지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

Sulforaphane protects against acetaminophen-induced hepatotoxicity

Noh, Jung-Ran,Kim, Yong-Hoon,Hwang, Jung Hwan,Choi, Dong-Hee,Kim, Kyoung-Shim,Oh, Won-Keun,Lee, Chul-Ho Elsevier 2015 Food and chemical toxicology Vol.80 No.-

<P><B>Abstract</B></P> <P>Oxidative stress is closely associated with acetaminophen (APAP)-induced toxicity. Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. This study investigated whether sulforaphane (SFN), as a HO-1 inducer, plays a protective role against APAP hepatotoxicity <I>in vitro</I> and <I>in vivo</I>. Pretreatment of primary hepatocyte with SFN induced nuclear factor E2-factor related factor (Nrf2) target gene expression, especially HO-1 mRNA and protein expression, and suppressed APAP-induced glutathione (GSH) depletion and lipid peroxidation, which eventually leads to hepatocyte cell death. A comparable effect was observed in mice treated with APAP. Mice were treated with 300 mg/kg APAP 30 min after SFN (5 mg/kg) administration and were then sacrificed after 6 h. APAP alone caused severe liver injuries as characterized by increased plasma AST and ALT levels, GSH depletion, apoptosis, and 4-hydroxynonenal (4-HNE) formations. This APAP-induced liver damage was significantly attenuated by pretreatment with SFN. Furthermore, while hepatic reactive oxygen species (ROS) levels were increased by APAP exposure, pretreatment with SFN completely blocked ROS formation. These results suggest that SFN plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. SFN has preventive action in oxidative stress-mediated liver injury.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SFN pretreatment increases the cell viability against APAP-induced toxicity. </LI> <LI> SFN pretreatment protects depletion of cellular GSH after APAP treatment. </LI> <LI> SFN pretreatment enhances Nrf2 target gene expression, especially HO-1 after APAP treatment. </LI> <LI> SFN has protective effect against APAP overdose-induced liver injury <I>in vivo</I> model as well. </LI> </UL> </P>

CMOS VLSI의 IDDQ 테스트세트 간략화에 관한 연구

김강철,송근호,한석봉 진주산업대학교 1996 論文集 Vol.35 No.-

This paper proposes a dynamic compaction algorithm which can detect intra-bridging faults for IDDQ testing in CMOS VLSI. X_gates which have X(don't care) values in the input of the gate may exist in the circuit after a test pattern in chosen. The compaction algorithm assigns the logic value 1 or 0 that can be applied to the primitive fault pattern to X in the X_gate, and it detects all detectable faults for a test pattern. The simulation results in the benchmark circuits show that the fault coverage of this dynamic compaction algorithm is much enhanced compared with the conventional static compaction algorithms, and the resulting test vector reduction is up to 30%.

유방에서 기원된 전이성 췌장암종 1예 : A case report

김윤신,이미숙,장원재,임성철,기근홍,전호종,서재홍 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Pancreas is known for the unfavorable soil to the metastatic carcinoma, and pancreatic metastasis is achieved after systemic dissemination was developed. The primary tumors of metastatic pancreatic carcinoma are breast, lung, Iymphoma, malignant melanoma, leukemia, stomach. and colon. The breast carcinoma is the commonest tumor to metastasize to pancreas and both tumors are related to estrogen receptor for tumor growth. In the present case, tumor cells had small round nucleus and showed indian file infltrating pattern and lack of cohesion, which are seen in infiltrative breast carcinoma. The patient was underwent radical mastectomy due to infiltrative ductal carcinoma three years ago. And also the tumor cells showed nuclear reactivity to immunostaining for estrogen receptor In combination of the histopathologic. immunohistochemical, and her past history, we concluded that breast carcinoma was metastasized to pancreas, and we report a case of metastatic pancreatic carcinoma from breast with review of literatures.

부신적출이 조직 Li분포에 미치는 영향

김형근,성호경,이상돈 중앙대학교 의과대학 의과학연구소 1975 中央醫大誌 Vol.1 No.1

Effect of adrenalectomy on lithium distribution in various tissues of rats was studied. Rats were divided into three groups; namely, untreated, Li treated, and Li treated after adrenalectomy was done on 3rd dat prior to lithium treatment. Animals were killed following lithium treatment, and tissues including blood were taken immediately and digested and Li and Na concentrations were measured by atomic absorption spectroscopy. Effect of adrenalectomy on lithium distribution in various tissues was abserved, e. g. : brain skeletal muscle, bone, liver, renal cortex, cardiac muscle as well as plasma and erythrocyte. Correlations of Li concentrations were analyzed for each tissues. Results were smmarized as follows: 1. Adrenalectomy resulted an increase of lithium concentrations of various tissues in rats. 2. Erythrocyte to plasma ratio of lithium concentration was elevated in adrenalectomized rats, and it was considered that Li passed fairly well into cell under the adrenalectomy. 3. Adrenalectomy promoted the lithium retention in some tissues, especially bone, skeletal muscle and brain. 4. No correlation between tissues Li and Na was observed every tissues examined. 5. Lithium retention mechanism and pattern of distribution in some tissues of adrenalectomized rats were discussed.

