노령의 대퇴 전자간 골절 치료에서 압박고 나사못의 안정성 및 유용성

김종오,노권재,윤여헌,고영도,유재두,정준모,방한천,정재학 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 노령의 대퇴 전자간 골절에서 압박고 나사못의 안정성에 영향을 주는 인자들간의 상관 관계와 골절 양상에 따른 술후 고관절 기능을 평가 및 분석하였다. 대상 및 방법: 압박고 나사를 이용하여 수술적 치료를 시행한 231명의 환자 중 6개월 이상 추시가 가능하였던 60세 이상 84명의 환자들을 대상으로 했다. 방사선적 계측은 압박고 나사못의 활강 길이 및 내반각, 가압 나사 위치, 정복 상태, 원위 골편의 내측 전위를 측정하였으며 술후 기능은 Clawson의 기능 평가표로 하였고 골절 양상에 따라 방사선 계측과 기능 회복과의 상관 관계를 평가하였다. 결 과: 임상 결과는 불안정 골절에서 양호가 10례, 불량이 23례, 안정 골절에서는 양호 40례, 불량이 11례로 안정 골절에서 임상 결과가 좋았고(p<0.001), 압박고 나사 활강은 10 ㎜ 이상일 때 양호가 4례, 불량이 21례, 10 ㎜ 이하에서 양호가 46례, 불량이 13례로 10 ㎜ 이상 활강시에 술후 결과가 불량했다(p<0.001). 다르 방사선적 계측 요인은 결과에 의미있는 차이를 보이지 않았다. 또한, 불안정 골절 중에서 전위 양상 골절의 경우 10㎜ 이상 활강이 12례, 10㎜ 이하 활강이 8례, 분쇄 양상 골절의 경우는 10㎜ 이상이 11례, 10㎜ 이하가 2례로 분쇄 양상의 불안정 골절에서 10㎜ 이상 활강이 의미있게 많았다 (p<0.001). 결 론: 10㎜ 이상의 지연 나사 활강은 고관절 기능 회복 약화를 유발시킬 수 있으며 불안정 골절 분쇄 양상 골절은 이런 지연 나사의 활강이 과도하게 유발될 수 있으므로 불안정 분쇄 양상 골절에서 압박고 나사의 단독 사용은 재고해 보아야 할 것이다. Purpose: To evaluate the relationship between fracture stability and functional results, and analyze the correlation between stability factors and the outcome in intertrochanteric fracture of the elderly. Materials and Methods: Of the 231 patients, 84 patients with age above 60 were able to follow up for minimum 6 months. We measured the sliding length of the lag screw, varus degree, position of lag screw, reduction status and medialization of distal fragment radiologically. The functional outcome of the treatment was evaluated with the Clawson's result classification and we evaluated the correlation between the radiological results of measurement and the functional recovery depending on the Evans fracture classification. Results: There were good results in 40 cases out of 51 stable fractures, and in 10 cases out of 33 unstable fractures (p<0.001). In case of sliding of lag screw more than 10㎜, good results were obtained in 4 cases, and poor in 21. And in case of sliding less than 10㎜, good results were obtained in 46, and poor in 13. (p<0.001).But there was no relationship between other radiologic factors and clinical results. In unstable type, there were 12 cases with lag screw sliding more than 10㎜ and 10 cases with less than 10㎜. In comminuted type, there were 11 cases with lag screw sliding more than 10㎜ and 2 cases with less than 10㎜(p<0.001). Conclusion: The sliding of lag screw more than 10㎜ may result in poor outcome. As in comminuted unstable pattern, sliding of lag screw might be excessive, the use of compression hip screw alone is not good treatment option.

