal development

김중선,Juhwan Kim,Yujin Kim,양미영,Hyosun Jang,Sungwoon Kang,김성호,신태균,문창종,김종춘 대한수의학회 2011 Journal of Veterinary Science Vol.12 No.1

Intermediate filaments, including nestin and glial fibrillary acidic protein (GFAP), are important for the brain to accommodate neural activities and changes during development. The present study examined the temporal changes of nestin and GFAP protein levels in the postnatal development of the mouse hippocampus. Mouse hippocampi were sampled on postnatal day (PND) 1, 3, 6, 18, and 48. Western blot analysis showed that nestin expression was high at PND 1 and markedly decreased until PND 18. Conversely, GFAP expression was acutely increased in the early phase of postnatal development. Nestin immunoreactivity was localized mainly in the processes of ramified cells at PND 1, but expression subsequently decreased. In contrast, GFAP was evident mainly in the marginal cells of the hippocampus at PND 1, but immunoreactivity revealed satellite, radial, or ramified shapes of the cells from PND 6-48. This study demonstrates that the opposing pattern of nestin and GFAP expressions in mouse hippocampus during postnatal development occur in the early development stage (PND 1-18), suggesting that the opposing change of nestin and GFAP in early postnatal development is important for neural differentiation and positioning in the mouse hippocampus.

감마선조사에 의한 돼지 피부장애에 cyclooxygenase-2 의 발현변화

김중선,장원석,이선주,박선후,이승숙 대한방사선방어학회 2015 대한방사선방어학회 학술발표회 논문요약집 Vol.2015 No.04

호흡곤란으로 내원하여 정상흉부 X-선 소견을 보인 52세 여자

김중선,양동규,김성규 한국의학사 1998 診斷과治療 Vol.18 No.7