경구용 Fluconazole 투여로 치유된 스포로트리쿰증 1예

김문범,오창근,장호선,권경술 대한의진균학회 1999 대한의진균학회지 Vol.4 No.2

We report a case of lymphocutaneous sporotrichosis in a 76-year-old female successfully treated with oral fluconazole. This case had showed almost complete clinical resolution by 200mg daily administration of oral fluconazole for 7 weeks and has got no relapse until 18 weeks after the completion of the treatment. We would emphasize good therapeutic effects of fluconazole such as more rapid therapeutic response than the previous reports and no observable side effects. [Kor J Med Mycol 4(2): 148-152]

이소성 타액선에 의한 경부 누공 1예

김병균,김문범,이재봉,오창근,장호선,권경술 대한피부과학회 2003 대한피부과학회지 Vol.41 No.3

Ectopic salivary tissue is an uncommon etiology of a neck mass in an infant. It is due to anomalous embryologic development of salivary tissue. We have experienced a case of cervical fistula due to ectopic salivary gland in 3-year-old male. The discharge is saliva-like and related to meals. Histopathologically, mucinous acini are located in lower dermis and subcutaneous fat. When a cystic neck mass or fistula is present on cervical area especially in children, an ectopic salivary gland should be considered as one of the causes. (Korean J Dermatol 2003;41(3) : 394∼396)

구조물의 정적보강에 따른 동적 응답 예측에 관한 연구

김강부,전종균,엄호성 선문대학교 2000 공학계열 논총 Vol.3 No.-

본 논문에서는 기존 반도체 공장의 세품 정밀도를 개선하기 위한 방안으로 정적보강올 실시하는 구조물에 대하여 동적 응답 을 실험적인 방법과 해석적 방법을 병행하여 예측하였다. 또한, 실험적인 방법과 해석적 방법의 상호적용을 위하여 진동제어 절차서를 제시하였다. 동특성 실험을 통하여 구조물의 지배 모드를 확인 하고, 모델해석과 비교하였다. 해석결과에서는 구조보강 前/後에 대하여 동일한 모드형상을 갖는 고유진동수를 4차까지 선정하여 강성 증가에 따른 변화를 비교하였다. 또한, 정적보강 前/後 구조물의 동적 특성을 비교하기 위하여 격자보 구조물에서 가장 취약할 것으로 판단되는 지점을 가진점으로 선정하여 주파수별 단위 하중에 대한 응답특성을 계산하였다. 실험/해석결과를 바탕으로 구조물의 정적보강을 통한 동적 응답의 기여도를 확인하였다. In this paper, dynamic response about the static stiffening reinforcement of structure by the experimental method and theoretical analysis has been predicted for the improvement of accuracy in the manufacturing process of semiconductor factory. Also, vibration control procedure is presented by the mutual working of the experimental method and theoretical analysis. Dominant vibration mode of the structure has been investigated by the experiments for the dynamic characteristics and compared with the model analysis of the structure. The change due to the increase of stiffening about the same mode shape for the four natural frequencies is investigated after(and before) the reinforcement of structure stiffness. Response characteristic about the weight at each band of frequency has been calculated at the exciting points in which the lattice-type structure has weakness mostly. The effect of dynamic response of the structure with reinforced static stiffness through the experimental and theoretical results is verified.

시공간 데이터 분석을 위한 집계연산

김상호,류근호 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.1

기존의 집계질의에 대한 연구는 시간 또는 공간에만 편중되어 시간과 공간 제약을 모두 가진 시공간 데이터에 직접 적용하기 어려운 문제점이 있다. 이와 같은 문제를 해결하기 위해 이 논문에서는 시공간 데이터를 위한 데이터 베이스 스키마를 제안하고, 이를 기반으로 시공간 데이터베이스에 저장된 다양한 유형의 시공간 데이터에 대한 이력정보와 공간정보의 통계적인 분석이 가능한 시공간 데이터 지원 집계연산을 제안하고 알고리즘을 설계한다. 그리고, 제안된 시공간 집계연산 알고리즘의 성능평가를 통해 타당성을 보인다. 제안된 집계연산은 지리 정보 시스템, 기상 정보 시스템, 농업 정보 시스템등과 같은 다양한 분야에 적용 될 수 있다. The previous works on aggregate operations have been attached only to temporal aggregate operations or spatial aggregate operation. So they have problems that are difficult to apply to spatiotemporal data directly which having spatial and temporal constraints. In order to solve these problems in this paper, we propose aggregate operations for spatiotemporal dat, which make it possible to statistical analysis for historical and spatial information of various types of spatiotemporal data that are stored in spatiotemporal database. The proposed aggregate opration are based on the database scheme has been designed for the spatiotemporal concepts. And, we showed the validity of our algorithms from the performance evaluation of the proposed aggregate operations. The proposed aggretaed operations can be applied to the various applications, such as GIS, WPS(Weather Forecast System), AIS(Agriculture Information System) and so on.