C형 간염바이러스항체 검출을 위한3세대 효소면역측정 시약의 비교

이장혁,서순팔,기승정,송정원,신명근,신종희,양동욱,김세종 대한임상병리학회 1997 대한임상병리학회지 Vol.17 No.4

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

급성 족관절 염좌에 대한 복합 침치료의 효과: 사례군 연구

조남훈 ( Nam Hoon Cho ),김미령 ( Mi Riong Kim ),정훈 ( Hoon Jeong ),김동섭 ( Dong Sub Kim ),김은수 ( Eun Soo Kim ),박지용 ( Ji Yong Park ),박현민 ( Hyun Min Park ),이진호 ( Jin Ho Lee ),하인혁 ( In Hyuk Ha ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.1

The purpose of this study is to report the effect of combined acupuncture treatment on acute ankle sprain patients. The subjects included in this study were 15 acute ankle sprain patients who visited Jaseng Hospital of Korean Medicine from Oct. 15th, 2012 to Feb. 8th, 2013. We treated 15 patients with combined acupuncture treatment. The treatment con-sisted of Hwangrunhaedok-tang (Huanglianjiedutang) pharmacupuncture, electroacupunc-ture (applied to GB39, ST36 on the affected side), acupuncture (applied to TE17, SI6 on the unaffected side with Dong-Qi therapy). To assess the effect of treatment, the numeric rating scale (NRS) was applied before and after treatment. After first combined acupuncture treat-ment, the NRS scores significantly decreased from 8.33±0.94 to 2.26±0.44 (p<0.01). We suggested that Combined acupuncture treatment are effective and useful on acute an-kle sprain. And, further studies will be needed. (J Korean Med Rehab 2014;24(1):119-123)

기존의 치료에 반응하지 않는 다발성 간전이 대장암 환자에서 방사선조사와 병합한 수지상세포 면역치료의 1, 2상 임상시험

최영민(Youngmin Choi),이형식(Hyung-Sik Lee),권혁찬(Hyuk-Chan Kwon),한상영(Sang-Young Han),최종철(Jong-Cheol Choi),정주섭(Ju-Seop Chung),김창원(Chang-Won Kim),김동원(Dong-Won Kim),강치덕(Chi-Duk Kang) 대한방사선종양학회 2008 Radiation Oncology Journal Vol.26 No.2

