항암화학요법 중 호중구감소증이 발생한 저위험군 발열 환자들을 대상으로 한 경구 항균제 요법의 임상적 유용성 및 안정성에 대한 연구

김연숙,이혁,기현균,김춘관,김신우,김성민,백경란,김원석,윤성수,이홍기,강원기,박찬형,박근칠,송재훈 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 항암화학요법 중 호중구감소증을 동반한 발열이 발생하는 암환자들을 치료하기 위한 다양한 항균제와 여러 가지 방법들이 시도되고 있는 가운데, 합병증과 사망률의 발생가능성이 적은 저위험군 환자들을 대상으로 초기 72시간동안 정주 항균제를 투여한 이후 경구 항균제로 전환하는 요법의 유용성과 안정성을 평가해보고자 본 연구를 시행하였다. 방법 : 1998년 2월부터 1999년 9월까지 본원에서 항암화학요법 중 호중구감소증과 발열이 발생한 환자들 가운데 기저 암질환이 고형암이거나 림프종이고, 입원당시 패혈증의 증후가 없으며 입원 72시간이내에 해열되고 백혈구수치가 증가 추세인 환자들을 대상으로 하여 72시간 동안 정주 항균제를 투여한 이후 경우 ciprofloxacin 750㎎을 하루 2회씩 투여하여 총 4일간 투여하였다. 모든 환자들은 열이 떨어지고 호중구감소증이 회복될 때까지 입원하도록 하였다. 결과 : 총 38명 환자의 40예가 등록이 되었고, 환자들의 기저암 질환은 고형함이 72.5%, 림프종이 27.5%였다. 입원당시 평균 호중구치수는 156/㎕였고, 호중구수치가 100/㎕미만인 경우는 65%였으며, 호중구감소증이 지속된 기간의 평균은 2.4일이었다. 40예 중 39예가 항균제의 변형이나 추가 없이 호중구감소증과 발열로부터 회복이 되어 97.5%의 성공율(95% 신뢰구간: 86.8-99.9%)을 보였다. 부작용으로 피부발진이 있었던 경우가 한 예 있었는데, 증상이 경하여 경구 항균제를 지속할 수 있었다. 심와부의 동통으로 복용을 지속할 수 없어서 대상에서 제외된 예가 또 한 예 있었다. 결론 : 항암요법 중 호중구감소증과 발열을 동반한 환자들 가운데 저위험군 환자들에서 항균제 72시간정주 이후 경구 항균제로의 전환요법은 효과적이고도 안전한 치료방법이라고 할 수 있다. Background : Oral antibiotic therapy following empirical intravenous antibiotics may be effective and safe for febrile neutropenic patients with lowrisk for complications. Methods : We conducted a prospective clinical trial of oral antibiotic therapy in the patients with neutropenia and fever during chemotherapy for cancer. Underlying malignancies were solid tumor or lymphoma with short duration of neurtropenia and the patients had no evidence of clinically or microbiologically documented infections. Oral ciprofloxacin was given to the patients who lacked signs of sepsis on admission, had a rising tendency of neutrophil count (ANC >100 /㎕ ) at 72 hours, and were afebrile at 72 hours. All patients were hospitalized until neutropenia and fever resolved. Results : A total of 40 episodes of 38 patients were enrolled from February 1998 to September 1999. The mean neutrophil counts on admission were 156/㎕ and the mean duration of neutropenia was 2.4 days. The episodes which had neutrophil count below 100 /㎕ were 26 (65%). Treatment was successful in 39 of 40 episodes (97.5% : 95 % confidence interval, 86.8% to 99.9%). Adverse reactions of oral ciprofloxacin were skin rash and epigastric soreness in two cases, respectively. There were no deaths during the study. Conclusions : For low-risk febrile patients with neutropenia during cancer chemotherapy, switch therapy to oral ciprofloxacin at 72 hours following intravenous broad-spectrum antibiotics is effective and safe,

Lidocaine, Thrombin, Epinephrine 의 항균효과

김진우,이동건,전혜선,김승준,김석찬,안중현,김치홍,권순석,김영균,김관형,문화식,신완식,송정섭,박성학 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