점증적 최대운동이 항산화 효소의 혈중 농도에 미치는 영향

강신범,이상우,김상권,서해근,김준모 東亞大學校附設스포츠科學硏究所 1999 스포츠科學硏究論文集 Vol.17 No.-

The purpose of this study is to examine how exercise stimulus effects on the boold concentration of antioxidant enzymes. And then, the results of analysing the boold concentration of antioxidant enzymes before and after graded maximal exercise based on high school's 7 males, are as follows: 1. The blood concentration of SOD is found to have a significant increase before and after graded maximal exercise. 2. The blood concentration of CAT is found to have a significant increase before and after graded maximal exercise. 3. The blood concentration of CAT is found to have a significant change. As the above results, the severe exercise of short time is found to increase the blood concentration of SOD as well as CAT. And then, the blood concentration of GPX is found not to have a significant exchange. To examine the mechanism of the above results manifestly, it is considered that the deep study based on exercise style, duration time and exercise intensity, should be continued.

Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells

( Ji Yong Kim ),( Jai Sung Lee ),( Yong Seok Han ),( Jun Hee Lee ),( Inhyu Bae ),( Yeo Min Yoon ),( Sang Mo Kwon ),( Sang Hun Lee ) 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6

Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although H2O2 (200 mM) increased intracellular ROS levels in human MSCs, lycopene (10 μmM) pretreatment suppressed H2O2-induced ROS generation and increased survival. H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.

Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells

Kim, Ji Yong,Lee, Jai-Sung,Han, Yong-Seok,Lee, Jun Hee,Bae, Inhyu,Yoon, Yeo Min,Kwon, Sang Mo,Lee, Sang Hun The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.6

Human mesenchymal stem cells (MSCs) have been used in cell-based therapy to promote revascularization after peripheral or myocardial ischemia. High levels of reactive oxygen species (ROS) are involved in the senescence and apoptosis of MSCs, causing defective neovascularization. Here, we examined the effect of the natural antioxidant lycopene on oxidative stress-induced apoptosis in MSCs. Although $H_2O_2$ ($200{\mu}M$) increased intracellular ROS levels in human MSCs, lycopene ($10{\mu}M$) pretreatment suppressed $H_2O_2$-induced ROS generation and increased survival. $H_2O_2$-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment. Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by $H_2O_2$ treatment. Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway. Our findings show that lycopene pretreatment prevents ischemic injury by suppressing apoptosis-associated signal pathway and enhancing anti-oxidant protein, suggesting that lycopene could be developed as a beneficial broad-spectrum agent for the successful MSC transplantation in ischemic diseases.

Development of Knot Quantification Method to Predict Bending Strength Using X-ray Scanner

Jun Kwon Oh,Keang Mo Kim,Jun Jae Lee 한국목재공학회 2008 목재공학 Vol.36 No.5

Changes in Grain Quality, Amylose and Protein Contents Under High Temperature During Grain Filling Stage Among Korean Rice Cultivars

Young-Jun Mo,Ki-Young Kim,Woon-Chul Shin,Jeong-Kwon Nam,Jong-Cheol Ko,Mun-Sik Shin,Bo-Kyeong Kim,Jae-Kwon Ko 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04

A total of 40 Korean rice cultivars were exposed to high temperature during grain filling stage in the greenhouse condition and changes in head rice ratio of brown rice, whiteness of milled rice, amylose and protein contents were investigated in comparison with field-grown plants. Testing cultivars were categorized into four groups according to maturation period and accumulated temperature was 1216.4~1775.8oC in the field condition and 1275.8~ 1893.7oC in the greenhouse condition during grain filling stage. Reduction ratio of head rice and whiteness under high temperature in the four groups were 23.6, 17.7, 13.0, 8.7% and 12.7, 12.3, 9.5, 6.0%, respectively, in which early-maturing group showed more severe deterioration due to the early exposure to high temperature. Rice cultivar Dongan and Daeya were the most tolerant to high temperature among the tested cultivars showing 0.5 and 6.6% of the head rice reduction ratio and 0 and 1.2% of whiteness reduction ratio under high temperature, respectively. Amylose contents of the four groups were reduced by 11.7, 11.3, 8.8, 8.5% under high temperature in group Ⅰ, Ⅱ, Ⅲ, Ⅳ, respectively, whereas protein contents were increased by 14.2, 6.3, 4.4, 4.4% in the four groups, respectively.

