사립체 DNA 뉴클레오타이드 3243 A→G 돌연변이 [MTTL1^*MELAS3243G]에 의한 MELAS 증후군

박기형,김승현,이영주,김희태,김주한,김명호,박성섭 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

편측관상봉합 조기유합증 환자에서 컴퓨터단층촬영을 이용한 두개 기저부의 술후 변화 예측

김영석,김진형,김용욱,유선국,이혜연,김기덕,박병윤 大韓成形外科學會 2004 Archives of Plastic Surgery Vol.31 No.2

肝吸蟲症 治療前後에 있어서 血淸 및 尿의 抗體價變動에 관한 比較硏究

金亨東,嚴基善,林漢鍾 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.3

The changes of IgG levels of sera and urine were observed with the enzyme-linked immunosorbent assay (ELISA) at before and after medication in human clonorchiasis. Sera and urine from 68 cases of confirmed clonorchiasis were tested at before and at 9 and 18 month after treatment with Distocide® (praziquantel). Group I (n=22) was cured after first medication and then followed up for 18 months. And Group Ⅲ (n=24) of patients with eggs in their feces after first medication showed egg reduction rate of 90%. Thirteen normal controls were parasite free healthy persons for clonorchiasis in non-endemic area. The antigen used was saline extract of crude Clonorchis sinensis adult worm with the protein concentration of 14.3㎍/㎖ and the results obtained were as follows: 1. When a serum dilution of 1:400 was used, the absorbance values (488 nm) were 1.122, 1.373 and 1.632 in groups Ⅰ,Ⅱ,Ⅲ respectively before medication. Antibody level decreased significantly at 9 months after medication showed 0.572, 0.749 and 1.155 in the respective group. Then the levels decreased slightly to 0.464, 0.516 and 1.107 at 18 months after medication. But the control group showed relatively constant absorbance values of 0.291 at before 0.301 and 0.286 respecively at 6 and 18 months. 2. Urine showed absorbance values of 0.484, 0.629 and 0.849 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. Then the values decreased about a half level revealed 0.261, 0.226 and 0.467 in the respective group at 18 months after medication. Control group showed relatively constant absorbance values 0.232 at before and 0.252 at 18 months. 3. The diameter of wheal size (mm) by intradermal test did not show substantial changes, i.e. 11.7, 13.3 and 12.7 in groups Ⅰ, Ⅱ, Ⅲ respectively before medication; 11.7, 12.9, and 11.4 in the respective group at 18 months after medication. 4. The relation of the absorbance values between sera (y) and urine (x) made the regression equation: y=0.707X+0.908, and showed relatively high correlation (r=0.619, n=68, p<0.001) before medication; y=0.760X+0.387 with some correlation (r=0.582, n=68, p<0.001) at 18 months after medication. 5. The relation between the absorbance values of urine and log EPG (eggs per gram of feces)/100 revealed more or less irregular correlations, i.e.r=0.566(p<0.01), 0.661(p<0.001)and 0.384(p<0.10)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication. 6. The relation between the absorbance values of urine and the wheal size (mm) by intradermal test showed low correlation, i,e, r=0.416(p<0.10), 0.416(p<0.10)and 0.421(p<0.05)in groups Ⅰ, Ⅱ, Ⅲ respectively before medication.

알코올성 췌장염 환자에서 CYP2E1 유전자형의 다형성

김일환,염윤기,채석,권준택,김형기,박상흠 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Cytochrome P4502E1(CYP2E1) is inducible by ethyl alcohol and activates procarcinogenic N-nitrosodimethylamine(NDMA), benzene, urethane and other lower molecular weight compound. CYP2E1 is also involved in metabolism of certain drugs, for example, alcohol, acetaminophen, tamoxifen, theophylline, flouorinated anesthetics, and chlorozoxazone. CYP2E1 activity was shown to be polymorphically distributed in humans and has been suggested to play a role in hepatocellular carcinoma and alcoholic related disorders. Although genetic predispodition to alcoholism and alcoholic liver disease has been reported, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. The aims of this study were to investigate the allelic frequency of CYP2E1 Rsa I polymorphism in Koreans with alcoholic pancreatitis patients. We investigated the frequency distribution of CYP2E1 Rsa I polymorphism in 212 unrelated healthy Koreans and 64 alcoholic pancreatitis patients. Detection of the CYP2E1 alleles was performed by polymerase chain reaction and restriction fragment length analysis. The genomic DNA was isolated from peripheral blood with conventional phenol: chloroforn extraction method. The allelic frequencies of c1 and c2 in healty volunteers were 0.85 and 0.15, respectively. The allelic frequencies of c1 and c2 in alcoholic pancreatitis patients were 0.8 and 0.2, respectively. The rare type (c2/c2) of CYP2E1 Rsa I polymorphism was 0.005 and 0.031 (p<0.001) in healthy volunteers and alcoholic pancreatitis patients, respectively. However, the CYP2E1 genotype showed no significant relation to the alcoholic pancreatitis patients. It was suggested that the risk of alcoholic pancreatitis diagnosed clinically seem to be not associated with the CYP2E1 genotype.