목적 : 기관지내시경 검사에서 흔히 사용되는 국소마취제인 lidocaine과 내시경시 지혈목적으로 사용되는 thrombin과 epinephrine이 각종 균주에 미치는 항균효과에 대해 알아보고자 하였다. 재료 및 방법 : 균주는 가톨릭대학교 성모병원에서 2004년 3월부터 2004년 9월까지 임상검체 에서 동정된 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 각각 42, 42, 42, 43주를 대상으로 하였다. Lidocaine, thrombin, epinephrine 감수성 검사는 National Committee for Clinical Laboratory Standards (NCCLS, 2002)의 기준에 따랐다. 결과 : Lidocaine은 S. aureus, S. pneumoniae, P. aeruginosa에서 MIC_(50), MIC_(90) 모두 20,000 ㎍/mL 이었다. K. pneumoniae는 각각 10,000 ㎍/mL이었다. Thrombin은 S. aureus와 P. aeruginosa에서 MIC50 500 lU/mL 과 MIC_(90) 500 IU/mL 이상이었고, K. pneumoniae에서는 MIC_(50)과 MIC_(90)이 모두 500 lU/mL이상이었으나 S. pneumoniae에서는 MIC_(50)과 MIC_(90)은 125 IU/mL이었다. Epinephrine은 K. pneumoniae, S. pneumoniae에 대한 MIC_(50), MIC_(90)가 모두 >500 ㎍/mL이었고, S. aureus와 P. aeruginosa에 대한 MIC_(50), MIC_(90)가 모두 500 ㎍/mL이었다. 결론 : 기관지 내시경 검사에서 흔히 쓰이는 lidocaine, thrombin, epinephrine 등의 약제들이 호흡기 질환의 흔한 병원균인 S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa 균주들에 대해 항균 효과가 있을 수 있어 세균배양검사에 영향을 미칠 수 있겠다. Background : We performed this stody to find out about antimicrobial effect of lidocaine which is commonly used local anesthetic, and thrombin and epinephrine used for hemostasis during bronchoscopic procedures. Materials and Methods : The microorganisms that were cultured from specimens obtained during bronchoscopy were Staphylococcus aureus (n=42), Streptococcus pneumoniae (n=42), Klebsiella pneumoniae (n=42), and Pseudomonas aeruginosa (n=43) collected from St. Mary's Hospital, from March to Sep 2004 were used for susceptibity testing. Susceptibility to lidocaine, thrombin, and epinephrine were tested according to the National Committee for Clinical Laboratory Standards. Result : MIC_(50) and MIC_(90) of lidocaine for S. aureus, S. pneumoniae, P. aeruginosa were all 20,000 ㎍/mL and that for K. pneumoniae were 10,000 ㎍/mL. MIC_(50) and MIC_(90) of thrombin for both S. aureus and P. aeruginosa was 500 IU/mL and above 500 IU/mL, respectively; that for K. pneumoniae were all above 500 IU/mL and for S. pneumoniae they were 125 IU/mL, MIC_(50) and MIC_(90) of epinephrine for K. pneumoniae and S. pneumoniae were above 500 ㎍/mL; that for S. aureus and P. aeruginosa were 500 ㎍/mL. Conclusion : We observed possible antimicrobial effect of lidocaine, thrombin, and epinephrine in vitro against pathogens such as S. aureus, S. pneumoniae, K. pneumoniae, P. aeruginosa, which are common respiratory microorganisms. The use of these agants could affect the result of bacterial culture.

전사수준에서 탄소원에 따른 효모 glucoamylase의 발현

김관천,진종언 광주보건대학 1996 論文集 Vol.21 No.-

Northern hybridization of putativa gene fragments of glucoamylase from Lipomyces kononenchoae or Candida tsukubaensis glucoamylase with poly(A^(+))RNA extracted from its cells grown in several carbon sources was carried out. The synthesis of L. kononenchoae glucoamyase was several repressed by glucose while that of C. tsukubaensis glucoamylase was better in glucose than in starch. This result was consistent with that of enzyme activity.