Relationship between Panicle Traits and Ripened Grain Ratio under High Temperature among Korean Rice Cultivars

Young-Jun Mo,Ki-Young Kim,Woon-Chul Shin,Jeong-Kwon Nam,Jong-Cheol Ko,Mun-Sik Shin,Bo-Kyeong Kim,Jae-Kwon Ko 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04

Temperature rise during grain filling stage by global warming causes deterioration in rice yield and quality. This study was conducted to investigate proper panicle traits for improving grain filling under high temperature. A total of 40 Korean rice cultivars were grouped according to maturation period and exposed to high temperature during grain filling stage in greenhouse with ventilating fans. Average temperature in greenhouse was 1.1~1.5oC higher than ambient condition. Main panicle traits such as number of spikelets per panicle, number of primary rachis branches(PRBs) and secondary rachis branches(SRBs) per panicle, number of spikelets setting on PRBs and SRBs were counted after harvest and their relationship with grain ripened ratio was investigated. Grain ripened ratio under high temperature showed significant negative correlations with number of spikelets per panicle, number of total rachis branches, number of SRBs, number of total and average spikelets setting on SRBs, and ratio of number of SRBs to number of PRBs. Especially, number of total and average spikelets setting on SRBs showed highly negative correlations with ripened grain ratio, which implies grain filling under high temperature might have been more severely decreased in the cultivars with bigger sink size due to higher number of spikelets setting on SRBs.

Acute ST-elevation myocardial infarction due to prosthetic valve endocarditis after transcatheter aortic valve implantation

( Jun Hwan Cho ),( Jung-kyu Han ),( Han-mo Yang ),( Bon-kwon Koo ),( Hyo-soo Kim ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4

Lnk is an important modulator of insulin-like growth factor-1/Akt/peroxisome proliferator-activated receptor-gamma axis during adipogenesis of mesenchymal stem cells

Jun Hee Lee,Sang Hun Lee,Hyang Seon Lee,Seung Taek Ji,Seok Yun Jung,Jae Ho Kim,Sun Sik Bae,Sang-Mo Kwon 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.5

Adipogenic differentiation of mesenchymal stem cells (MSCs) is critical for metabolic homeostasis and nutrient signaling during development. However, limited information is available on the pivotal modulators of adipogenic differentiation of MSCs. Adaptor protein Lnk (Src homology 2B3 [SH2B3]), which belongs to a family of SH2-containing proteins, modulates the bioactivities of different stem cells, including hematopoietic stem cells and endothelial progenitor cells. In this study, we investigated whether an interaction between insulin-like growth factor-1 receptor (IGF-1R) and Lnk regulated IGF-1-induced adipogenic differentiation of MSCs. We found that wild-type MSCs showed greater adipogenic differentiation potential than Lnk^–/– MSCs. An <i>ex vivo</i> adipogenic differentiation assay showed that Lnk^–/–MSCs had decreased adipogenic differentiation potential compared with wild-type MSCs. Interestingly, we found that Lnk formed a complex with IGF-1R and that IGF-1 induced the dissociation of this complex. In addition, we observed that IGF-1-induced increase in the phosphorylation of Akt and mammalian target of rapamycin was triggered by the dissociation of the IGF-1R–Lnk complex. Expression levels of a pivotal transcription factor peroxisome proliferatoractivated receptor gamma (PPAR-γ) and its adipogenic target genes (LPL and FABP4) significantly decreased in Lnk^–/–MSCs. These results suggested that Lnk adaptor protein regulated the adipogenesis of MSCs through the IGF-1/Akt/PPAR-γ pathway.

Special Issue of Professor Kiehwa Lee`s Retirement: Geophysical Environments of the Korean Peninsula : Articles ; Interpretation on GDS (Geomagnetic Depth Sounding) Data in and around the Korean Peninsula through the 3-D Sea Effect Modeling

( Jun Mo Yang ),( Byung Doo Kwon ) 대한지구물리학회 2006 지구물리 Vol.9 No.3