목 적: 기존치료에 반응하지 않는 다발성 간전이를 동반한 대장암 환자에서 방사선치료와 병합한 수지상세포 면역 치료의 독성과 반응도를 조사하였다. 대상 및 방법: 2004년 5월부터 2006년 11월까지 다발성 간전이가 동반된 대장암 환자들 중에서 항암화학 요법에 반응하지 않은 환자 중 지원자를 대상으로 연구를 시행하였다. 본 임상 시험에 대하여 동아대학교병원과 부산대학교병원의 임상윤리심의위원회의 허가를 획득하였고, 동의서에 서명한 환자들을 임상 시험의 대상으로 등록하였다. 환자의 말초 혈액으로부터 수지상세포를 추출하여 배양하였다. 임상시험 일자에 맞추어서 6×106개의 수지상세포를 바이알(0.5 ml)에 넣어서 디씨백/아이알 주사를 만들었다. 수지상세포 면역치료는 2주 간격으로 간전이암조직에 3회 주사하고, 5주에 내약성 평가를 하였다. 내약성 평가를 통과한 환자에게는 8주에 4번째 수지상세포 면 역치료를 하였다. 병의 악화가 없거나 임상시험에 대한 환자의 동의 철회가 없는 경우에는 5, 6번째 수지상세포면역치료를 각각 12, 16주에 시행하였다. 방사선치료는 수지상세포 면역치료를 주사할 간전이암 부위에 주사하기 전일 및 당일에 4 Gy씩을 조사하였다. 내약성 평가는 3×106개의 수지상세포로부터 시작하여, 12×106개의 수지상세포까지 시행하였다. 내약성 평가의 최대 내성 용량으로 추가 임상시험을 하였다. 수지상세포 면역치료 주사를 맞은 모든 환자들에서 안전성 평가를 하였다. 4회 이상 주사를 맞은 환자들을 대상으로 10주에 치료 반응을 평가하여 유효성을 조사하였다. 결 과: 임상시험에 등록한 24명 중 22명에서 수지상세포 면역치료를 시행하였다. 내성약 평가에는 14명이 등록하여 11명에서 평가를 완료하였다. 시험약과의 관련성이 있을 것으로 생각되는 grade 3 이상의 약물반응으로 인한 이상반응은 없었다. 12×106개의 수지상세포를 내성용량으로 확인하였고, 내성용량인 12×106개 수지상세포 면역치료를 이용하여 8명에서 추가로 시험을 하였다. 치료에 대한 환자들의 내성은 양호하였고, grade 3을 초과하는 치명적인 부작용은 발생되지 않았다. 4회 이상의 수지상세포 면역치료 주사를 받은 환자가 17명이었고, 이 중의15명에서는 종양의 반응도 평가가 이루어졌다. 본 연구의 목적은 안전성 평가이지만, 면역치료의 유효성 평가를 위해, 방사선치료와 수지상세포 면역치료 주사가 시행된 부위 외의 간전이암에서 반응도를 조사 하였다. 면역치료의 반응은 평가가 이루어진 환자들에서 정지성 병변이 4명, 진행성 병변이 11명 이었다. 결 론: 수지상세포 면역치료와 병행한 방사선치료는 이론적으로 국소 및 전신 제어에 상승효과가 있을 것으로 기대할 수 있다. 하지만 기존 치료에 반응하지 않는 매우 진행된 직장암 환자들을 대상으로 한 본 연구에서는 방사선 치료와 병합한 수지상세포 면역치료로 인한 심각한 부작용의 발생은 없었다는 결과와 4예에서의 정지성 병변의 관찰을 보고한다. 수지상세포의 최대 투여 용량, 적절한 투여 방법, 적절한 방사선의 양, 방사선과 수지상 세포의적절한 투여 간격 등에 관한 추가 연구를 통하여, 향후 제 2상, 3상 시험으로서의 진행 여부에 긍정적인 결과를얻을 수 있다고 판단한다. Purpose: To assess the toxicity and tumor response induced by DCVac/IRⓇ dendritic cell (DC) immunotherapy combined with irradiation for refractory colorectal cancer patients with multiple liver metastases. Materials and Methods: Between May 2004 and November 2006, applicants from a pool of refractory colorectal cancer patients with multiple liver metastases were enrolled. The patients were registered after having signed the informed consent form, which had been approved by the Institutional Review Board from the Dong-A University and Busan National University Hospital. DCs were obtained from peripheral blood of each patient, and then cultured in vitro. A total of 6×106 DCs were packed into a vial (DCVac/IRⓇ, 0.5 ml) at the convenience of each patient’s schedule. On the day before and on the day of each vaccination, each patient received a 4 Gy radiation dose to the target tumor. On the day of vaccination, the indicated dose of autologous DCs was injected into the irradiated tumor using ultrasound-guided needle injection procedures. A total of four vaccinations were scheduled at three 2-week intervals and one 4 week interval at the Dong-A University and Busan National University Hospital. If the tumor status was deemed to be stable or responding to therapy, an additional vaccination dose or two was approved at 4 week intervals beyond the fourth immunization. A tolerance test for DCs was conducted by injecting a range of doses (3×106 to 12×106 DCs) after the 3rd injection. Moreover, the maximal tolerable dose was applied to additional patients. Treatment safety was evaluated in all patients who had at least one injection. Treatment feasibility was evaluated by the 10th week by assessing the response of patients having at least 4 injections. For systemic toxicities, the evaluation was performed using the National Cancer Institute Common Toxicity Criteria, whereas adverse effects were recorded using common WHO toxicity criteria. Results: Of the 24 registered patients, 22 received the DCs injections. Moreover, of the 14 patients that applied for the tolerance test, only 11 patients completed it because 3 patients withdrew their testing agreement. A grade 3 or more side effect, which was possibly related to the DC injection, did not occur in additional patients. The 12×106 DC injection was identified as the maximum tolerable dose, and was then injected in an additional 8 patients. Patients tolerated the injection fairly well, with no fatal side effects. In order to assess the feasibility of DC immunotherapy, the response was evaluated in other hepatic lesions outside of the targeted hepatic lesion. The response evaluation was performed in 15 of the 17 patients who received at least 4 injections. Stable and progressive disease was found in 4 and 11 patients, respectively. Conclusion: The DC-based immunotherapy and radiotherapy is theoretically synergistic for the local control and systemic control. The DCVac/IRⓇ immunotherapy combined with irradiation was tolerable and safe in the evaluated cases of refractory colorectal cancer with multiple liver metastases. Future work should include well designed a phase II clinical trials

Ezen Good Arch 21(orthotics) 착용이 체지방 및 혈액성분변화에 미치는 영향

김영빈,박병근,정동혁,이정윤 圓光大學校 附設 體力科學硏究所 2004 體力科學硏究 Vol.27 No.-

The aim of this study is to evaluate the effect of Ezen Good Arch 21(orthotics) wearing on GOT, GPT, Glucose, Cholesterol, Uric acid, Body fat in 10 college women. In this study, experiment was performed wearing the Ezen Good Arch 21(orthotics) during 12 weeks, an variables were analyzed after 4 weeks, 8 weeks and 12 weeks. The results of this study were as follows. 1. GOT, GPT were significantly reduced after 8 weeks, 12 weeks(p<.001). 2. Total cholesterol was significantly reduced after 12 weeks(p<.05). 3. Body fat was significantly reduced after 12 weeks(p<.001). 4. Glucose was significantly reduced after 8 weeks, 12 weeks(p<.05). In conclusion, the wearing Ezen Good Arch 21(orthotics) have a good effect on blood components and Body fat improvement, We suggest the study through clinical experiment are needed for the subject who have particular disease.