십대자살 예방과 치료를 위한 위기상담적 고찰 : 학교상담 개입을 중심으로

김춘경,홍종관 대구교육대학교 2003 論文集 Vol.38 No.-

스피드 트레이닝 방법에 따른 Creatime Kinase의 변화가 30M 전력달리기 기록에 미치는 영향

金基榮,田寬錫,曺圭權,鄭宇鎭 江原大學校附設體育科學硏究所 1994 江原大學校附設體育科學硏究所論文集 Vol.- No.18

The enhancement of sport performance is made possible by scientific training methods which can back up all area osf sports. The subjects of this study were 16 students of Department of P. E., Kangnung National University, They were divided into 4 groups (4 students in each group) - Control Group, Box Drill Group, Rubber Resistance Training Group and Air Resistance Training Group. All of them had 12 weeks of speed training by the same load and intensity. We measured the mean of each group's Serum CK and the Record on 30M Dash before and 2,4,6,8,10,12 weeks after the begining of training, By the measurements, we could trace the correlations of training periods, groups and the mean, After the analysis (Which may be used on materials for the development of speed training methods), we came to the following conclusion. ▷표 삽입◁(원문을 참조하세요.) From the test results above, we conclude that Box Drill and Rubber Resistance Training are more effective way of developing speed ability than any other speed training. With the same training load and intensity. the subjects do not show much difference in their record on 30M Dash by the change of Serum CK activity. We make the following suggestions to see a better speed training method and post research that was felt in the study to be dusirable. 1. For more exact accounts of CK in the blood, it is required to have a careful medical check up and also control of the subjects before and after the test, respectively. 2. To make the study of biochemical enzymes more useful in terms of the player's competiveness, we should do research on the spot. 3. The parachute employed for Air Resistance Group should be readapted each time and applied to each one according to his body structure and physical fitness, and a new method of parachute used training should be developed for more speed endurance of the player on the slope of 5°-10° rather than speed power at a short distance. 4. For more effective Rubber Resistance Training, a new training method should be developed whereby the player can have more impact against the floor and than absorb it and he can improve his speed power.

Cellulose 분해효소를 분비하는 Trichoderma 속의 섬유소분리 및 특성에 관한 연구

김관천 광주보건대학 2001 論文集 Vol.26 No.-

Isolation and characterization of Trichoderma SP. Producing cellulases. Based on taxamomaricc studies, the fungus could be classified as a strain of Trichoderma SP. Trichoderma is known source of an extracellular cellulase. The culture was grown at 28℃ for 3 days before storing at 4℃. Induction medium according to the mineral component of minimal medium. Growth inhibitor is L-sorbose, oxgall, Sodium deoxy-cholate and triton X-100. This results suggest that triton X-100 is more then the growth inhibitor of Trichoderma SP. It is the more efficient in oxgall.

작은 피질하 병변에 대한 정위적 개두술 및 경-구 접근법

손병철,김문찬,이관성,박춘근,홍용길,강준기 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.12

ENHANCED HUMUS FORMATION IN A SUBSTRATE- CONTROLLED COMPOSTING REACTOR

황은주,김준수,전관수 대구대학교 환경기술연구소 2004 미래환경기술 Vol.1 No.1

A substrate-amended fed-batch composting of food waste was investigated and its effect on humus formation and cellulose decomposition were studied. Various substrates were added to the reactor in fed-batch mode while no additional feed was introduced into the other reactor for comparison. Active composting was prolonged by the amendment of substrate. Cellulose composition changed from initial value of 33.4% to 32.6% in conventional batch composting. Cellulose decreased to 30.2% in the substrate-amended, fed-batch composting. It decreased further to 24.2% when the amount of substrate amendment increased in the fed-batch composting. Humus formation was enhanced in the substrate-amended composting. Humic substances were produced more in the fed-batch composting (7.47% and 8.76%) as compared to conventional batch composting (7.12%). About 5% to 23% increase in humic substance was achieved in the fed-batch composting. It was confirmed that the substrate-amended, fed-batch composting improved the degradation of cellulose and the formation of humus.

全北地方의 放射能資源 探査

盧鈑愚,金駿培,嚴大翼,朴鎭夏,黃鎬觀,李春鎬 全北大學校 文理科大學 1975 論文集 Vol.2 No.-

For the utilization of atomic energy, radioactive mineral survey was projected in Jeonbuk District of the north of 3°50′ N. L. and 127°00 E-127°45′ E. Consequently, Mt. Yongwha, Mt. Chonho and Bibong areas were chemically and physically selected as the most prospective ones, and these areas, which have the radioactivities more than 28 cpm, were assumed to have the radioactive minerals related with black slates of Ockchon System.

FEM을 이용한 선삭가공 절삭조건의 영향 분석

임세환,송춘삼,홍석관,강정진,김주현 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

A plane strain finite element model is developed to simulate turning with continuous chip formation using adaptive remeshing during the thermal-mechanical coupled analysis. Comparisons between the experimental and simulation results for cutting forces are performed to validate FE analysis results. Influences of machining parameters such as depth of cut, cutting speed and feed rate on cuting force and shear angle are analyzed by Taguchi method. The more depth of cut and feed rate result in the increase of cutting forces, but the rates of increase are decrease due to the larger shear angle. As the cutting speed increases, von Mises stress of workpiece near the tool tip decreases because the strength of specimen decreases at high temperature above 500℃. This thermal effect on cutting force is negligible because the affected area is very localized and the average values of von Mises stress in the shear plane are the same among the diverse cutting parameters.