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윤성수 영남대학교 기초/임상의학연구소 2006 Yeungnam University Journal of Medicine Vol.23 No.2
담낭암은 조기에 진단되지 않아 예후가 아주 나쁜 소화기암 중의 하나로, 담낭암 발생의 위험성을 예견한 담낭절제술의 대상을 정확히 규명하는 것이 중요하다. 담낭 용종의 크기, 개수, 담석의 유무, 환자의 나이가 담낭암 발생과 관련된 인자이며, 용종 크기 1 cm 이상, 동반된 담석증, 50세 이상, 증상이 있을 때, 관찰 기간 중 급격한 크기 변화가 있을 때 수술을 권하는 것이 좋을 것으로 판단되며, 췌담관 합류 기형이 발견되면 담낭을 반드시 절제 하여야 하며 수술 전 및 수술 중 담낭암의 존재 여부를 세밀히 조사하는 것이 좋겠다. 만성 담낭염에서 보이는 담낭 점막의 화생 변화는 전암 병변으로 생각이 되며, 담낭염의 변종으로 생기는 황색육아종성 담낭염, 도재담낭 및 담낭 장관루 등에서 고빈도로 담낭암이 발생하고 있어, 염증성 변화 및 이의 지속되는 기간과 암 발생과는 밀접한 관계가 있을 것으로 사료 된다. Carcinoma of the gallbladder is an uncommon but highly malignant tumor with a poor five year survival rate. Early detection is very important for successful treatment because this tumor is very hard to cure in cases where it has advanced beyond the reach of surgical treatment. The purpose of this review was to evaluate risk factors for carcinoma of the gallbladder and determine the best management approach.. Solitary polys, more than one cm are considered to be predisposing factors for gallbladder carcinoma when they are found to be echopenic, sessile, and with a high cell density. Anomalous union of the pacreato-biliary duct(AUPBD) without a choledochal cyst is also considered to increase risk for gallbladder carcinoma. A polyps size of more than one cm and an AUPBD are indications for prophylactic cholecystectomy. The presence of gallstones is a well-established risk factor for the development of gallbladder carcinoma; risk appears to correlate with the stone size and the duration of chronic cholecystitis. Metaplastic changes of the gallbladder epithelium present with chronic cholecystitis and may indicate a premalignant lesion. Abnormal forms of cholecystitis such as xanthogranulomatous or a porcelain gallbladder also have malignant potential; cholecystoenteric fistula as well as bacterial infection of the gallbladder(typhoid, helicobacter species) also has malignant potential. In this review, the risk factors associated with carcinoma of the gallbladder are summarized with special attention to gallstones, polyps, AUPBD, and chronic inflammation.
윤성수 가톨릭대학교 가톨릭암센터 2000 암심포지움 Vol.- No.1
혈관형성(angiogenesis)은 기존의 혈관계로부터 새로운 혈관이 생기는 것으로 종양의 성장과 전이에 필수적이다. 혈관형성은 내피세포의 이동과 성장, tube 형성, 문합(anastomosis) 등이 angiogenic factor에 의해 조절되며 종양세포 뿐만 아니라 세포외 간질 및 주위 세포들이 다같이 관여한다
Laparoscopic hepatobiliary and pancreatic surgery: my trials and current status in Korea
윤성수 대한내시경복강경외과학회 2021 Journal of Minimally Invasive Surgery Vol.24 No.2
There has been a dramatic change in surgical care over the past 30 years with the introduction of laparoscopic surgery. It was my great fortune that I could experience laparoscopic surgery during my resident training period. After beginning to work for my hospital in 1995, I tried laparoscopic surgery in many surgical fields, including hepatobiliary and pancreatic (HBP), colon, stomach, and vascular surgery (endoscopic saphenous vein harvesting, endoscopic subfascial perforating vein interruption to treat skin complications in patients with deep vein insufficiency in the lower leg). In Sabiston, Textbook of Surgery, published in 1997, laparoscopic Whipple and major liver resection were not accepted at the time but now are. There are three possible reasons that may explain this shift. The first one is the 30 years of experience using advanced techniques; all of us know that “Seeing is believing,” and “A thousand hearings are not worth one seeing.” Next is the availability of three-dimensional imaging with magnification which enables us to perform difficult surgeries. The last one is the use of good instruments and an advanced surgical platform. In this paper, I would like to share my past and recent trials with advanced HBP laparoscopic surgery, as well as its current status in Korea and future directions.