韓國에서 外國人 勞動者의 流入實態와 勞動問題

金炯基 慶北大學校出版部 1994 經商論集 Vol.22 No.4

혈장 중 theophyline 분석법 확립 및 약동학적 연구

김형기,권준택,염윤기 순천향대학교 의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

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유한요소법을 이용한 판 구조물의 동적거동 해석 연구

김영권,이기형,박태원,정인성 全北大學校 1995 論文集 Vol.39 No.-

This study discusses the finite element approximation and the choice of elements is dictated by the need to perform accuate for both thin and thick shells and by the complexity of the sensitivity calculations. A number of very accurate plate and shell elements exist for which the sensitivity computation become hopelessly complex. On the other hand, most very simple elements, which would lend themselves to compact and efficient sensitivity computation, do not posses sufficient accuracy for routine use.

대퇴-대퇴동맥간 우회로술 후 하지 허혈증상 재발 및 이식편 폐색의 원인

김형기,김영욱,허승,나목찬 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

With increasing number of high-risk advanced atherosclerotic patients, crossover femoro-femoral pypass (FFB) became commonly chosen extra-anatomic bypass for symptomatic iliac artery occlusive disease. But the causes FFB graft failure have not been clarified yet. Purpose: We aimed to investigate the natural course of native artery disease, the causes of graft occlusion and recurrent leg ischemia after FFBs. Method: Among 162 primary FFBs for ??atherosclerotic iliac occlusive disease, 45 patients who underwent follow-up arteriography for recurrent ischemic symptom were enrolled. We investigated the interval changes between initial preoperative and follow-up angiograms and categorized then as inflow, outflow and/or graft lesion into stenosis >50% or occlusion. And the patients were divided into 2 groups as patent FFB group and occluded FFB group. We compared interval changes on angiograms between patient and occluded FFB groups to find out any difference and tried to determine the ultimate causes of recurrent leg ischemia considering not only the interval changes but the preexisting, untreated leg arterial lesions. Result: The follow-up angiography was most commonly performed within 1 year after FFV with mean interval of 21.2 ± 21.6 months. Interval changes between 2 angiograms were 24 (53.3%) FFB grafts occlusion, 8 (17.8%) inflow iliac disease progression, and 26 (57.8%) outflow arterial occlusion. Comparing the interval changes between patent and occluded FFB groups, the significantly higher frequency of outflow occlusion was noted in occluded FFB group (75% ??vs 38.1%, P=0.012). The most common finding on follow-up ??angiongram responsible for the recurrent ischemia was also outflowarterial occlusion even in patent FFB group. Conclusion: The most common cause of graft occlusion and recurrent leg ischemia was outflow arterial occlusion after FFB.

韓國의 賃金勞動者의 內部構成에 관한 一試論

金炳基 慶北大學校 1984 論文集 Vol.37 No.-

In this paper we aim to analyse the internal structure and its over time changes of the working class in Korea. Since, in its permanent existence, working class is the living part of capital, its structure is determined by the ongoing processes of the accumulation of capital. Export-led industrialization of Korea during last twenty years, promoted by the continuous inflow of foreign capital and prevailing surplus population, has created enormous wage-workers and has changed considerably the structure of the working class. We will clarify the consequences of the dependent accumulation in Korea upon the structure of the working class. And we will discuss the determinants of differentiation of the working class in Korea. We choice the 'broad' definition of the working class which embraces all those who sell their labor-power and are non-owners of capital. With this conception of the working class we make use of the existence of different places within the labor process to distinguish between different fractions and strata. By using empirical data we will identify three fractions of the working class in Korea on economic, political and ideological levels; "middle layers", "core" and "periphery" of the working class. Each fraction has its own chracteristics. We will discuss the nature of the labor process, labor conditions and political and ideological orientation of each fraction, as well as the power and authority relations of each fraction within the job structures of firms and the broad social work organizations.

高成果 企業의 生産體制 特性

김형기 慶北大學校 經濟經營硏究所 2002 經商論集 Vol.30 No.1