Hematite의 還元速度에 미치는 Al₂O₃, CaO, SiO₂의 影響

金東義,尹秉河,朴漢赫 경북대학교 공과대학 1985 工大硏究誌 Vol.14 No.-

Reduction of hematite by H_2 and CO-CO_2 gas was performed at 800℃, 900℃, 1000℃ after the addition of Al_2O_3, CaO and SiO_2 as an impurity substances. The reduction rate was appeared maximum by CaO and minimum by Al_2O_3 addition, when their amounts were equal at any temperatures, and regardless of the kinds of foreign oxides, the effects on the reduction rate revealed maximum, when the amount was about 1.0wt%. The reduction rate by the mixed control rate equation was showed straight lines by adopting the values of De and Kr from those experimental data. As the results, effects on the reduction rate when hematite contains foreign oxides, such as Al_2O_3, CaO and SiO_2, at high temperature, it was controlled by chemical reaction, and at low temperature it was controlled by interparticle pore diffusion.

건강과 질병에 대한 저항트레이닝 처방에 관한 탐색

김도희,김수근,정동혁 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.1

Resistance training, also known as strength or weight training, has become one of the most popular forms of exercise both for enhancing an individual's physical fitness and for conditioning athletes. Individuals who participate in a resistance training program expect the program to produce certain benefits, such as increased strength, increased muscle size, improved sports performance, increased fat-free mass, and decreased body fat. A well-designed and consistently performed resistance training program can produce all these benefits. When prescribed appropriately, resistance training is effective for developing physical fitness, health, wellness and for the prevention and rehabilitation of orthopedic injuries. Because resistance training is an integral component in the comprehensive health program promoted by the major health organizations, population-specific guidelines have recently been published. The current research indicates that, for healthy persons of all ages and many patients with chronic diseases, single set programs of up to 15 repetitions performed a minimum of 2 d ·wk-1 are recommended. Each workout session should consist 8-10 different exercises that train the major muscle groups. Single set programs are less time consuming and more cost efficient, which generally translates into improved program compliance. Further, single set programs are recommended for the above-mentioned populations because they produce most of the health and fitness benefits of multiple set programs. The goal of this type of program is to develop and maintain a significant amount of muscle mass, strength, and endurance to contribute to overall physical fitness and health. Patients with chronic diseases may have to limit range of motion for some exercises and use lighter weights with more repetitions. The results of data provided by this research on resistance training for health shows that there is enough existing evidence to conclude that resistance training, particularly when incorporated into a comprehensive fitness program, can offer substantial health benefits which can be obtained by persons of all ages. These benefits, including improvements in functional capacity, translate into an improved quality of life.

Mn-nodule의 선광에 관한 연구(제1보)

김익수,박동기,성일용,김승혁,엄제현 三陟大學校 2000 論文集 Vol.33 No.1

For the purpose of reserching the floatability of Managanese-nodule, the test was proformed by means of Zeta potential measuring and the flotation experiment for 10Å Manganite. The flotation condition in the flotation experiment were as follow. sample : Todorokite (0.3gr) sample size : 65 mesh ~ 200 mesh condition size : 10 min flotation time : 4 min air amount : 20 ㎖/min promoter : D.A.cl, S.D.S. PH regular : Hcl, CaO From the test the flotation result were summerized as follow. 1. The isoelectric point of 10Å Manganite in the Zeta potential measuring was pH 4.3. 2. The floatability of 10Å Manganite was 80% as a function of pH5 using 10mg/ℓ of D.A.cl. 3. The recovery of 10Å Manganite was best when the floatability of 10Å Manganite was 90% as using D.A.cl 80mg/ℓat PH 2.7.

수분흡수가 섬유강화 고분자 복합판의 기계적 성질에 미치는 영향

김혁,한길영,이동기 조선대학교 생산기술연구소 1995 生産技術硏究 Vol.17 No.1

Nowadays, it is common and becoming more popular to use fiber-reinforced polymeric composites(FRP) in order to reduce the lightweight of the structures such as marine vehicles, automobiles and airplane. It investigates the residual strength characteristics of composite under the environment of high temperature and humidity. The residual strength of FRP is known to be greatly influenced by temperature, humidity etc. In this context, the hygrothermal effect of changing the fiber contents and orientation are investigated in order to provide better residual strength characteristics. When exposed long terms in high temperature and humidity, the randomly oriented composites is to be more stable than the unidirection one.